{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:06:19Z","timestamp":1792389979531,"version":"4.4.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0086252","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T21:26:16Z","timestamp":1390944376000},"page":"e86252","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association Study to Evaluate FoxO1 and FoxO3 Gene in CHD in Han Chinese"],"prefix":"10.1371","volume":"9","author":[{"given":"Ying","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maowei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/07853890.2011.645498","article-title":"Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease","volume":"45","author":"MM Bachschmid","year":"2013","journal-title":"Ann Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s11883-012-0237-0","article-title":"Mitochondrial reactive oxygen species and risk of atherosclerosis","volume":"14","author":"M Hulsmans","year":"2012","journal-title":"Curr Atheroscler Rep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrm3507","article-title":"FOXOs: signalling integrators for homeostasis maintenance","volume":"14","author":"A Eijkelenboom","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1242\/jcs.001222","article-title":"Dynamic FoxO transcription factors","volume":"120","author":"H Huang","year":"2007","journal-title":"J Cell Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/978-1-4419-1599-3_18","article-title":"The \u201cO\u201d class: crafting clinical care with FoxO transcription factors","volume":"665","author":"K Maiese","year":"2009","journal-title":"Adv Exp Med Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.2337\/db11-1658","article-title":"Reactive oxygen species signaling facilitates FOXO-3a\/FBXO-dependent vascular BK channel beta1 subunit degradation in diabetic mice","volume":"61","author":"T Lu","year":"2012","journal-title":"Diabetes"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.diabres.2012.04.013","article-title":"Increase of INS-1 cell apoptosis under glucose fluctuation and the involvement of FOXO-SIRT pathway","volume":"98","author":"M Kim","year":"2012","journal-title":"Diabetes Res Clin Pract"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"7468","DOI":"10.1074\/jbc.M110.179242","article-title":"FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress","volume":"286","author":"A Sengupta","year":"2011","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e1003141","DOI":"10.1371\/journal.pgen.1003141","article-title":"Diapause formation and downregulation of insulin-like signaling via DAF-16\/FOXO delays axonal degeneration and neuronal loss","volume":"8","author":"A Calixto","year":"2012","journal-title":"PLoS Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.canlet.2012.09.017","article-title":"Cancer genetics and genomics of human FOX family genes","volume":"328","author":"M Katoh","year":"2013","journal-title":"Cancer Lett"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.cmet.2012.04.007","article-title":"TOR signaling and rapamycin influence longevity by regulating SKN-1\/Nrf and DAF-16\/FoxO","volume":"15","author":"S Robida-Stubbs","year":"2012","journal-title":"Cell Metab"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/gcc.2870110203","article-title":"Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family","volume":"11","author":"P Parry","year":"1994","journal-title":"Genes Chromosomes Cancer"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/ng1193-230","article-title":"Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma","volume":"5","author":"N Galili","year":"1993","journal-title":"Nat Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1186\/1471-2350-8-S1-S13","article-title":"Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study","volume":"8 Suppl 1","author":"KL Lunetta","year":"2007","journal-title":"BMC Med Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"13987","DOI":"10.1073\/pnas.0801030105","article-title":"FOXO3A genotype is strongly associated with human longevity","volume":"105","author":"BJ Willcox","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1073\/pnas.0809594106","article-title":"Association of FOXO3A variation with human longevity confirmed in German centenarians","volume":"106","author":"F Flachsbart","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1089\/rej.2008.0827","article-title":"Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study","volume":"12","author":"CV Anselmi","year":"2009","journal-title":"Rejuvenation Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/01.hjh.0000203846.34314.94","article-title":"High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis","volume":"24","author":"DP Relling","year":"2006","journal-title":"J Hypertens"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/CIRCULATIONAHA.106.637124","article-title":"Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling","volume":"114","author":"YG Ni","year":"2006","journal-title":"Circulation"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10528-007-9137-3","article-title":"Oligonucleotide microarray analysis of genes regulating apoptosis in chronically ischemic and postinfarction myocardium","volume":"46","author":"J Dabek","year":"2008","journal-title":"Biochem Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/CIRCRESAHA.107.163428","article-title":"Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors","volume":"102","author":"HJ Evans-Anderson","year":"2008","journal-title":"Circ Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1172\/JCI31757","article-title":"Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins","volume":"117","author":"HH Li","year":"2007","journal-title":"J Clin Invest"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"29864","DOI":"10.1074\/jbc.M502149200","article-title":"Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia","volume":"280","author":"MR Abid","year":"2005","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1210\/en.2005-0162","article-title":"Regulation of the proapoptotic factor FOXO1 (FKHR) in cardiomyocytes by growth factors and alpha1-adrenergic agonists","volume":"146","author":"JB Morris","year":"2005","journal-title":"Endocrinology"},{"key":"ref26","first-page":"69","article-title":"Generation of transgenic mice for cardiovascular research","volume":"129","author":"XL Tian","year":"2006","journal-title":"Methods Mol Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.febslet.2007.11.025","article-title":"The FoxO transcription factors and metabolic regulation","volume":"582","author":"J Nakae","year":"2008","journal-title":"FEBS Lett"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/CIRCRESAHA.112.277442","article-title":"FoxO1 and FoxM1 transcription factors have antagonistic functions in neonatal cardiomyocyte cell-cycle withdrawal and IGF1 gene regulation","volume":"112","author":"A Sengupta","year":"2013","journal-title":"Circ Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1172\/JCI60329","article-title":"Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice","volume":"122","author":"PK Battiprolu","year":"2012","journal-title":"J Clin Invest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1016\/j.ajpath.2011.01.005","article-title":"PGC-1alpha promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice","volume":"178","author":"T Geng","year":"2011","journal-title":"Am J Pathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"13944","DOI":"10.1074\/jbc.M111.332767","article-title":"Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene","volume":"287","author":"L Qiang","year":"2012","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.1074\/jbc.M710610200","article-title":"FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts","volume":"283","author":"CB Chiribau","year":"2008","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/1358863X07083392","article-title":"Arterial aging: pathophysiological principles","volume":"12","author":"MF O'Rourke","year":"2007","journal-title":"Vasc Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/CIRCRESAHA.111.261388","article-title":"Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence","volume":"111","author":"JC Wang","year":"2012","journal-title":"Circ Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1161\/01.RES.0000258450.44413.96","article-title":"Mitochondrial dysfunction in atherosclerosis","volume":"100","author":"NR Madamanchi","year":"2007","journal-title":"Circ Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1161\/01.HYP.0000142232.29764.a7","article-title":"Modulation of oxidant and antioxidant enzyme expression and function in vascular cells","volume":"44","author":"S Wassmann","year":"2004","journal-title":"Hypertension"},{"key":"ref37","first-page":"110","article-title":"Interaction between inflammation and thrombosis in acute coronary syndrome","volume":"61","author":"OI Lytvyn","year":"2004","journal-title":"Kardiol Pol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1001\/archinte.168.20.2245","article-title":"Inflammatory, lipid, thrombotic, and genetic markers of coronary heart disease risk in the women&apos;s health initiative trials of hormone therapy","volume":"168","author":"JE Rossouw","year":"2008","journal-title":"Arch Intern Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s11883-012-0267-7","article-title":"Novel immune signals and atherosclerosis","volume":"14","author":"H Iwata","year":"2012","journal-title":"Curr Atheroscler Rep"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11882-011-0236-1","article-title":"Accelerated atherosclerosis in systemic lupus erythematosus: role of proinflammatory cytokines and therapeutic approaches","volume":"12","author":"M Frieri","year":"2012","journal-title":"Curr Allergy Asthma Rep"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.2538","article-title":"Atherosclerosis: current pathogenesis and therapeutic options","volume":"17","author":"C Weber","year":"2011","journal-title":"Nat Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1161\/ATVBAHA.107.155606","article-title":"Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE\u2212\/\u2212 mice","volume":"28","author":"C Cuaz-Perolin","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1080\/08916930701464913","article-title":"Immune regulation by Foxo transcription factors","volume":"40","author":"SL Peng","year":"2007","journal-title":"Autoimmunity"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3132\/dvdr.2005.018","article-title":"Inflammation, thrombosis and acute coronary syndromes","volume":"2","author":"AM Carter","year":"2005","journal-title":"Diab Vasc Dis Res"},{"key":"ref45","first-page":"449","article-title":"NF-kappaB in Aging and Disease","volume":"2","author":"JS Tilstra","year":"2011","journal-title":"Aging Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"MS Hayden","year":"2008","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2119\/2007-00021.Kuo","article-title":"Altered FOXO1 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients","volume":"13","author":"CC Kuo","year":"2007","journal-title":"Mol Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/CS20080113","article-title":"FoxO proteins: cunning concepts and considerations for the cardiovascular system","volume":"116","author":"K Maiese","year":"2009","journal-title":"Clin Sci (Lond)"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"MF Gregor","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.4161\/cc.8.16.9386","article-title":"NFkappaB-mediated metabolic inflammation in peripheral tissues versus central nervous system","volume":"8","author":"D Cai","year":"2009","journal-title":"Cell Cycle"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1172\/JCI200112876","article-title":"The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression","volume":"108","author":"J Nakae","year":"2001","journal-title":"J Clin Invest"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"36324","DOI":"10.1074\/jbc.M003616200","article-title":"Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity","volume":"275","author":"D Schmoll","year":"2000","journal-title":"J Biol Chem"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"33705","DOI":"10.1074\/jbc.M101215200","article-title":"Gene- and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like growth factor binding protein-1 and phosphoenolpyruvate carboxykinase transcription. Roles of forkhead and insulin response sequences","volume":"276","author":"D Yeagley","year":"2001","journal-title":"J Biol Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0086252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T03:23:07Z","timestamp":1565148187000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0086252"}},"subtitle":[],"editor":[{"given":"Balraj","family":"Mittal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,28]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0086252","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,28]]}}}