{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:38:38Z","timestamp":1785260318560,"version":"3.55.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0086354","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T22:06:59Z","timestamp":1391119619000},"page":"e86354","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Amantadine Ameliorates Dopamine-Releasing Deficits and Behavioral Deficits in Rats after Fluid Percussion Injury"],"prefix":"10.1371","volume":"9","author":[{"given":"Eagle Yi-Kung","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi-Fen","family":"Tsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung-Tai","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jr.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ching","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-I","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Hsiao","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1080\/01688639708403871","article-title":"A review of mild head trauma. Part II: Clinical implications","volume":"19(3)","author":"LM Binder","year":"1997","journal-title":"J Clin Exp Neuropsychol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1179\/016164101101198334","article-title":"Impaired motor learning and diffuse axonal damage in motor and visual systems of the rat following traumatic brain injury","volume":"23(2\u20133)","author":"Y Ding","year":"2001","journal-title":"Neurol Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/00019052-199712000-00008","article-title":"Minor head injury","volume":"10(6)","author":"TM McMillan","year":"1997","journal-title":"Curr Opin Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1471-4159.2005.03382.x","article-title":"Controlled cortical impact injury affects dopaminergic transmission in the rat striatum","volume":"95(2)","author":"AK Wagner","year":"2005","journal-title":"J Neurochem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neulet.2004.09.026","article-title":"Time dependent alterations in dopamine tissue levels and metabolism after experimental traumatic brain injury in rats","volume":"372(1\u20132)","author":"JL Massucci","year":"2004","journal-title":"Neurosci Lett"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00001199-200208000-00004","article-title":"Amantadine to improve neurorecovery in traumatic brain injury-associated diffuse axonal injury: a pilot double-blind randomized trial","volume":"17(4)","author":"JM Meythaler","year":"2002","journal-title":"J Head Trauma Rehabil"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1080\/026990598122386","article-title":"Amantadine: a potential treatment for the minimally conscious state","volume":"12(7)","author":"RD Zafonte","year":"1998","journal-title":"Brain Inj"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1056\/NEJMoa1102609","article-title":"Placebo-controlled trial of amantadine for severe traumatic brain injury","volume":"366(9)","author":"JT Giacino","year":"2012","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1017\/S0012162206001472","article-title":"Medication in the treatment of the behavioural sequelae of traumatic brain injury","volume":"48(8)","author":"G Bates","year":"2006","journal-title":"Dev Med Child Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/02699058809150936","article-title":"Pharmacotherapy and the neurobehavioural sequelae of traumatic brain injury","volume":"2(2)","author":"CT Gualtieri","year":"1988","journal-title":"Brain Inj"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/00002060-199711000-00002","article-title":"Effects of methylphenidate on attentional function after traumatic brain injury. A randomized, placebo-controlled trial","volume":"76(6)","author":"J Whyte","year":"1997","journal-title":"Am J Phys Med Rehabil"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00001199-199806000-00007","article-title":"Recovery in pediatric brain injury: is psychostimulant medication beneficial?","volume":"13(3)","author":"SE Williams","year":"1998","journal-title":"J Head Trauma Rehabil"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Wang T, Huang XJ, Van KC, Went GT, Nguyen JT, <etal>et al<\/etal>.. (2013) Amantadine Improves Cognitive Outcome and Increases Neuronal Survival after Fluid Percussion TBI in Rats. J Neurotrauma.","DOI":"10.1089\/neu.2013.2917"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1345\/aph.1K284","article-title":"Amantadine enhancement of arousal and cognition after traumatic brain injury","volume":"42(2)","author":"E Sawyer","year":"2008","journal-title":"Ann Pharmacother"},{"key":"ref15","first-page":"285","article-title":"Amantadine improves water maze performance without affecting motor behavior following traumatic brain injury in rats","volume":"14(4)","author":"CE Dixon","year":"1999","journal-title":"Restor Neurol Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Matsushita Y, Shima K, Nawashiro H, Wada K, Tsuzuki N, <etal>et al<\/etal>.. (2000) Real time monitoring of glutamate following fluid percussion brain injury with hypoxia in the rat. Acta Neurochir Suppl 76: 207\u201312.","DOI":"10.1007\/978-3-7091-6346-7_42"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.brainres.2006.01.063","article-title":"Changes in localization of synaptophysin following fluid percussion injury in the rat brain","volume":"1078(1)","author":"H Shojo","year":"2006","journal-title":"Brain Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1089\/neu.1994.11.629","article-title":"Widespread metabolic depression and reduced somatosensory circuit activation following traumatic brain injury in rats","volume":"11(6)","author":"WD Dietrich","year":"1994","journal-title":"J Neurotrauma"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1096\/fj.07-8797com","article-title":"MPTP-induced deficits in striatal synaptic plasticity are prevented by glial cell line-derived neurotrophic factor expressed via an adeno-associated viral vector","volume":"22(1)","author":"YH Chen","year":"2008","journal-title":"FASEB J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1096\/fj.10-173625","article-title":"Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson&apos;s disease","volume":"25(4)","author":"CH Good","year":"2011","journal-title":"FASEB J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0165-0270(93)90094-8","article-title":"Principles of voltammetry and microelectrode surface states","volume":"48(3)","author":"KT Kawagoe","year":"1993","journal-title":"J Neurosci Methods"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0165-0270(02)00229-7","article-title":"Kinetic analysis of striatal clearance of exogenous dopamine recorded by chronoamperometry in freely-moving rats","volume":"121(1)","author":"J Sabeti","year":"2002","journal-title":"J Neurosci Methods"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s00210-003-0803-7","article-title":"Co-administration of dextromethorphan with morphine attenuates morphine rewarding effect and related dopamine releases at the nucleus accumbens","volume":"368(5)","author":"EY Huang","year":"2003","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data","volume":"31(1)","author":"A Ennaceur","year":"1988","journal-title":"Behav Brain Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0306-4522(83)90137-9","article-title":"Intracellular and extracellular electrophysiology of nigral dopaminergic neurons\u20133. Evidence for electrotonic coupling","volume":"10(2)","author":"AA Grace","year":"1983","journal-title":"Neuroscience"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.neuro.28.061604.135722","article-title":"Multiple dopamine functions at different time courses","volume":"30","author":"W Schultz","year":"2007","journal-title":"Annu Rev Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3233\/NRE-2002-17407","article-title":"Executive dysfunction following traumatic brain injury: neural substrates and treatment strategies","volume":"17(4)","author":"BC McDonald","year":"2002","journal-title":"NeuroRehabilitation"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biopsycho.2006.01.005","article-title":"Functions of frontostriatal systems in cognition: comparative neuropsychopharmacological studies in rats, monkeys and humans","volume":"73(1)","author":"Y Chudasama","year":"2006","journal-title":"Biol Psychol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.brainres.2010.10.096","article-title":"Traumatic brain injury reduces striatal tyrosine hydroxylase activity and potassium-evoked dopamine release in rats","volume":"1369","author":"SS Shin","year":"2011","journal-title":"Brain Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.neubiorev.2009.03.011","article-title":"Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis","volume":"33(7)","author":"JW Bales","year":"2009","journal-title":"Neurosci Biobehav Rev"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbr.2005.08.007","article-title":"Neglect of memory after dopaminergic lesions in monkeys","volume":"166(2)","author":"RM Ridley","year":"2006","journal-title":"Behav Brain Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1017\/S135561770397010X","article-title":"Left and right basal ganglia and frontal activity during language generation: contributions to lexical, semantic, and phonological processes","volume":"9(7)","author":"B Crosson","year":"2003","journal-title":"J Int Neuropsychol Soc"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"7723","DOI":"10.1523\/JNEUROSCI.1454-06.2006","article-title":"Dopamine D1\/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression","volume":"26(29)","author":"N Lemon","year":"2006","journal-title":"J Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cercor\/bhm026","article-title":"D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-Induced arc and zif268 expression in the hippocampus","volume":"18(1)","author":"N Granado","year":"2008","journal-title":"Cereb Cortex"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1097\/00001756-200210280-00013","article-title":"Traumatic brain injury reduces dopamine transporter protein expression in the rat frontal cortex","volume":"13(15)","author":"HQ Yan","year":"2002","journal-title":"Neuroreport"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0014-4886(90)90134-E","article-title":"Excitotoxicity of L-dopa and 6-OH-dopa: implications for Parkinson&apos;s and Huntington&apos;s diseases","volume":"108(3)","author":"JW Olney","year":"1990","journal-title":"Exp Neurol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0304-3940(89)90827-6","article-title":"Excitotoxicity of NMDA and kainic acid is modulated by nigrostriatal dopaminergic fibres","volume":"107(1\u20133)","author":"AG Chapman","year":"1989","journal-title":"Neurosci Lett"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/syn.890080406","article-title":"Dopaminergic modulation of excitotoxicity in rat striatum: evidence from nigrostriatal lesions","volume":"8(4)","author":"F Filloux","year":"1991","journal-title":"Synapse"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/cne.903210309","article-title":"Restoration of ascending noradrenergic projections by residual locus coeruleus neurons: compensatory response to neurotoxin-induced cell death in the adult rat brain","volume":"321(3)","author":"JM Fritschy","year":"1992","journal-title":"J Comp Neurol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0006-8993(86)90894-2","article-title":"Effects of intraventricular 6-hydroxydopamine on the dopaminergic innervation of striatum: histochemical and neurochemical analysis","volume":"376(1)","author":"SP Onn","year":"1986","journal-title":"Brain Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/jnr.20419","article-title":"Synaptosomal dopamine uptake in rat striatum following controlled cortical impact","volume":"80(1)","author":"MS Wilson","year":"2005","journal-title":"J Neurosci Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1046\/j.1471-4159.1996.67020593.x","article-title":"Modification of dopamine transporter function: effect of reactive oxygen species and dopamine","volume":"67(2)","author":"SB Berman","year":"1996","journal-title":"J Neurochem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1097\/00004647-199710000-00002","article-title":"Oxidative stress in closed-head injury: brain antioxidant capacity as an indicator of functional outcome","volume":"17(10)","author":"E Shohami","year":"1997","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1046\/j.1471-4159.2000.0752178.x","article-title":"Oxidative stress following traumatic brain injury in rats: quantitation of biomarkers and detection of free radical intermediates","volume":"75(5)","author":"VA Tyurin","year":"2000","journal-title":"J Neurochem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.expneurol.2011.02.013","article-title":"The dopamine and cAMP regulated phosphoprotein, 32 kDa (DARPP-32) signaling pathway: a novel therapeutic target in traumatic brain injury","volume":"229(2)","author":"JW Bales","year":"2011","journal-title":"Exp Neurol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.yfrne.2012.09.003","article-title":"Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise","volume":"33(3)","author":"JC Felger","year":"2012","journal-title":"Front Neuroendocrinol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/j.1471-4159.2008.05840.x","article-title":"Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury","volume":"108(4)","author":"AK Wagner","year":"2009","journal-title":"J Neurochem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0091-3057(94)90345-X","article-title":"Methylphenidate treatment following ablation-induced hemiplegia in rat: experience during drug action alters effects on recovery of function","volume":"48(3)","author":"AE Kline","year":"1994","journal-title":"Pharmacol Biochem Behav"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3940(00)00797-7","article-title":"Chronic methylphenidate treatment enhances water maze performance following traumatic brain injury in rats","volume":"280(3)","author":"AE Kline","year":"2000","journal-title":"Neurosci Lett"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1080\/0269905031000107179","article-title":"Neuropharmacology of TBI-induced plasticity","volume":"17(8)","author":"LB Goldstein","year":"2003","journal-title":"Brain Inj"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/01.PHM.0000128789.75375.D3","article-title":"Effects of methylphenidate on attention deficits after traumatic brain injury: a multidimensional, randomized, controlled trial","volume":"83(6)","author":"J Whyte","year":"2004","journal-title":"Am J Phys Med Rehabil"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1073\/pnas.98.4.1982","article-title":"Hyperactivity and impaired response habituation in hyperdopaminergic mice","volume":"98(4)","author":"X Zhuang","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/(SICI)1098-2396(199809)30:1<79::AID-SYN10>3.0.CO;2-K","article-title":"Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter","volume":"30(1)","author":"ZB Pristupa","year":"1998","journal-title":"Synapse"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2165\/00003088-198814010-00003","article-title":"Clinical pharmacokinetics of amantadine hydrochloride","volume":"14(1)","author":"FY Aoki","year":"1988","journal-title":"Clin Pharmacokinet"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0006-8993(94)90821-4","article-title":"Amantadine increases the extracellular dopamine levels in the striatum by re-uptake inhibition and by N-methyl-D-aspartate antagonism","volume":"662(1\u20132)","author":"K Mizoguchi","year":"1994","journal-title":"Brain Res"},{"key":"ref56","first-page":"222","article-title":"Effect of amantadine hydrochloride on symptoms of frontal lobe dysfunction in brain injury: case studies and review","volume":"9(2)","author":"MF Kraus","year":"1997","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1080\/02699050701553213","article-title":"Amantadine treatment following traumatic brain injury in children","volume":"21(9)","author":"SE Williams","year":"2007","journal-title":"Brain Inj"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.174.4007.408","article-title":"Dopamine: release from the brain in vivo by amantadine","volume":"174(4007)","author":"PF Von Voigtlander","year":"1971","journal-title":"Science"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0014-2999(72)90144-6","article-title":"Evaluation of amantadine as a releasing agent or uptake blocker for H 3 -dopamine in rat brain slices","volume":"20(2)","author":"RE Heikkila","year":"1972","journal-title":"Eur J Pharmacol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1523\/JNEUROSCI.5386-08.2009","article-title":"Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: live-cell imaging using total internal reflection fluorescence microscopy","volume":"29(10)","author":"CA Furman","year":"2009","journal-title":"J Neurosci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1089\/neu.1994.11.641","article-title":"Combined fluid percussion brain injury and entorhinal cortical lesion: a model for assessing the interaction between neuroexcitation and deafferentation","volume":"11(6)","author":"LL Phillips","year":"1994","journal-title":"J Neurotrauma"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/neu.1994.11.187","article-title":"The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury","volume":"11(2)","author":"RJ Hamm","year":"1994","journal-title":"J Neurotrauma"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0361-9230(96)00211-0","article-title":"Inhibitory effect of MK-801 on amantadine-induced dopamine release in the rat striatum","volume":"41(6)","author":"T Takahashi","year":"1996","journal-title":"Brain Res Bull"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0086354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T20:15:13Z","timestamp":1716495313000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0086354"}},"subtitle":[],"editor":[{"given":"Yong-hui","family":"Dang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,30]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0086354","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,30]]}}}