{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:33:37Z","timestamp":1791304417480,"version":"4.3.1"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0087490","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T22:23:24Z","timestamp":1391120604000},"page":"e87490","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of Angiopoietin-2 and Dimethylarginines with Complicated Course in Patients with Leptospirosis"],"prefix":"10.1371","volume":"9","author":[{"given":"Alexander","family":"Lukasz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodo","family":"Hoffmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno","family":"W\u00f6lk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Noeckler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie M.","family":"Bode-B\u00f6ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Hadem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Pischke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan T.","family":"Kielstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1473-3099(03)00830-2","article-title":"Leptospirosis: a zoonotic disease of global importance","volume":"3","author":"AR Bharti","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S1286-4579(00)01280-6","article-title":"Overview of the epidemiology, microbiology, and pathogenesis of Leptospira spp. in humans","volume":"2","author":"R Plank","year":"2000","journal-title":"Microbes Infect"},{"key":"ref3","first-page":"532376","article-title":"Commonly used severity scores are not good predictors of mortality in sepsis from severe leptospirosis: a series of ten patients","volume":"2012","author":"D Velissaris","year":"2012","journal-title":"Crit Care Res Pract"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e17260","DOI":"10.1371\/journal.pone.0017260","article-title":"Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis","volume":"6","author":"JS Davis","year":"2011","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1371\/journal.pmed.0030046","article-title":"Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans","volume":"3","author":"SM Parikh","year":"2006","journal-title":"PLoS Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4269\/ajtmh.2010.10-0040","article-title":"Differences in clinical manifestations of imported versus autochthonous leptospirosis in Austria and Germany","volume":"83","author":"B Hoffmeister","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"R94","DOI":"10.1186\/cc6966","article-title":"Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays","volume":"12","author":"A Lukasz","year":"2008","journal-title":"Crit Care"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1373\/clinchem.2005.060152","article-title":"Fast and efficient determination of arginine, symmetric dimethylarginine, and asymmetric dimethylarginine in biological fluids by hydrophilic-interaction liquid chromatography-electrospray tandem mass spectrometry","volume":"52","author":"J Martens-Lobenhoffer","year":"2006","journal-title":"Clin Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e918","DOI":"10.1371\/journal.pntd.0000918","article-title":"Responses of human endothelial cells to pathogenic and non-pathogenic Leptospira species","volume":"4","author":"DG Martinez-Lopez","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.transci.2011.07.012","article-title":"Potential benefits of plasma exchange by apheresis on the treatment of severe Icteric Leptospirosis: case report and literature review","volume":"45","author":"C Cerdas-Quesada","year":"2011","journal-title":"Transfus Apher Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1160\/TH10-02-0138","article-title":"Removal of elevated circulating angiopoietin-2 by plasma exchange\u2013a pilot study in critically ill patients with thrombotic microangiopathy and anti-glomerular basement membrane disease","volume":"104","author":"S Lovric","year":"2010","journal-title":"Thromb Haemost"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2174\/157340310791162659","article-title":"The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease","volume":"6","author":"L Sibal","year":"2010","journal-title":"Curr Cardiol Rev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/ndt\/gfl719","article-title":"Asymmetric dimethyl-arginine (ADMA) response to inflammation in acute infections","volume":"22","author":"C Zoccali","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"F1042","DOI":"10.1152\/ajprenal.00640.2010","article-title":"Unilateral nephrectomy causes an abrupt increase in inflammatory mediators and a simultaneous decrease in plasma ADMA: a study in living kidney donors","volume":"301","author":"JT Kielstein","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/ndt\/gfq395","article-title":"SDMA is an early marker of change in GFR after living-related kidney donation","volume":"26","author":"JT Kielstein","year":"2011","journal-title":"Nephrol Dial Transplant"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0087490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T13:06:42Z","timestamp":1589029602000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0087490"}},"subtitle":[],"editor":[{"given":"Antonio Carlos","family":"Seguro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,30]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0087490","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,30]]}}}