{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:59:22Z","timestamp":1780516762643,"version":"3.54.1"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0087627","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T22:27:30Z","timestamp":1391120850000},"page":"e87627","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chloroquine Stimulates Cl\u2212 Secretion by Ca2+ Activated Cl\u2212 Channels in Rat Ileum"],"prefix":"10.1371","volume":"9","author":[{"given":"Ning","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1136\/bmj.296.6625.820","article-title":"Malaria chemoprophylaxis in travellers to east Africa: a comparative prospective study of chloroquine plus proguanil with chloroquine plus sulfadoxine-pyrimethamine","volume":"296","author":"S Fogh","year":"1988","journal-title":"Br Med J (Clin Res Ed)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/0140-6736(93)90814-W","article-title":"Mefloquine compared with other malaria chemoprophylactic regimens in tourists visiting east Africa","volume":"341","author":"R Steffen","year":"1993","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1136\/bmj.313.7056.525","article-title":"Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers","volume":"313","author":"PJ Barrett","year":"1996","journal-title":"Bmj"},{"key":"ref4","first-page":"170","article-title":"Antimalarial prophylaxis\u2013use and adverse events in visitors to the Kruger National Park","volume":"89","author":"DN Durrheim","year":"1999","journal-title":"S Afr Med J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/molehr\/gas040","article-title":"Xu J, Cao J, Iguchi N, Riethmacher D, Huang L Functional characterization of bitter-taste receptors expressed in mammalian testis","volume":"19","journal-title":"Mol Hum Reprod"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nm.2237","article-title":"Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, et al. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction","volume":"16","journal-title":"Nat Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1073\/pnas.93.13.6631","article-title":"Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin","volume":"93","author":"D Hofer","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"G971","DOI":"10.1152\/ajpgi.90514.2008","article-title":"Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors, T2Rs, in the human and rat large intestine","volume":"296","author":"I Kaji","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1073\/pnas.042617699","article-title":"Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells","volume":"99","author":"SV Wu","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"G171","DOI":"10.1152\/ajpgi.00073.2006","article-title":"Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and alpha-gustducin in the mammalian gut","volume":"291","author":"E Rozengurt","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"G792","DOI":"10.1152\/ajpgi.00074.2006","article-title":"Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon","volume":"291","author":"N Rozengurt","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1172\/JCI36461","article-title":"SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice","volume":"118","author":"TI Jeon","year":"2008","journal-title":"J Clin Invest"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/jphp.12041","article-title":"Jing F, Liu M, Yang N, Liu Y, Li X, et al. Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa","volume":"65","journal-title":"J Pharm Pharmacol"},{"key":"ref14","first-page":"G922","article-title":"Nutrient tasting and signaling mechanisms in the gut. II. The intestine as a sensory organ: neural, endocrine, and immune responses","volume":"277","author":"JB Furness","year":"1999","journal-title":"Am J Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejphar.2011.01.026","article-title":"Li Y, Li XF, Hua G, Xu JD, Zhang XH, et al. Colonic submucosal 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in water-immersion restraint stressed rats","volume":"656","journal-title":"Eur J Pharmacol"},{"key":"ref16","first-page":"G117","article-title":"Chloroquine stimulates absorption and inhibits secretion of ileal water and electrolytes","volume":"243","author":"R Fogel","year":"1982","journal-title":"Am J Physiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.coph.2003.06.012","article-title":"CFTR pharmacology and its role in intestinal fluid secretion","volume":"3","author":"JR Thiagarajah","year":"2003","journal-title":"Curr Opin Pharmacol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jcp.20085","article-title":"Chloride channels in the small intestinal cell line IEC-18","volume":"202","author":"S Basavappa","year":"2005","journal-title":"J Cell Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"24556","DOI":"10.1074\/jbc.272.39.24556","article-title":"Ion and bumetanide binding by the Na-K-Cl cotransporter. Importance of transmembrane domains","volume":"272","author":"P Isenring","year":"1997","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2008.09.003","article-title":"Expression cloning of TMEM16A as a calcium-activated chloride channel subunit","volume":"134","author":"BC Schroeder","year":"2008","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1126\/science.1163518","article-title":"TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity","volume":"322","author":"A Caputo","year":"2008","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"C742","DOI":"10.1152\/ajpcell.2001.280.4.C742","article-title":"Bitter taste transduced by PLC-beta(2)-dependent rise in IP(3) and alpha-gustducin-dependent fall in cyclic nucleotides","volume":"280","author":"W Yan","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1523\/JNEUROSCI.17-10-03580.1997","article-title":"Bitter taste transduction of denatonium in the mudpuppy Necturus maculosus","volume":"17","author":"T Ogura","year":"1997","journal-title":"J Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1152\/jn.2002.87.6.3152","article-title":"Taste receptor cell responses to the bitter stimulus denatonium involve Ca2+ influx via store-operated channels","volume":"87","author":"T Ogura","year":"2002","journal-title":"J Neurophysiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0087627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T04:53:45Z","timestamp":1565153625000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0087627"}},"subtitle":[],"editor":[{"given":"Sanjoy","family":"Bhattacharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,30]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0087627","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,30]]}}}