{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:15:31Z","timestamp":1791400531294,"version":"4.3.3"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T00:00:00Z","timestamp":1391472000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0087801","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T22:09:20Z","timestamp":1391551760000},"page":"e87801","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Mobile Insertion Cassette Elements Found in Small Non-Transmissible Plasmids in Proteeae May Explain qnrD Mobilization"],"prefix":"10.1371","volume":"9","author":[{"given":"Thomas","family":"Guillard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Grillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"de Champs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Cartier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janick","family":"Madoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Ber\u00e7ot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Lebreil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Lozniewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Riahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Vernet-Garnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Cambau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Hooper D (2000) Mechanisms of action and resistance of older and newer fluoroquinolones. Clin Infect Dis. Suppl 2: S24\u20138.","DOI":"10.1086\/314056"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1128\/AAC.01617-06","article-title":"Quinolone-Mediated Bacterial Death","volume":"52","author":"K Drlica","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1469-0691.2009.02725.x","article-title":"Antibiotic consumption and link to resistance","volume":"15","author":"H Goossens","year":"2009","journal-title":"Clin Microbiol Infect"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1128\/AAC.43.11.2736","article-title":"Emergence and dissemination of quinolone-resistant <italic>Escherichia coli<\/italic> in the community","volume":"43","author":"J Garau","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1128\/CMR.00016-09","article-title":"Plasmid-mediated quinolone resistance: a multifaceted threat","volume":"22","author":"J Strahilevitz","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0140-6736(97)07322-4","article-title":"Quinolone resistance from a transferable plasmid","volume":"351","author":"L Mart\u00ednez-Mart\u00ednez","year":"1998","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1128\/AAC.00147-08","article-title":"<italic>qnr<\/italic> Gene nomenclature","volume":"52","author":"G Jacoby","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1128\/AAC.01400-08","article-title":"New plasmid-mediated quinolone resistance gene, <italic>qnrC<\/italic>, found in a clinical isolate of <italic>Proteus mirabilis<\/italic>","volume":"53","author":"M Wang","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/AAC.00997-08","article-title":"<italic>qnrD<\/italic>, a novel gene conferring transferable quinolone resistance in <italic>Salmonella enterica<\/italic> serovar Kentucky and Bovismorbificans strains of human origin","volume":"53","author":"LM Cavaco","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1099\/jmm.0.062661-0","article-title":"Epidemiology of <italic>qnrVC<\/italic> alleles and emergence out of the <italic>Vibrionaceae<\/italic> family","volume":"62","author":"EL Fonseca","year":"2013","journal-title":"J Med Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1128\/AAC.49.8.3523-3525.2005","article-title":"Origin of plasmid-mediated quinolone resistance determinant QnrA","volume":"49","author":"L Poirel","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1128\/AAC.05187-11","article-title":"<italic>Citrobacter<\/italic> spp. as a Source of <italic>qnrB<\/italic> Alleles","volume":"55","author":"GA Jacoby","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1128\/AAC.00070-07","article-title":"<italic>Vibrio splendidus<\/italic> as the source of plasmid-mediated QnrS-like quinolone resistance determinants","volume":"51","author":"V Cattoir","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1469-0691.2006.01529.x","article-title":"Occurrence of <italic>qnrA<\/italic>-positive clinical isolates in French teaching hospitals during 2002\u20132005","volume":"12","author":"E Cambau","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1128\/JB.00243-08","article-title":"A plasmid-borne Shewanella algae Gene, <italic>qnrA3<\/italic>, and its possible transfer in vivo between <italic>Kluyvera ascorbata<\/italic> and <italic>Klebsiella pneumoniae<\/italic>","volume":"190","author":"C Lascols","year":"2008","journal-title":"J Bacteriol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/jac\/dkm283","article-title":"Complete nucleotide sequence of a small <italic>qnrS1<\/italic>-carrying plasmid from <italic>Salmonella enterica<\/italic> subsp. enterica Typhimurium DT193","volume":"60","author":"C Kehrenberg","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1086\/505397","article-title":"Plasmid-mediated quinolone resistance in non-Typhi serotypes of <italic>Salmonella enterica<\/italic>","volume":"43","author":"K Gay","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1128\/AAC.00081-11","article-title":"Description of a 2,683-base-pair plasmid containing <italic>qnrD<\/italic> in two <italic>Providencia rettgeri<\/italic> isolates","volume":"56","author":"T Guillard","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.diagmicrobio.2011.01.004","article-title":"Rapid detection of <italic>qnr<\/italic> and <italic>qepA<\/italic> plasmid-mediated quinolone resistance genes using real-time PCR","volume":"70","author":"T Guillard","year":"2011","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0147-619X(84)90063-5","article-title":"Factors affecting the isolation of CCC DNA from <italic>Streptomyces lividans<\/italic> and <italic>Escherichia coli<\/italic>","volume":"12","author":"T Kieser","year":"1984","journal-title":"Plasmid"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0097-8485(01)00099-7","article-title":"Application of a time-delay neural network to promoter annotation in the <italic>Drosophila melanogaster<\/italic> genome","volume":"26","author":"MG Reese","year":"2001","journal-title":"Comput Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.mimet.2005.03.018","article-title":"Identification of plasmids by PCR-based replicon typing","volume":"63","author":"A Carattoli","year":"2005","journal-title":"J Microbiol Methods"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/AAC.45.4.1278-1280.2001","article-title":"New TEM variant (TEM-92) produced by <italic>Proteus mirabilis<\/italic> and <italic>Providencia stuartii<\/italic> isolates","volume":"45","author":"C De Champs","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0960-9822(02)01220-4","article-title":"A ubiquitous and conserved signal for RNA localization in chordates","volume":"12","author":"JN Betley","year":"2002","journal-title":"Curr Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1093\/jac\/dkn077","article-title":"Low selection of topoisomerase mutants from strains of <italic>Escherichia coli<\/italic> harbouring plasmid-borne <italic>qnr<\/italic> genes","volume":"61","author":"A Cesaro","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1128\/AAC.00139-10","article-title":"Prevalence and dissemination of <italic>oqxAB<\/italic> in <italic>Escherichia coli<\/italic> isolates from animals, farmworkers, and the environment","volume":"54","author":"J Zhao","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijantimicag.2010.08.019","article-title":"High levels of multidrug resistance in clinical isolates of Gram-negative pathogens from Nigeria","volume":"37","author":"DO Ogbolu","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Li J, Wang T, Shao B, Shen J, Wang S, et al. (2012) Plasmid-Mediated Quinolone Resistance Genes and Antibiotic Residues in Wastewater and Soil Adjacent to Swine Feedlots: Potential Transfer to Agricultural Lands. Environ Health Perspect.","DOI":"10.1289\/ehp.1104776"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Zhao J-Y, Dang H (2012) Coastal Seawater Bacteria Harbor a Large Reservoir of Plasmid-Mediated Quinolone Resistance Determinants in Jiaozhou Bay, China. Microb Ecol.","DOI":"10.1007\/s00248-012-0008-z"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e17038","DOI":"10.1371\/journal.pone.0017038","article-title":"Pyrosequencing of Antibiotic-Contaminated River Sediments Reveals High Levels of Resistance and Gene Transfer Elements","volume":"6","author":"E Kristiansson","year":"2011","journal-title":"PLoS ONE"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"E46","DOI":"10.1111\/j.1469-0691.2011.03728.x","article-title":"Description and plasmid characterization of qnrD determinants in Proteus mirabilis and Morganella morganii","volume":"18","author":"A Mazzariol","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1089\/mdr.2012.0146","article-title":"Prevalence and plasmid characterization of the <italic>qnrD<\/italic> determinant in <italic>Enterobacteriaceae<\/italic> isolated from animals, retail meat products, and humans","volume":"19","author":"S Zhang","year":"2013","journal-title":"Microbial Drug Resistance"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.micinf.2011.02.005","article-title":"Comparative pathology of bacteria in the genus Providencia to a natural host, <italic>Drosophila melanogaster<\/italic>","volume":"13","author":"MR Galac","year":"2011","journal-title":"Microbes and Infection"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1046\/j.1365-2958.1999.01388.x","article-title":"MIC231, a naturally occurring mobile insertion cassette from <italic>Bacillus cereus<\/italic>","volume":"32","author":"Y Chen","year":"1999","journal-title":"Mol Microbiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2958.2004.04146.x","article-title":"IS231-MIC231 elements from <italic>Bacillus cereus<\/italic> sensu lato are modular","volume":"53","author":"D De Palmenaer","year":"2004","journal-title":"Mol Microbiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3201\/eid1402.070677","article-title":"Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental <italic>Aeromonas<\/italic> spp","volume":"14","author":"V Cattoir","year":"2008","journal-title":"Emerging Infect Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1128\/AAC.00349-08","article-title":"IS<italic>Ecp<\/italic>1-mediated transposition of <italic>qnrB<\/italic>-like gene in <italic>Escherichia coli<\/italic>","volume":"52","author":"V Cattoir","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1128\/AAC.50.4.1178-1182.2006","article-title":"<italic>qnrB<\/italic>, another plasmid-mediated gene for quinolone resistance","volume":"50","author":"GA Jacoby","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/AAC.01082-06","article-title":"Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1","volume":"51","author":"L Poirel","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1093\/jac\/dki371","article-title":"<italic>Vibrionaceae<\/italic> as a possible source of Qnr-like quinolone resistance determinants","volume":"56","author":"L Poirel","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1128\/AAC.49.5.2144-2145.2005","article-title":"<italic>Vibrio parahaemolyticus<\/italic> chromosomal qnr homologue VPA0095: demonstration by transformation with a mutated gene of its potential to reduce quinolone susceptibility in <italic>Escherichia coli<\/italic>","volume":"49","author":"T Saga","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1128\/AAC.01664-08","article-title":"Impact of low-level resistance to fluoroquinolones due to <italic>qnrA1<\/italic> and <italic>qnrS1<\/italic> genes or a gyrA mutation on ciprofloxacin bactericidal activity in a murine model of <italic>Escherichia coli<\/italic> urinary tract infection","volume":"53","author":"N Allou","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1469-0691.2008.02020.x","article-title":"Activity of ciprofloxacin and levofloxacin in experimental pneumonia caused by <italic>Klebsiella pneumoniae<\/italic> deficient in porins, expressing active efflux and producing QnrA1","volume":"14","author":"JM Rodr\u00edguez-Mart\u00ednez","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"ref44","first-page":"2438","article-title":"Impact of low-level fluoroquinolone resistance genes <italic>qnrA1<\/italic>, <italic>qnrB19<\/italic> and <italic>qnrS1<\/italic> on ciprofloxacin treatment of isogenic <italic>Escherichia coli<\/italic> strains in a murine urinary tract infection model. J Antimicrob Chemother","volume":"67","author":"L Jakobsen","year":"2012"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e24552","DOI":"10.1371\/journal.pone.0024552","article-title":"Plasmidic <italic>qnrA3<\/italic> Enhances <italic>Escherichia coli<\/italic> Fitness in Absence of Antibiotic Exposure","volume":"6","author":"A Michon","year":"2011","journal-title":"PLoS ONE"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0087801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:51:35Z","timestamp":1589043095000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0087801"}},"subtitle":[],"editor":[{"given":"Ulrike Gertrud","family":"Munderloh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,4]]},"references-count":45,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0087801","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,4]]}}}