{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:16:45Z","timestamp":1791598605528,"version":"4.3.4"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0086155","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T23:38:51Z","timestamp":1390520331000},"page":"e86155","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Chronic Kidney Disease Is Characterized by \u201cDouble Trouble\u201d Higher Pulse Pressure plus Night-Time Systolic Blood Pressure and More Severe Cardiac Damage"],"prefix":"10.1371","volume":"9","author":[{"given":"Massimiliano","family":"Fedecostante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Spannella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Cola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Dess\u00ec-Fulgheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Sarzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,23]]},"reference":[{"key":"ref1","unstructured":"(2000) U.S. Renal Data System, USRDS 2000 Annual Data Report, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, June 2000. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, June 2000."},{"issue":"suppl 1","key":"ref2","first-page":"S1","article-title":"K\/DOQI Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification and Stratification","volume":"39","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","article-title":"Prevalence of Chronic Kidney Disease in the USA","volume":"298","author":"J Coresh","year":"2007","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0140-6736(05)17789-7","article-title":"Chronic Kidney Disease: the global challenge","volume":"365","author":"A Meguid El Nahas","year":"2005","journal-title":"Lancet"},{"key":"ref5","first-page":"401","article-title":"Epidemiologia della malattia renale cronica in Italia: stato dell'arte e contributo dello studio CARHES","volume":"28","author":"L De Nicola","year":"2011","journal-title":"G Ital Nefrol"},{"key":"ref6","unstructured":"(2007) U.S. Renal Data System, USRDS 2007 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2007."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1093\/ndt\/gfs054","article-title":"Pre-hypertension as a significant predictor of chronic kidney disease in a general population: the Ohasama Study","volume":"27","author":"A Kanno","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0272-6386(96)90380-7","article-title":"Prevalence of hypertension in 1,795 subjects with chronic renal disease: the modification of diet in renal disease study baseline cohort. Modification of Diet in Renal Disease Study Group","volume":"28","author":"VM Buckalew Jr","year":"1996","journal-title":"Am J Kidney Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1001\/archinte.161.9.1207","article-title":"Prevalence of high blood pressure and elevated serum creatinine level in the United States: findings from the third National Health and Nutrition Examination Survey (1988\u20131994)","volume":"161","author":"J Coresh","year":"2001","journal-title":"Arch Intern Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1097\/00004872-200211000-00017","article-title":"Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study","volume":"20","author":"T Ohkubo","year":"2002","journal-title":"J Hypertens"},{"issue":"8607","key":"ref11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(88)92867-X","article-title":"Dippers and non-dippers","volume":"13; 2","author":"E O'Brien","year":"1988","journal-title":"Lancet"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/01.HYP.24.6.793","article-title":"Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension","volume":"24","author":"P Verdecchia","year":"1994","journal-title":"Hypertension"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1524-6175.2001.00445.x","article-title":"Prognostic value of direct, continuous ambulatory blood pressure monitoring in essential hypertension","volume":"3","author":"RS Khattar","year":"2001","journal-title":"J Clin Hypertens"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1161\/HYPERTENSIONAHA.109.135822","article-title":"Nocturia, Nocturnal Activity, and Non dipping","volume":"54","author":"R Agarwal","year":"2009","journal-title":"Hypertension"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.mcna.2004.12.001","article-title":"Etiology and management of hypertension in chronic kidney disease","volume":"89","author":"MJ Andersen","year":"2005","journal-title":"Med Clin North Am"},{"key":"ref16","first-page":"1462","article-title":"2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"28","author":"G Mancia","year":"2007","journal-title":"Eur Heart J"},{"key":"ref17","first-page":"30","article-title":"Nocturnal blood pressure fall on ambulatory monitoring in a large international database","volume":"29","author":"JA Staessen","year":"1997","journal-title":"The \u201cAd Hoc\u2019 Working Group. Hypertension"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1751-7176.2008.07572.x","article-title":"Predictive validity of a medication adherence measure in an outpatient setting","volume":"10","author":"DE Morisky","year":"2008","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/HYPERTENSIONAHA.107.101659","article-title":"Novel use of Kaplan-Meier methods to explain age and gender differences in hypertension control rates","volume":"51","author":"KR Bailey","year":"2008","journal-title":"Hypertension"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0272-6386(99)70254-4","article-title":"Circadian rhythm of natriuresis is disturbed in non-dipper type of essential hypertension","volume":"33","author":"T Fujii","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.HYP.28.1.139","article-title":"High sodium sensitivity implicates nocturnal hypertension in essential hypertension","volume":"28","author":"T Uzu","year":"1996","journal-title":"Hypertension"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1161\/01.CIR.96.6.1859","article-title":"Sodium restriction shifts circadian rhythm of blood pressure from non dipper to dipper in essential hypertension","volume":"96","author":"T Uzu","year":"1997","journal-title":"Circulation"},{"key":"ref23","unstructured":"Kimura G, Brenner BM (1995) The renal basis for salt sensitivity in hypertension. In: Hypertension: Pathophysiology, Diagnosis and Management, ed. Laragh JH, Brenner BM. Raven Press: New York. pp. 1569\u20131588."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1097\/00004872-199715100-00002","article-title":"Implications of linear pressure-natriuresis relationship and importance of sodium sensitivity in hypertension","volume":"15","author":"G Kimura","year":"1997","journal-title":"J Hypertens"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1523-1755.2004.00419.x","article-title":"Nocturnal blood pressure is elevated with natriuresis and proteinuria as renal function deteriorates in nephropathy","volume":"65","author":"M Fukuda","year":"2004","journal-title":"Kidney Int"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1681\/ASN.2011111062","article-title":"Renal Denervation in Moderate to Severe CKD","volume":"23","author":"D Hering","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/ndt\/gfm660","article-title":"Associations between vascular calcification, arterial stiffness and bone mineral density in chronic kidney disease","volume":"23","author":"ND Toussaint","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/01.CIR.103.9.1245","article-title":"Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study","volume":"103","author":"SS Franklin","year":"2001","journal-title":"Circulation"},{"key":"ref29","unstructured":"Nichols WW, O'Rourke MF (1998) McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles 4th ed. Edward Arnold, Hodder Headline Group: London."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1161\/01.CIR.0000160923.04524.5B","article-title":"Prognostic value of ambulatory and home blood pressures compared with office blood pressure in the general population: Follow-up results from the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study","volume":"111","author":"R Sega","year":"2005","journal-title":"Circulation"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/jhh.2009.9","article-title":"Night-day blood pressure ratio and dipping pattern as predictors of death and cardiovascular events in hypertension","volume":"23","author":"RH Fagard","year":"2009","journal-title":"J Hum Hypertens"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1161\/HYPERTENSIONAHA.109.133900","article-title":"Predictive Role of the Nighttime Blood Pressure","volume":"57","author":"TW Hansen","year":"2011","journal-title":"Hypertension"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/HJH.0b013e32834de621","article-title":"Ambulatory blood pressure monitoring in Australia: 2011 consensus position statement","volume":"30","author":"GA Head","year":"2012","journal-title":"J Hypertens"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0086155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T07:41:52Z","timestamp":1540021312000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0086155"}},"subtitle":[],"editor":[{"given":"Partha","family":"Mukhopadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,23]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0086155","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,23]]}}}