{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:53:46Z","timestamp":1790031226493,"version":"4.0.1"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0086702","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T21:45:21Z","timestamp":1391031921000},"page":"e86702","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Long-Term Alteration of Intestinal Microbiota in Patients with Ulcerative Colitis by Antibiotic Combination Therapy"],"prefix":"10.1371","volume":"9","author":[{"given":"Shigeo","family":"Koido","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Ohkusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Kajiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Shinozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Takakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Tsukinaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Odahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyokazu","family":"Yukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimi","family":"Mitobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Kajihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Tajiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1136\/gut.2003.026807","article-title":"Human lymphocyte stimulation with pouchitis flora is greater than with flora from a healthy pouch but is suppressed by metronidazole","volume":"53","author":"AJ Bell","year":"2004","journal-title":"Gut"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1099\/jmm.0.005801-0","article-title":"Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis","volume":"58","author":"T Ohkusa","year":"2009","journal-title":"J Med Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/gut.53.1.91","article-title":"Systemic antibodies towards mucosal bacteria in ulcerative colitis and Crohn&apos;s disease differentially activate the innate immune response","volume":"53","author":"E Furrie","year":"2004","journal-title":"Gut"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1440-1827.2012.02807.x","article-title":"Development of ulcerative colitis and its associated colorectal neoplasia as a model of the organ-specific chronic inflammation-carcinoma sequence","volume":"62","author":"I Okayasu","year":"2012","journal-title":"Pathol Int"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.trsl.2006.11.009","article-title":"Immune dysfunction in inflammatory bowel disease","volume":"149","author":"MG Neuman","year":"2007","journal-title":"Transl Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/00054725-200203000-00008","article-title":"Etiopathogenesis of inflammatory bowel disease: the importance of the pediatric perspective","volume":"8","author":"M Oliva-Hemker","year":"2002","journal-title":"Inflamm Bowel Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.3748\/wjg.v12.i30.4807","article-title":"Etiopathogenesis of inflammatory bowel diseases","volume":"12","author":"S Danese","year":"2006","journal-title":"World J Gastroenterol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/00001574-200411000-00010","article-title":"Increased incidence of inflammatory bowel disease: the price of the decline of infectious burden?","volume":"20","author":"H Feillet","year":"2004","journal-title":"Curr Opin Gastroenterol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1440-1746.2002.02834.x","article-title":"Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody","volume":"17","author":"T Ohkusa","year":"2002","journal-title":"J Gastroenterol Hepatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/gut.52.1.79","article-title":"Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis","volume":"52","author":"T Ohkusa","year":"2003","journal-title":"Gut"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1038\/ajg.2010.84","article-title":"Newly developed antibiotic combination therapy for ulcerative colitis: a double-blind placebo-controlled multicenter trial","volume":"105","author":"T Ohkusa","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1056\/NEJM199406303302601","article-title":"Cyclosporine in severe ulcerative colitis refractory to steroid therapy","volume":"330","author":"S Lichtiger","year":"1994","journal-title":"N Engl J Med"},{"key":"ref13","first-page":"393","article-title":"The value of rectal biopsy in the diagnosis of ulcerative colitis","volume":"30","author":"SG Matts","year":"1961","journal-title":"Q J Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"640","DOI":"10.2144\/00284bm06","article-title":"Isolating PCR-quality DNA from human feces with a soil DNA kit","volume":"28","author":"BG Clement","year":"2000","journal-title":"Biotechniques"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1099\/00207713-41-2-240","article-title":"Phylogenetic analysis of the genus Listeria based on reverse transcriptase sequencing of 16S rRNA","volume":"41","author":"MD Collins","year":"1991","journal-title":"Int J Syst Bacteriol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1590\/S0074-02762009000700011","article-title":"RFLP analysis of a PCR-amplified fragment of the 16S rRNA gene as a tool to identify Enterococcus strains","volume":"104","author":"EM Scheidegger","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1348-0421.2002.tb02731.x","article-title":"Phylogenetic analysis of the human gut microbiota using 16S rDNA clone libraries and strictly anaerobic culture-based methods","volume":"46","author":"H Hayashi","year":"2002","journal-title":"Microbiol Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/193855a0","article-title":"Numerical taxonomy","volume":"193","author":"PH Sneath","year":"1962","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1128\/AEM.62.4.1242-1247.1996","article-title":"PCR detection and quantitation of predominant anaerobic bacteria in human and animal fecal samples","volume":"62","author":"RF Wang","year":"1996","journal-title":"Appl Environ Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"JD Thompson","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/00001574-200107000-00005","article-title":"Intestinal microflora in human and experimental inflammatory bowel disease","volume":"17","author":"RB Sartor","year":"2001","journal-title":"Curr Opin Gastroenterol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1053\/j.gastro.2008.10.080","article-title":"Microbes in gastrointestinal health and disease","volume":"136","author":"AS Neish","year":"2009","journal-title":"Gastroenterology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1128\/AEM.64.10.3854-3859.1998","article-title":"Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria","volume":"64","author":"EG Zoetendal","year":"1998","journal-title":"Appl Environ Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/j.1365-2036.2005.02428.x","article-title":"Mucosa-associated bacteria in ulcerative colitis before and after antibiotic combination therapy","volume":"21","author":"T Nomura","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"ref25","first-page":"294","article-title":"Toll and Toll-like proteins: an ancient family of receptors signaling infection","volume":"2","author":"JL Imler","year":"2000","journal-title":"Rev Immunogenet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2249.2007.03531.x","article-title":"Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease","volume":"151","author":"B Szebeni","year":"2008","journal-title":"Clin Exp Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0086702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T20:45:15Z","timestamp":1597437915000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0086702"}},"subtitle":[],"editor":[{"given":"Fabio","family":"Cominelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,29]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0086702","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,29]]}}}