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Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/rabies\/location\/usa\/cost.html\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/rabies\/location\/usa\/cost.html<\/ext-link>. Accessed 2014 Jan 6."},{"key":"ref2","unstructured":"WHO (2013) WHO rabies fact sheet, no.99."},{"key":"ref3","first-page":"851","volume":"38","unstructured":"Lackay SN, Kuang Y, Fu ZF (2008) Rabies in small animals. Vet Clin North Am Small Anim Pract <volume>38<\/volume> : <fpage>851<\/fpage>\u2013\u2013<lpage>61<\/lpage>, ix. 10.1016\/j.cvsm.2008.03.003; 10.1016\/j.cvsm.2008.03.003."},{"key":"ref4","first-page":"1","article-title":"Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies: Recommendations of the advisory committee on immunization practices","volume":"59","author":"CE Rupprecht","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1586\/erv.10.105","article-title":"Experimental rabies vaccines for humans","volume":"9","author":"JP McGettigan","year":"2010","journal-title":"Expert Rev Vaccines"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e515","DOI":"10.1371\/journal.pntd.0000515","article-title":"Novel vaccines to human rabies","volume":"3","author":"HC Ertl","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.trstmh.2009.03.007","article-title":"Immunogenicity and booster efficacy of pre-exposure rabies vaccination","volume":"103","author":"C Strady","year":"2009","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1086\/605949","article-title":"Replication-deficient rabies virus-based vaccines are safe and immunogenic in mice and nonhuman primates","volume":"200","author":"J Cenna","year":"2009","journal-title":"Journal of Infectious Diseases"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"11533","DOI":"10.1128\/JVI.00615-12","article-title":"Protective vaccine-induced CD4(+) T cell-independent B cell responses against rabies infection","volume":"86","author":"CL Dorfmeier","year":"2012","journal-title":"J Virol"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Dorfmeier CL, Shen S, Tzvetkov EP, McGettigan JP (2013) Reinvestigating the role of IgM in rabies virus post-exposure vaccination. 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