{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:58:32Z","timestamp":1787021912849,"version":"build-2736575974"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0087284","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T17:02:50Z","timestamp":1391533370000},"page":"e87284","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Mobilization of Endogenous Bone Marrow Derived Endothelial Progenitor Cells and Therapeutic Potential of Parathyroid Hormone after Ischemic Stroke in Mice"],"prefix":"10.1371","volume":"9","author":[{"given":"Li-Li","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghina","family":"Alaaeddine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan Ping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/CIR.0b013e31823ac046","article-title":"Heart disease and stroke statistics\u20132012 update: a report from the American Heart Association","volume":"125","author":"VL Roger","year":"2012","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1474-4422(07)70031-5","article-title":"Preventing stroke: saving lives around the world","volume":"6","author":"K Strong","year":"2007","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.nbd.2012.03.002","article-title":"Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats","volume":"46","author":"L Wei","year":"2012","journal-title":"Neurobiol Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.1212\/WNL.0b013e31826959d2","article-title":"Stem cell therapy in ischemic stroke: role of IV and intra-arterial therapy","volume":"79","author":"V Misra","year":"2012","journal-title":"Neurology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3324\/haematol.12616","article-title":"Hematopoietic stem cell mobilization","volume":"93","author":"RM Lemoli","year":"2008","journal-title":"Haematologica"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/bmt.2008.410","article-title":"Improving stem cell mobilization strategies: future directions","volume":"43","author":"W Bensinger","year":"2009","journal-title":"Bone Marrow Transplant"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1161\/01.RES.85.3.221","article-title":"Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization","volume":"85","author":"T Asahara","year":"1999","journal-title":"Circ Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/ana.21919","article-title":"Endothelial progenitor cell transplantation improves long-term stroke outcome in mice","volume":"67","author":"Y Fan","year":"2010","journal-title":"Ann Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12015-010-9157-y","article-title":"Transplanted late outgrowth endothelial progenitor cells as cell therapy product for stroke","volume":"7","author":"C Moubarik","year":"2011","journal-title":"Stem Cell Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1172\/JCI17902","article-title":"HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver","volume":"112","author":"O Kollet","year":"2003","journal-title":"J Clin Invest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1634\/stemcells.2006-0333","article-title":"Mobilization of bone marrow-derived hematopoietic and endothelial stem cells after orthotopic liver transplantation and liver resection","volume":"24","author":"RM Lemoli","year":"2006","journal-title":"Stem Cells"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00415-006-0362-1","article-title":"Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization","volume":"254","author":"A Dunac","year":"2007","journal-title":"J Neurol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/01.CIR.0000058702.69484.A0","article-title":"Peripheral blood \u201cendothelial progenitor cells\u201d are derived from monocyte\/macrophages and secrete angiogenic growth factors","volume":"107","author":"J Rehman","year":"2003","journal-title":"Circulation"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/01.STR.0000149944.15406.16","article-title":"Endothelial progenitor cells during cerebrovascular disease","volume":"36","author":"U Ghani","year":"2005","journal-title":"Stroke"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1161\/hh0302.104460","article-title":"Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse","volume":"90","author":"ZG Zhang","year":"2002","journal-title":"Circ Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pneurobio.2011.08.005","article-title":"The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders","volume":"95","author":"CV Borlongan","year":"2011","journal-title":"Prog Neurobiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1111\/j.1742-4658.2009.07176.x","article-title":"Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke","volume":"276","author":"K Arai","year":"2009","journal-title":"FEBS J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1365-2184.2008.00486.x","article-title":"Stem cells and neurological diseases","volume":"41","author":"DC Hess","year":"2008","journal-title":"Cell Prolif"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nbt1281","article-title":"Therapeutic targeting of a stem cell niche","volume":"25","author":"GB Adams","year":"2007","journal-title":"Nat Biotechnol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.exphem.2008.03.014","article-title":"Parathyroid hormone effectively induces mobilization of progenitor cells without depletion of bone marrow","volume":"36","author":"S Brunner","year":"2008","journal-title":"Exp Hematol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1042\/BST20110615","article-title":"From parathyroid hormone to cytosolic Ca2+ signals","volume":"40","author":"CW Taylor","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"15455","DOI":"10.1074\/jbc.270.26.15455","article-title":"Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor","volume":"270","author":"TB Usdin","year":"1995","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1210\/endo.138.2.5031","article-title":"Evidence for a parathyroid hormone-2 receptor selective ligand in the hypothalamus","volume":"138","author":"TB Usdin","year":"1997","journal-title":"Endocrinology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3181\/00379727-176-41894","article-title":"Intact and carboxyterminal PTH do not cross the blood-cerebrospinal fluid barrier","volume":"176","author":"M Akmal","year":"1984","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1043-2760(02)00002-4","article-title":"Emerging functions for tuberoinfundibular peptide of 39 residues","volume":"14","author":"TB Usdin","year":"2003","journal-title":"Trends Endocrinol Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"E1670","DOI":"10.1152\/ajpendo.00287.2007","article-title":"Primary hyperparathyroidism is associated with increased circulating bone marrow-derived progenitor cells","volume":"293","author":"S Brunner","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.bbmt.2007.03.007","article-title":"Phase I trial of parathyroid hormone to facilitate stem cell mobilization","volume":"13","author":"KK Ballen","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"823","DOI":"10.2310\/JIM.0b013e318214edf8","article-title":"Parathyroid hormone and mobilization of circulating bone marrow-derived cells in uremic patients","volume":"59","author":"G Coppolino","year":"2011","journal-title":"J Investig Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1093\/cvr\/cvm080","article-title":"Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survival","volume":"77","author":"MM Zaruba","year":"2008","journal-title":"Cardiovasc Res"},{"key":"ref30","first-page":"523","article-title":"Parathyroid hormone reduces acute ischemic injury of the myocardium","volume":"163","author":"M Feola","year":"1986","journal-title":"Surg Gynecol Obstet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1161\/01.STR.26.8.1459","article-title":"Ministrokes in rat barrel cortex","volume":"26","author":"L Wei","year":"1995","journal-title":"Stroke"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1258\/ebm.2012.012261","article-title":"Blood gases and energy metabolites in mouse blood before and after cerebral ischemia: the effects of anesthetics","volume":"238","author":"TM Schwarzkopf","year":"2013","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.neuint.2010.09.014","article-title":"Lactate levels in the brain are elevated upon exposure to volatile anesthetics: a microdialysis study","volume":"57","author":"T Horn","year":"2010","journal-title":"Neurochem Int"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/0269881105062484","article-title":"Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways","volume":"21","author":"BA Chizh","year":"2007","journal-title":"J Psychopharmacol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"11055","DOI":"10.1073\/pnas.191353598","article-title":"Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity","volume":"98","author":"P Manzerra","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/jcbfm.1990.47","article-title":"A semiautomated method for measuring brain infarct volume","volume":"10","author":"RA Swanson","year":"1990","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/dneu.20674","article-title":"Enhanced neurogenesis and cell migration following focal ischemia and peripheral stimulation in mice","volume":"68","author":"WL Li","year":"2008","journal-title":"Dev Neurobiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuroscience.2004.08.050","article-title":"Design-based stereology in neuroscience","volume":"130","author":"C Schmitz","year":"2005","journal-title":"Neuroscience"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2013.04.011","article-title":"Citalopram enhances neurovascular regeneration and sensorimotor functional recovery after ischemic stroke in mice","volume":"247C","author":"AR Espinera","year":"2013","journal-title":"Neuroscience"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/sj.jcbfm.9600417","article-title":"Erythropoietin-induced neurovascular protection, angiogenesis, and cerebral blood flow restoration after focal ischemia in mice","volume":"27","author":"Y Li","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1037\/a0014157","article-title":"Behavioral deficits after distal focal cerebral ischemia in mice: Usefulness of adhesive removal test","volume":"123","author":"T Freret","year":"2009","journal-title":"Behav Neurosci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/sj.jcbfm.9600318","article-title":"Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice","volume":"27","author":"VR Whitaker","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuroscience.2013.03.045","article-title":"The regulatory role of NF-kappaB in autophagy-like cell death after focal cerebral ischemia in mice","volume":"244","author":"WL Li","year":"2013","journal-title":"Neuroscience"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/cvr\/cvr014","article-title":"Parathyroid hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4(+) stem cells into the ischaemic heart","volume":"90","author":"BC Huber","year":"2011","journal-title":"Cardiovasc Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"H1466","DOI":"10.1152\/ajpheart.00033.2010","article-title":"Comparison of parathyroid hormone and G-CSF treatment after myocardial infarction on perfusion and stem cell homing","volume":"298","author":"BC Huber","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e20219","DOI":"10.1371\/journal.pone.0020219","article-title":"CD34+ cells represent highly functional endothelial progenitor cells in murine bone marrow","volume":"6","author":"J Yang","year":"2011","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3940(99)00664-3","article-title":"Parathyroid hormone-related protein protects against kainic acid excitotoxicity in rat cerebellar granule cells by regulating L-type channel calcium flux","volume":"274","author":"ML Brines","year":"1999","journal-title":"Neurosci Lett"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/sj.jcbfm.9600172","article-title":"Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia","volume":"26","author":"AM Robin","year":"2006","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1460-9568.2004.03813.x","article-title":"Doublecortin expression levels in adult brain reflect neurogenesis","volume":"21","author":"S Couillard-Despres","year":"2005","journal-title":"Eur J Neurosci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrn2735","article-title":"Plasticity during stroke recovery: from synapse to behaviour","volume":"10","author":"TH Murphy","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"11759","DOI":"10.1073\/pnas.0812695106","article-title":"Imaging rapid redistribution of sensory-evoked depolarization through existing cortical pathways after targeted stroke in mice","volume":"106","author":"A Sigler","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.nbd.2011.10.020","article-title":"Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1alpha","volume":"45","author":"ME Ogle","year":"2012","journal-title":"Neurobiol Dis"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.expneurol.2006.09.006","article-title":"Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse","volume":"203","author":"V Bouet","year":"2007","journal-title":"Exp Neurol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jneumeth.2009.07.029","article-title":"Functional testing in a mouse stroke model induced by occlusion of the distal middle cerebral artery","volume":"184","author":"J Lubjuhn","year":"2009","journal-title":"J Neurosci Methods"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1\u201334) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"RM Neer","year":"2001","journal-title":"N Engl J Med"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/clinchem\/48.10.1731","article-title":"Kinetic analyses of parathyroid hormone clearance as measured by three rapid immunoassays during parathyroidectomy","volume":"48","author":"C Bieglmayer","year":"2002","journal-title":"Clin Chem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1161\/STROKEAHA.107.513499","article-title":"Serum calcium as prognosticator in ischemic stroke","volume":"39","author":"B Ovbiagele","year":"2008","journal-title":"Stroke"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1172\/JCI200420622","article-title":"Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model","volume":"114","author":"A Taguchi","year":"2004","journal-title":"J Clin Invest"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.mvr.2010.05.008","article-title":"Mobilization, endothelial differentiation and functional capacity of endothelial progenitor cells after ischemic stroke","volume":"80","author":"M Navarro-Sobrino","year":"2010","journal-title":"Microvasc Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.atherosclerosis.2011.01.030","article-title":"A large screening of angiogenesis biomarkers and their association with neurological outcome after ischemic stroke","volume":"216","author":"M Navarro-Sobrino","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"5544","DOI":"10.1182\/blood-2007-10-119073","article-title":"The combination of granulocyte colony-stimulating factor and stem cell factor significantly increases the number of bone marrow-derived endothelial cells in brains of mice following cerebral ischemia","volume":"111","author":"ZE Toth","year":"2008","journal-title":"Blood"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/sj.jcbfm.9600475","article-title":"Angiopoietin1\/Tie2 and VEGF\/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke","volume":"27","author":"A Zacharek","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/00004647-200002000-00021","article-title":"Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion","volume":"20","author":"TN Lin","year":"2000","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.bbrc.2007.05.182","article-title":"CXCR4\/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway","volume":"359","author":"Z Liang","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"13007","DOI":"10.1523\/JNEUROSCI.4323-06.2006","article-title":"A neurovascular niche for neurogenesis after stroke","volume":"26","author":"JJ Ohab","year":"2006","journal-title":"J Neurosci"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1126\/science.1095505","article-title":"Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells","volume":"304","author":"Q Shen","year":"2004","journal-title":"Science"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1097\/00000478-199310000-00009","article-title":"CD-34 is expressed by a distinctive cell population in peripheral nerve, nerve sheath tumors, and related lesions","volume":"17","author":"SW Weiss","year":"1993","journal-title":"Am J Surg Pathol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/BF00389498","article-title":"CD34 immunoreactivity in nervous system tumors","volume":"88","author":"A Chaubal","year":"1994","journal-title":"Acta Neuropathol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0087284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T22:07:47Z","timestamp":1597442867000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0087284"}},"subtitle":[],"editor":[{"given":"Qingzhong","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,4]]},"references-count":68,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0087284","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,4]]}}}