{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:19:51Z","timestamp":1790173191226,"version":"4.1.0"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0087343","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T21:53:12Z","timestamp":1391032392000},"page":"e87343","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":52,"title":["Roles of PPAR\u03b3\/NF-\u03baB Signaling Pathway in the Pathogenesis of Intrahepatic Cholestasis of Pregnancy"],"prefix":"10.1371","volume":"9","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingqing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0140-6736(09)61495-1","article-title":"Liver disease in pregnancy","volume":"375","author":"D Joshi","year":"2010","journal-title":"Lancet"},{"key":"ref2","unstructured":"Kenyon AP, Girling JC (2011) Obstetricscholestasis. RCOG green-top guidelines No 43. London: RCOG."},{"key":"ref3","first-page":"2049","article-title":"Intrahepatic cholestasis of pregnancy","volume":"Gastroenterol15","author":"V Geenes","year":"2009","journal-title":"World J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e28343","DOI":"10.1371\/journal.pone.0028343","article-title":"Fetal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy in a Northern California cohort","volume":"7","author":"M Rook","year":"2012","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ijgo.2013.02.015","article-title":"Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy","volume":"122","author":"J Chen","year":"2013","journal-title":"Int J Gynaecol Obstet"},{"key":"ref6","first-page":"1025","article-title":"Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy","volume":"Gut52","author":"M Savander","year":"2003"},{"key":"ref7","first-page":"321","article-title":"Pay more attention to standardizing the diagnosis and treatment of intrahepatic cholestasis of pregnancy","volume":"46","author":"XH Liu","year":"2011","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/sj.ejhg.5201355","article-title":"Sequence variation in the ATP8B1 gene and intrahepatic cholestasis of pregnancy","volume":"13","author":"JN Painter","year":"2005","journal-title":"Eur J Hum Genet"},{"key":"ref9","first-page":"376","article-title":"Sex hormones and bile acids in intrahepatic cholestasis of pregnancy","volume":"Hepatology47","author":"H Reyes","year":"2008"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Diken Z, Usta IM, Nassar AH (2013) A Clinical Approach to Intrahepatic Cholestasis of Pregnancy. Am J Perinatol.","DOI":"10.1055\/s-0033-1333673"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1600-0897.2009.00798.x","article-title":"Immunologic abnormality of intrahepatic cholestasis of pregnancy","volume":"63","author":"H Yayi","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.placenta.2013.02.006","article-title":"Expression of corticotrophin-releasing hormone and its receptor in patients with intrahepatic cholestasis of pregnancy","volume":"34","author":"F Zhou","year":"2013","journal-title":"Placenta"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00404-009-1156-3","article-title":"Altered gene profile of placenta from women with intrahepatic cholestasis of pregnancy","volume":"281","author":"J Wei","year":"2010","journal-title":"Arch Gynecol Obstet"},{"key":"ref14","first-page":"71","article-title":"Cell-mediated immunity imbalance in patients with intrahepatic cholestasis of pregnancy","volume":"4","author":"B Ling","year":"2007","journal-title":"Cell Mol Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cyto.2010.11.005","article-title":"Longitudinal modulation of immune system cytokine profile during pregnancy","volume":"53","author":"JM Denney","year":"2011","journal-title":"Cytokine"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/molehr\/8.3.255","article-title":"Th1- and Th2-like cytokine production by first trimester decidual large granular lymphocytes is influenced by HLA-G and HLA-E","volume":"8","author":"L Rieger","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0167-5699(93)90235-D","article-title":"Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?","volume":"14","author":"TG Wegmann","year":"1993","journal-title":"Immunol Today"},{"key":"ref18","first-page":"292","article-title":"The changes of serum estrogen, progesterone and the function of immune system in intrahepatic cholestasis of pregnancy","volume":"33","author":"Q Shi","year":"1998","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.4049\/jimmunol.172.7.4583","article-title":"Pregnancy-specific down-regulation of NF-kappa B expression in T cells in humans is essential for the maintenance of the cytokine profile required for pregnancy success","volume":"172","author":"SA McCracken","year":"2004","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2010.11.008","article-title":"Regulated suppression of NF-\u03baB throughout pregnancy maintains a favourable cytokine environment necessary for pregnancy success","volume":"89","author":"KA Hadfield","year":"2011","journal-title":"J Reprod Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mce.2006.02.009","article-title":"The pleiotropic function of PPAR gamma in the placenta","volume":"249","author":"WT Schaiff","year":"2001","journal-title":"Mol Cell Endocrinol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.placenta.2006.04.009","article-title":"PPARs and the placenta","volume":"28","author":"T Fournier","year":"2007","journal-title":"Placenta"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"970276","DOI":"10.1155\/2013\/970276","article-title":"The Role of PPARs in Placental Immunology: A Systematic Review of the Literature","volume":"2013","author":"S Hutter","year":"2013","journal-title":"PPAR Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1210\/jc.2009-1487","article-title":"Fenofibrate reduces systemic inflammation markers independent of its effects on lipid and glucose metabolism in patients with the metabolic syndrome","volume":"95","author":"R Belfort","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI27989","article-title":"Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis","volume":"116","author":"P Lefebvre","year":"2006","journal-title":"J Clin Invest"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1530\/REP-08-0028","article-title":"Peroxisome proliferator-activated receptor alpha activation regulates lipid metabolism in the feto-placental unit from diabetic rats","volume":"136","author":"N Mart\u00ednez","year":"2008","journal-title":"Reproduction"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-1-4419-9072-3_22","article-title":"A paradigm for gene regulation: inflammation, NF-kappaB and PPAR","volume":"544","author":"W Vanden Berghe","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"32833","DOI":"10.1074\/jbc.273.49.32833","article-title":"Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging","volume":"273","author":"ME Poynter","year":"1998","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev.med.57.121304.131428","article-title":"Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia","volume":"57","author":"SW Beaven","year":"2006","journal-title":"Annu Rev Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1155\/S1110724304308065","article-title":"Role of Peroxisome Proliferator-Activated Receptors in Inflammation Control","volume":"2004","author":"J Youssef","year":"2004","journal-title":"J Biomed Biotechnol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"613864","DOI":"10.1155\/2013\/613864","article-title":"Nuclear control of the inflammatory response in mammals by peroxisome proliferator-activated receptors","volume":"2013","author":"S Mandard","year":"2013","journal-title":"PPAR Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1210\/jc.2002-020613","article-title":"Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone","volume":"87","author":"M Lappas","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2174\/1568010042634578","article-title":"PPARs as drug targets to modulate inflammatory responses?","volume":"3","author":"R Genolet","year":"2004","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/ni1018","article-title":"Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA","volume":"5","author":"D Kelly","year":"2004","journal-title":"Nat Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1172\/JCI7145","article-title":"A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response","volume":"104","author":"CG Su","year":"1999","journal-title":"J Clin Invest"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1182\/blood-2006-07-038026","article-title":"Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C\/EBP","volume":"110","author":"LH Wang","year":"2007","journal-title":"Blood"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2012.05.004","article-title":"Interleukin-6 in pregnancy and gestational disorders","volume":"95","author":"JR Prins","year":"2012","journal-title":"J Reprod Immunol"},{"key":"ref38","unstructured":"Fitzgerald K (2001) The cytokine factsbook, 2nd ed. The factsbook series. San Diego, CA: Academic Pressp: 515."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.placenta.2005.08.009","article-title":"The placenta cytokine network and inflammatory signals","volume":"27","author":"S Hauguel-de Mouzon","year":"2006","journal-title":"Placenta"},{"key":"ref40","first-page":"322","article-title":"Influence of transforming growth factor-beta2 on production of tumor necrosis factor-alpha and interferon-gamma from placenta of intrahepatic cholestasis of pregnancy","volume":"39","author":"Y Ai","year":"2004","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.2337\/dc07-s203","article-title":"The human placenta in gestational diabetes mellitus. The insulin and cytokine network","volume":"30","author":"G Desoye","year":"2011","journal-title":"Diabetes Care"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1530\/REP-10-0074","article-title":"Obesity, pregnancy, inflammation, and vascular function","volume":"140","author":"FC Denison","year":"2010","journal-title":"Reproduction"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/molehr\/gas001","article-title":"Oxysterols exert proinflammatory effects in placental trophoblasts via TLR4-dependent, cholesterol-sensitive activation of NF-\u03baB","volume":"8","author":"IL Aye","year":"2012","journal-title":"Mol Hum Reprod"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/excr.1993.1139","article-title":"Establishment and characterization of first trimester human trophoblast cells with extended lifespan","volume":"206","author":"CH Graham","year":"1993","journal-title":"Exp Cell Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/hep.20336","article-title":"Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates","volume":"40","author":"A Glantz","year":"2004","journal-title":"Hepatology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.placenta.2011.09.006","article-title":"A placental phenotype for intrahepatic cholestasis of pregnancy","volume":"32","author":"VL Geenes","year":"2011","journal-title":"Placenta"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/humrep\/der402","article-title":"Investigation of systemic inflammatory response in first trimester pregnancy failure","volume":"27","author":"J Calleja-Agius","year":"2012","journal-title":"Hum Reprod"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0145-305X(92)90026-9","article-title":"Immune signalling at the maternal-fetal interface and trophoblast differentiation","volume":"16","author":"TG Wegmann","year":"1992","journal-title":"Dev Comp Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"416739","DOI":"10.1155\/2012\/416739","article-title":"Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-\u0394(12,14)-prostaglandin J2","volume":"2012","author":"L Sykes","year":"2012","journal-title":"Mediators Inflamm"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1155\/S0962935196000488","article-title":"Regulation by anti-inflammatory cytokines (IL-4, IL-10, IL-13, TGFbeta) of interleukin-8 production by LPS- and\/or TNFalpha-activated human polymorphonuclear cells","volume":"5","author":"C Marie","year":"1996","journal-title":"Mediators Inflamm"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0962-8924(00)01856-0","article-title":"The molecular basis of T helper 1 and T helper 2 cell differentiation","volume":"10","author":"A O\u2019Garra","year":"2000","journal-title":"Trends Cell Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0029-7844(97)00294-9","article-title":"Maternal serum interleukin-6 during pregnancy and during term and preterm labor","volume":"90","author":"PC Greig","year":"1997","journal-title":"Obstet Gynecol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"8552","DOI":"10.3390\/molecules16108552","article-title":"Beneficial effects of THSG on acetic acid-induced experimental colitis: involvement of upregulation of PPAR-\u03b3 and inhibition of the Nf-\u039ab inflammatory pathway","volume":"16","author":"C Zeng","year":"2011","journal-title":"Molecules"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1016\/j.ajpath.2011.02.042","article-title":"Placental TNF-\u03b1 signaling in illness-induced complications of pregnancy","volume":"178","author":"PA Carpentier","year":"2011","journal-title":"Am J Pathol"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Du Q, Zhang Y, Pan Y, Duan T (2013) Lithocholic acid-induced placental tumor necrosis factor-\u03b1 upregulation and syncytiotrophoblast cell apoptosis in intrahepatic cholestasis of pregnancy. Hepatol Res.","DOI":"10.1111\/hepr.12150"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1177\/1933719108329095","article-title":"Inflammation and pregnancy","volume":"16","author":"JR Challis","year":"2009","journal-title":"Reprod Sci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.placenta.2013.01.005","article-title":"Homeobox genes and down-stream transcription factor PPAR\u03b3 in normal and pathological human placental development","volume":"34","author":"P Murthi","year":"2013","journal-title":"Placenta"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00281-007-0071-6","article-title":"Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia","volume":"29","author":"C Rusterholz","year":"2007","journal-title":"Semin Immunopathol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S1097-2765(00)80209-9","article-title":"PPAR gamma is required for placental, cardiac, and adipose tissue development","volume":"4","author":"Y Barak","year":"1999","journal-title":"Mol Cell"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"142082","DOI":"10.1155\/2008\/142082","article-title":"PPAR Signaling in Placental Development and Function","volume":"2008","author":"Y Barak","year":"2008","journal-title":"PPAR Res"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2008\/758562","article-title":"Placental implications of peroxisome proliferator-activated receptors in gestation and parturition","volume":"2008","author":"V Borel","year":"2008","journal-title":"PPAR Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jri.2011.05.003","article-title":"PPAR\u03b3 and human trophoblast differentiation","volume":"90","author":"T Fournier","year":"2011","journal-title":"J Reprod Immunol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ydbio.2012.08.021","article-title":"Placental PPAR\u03b3 regulates spatiotemporally diverse genes and a unique metabolic network","volume":"372","author":"T Shalom-Barak","year":"2012","journal-title":"Dev Biol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.steroids.2009.10.012","article-title":"Peroxisome proliferator-activated receptor gamma (PPARgamma): is the genomic activity the only answer?","volume":"75","author":"M Luconi","year":"2010","journal-title":"Steroids"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.plipres.2005.12.002","article-title":"From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions","volume":"45","author":"JN Feige","year":"2012","journal-title":"Prog Lipid Res"},{"key":"ref66","first-page":"3808","article-title":"Placental peroxisome proliferator-activated receptor-gamma is up-regulated by pregnancy serum","volume":"85","author":"LL Waite","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ni0102-20","article-title":"Regulatory functions of ubiquitination in the immune system","volume":"3","author":"Y Ben-Neriah","year":"2002","journal-title":"Nat Immunol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/S0092-8674(02)00703-1","article-title":"Missing pieces in the NF-kappaB puzzle","volume":"109","author":"S Ghosh","year":"2002","journal-title":"Cell"},{"key":"ref69","first-page":"292","article-title":"Expression of NF-kappaB and COX-2 in placenta tissues of patients with intrahepatic cholestasis of pregnancy and its significance","volume":"43","author":"ZJ Liu","year":"2008","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1095\/biolreprod67.2.668","article-title":"Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro","volume":"67","author":"M Lappas","year":"2002","journal-title":"Biol Reprod"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1210\/jc.2002-021677","article-title":"N-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitro","volume":"88","author":"M Lappas","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/34178","article-title":"The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation","volume":"391","author":"M Ricote","year":"1998","journal-title":"Nature"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.pharmthera.2005.08.007","article-title":"Peroxisome proliferator-activated receptors and inflammation","volume":"110","author":"LA Moraes","year":"2006","journal-title":"Pharmacol Ther"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.imlet.2004.01.011","article-title":"Reproductive immunology 2003: reassessing the Th1\/Th2 paradigm?","volume":"92","author":"G Chaouat","year":"2012","journal-title":"Immunol Lett"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/01.AOG.0000189096.94874.9c","article-title":"Plasma lipid profiles of women with intrahepatic cholestasis of pregnancy","volume":"107","author":"AT Dann","year":"2006","journal-title":"Obstet Gynecol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/hep.26055","article-title":"Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype","volume":"57","author":"S Abu-Hayyeh","year":"2013","journal-title":"Hepatology"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.placenta.2012.08.005","article-title":"Stereological assessment of placental morphology in intrahepatic cholestasis of pregnancy","volume":"33","author":"E Wikstr\u00f6m Shemer","year":"2012","journal-title":"Placenta"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0087343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:02:38Z","timestamp":1588971758000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0087343"}},"subtitle":[],"editor":[{"given":"Bart O.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,29]]},"references-count":77,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0087343","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,29]]}}}