{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:02:40Z","timestamp":1785578560739,"version":"3.56.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T00:00:00Z","timestamp":1390780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0087498","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T21:54:02Z","timestamp":1390859642000},"page":"e87498","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Fronto-Parietal Connectivity Is a Non-Static Phenomenon with Characteristic Changes during Unconsciousness"],"prefix":"10.1371","volume":"9","author":[{"given":"Gisela","family":"Untergehrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard F.","family":"Kochs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Ilg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.concog.2009.04.004","article-title":"The directionality and functional organization of frontoparietal connectivity during consciousness and anesthesia in humans","volume":"18","author":"U Lee","year":"2009","journal-title":"Conscious Cogn"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e25155","DOI":"10.1371\/journal.pone.0025155","article-title":"Preferential inhibition of frontal-to-parietal feedback connectivity is a neurophysiologic correlate of general anesthesia in surgical patients","volume":"6","author":"SW Ku","year":"2011","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1126\/science.1117256","article-title":"Breakdown of cortical effective connectivity during sleep","volume":"309","author":"M Massimini","year":"2005","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"7082","DOI":"10.1523\/JNEUROSCI.3769-11.2012","article-title":"Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness","volume":"32","author":"M Boly","year":"2012","journal-title":"J Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1196\/annals.1417.015","article-title":"Intrinsic brain activity in altered states of consciousness: how conscious is the default mode of brain function?","volume":"1129","author":"M Boly","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1097\/ALN.0b013e3181f697f5","article-title":"Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness","volume":"113","author":"P Boveroux","year":"2010","journal-title":"Anesthesiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neuroimage.2011.04.020","article-title":"Brain functional integration decreases during propofol-induced loss of consciousness","volume":"57","author":"J Schrouff","year":"2011","journal-title":"Neuroimage"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1097\/ALN.0b013e31829103f5","article-title":"Disruption of frontal-parietal communication by ketamine, propofol, and sevoflurane","volume":"118","author":"U Lee","year":"2013","journal-title":"Anesthesiology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/ALN.0b013e3182a7ca92","article-title":"Simultaneous electroencephalographic and functional magnetic resonance imaging indicate impaired cortical top-down processing in association with anesthetic-induced unconsciousness","volume":"119","author":"D Jordan","year":"2013","journal-title":"Anesthesiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neulet.2005.06.018","article-title":"Volatile anesthetics disrupt frontal-posterior recurrent information transfer at gamma frequencies in rat","volume":"387","author":"OA Imas","year":"2005","journal-title":"Neurosci Lett"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1053\/j.sane.2006.09.003","article-title":"Suppressing consciousness: Mechanisms of general anesthesia","volume":"25","author":"AG Hudetz","year":"2006","journal-title":"Semin Anesth Peri M"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuroimage.2009.12.011","article-title":"Time-frequency dynamics of resting-state brain connectivity measured with fMRI","volume":"50","author":"C Chang","year":"2010","journal-title":"Neuroimage"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3389\/fnhum.2012.00339","article-title":"Dynamic BOLD functional connectivity in humans and its electrophysiological correlates","volume":"6","author":"E Tagliazucchi","year":"2012","journal-title":"Front Hum Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1073\/pnas.0701519104","article-title":"Network structure of cerebral cortex shapes functional connectivity on multiple time scales","volume":"104","author":"CJ Honey","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1093\/cercor\/bhr181","article-title":"Resting-state connectivity identifies distinct functional networks in macaque cingulate cortex","volume":"22","author":"RM Hutchison","year":"2012","journal-title":"Cereb Cortex"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrn2961","article-title":"Emerging concepts for the dynamical organization of resting-state activity in the brain","volume":"12","author":"G Deco","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e55809","DOI":"10.1371\/journal.pone.0055809","article-title":"Measuring information-transfer delays","volume":"8","author":"M Wibral","year":"2013","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"E3377","DOI":"10.1073\/pnas.1210907109","article-title":"Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness","volume":"109","author":"LD Lewis","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"158101","DOI":"10.1103\/PhysRevLett.100.158101","article-title":"Symbolic transfer entropy","volume":"100","author":"M Staniek","year":"2008","journal-title":"Phys Rev Lett"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1515\/BMT.2009.040","article-title":"Symbolic transfer entropy: inferring directionality in biosignals","volume":"54","author":"M Staniek","year":"2009","journal-title":"Biomed Tech (Berl)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10827-010-0262-3","article-title":"Transfer entropy\u2014a model-free measure of effective connectivity for the neurosciences","volume":"30","author":"R Vicente","year":"2011","journal-title":"J Comput Neurosci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1007\/978-3-540-89208-3_302","article-title":"Effects of propofol anesthesia on nonlinear properties of EEG: Time-lag and embedding dimension","volume":"22","author":"JR Gonz\u00e1lez","year":"2009","journal-title":"4th European Conference of the International Federation for Medical and Biological Engineering"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.neuron.2010.12.027","article-title":"Oscillatory synchronization in large-scale cortical networks predicts perception","volume":"69","author":"JF Hipp","year":"2011","journal-title":"Neuron"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1152\/physrev.00035.2008","article-title":"Neurophysiological and computational principles of cortical rhythms in cognition","volume":"90","author":"XJ Wang","year":"2010","journal-title":"Physiol Rev"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0167-2789(00)00043-9","article-title":"Surrogate time series","volume":"142","author":"T Schreiber","year":"2000","journal-title":"Physica D"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1126\/science.1149213","article-title":"Consciousness and anesthesia","volume":"322","author":"MT Alkire","year":"2008","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2307\/25470707","article-title":"Consciousness as integrated information: a provisional manifesto","volume":"215","author":"G Tononi","year":"2008","journal-title":"Biol Bull"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1097\/ALN.0b013e3182a8ec8c","article-title":"Reconfiguration of Network Hub Structure after Propofol-induced Unconsciousness","volume":"119","author":"H Lee","year":"2013","journal-title":"Anesthesiology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1213\/ANE.0b013e3182405228","article-title":"Propofol and etomidate depress cortical, thalamic, and reticular formation neurons during anesthetic-induced unconsciousness","volume":"114","author":"J Andrada","year":"2012","journal-title":"Anesth Analg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0896-6273(01)00582-7","article-title":"Thalamic relay functions and their role in corticocortical communication: generalizations from the visual system","volume":"33","author":"RW Guillery","year":"2002","journal-title":"Neuron"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.1523\/JNEUROSCI.19-13-05506.1999","article-title":"Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study","volume":"19","author":"P Fiset","year":"1999","journal-title":"J Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.neuroimage.2010.08.022","article-title":"Variations of response time in a selective attention task are linked to variations of functional connectivity in the attentional network","volume":"54","author":"J Prado","year":"2011","journal-title":"Neuroimage"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1093\/brain\/awp086","article-title":"Impaired consciousness during temporal lobe seizures is related to increased long-distance cortical-subcortical synchronization","volume":"132","author":"M Arthuis","year":"2009","journal-title":"Brain"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1523\/JNEUROSCI.4623-06.2007","article-title":"Synchronization of neural activity across cortical areas correlates with conscious perception","volume":"27","author":"L Melloni","year":"2007","journal-title":"J Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e29072","DOI":"10.1371\/journal.pone.0029072","article-title":"Granger causality analysis of steady-state electroencephalographic signals during propofol-induced anaesthesia","volume":"7","author":"AB Barrett","year":"2012","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e33869","DOI":"10.1371\/journal.pone.0033869","article-title":"EEG-based automatic classification of \u2018awake\u2019 versus \u2018anesthetized\u2019 state in general anesthesia using Granger causality","volume":"7","author":"N Nicolaou","year":"2012","journal-title":"PLoS One"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0087498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T02:29:23Z","timestamp":1565144963000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0087498"}},"subtitle":[],"editor":[{"given":"Lawrence M.","family":"Ward","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,27]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0087498","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,27]]}}}