{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:55:07Z","timestamp":1792601707728,"version":"4.5.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0086223","type":"journal-article","created":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T16:34:15Z","timestamp":1390581255000},"page":"e86223","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":88,"title":["Mealtime, Temporal, and Daily Variability of the Human Urinary and Plasma Metabolomes in a Tightly Controlled Environment"],"prefix":"10.1371","volume":"9","author":[{"given":"Kyoungmi","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Mall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacie","family":"Hitchcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi I.","family":"Wettersten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Daniel","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11306-005-1102-8","article-title":"Metabolomics: building on a century of biochemistry to guide human health","volume":"1","author":"JB German","year":"2005","journal-title":"Metabolomics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrneph.2011.152","article-title":"Metabolomics in the study of kidney diseases","volume":"8","author":"RH Weiss","year":"2011","journal-title":"Nat Rev Nephrology"},{"key":"ref3","first-page":"584","article-title":"The promise of metabolomics in cancer molecular therapeutics","volume":"6","author":"TW Fan","year":"2004","journal-title":"Curr Opin Mol Ther"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.urolonc.2011.05.013","article-title":"Urine metabolomics for kidney cancer detection and biomarker discovery","volume":"29","author":"S Ganti","year":"2011","journal-title":"Urol Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature12564","article-title":"Criteria for the use of omics-based predictors in clinical trials","volume":"502","author":"LM McShane","year":"2013","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1373\/clinchem.2012.184598","article-title":"New opportunities from the cancer metabolome","volume":"59","author":"OA Aboud","year":"2012","journal-title":"Clinical Chemistry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3945\/ajcn.2009.28234","article-title":"Effects of a prolonged standardized diet on normalizing the human metabolome","volume":"90","author":"JH Winnike","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1073\/pnas.1114410109","article-title":"The human circadian metabolome","volume":"109","author":"R Dallmann","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1021\/pr900344m","article-title":"Individual human phenotypes in metabolic space and time","volume":"8","author":"P Bernini","year":"2009","journal-title":"J Proteome Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1073\/pnas.0705685105","article-title":"Evidence of different metabolic phenotypes in humans","volume":"105","author":"M Assfalg","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1021\/pr2005764","article-title":"Stability and robustness of human metabolic phenotypes in response to sequential food challenges","volume":"11","author":"SS Heinzmann","year":"2012","journal-title":"J Proteome Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1021\/jf0403282","article-title":"A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion","volume":"53","author":"Y Wang","year":"2005","journal-title":"J Agric Food Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1021\/pr060265y","article-title":"Susceptibility of human metabolic phenotypes to dietary modulation","volume":"5","author":"C Stella","year":"2006","journal-title":"J Proteome Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.1021\/jf061016x","article-title":"Metabonomics approach to determine metabolic differences between green tea and black tea consumption","volume":"54","author":"FA Van Dorsten","year":"2006","journal-title":"J Agric Food Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1681\/ASN.2008050507","article-title":"Unified criteria for ultrasonographic diagnosis of ADPKD","volume":"20","author":"Y Pei","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1365-313X.2009.04083.x","article-title":"Broad connections in the Arabidopsis seed metabolic network revealed by metabolite profiling of an amino acid catabolism mutant","volume":"61","author":"L Gu","year":"2010","journal-title":"Plant J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"D521","DOI":"10.1093\/nar\/gkl923","article-title":"HMDB: the Human Metabolome Database","volume":"35","author":"DS Wishart","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1021\/pr200093w","article-title":"Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1)","volume":"10","author":"WR Wikoff","year":"2011","journal-title":"J Proteome Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.1021\/ac0708588","article-title":"Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles","volume":"79","author":"CM Slupsky","year":"2007","journal-title":"Anal Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/ajcn\/84.3.531","article-title":"Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans","volume":"84","author":"MC Walsh","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1093\/humrep\/deq011","article-title":"Effects of menstrual cycle phase on metabolomic profiles in premenopausal women","volume":"25","author":"M Wallace","year":"2010","journal-title":"Hum Reprod"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1093\/ajcn\/86.6.1687","article-title":"Influence of acute phytochemical intake on human urinary metabolomic profiles","volume":"86","author":"MC Walsh","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1074\/mcp.M800165-MCP200","article-title":"Urine metabolomics analysis for kidney cancer detection and biomarker discovery","volume":"8","author":"K Kim","year":"2009","journal-title":"Mol Cell Proteomics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1158\/0008-5472.CAN-11-3105","article-title":"Kidney tumor biomarkers revealed by simultaneous multiple matrix metabolomics analysis","volume":"72","author":"S Ganti","year":"2012","journal-title":"Cancer Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11306-010-0234-7","article-title":"Standardization of factors that influence human urine metabolomics","volume":"7","author":"LG Rasmussen","year":"2011","journal-title":"Metabolomics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1096\/fj.11-198093","article-title":"The dynamic range of the human metabolome revealed by challenges","volume":"26","author":"S Krug","year":"2012","journal-title":"FASEB J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jpba.2009.06.033","article-title":"Methodological aspects for metabolome visualization and characterization: a metabolomic evaluation of the 24 h evolution of human urine after cocoa powder consumption","volume":"51","author":"R Llorach-Asuncion","year":"2010","journal-title":"J Pharm Biomed Anal"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1021\/pr900470a","article-title":"An LC-MS-based metabolomics approach for exploring urinary metabolome modifications after cocoa consumption","volume":"8","author":"R Llorach","year":"2009","journal-title":"J Proteome Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/nbm.1176","article-title":"Gender-related and age-related urinalysis of healthy subjects by NMR-based metabonomics","volume":"21","author":"NG Psihogios","year":"2008","journal-title":"NMR Biomed"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0086223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T21:05:14Z","timestamp":1565125514000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0086223"}},"subtitle":[],"editor":[{"given":"Lorraine","family":"Brennan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,24]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0086223","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,24]]}}}