{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:48:51Z","timestamp":1784616531200,"version":"3.55.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0086353","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T21:28:08Z","timestamp":1390944488000},"page":"e86353","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":50,"title":["A1M\/\u03b11-Microglobulin Protects from Heme-Induced Placental and Renal Damage in a Pregnant Sheep Model of Preeclampsia"],"prefix":"10.1371","volume":"9","author":[{"given":"Lena","family":"Wester-Rosenl\u00f6f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Cassl\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefin","family":"Axelsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneli","family":"Edstr\u00f6m-H\u00e4gerwall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Gram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madlene","family":"Holmqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E.","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ir\u00e9ne","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Marsal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"M\u00f6rgelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Rippe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurbj\u00f6rg","family":"Rutardottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnaz","family":"Shohani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"\u00c5kerstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan R.","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(00)03577-7","article-title":"Pathogenesis and genetics of pre-eclampsia","volume":"357","author":"JM Roberts","year":"2001","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0140-6736(99)00284-6","article-title":"Is oxidative stress the link in the two-stage model of pre-eclampsia?","volume":"354","author":"JM Roberts","year":"1999","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/S0140-6736(00)04694-8","article-title":"Prevention of pre-eclampsia","volume":"357","author":"AH Shennan","year":"2001","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"472354","DOI":"10.1155\/2011\/472354","article-title":"Differential gene expression analysis of placentas with increased vascular resistance and pre-eclampsia using whole-genome microarrays","volume":"2011","author":"M Centlow","year":"2011","journal-title":"J Pregnancy"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/01.RES.0000024411.22110.AA","article-title":"Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia","volume":"90","author":"TH Hung","year":"2002","journal-title":"Circ Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0735-6757(02)42241-3","article-title":"A current concept of eclampsia","volume":"21","author":"H Lipstein","year":"2003","journal-title":"Am J Emerg Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.preghy.2012.01.001","article-title":"The placenta in preeclampsia","volume":"2","author":"JM Roberts","year":"2012","journal-title":"Pregnancy Hypertens"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.fertnstert.2007.09.030","article-title":"Placental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changes","volume":"90","author":"M Centlow","year":"2008","journal-title":"Fertil Steril"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1089\/ars.2009.2799","article-title":"Toxicological consequences of extracellular hemoglobin: biochemical and physiological perspectives","volume":"12","author":"PW Buehler","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nm1202-799","article-title":"Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease","volume":"8","author":"CD Reiter","year":"2002","journal-title":"Nat Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.placenta.2011.01.017","article-title":"Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by alpha1-microglobulin","volume":"32","author":"K May","year":"2011","journal-title":"Placenta"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.freeradbiomed.2009.10.052","article-title":"Increased levels of cell-free hemoglobin, oxidation markers, and the antioxidative heme scavenger alpha(1)-microglobulin in preeclampsia","volume":"48","author":"MG Olsson","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"520 e521","DOI":"10.1016\/j.ajog.2011.01.058","article-title":"Fetal hemoglobin and alpha1-microglobulin as first- and early second-trimester predictive biomarkers for preeclampsia","volume":"204","author":"UD Anderson","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-2007-1016248","article-title":"Endothelial dysfunction in preeclampsia","volume":"16","author":"JM Roberts","year":"1998","journal-title":"Semin Reprod Endocrinol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.placenta.2008.11.009","article-title":"The two stage model of preeclampsia: variations on the theme","volume":"30 Suppl A","author":"JM Roberts","year":"2009","journal-title":"Placenta"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1080\/15216540500380871","article-title":"Hemoglobin and heme scavenging","volume":"57","author":"P Ascenzi","year":"2005","journal-title":"IUBMB Life"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1089\/ars.2009.2760","article-title":"Evolutionary aspects of hemoglobin scavengers","volume":"12","author":"KB Wicher","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1089\/ars.2011.4282","article-title":"Pathological conditions involving extracellular hemoglobin: molecular mechanisms, clinical significance, and novel therapeutic opportunities for alpha(1)-microglobulin","volume":"17","author":"MG Olsson","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1080\/10715760802337265","article-title":"The lipocalin alpha1-microglobulin protects erythroid K562 cells against oxidative damage induced by heme and reactive oxygen species","volume":"42","author":"MG Olsson","year":"2008","journal-title":"Free Radic Res"},{"key":"ref20","unstructured":"\u00c5kerstr\u00f6m B, L\u00f6gdberg L. (2006) Alpha(1)-microglobulin. In: \u00c5kerstr\u00f6m B., Borregaard N., Flower DR., JS S, editors. Lipocalins. Georgetown, TX: Landes Bioscience. pp. 110\u2013120."},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"\u00c5kerstr\u00f6m B, Borregaard N, Flower DR, Salier JS. (2006) Lipocalins. GeorgetownTX: Landes Bioscience. 204 p.","DOI":"10.1201\/9781498712736"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1067\/mlc.2001.112957","article-title":"Distribution of iodine 125-labeled alpha1-microglobulin in rats after intravenous injection","volume":"137","author":"J Larsson","year":"2001","journal-title":"J Lab Clin Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.freeradbiomed.2006.12.017","article-title":"Up-regulation of alpha1-microglobulin by hemoglobin and reactive oxygen species in hepatoma and blood cell lines","volume":"42","author":"MG Olsson","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/bmme.1997.2602","article-title":"The pathogenetic role of heme in pregnancy-induced hypertension-like disease in ewes","volume":"62","author":"G Talosi","year":"1997","journal-title":"Biochem Mol Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0002-9378(86)90111-0","article-title":"Pregnancy-induced hypertension: development of a model in the pregnant sheep","volume":"155","author":"CD Thatcher","year":"1986","journal-title":"Am J Obstet Gynecol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.theriogenology.2007.09.021","article-title":"The pregnant sheep as a model for human pregnancy","volume":"69","author":"JS Barry","year":"2008","journal-title":"Theriogenology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0301-2115(01)00351-7","article-title":"Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewes","volume":"99","author":"G Talosi","year":"2001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pep.2006.10.023","article-title":"Production of recombinant human alpha1-microglobulin and mutant forms involved in chromophore formation","volume":"53","author":"A Kwasek","year":"2007","journal-title":"Protein Expr Purif"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"31493","DOI":"10.1074\/jbc.M702624200","article-title":"The lipocalin alpha1-microglobulin has radical scavenging activity","volume":"282","author":"B \u00c5kerstr\u00f6m","year":"2007","journal-title":"J Biol Chem"},{"key":"ref30","unstructured":"Pourcelot L. (1974) Applications cliniques de l&apos;examen Doppler transcutane.; Peronneau P., editor. Paris: INSERM."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"F790","DOI":"10.1152\/ajprenal.00153.2012","article-title":"Rapid, dynamic changes in glomerular permeability to macromolecules during systemic angiotensin II (ANG II) infusion in rats","volume":"303","author":"J Axelsson","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"F237","DOI":"10.1152\/ajprenal.00154.2013","article-title":"Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeability","volume":"305","author":"J Axelsson","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1016\/S0021-9258(18)89147-5","article-title":"Immunological analysis of alpha 1-microglobulin in different mammalian and chicken serum. alpha 1-Microglobulin is 5\u20138 kilodaltons larger in primates","volume":"260","author":"B \u00c5kerstr\u00f6m","year":"1985","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0165-2427(99)00158-0","article-title":"Characterisation of monoclonal antibodies to ovine interleukin-6 and the development of a sensitive capture ELISA","volume":"73","author":"P McWaters","year":"2000","journal-title":"Vet Immunol Immunopathol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000232587","article-title":"Collagen VI is a subepithelial adhesive target for human respiratory tract pathogens","volume":"2","author":"M Bober","year":"2010","journal-title":"J Innate Immun"},{"key":"ref36","first-page":"H648","article-title":"Oxidative-stress response in vascular endothelial cells exposed to acellular hemoglobin solutions","volume":"269","author":"R Motterlini","year":"1995","journal-title":"Am J Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1089\/ars.2007.1787","article-title":"Heme, heme oxygenase, and ferritin: how the vascular endothelium survives (and dies) in an iron-rich environment","volume":"9","author":"J Balla","year":"2007","journal-title":"Antioxid Redox Signal"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ajh.20172","article-title":"Acute renal failure in a patient with paroxysmal nocturnal hemoglobinuria and autoimmune hemolytic anemia","volume":"78","author":"T Masuda","year":"2005","journal-title":"Am J Hematol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1177\/002215549804600803","article-title":"Alpha1-microglobulin is found both in blood and in most tissues","volume":"46","author":"T Bergg\u00e5rd","year":"1998","journal-title":"J Histochem Cytochem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1432-1033.1985.tb08660.x","article-title":"Rat alpha 1-microglobulin. Purification from urine and synthesis by hepatocyte monolayers","volume":"146","author":"B \u00c5kerstr\u00f6m","year":"1985","journal-title":"Eur J Biochem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.placenta.2005.10.013","article-title":"Comparative placentation: some interesting modifications for histotrophic nutrition \u2013 a review","volume":"27 Suppl A","author":"AC Enders","year":"2006","journal-title":"Placenta"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1182\/blood.V99.6.1894","article-title":"Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties","volume":"99","author":"M Allhorn","year":"2002","journal-title":"Blood"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.freeradbiomed.2004.12.013","article-title":"Redox properties of the lipocalin alpha1-microglobulin: reduction of cytochrome c, hemoglobin, and free iron","volume":"38","author":"M Allhorn","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e27505","DOI":"10.1371\/journal.pone.0027505","article-title":"Up-regulation of A1M\/alpha1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damage","volume":"6","author":"MG Olsson","year":"2011","journal-title":"PLoS One"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1667\/RR2213.1","article-title":"Bystander cell death and stress response is inhibited by the radical scavenger alpha(1)-microglobulin in irradiated cell cultures","volume":"174","author":"MG Olsson","year":"2010","journal-title":"Radiat Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1056\/NEJMoa055352","article-title":"Soluble endoglin and other circulating antiangiogenic factors in preeclampsia","volume":"355","author":"RJ Levine","year":"2006","journal-title":"N Engl J Med"},{"key":"ref47","first-page":"393","article-title":"In vivo rat model of preeclampsia","volume":"122","author":"SA Karumanchi","year":"2006","journal-title":"Methods Mol Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1002\/jps.21152","article-title":"Endotoxin limits in formulations for preclinical research","volume":"97","author":"P Malyala","year":"2008","journal-title":"J Pharm Sci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0167-4838(00)00164-3","article-title":"Immunocalins: a lipocalin subfamily that modulates immune and inflammatory responses","volume":"1482","author":"L L\u00f6gdberg","year":"2000","journal-title":"Biochim Biophys Acta"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0086353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T16:25:03Z","timestamp":1648139103000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0086353"}},"subtitle":[],"editor":[{"given":"David","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,28]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0086353","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,28]]}}}