{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:47:00Z","timestamp":1785577620487,"version":"3.56.0"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0087603","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T21:55:29Z","timestamp":1391032529000},"page":"e87603","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Study on Risk Factors for Severe Hand, Foot and Mouth Disease in China"],"prefix":"10.1371","volume":"9","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangju","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1572-0241.2005.40310.x","article-title":"Pyogenic liver abscess with a focus on Klebsiella pneumoniae as a primary pathogen: an emerging disease with unique clinical characteristics","volume":"100","author":"ER Lederman","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","article-title":"Clinical features, diagnosis, and management of enterovirus 71","volume":"9","author":"MH Ooi","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1086\/314032","article-title":"Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group","volume":"31","author":"LG Chan","year":"2000","journal-title":"Clin Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3201\/eid1311.070632","article-title":"Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005","volume":"13","author":"PV Tu","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3201\/eid0904.020395","article-title":"Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: comparative analysis of the VP1 and VP4 genes","volume":"9","author":"MJ Cardosa","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1542\/peds.2006-3331","article-title":"Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998\u20132005","volume":"120","author":"KT Chen","year":"2007","journal-title":"Pediatrics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"T Solomon","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1086\/520149","article-title":"Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications","volume":"29","author":"SM Wang","year":"1999","journal-title":"Clin Infect Dis"},{"key":"ref9","unstructured":"Organization WH (2011) A Guide to Clinical Management and Public Health Response for Hand, Foot and Mouth Disease (HFMD). World Health Organization Regional Office for the Western Pacific and the Regional Emerging Diseases Intervention (REDI) Centre. pp. 4\u201310, 38, 53\u201360."},{"key":"ref10","first-page":"3","article-title":"The comparison between mild cases and severe cases of hand-foot-mouth disease","volume":"26","author":"G Mao","year":"2008","journal-title":"Chin J Infect Dis"},{"key":"ref11","first-page":"2","article-title":"The pre-albumin and blood glucose in serum of severe cases of hand foot and mouth disease and its significance","volume":"18","author":"L Yu","year":"2011","journal-title":"Chin Pediatr Emerg Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e29003","DOI":"10.1371\/journal.pone.0029003","article-title":"The characteristics of blood glucose and WBC counts in peripheral blood of cases of hand foot and mouth disease in China: a systematic review","volume":"7","author":"Y Li","year":"2012","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.1994.tb00854.x","article-title":"Anti-cytokine nature of natural human immunoglobulin: one possible mechanism of the clinical effect of intravenous immunoglobulin therapy","volume":"139","author":"Y Abe","year":"1994","journal-title":"Immunol Rev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1651-2227.2002.tb03292.x","article-title":"Different proinflammatory reactions in fatal and non-fatal enterovirus 71 infections: implications for early recognition and therapy","volume":"91","author":"TY Lin","year":"2002","journal-title":"Acta Paediatr"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1086\/345905","article-title":"Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system","volume":"36","author":"TY Lin","year":"2003","journal-title":"Clin Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1469-0691.2007.01729.x","article-title":"Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity","volume":"13","author":"SM Wang","year":"2007","journal-title":"Clin Microbiol Infect"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e67430","DOI":"10.1371\/journal.pone.0067430","article-title":"Comparative study of the cytokine\/chemokine response in children with differing disease severity in enterovirus 71-induced hand, foot, and mouth disease","volume":"8","author":"Y Zhang","year":"2013","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1086\/376998","article-title":"Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema","volume":"188","author":"SM Wang","year":"2003","journal-title":"J Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/infdis\/jis446","article-title":"In enterovirus 71 encephalitis with cardio-respiratory compromise, elevated interleukin 1beta, interleukin 1 receptor antagonist, and granulocyte colony-stimulating factor levels are markers of poor prognosis","volume":"206","author":"MJ Griffiths","year":"2012","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.bjid.2012.08.001","article-title":"Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases","volume":"16","author":"XN Zou","year":"2012","journal-title":"Braz J Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1086\/591462","article-title":"Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis","volume":"198","author":"SM Wang","year":"2008","journal-title":"J Infect Dis"},{"key":"ref22","first-page":"876241","article-title":"Cytokine immunopathogenesis of enterovirus 71 brain stem encephalitis","volume":"2012","author":"SM Wang","year":"2012","journal-title":"Clin Dev Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0087603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:44:00Z","timestamp":1589024640000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0087603"}},"subtitle":[],"editor":[{"given":"Lijun","family":"Rong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,29]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0087603","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,29]]}}}