{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:21:57Z","timestamp":1777263717917,"version":"3.51.4"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0087826","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T21:49:16Z","timestamp":1390945756000},"page":"e87826","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Therapeutic Effect of Intravenous Infusion of Perfluorocarbon Emulsion on LPS-Induced Acute Lung Injury in Rats"],"prefix":"10.1371","volume":"9","author":[{"given":"Shike","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqi","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning Xu","family":"Land\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haojun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(67)90168-7","article-title":"Acute respiratory distress in adults","volume":"2","author":"DG Ashbaugh","year":"1967","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.2741\/4051","article-title":"Neutrophils in acute lung injury","volume":"17","author":"X Zhou","year":"2012","journal-title":"Front Biosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2169\/internalmedicine.48.1741","article-title":"Acute Lung Injury Review","volume":"48","author":"K Tsushima","year":"2009","journal-title":"Intern Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s00134-004-2479-y","article-title":"A 12-month clinical survey of incidence and outcome of acute respiratory distress syndrome in Shanghai intensive care units","volume":"30","author":"Y Lu","year":"2004","journal-title":"Intensive Care Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/00003246-199604000-00023","article-title":"Adult respiratory distress syndrome: a systematic overview of incidence and risk factors","volume":"24","author":"BG Garber","year":"1996","journal-title":"Crit Care Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJMoa032193","article-title":"Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome","volume":"351","author":"RG Brower","year":"2004","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"R430","DOI":"10.1186\/cc3737","article-title":"High frequency oscillatory ventilation compared with conventional mechanical ventilation in adult respiratory distress syndrome: a randomized controlled trial","volume":"9","author":"CW Bollen","year":"2005","journal-title":"Crit Care"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1056\/NEJMoa1215716","article-title":"High-frequency oscillation for acute respiratory distress syndrome","volume":"368","author":"D Young","year":"2013","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1097\/TA.0b013e318247cd4f","article-title":"Prone positioning improves oxygenation in adult burn patients with severe acute respiratory distress syndrome","volume":"72","author":"DF Hale","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ccc.2011.05.010","article-title":"Prone-positioning therapy in ARDS","volume":"27","author":"S Dickinson","year":"2011","journal-title":"Crit Care Clin"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1001\/jama.291.13.1603","article-title":"Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial","volume":"291","author":"RW Taylor","year":"2004","journal-title":"JAMA"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1097\/01.CCM.0000248727.29055.25","article-title":"Healthcare costs and long-term outcomes after acute respiratory distress syndrome: A phase III trial of inhaled nitric oxide","volume":"34","author":"DC Angus","year":"2006","journal-title":"Crit Care Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"S253","DOI":"10.1097\/01.CCM.0000057900.19201.55","article-title":"Glucocorticoids and acute lung injury","volume":"31","author":"BT Thompson","year":"2003","journal-title":"Crit Care Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1164\/rccm.200508-1302OC","article-title":"The beta agonist lung injury trial (BALTI): a randomised placebo-controlled clinical trial","volume":"173","author":"GD Perkins","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0140-6736(11)61623-1","article-title":"BALTI-2 study investigators: Effect of intravenous \u03b2-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial","volume":"379","author":"F Gao Smith","year":"2012","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1378\/chest.08-0362","article-title":"A Search for subgroups of patients with ARDS who may benefit from surfactant replacement therapy: a pooled analysis of five studies with recombinant surfactant protein-C surfactant (Venticute)","volume":"134","author":"FJ Taut","year":"2008","journal-title":"Chest"},{"key":"ref17","volume":"116 (Suppl)","unstructured":"Bernard G, Wheeler A, Naum C, Morris P, Nelson L, et al. (1999) A placebo controlled, randomised trail of IL-10 in acute lung injury (ALI). Chest <volume>116 (Suppl)<\/volume>: : 260S."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1423-0410.1998.tb05426.x","article-title":"Perfluorocarbon compounds","volume":"74","author":"NS Faithfull","year":"1998","journal-title":"Vox Sang"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1525-1594.2009.00944.x","article-title":"Perfluorocarbon-based oxygen carriers: review of products and trials","volume":"34","author":"CI Castro","year":"2010","journal-title":"Artif Organs"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/sper.2000.20092","article-title":"Liquid ventilation","volume":"24","author":"JS Greenspan","year":"2000","journal-title":"Semin Perinatol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/10731190600973824","article-title":"Perfluorocarbon-based oxygen delivery","volume":"34","author":"JG Riess","year":"2006","journal-title":"Artif Cells Blood Substit Immobil Biotechnol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0022-3476(05)82457-6","article-title":"Liquid ventilation of human preterm neonates","volume":"117","author":"JS Greenspan","year":"1990","journal-title":"J Pediatr"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-2000-9852","article-title":"Partial liquid ventilation","volume":"21","author":"D Hadjiliadis","year":"2000","journal-title":"Semin Respir Crit Care Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1136\/thx.52.2008.S3","article-title":"Liquid ventilation in the preterm neonate","volume":"52","author":"CW Yoxall","year":"1997","journal-title":"Thorax"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Wang X, Zhang J, Li X, Liu Y, Yang H, et al. (2013) Sustained Improvement of Gas Exchange and Lung Mechanics by Vaporized Perfluorocarbon Inhalation in Piglet Acute Lung Injury Model. Clin Respir J. 2013 Sep 13. doi:<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1111\/crj.12053\" xlink:type=\"simple\">10.1111\/crj.12053<\/ext-link>. [Epub ahead of print]","DOI":"10.1111\/crj.12053"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"R93","DOI":"10.1186\/cc364","article-title":"Blood substitutes. Artificial oxygen carriers: perfluorocarbon emulsions","volume":"3","author":"DR Spahn","year":"1999","journal-title":"Crit Care"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00000441-199403000-00009","article-title":"Role of perfluorocarbon Fluosol-DA in coronary angioplasty","volume":"307","author":"DM Kerins","year":"1994","journal-title":"Am J Med Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1152\/japplphysiol.90995.2008","article-title":"Perfluorocarbon emulsions as a promising technology: a review of tissue and vascular gas dynamics","volume":"106","author":"BD Spiess","year":"2009","journal-title":"J Appl Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1055\/s-2001-18189","article-title":"Perflubron emulsion (Oxygent(tm)): a temporary intravenous oxygen carrier","volume":"36","author":"PE Keipert","year":"2001","journal-title":"Anasthesiol Intensivmed Notfallmed Schmerzther"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jim.2009.09.008","article-title":"Polymorphonuclear leukocytes isolated from umbilical cord blood as a useful research tool to study adherence to cell monolayers","volume":"351","author":"J Sharma","year":"2009","journal-title":"J Immunol Methods"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0092-8674(91)90279-8","article-title":"Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity","volume":"67","author":"EC Butcher","year":"1991","journal-title":"Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1074\/jbc.M406968200","article-title":"Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2","volume":"280","author":"DA Solovjov","year":"2005","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1586\/ers.10.80","article-title":"Role of CCR2 and IL-8 in acute lung injury: a new mechanism and therapeutic target","volume":"5","author":"Y Shen","year":"2011","journal-title":"Expert Rev Respir Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1460-9592.2003.01206.x","article-title":"Liquid ventilation: an adjunct for respiratory management","volume":"14","author":"MR Wolfson","year":"2004","journal-title":"Paediatr Anaesth"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.resuscitation.2009.11.018","article-title":"Perfluorocarbon induced intra-arrest hypothermia does not improve survival in a swine model of asphyxial cardiac arrest","volume":"81","author":"AS Albaghdadi","year":"2010","journal-title":"Resuscitation"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1097\/01.CCM.0000163218.79770.29","article-title":"Differential impact of perfluorochemical physical properties on the physiologic, histologic, and inflammatory profile in acute lung injury","volume":"33","author":"BN Shashikant","year":"2005","journal-title":"Crit Care Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.4049\/jimmunol.176.8.4995","article-title":"Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury","volume":"176","author":"MB Everhart","year":"2006","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3181\/0811-MR-318","article-title":"Acute lung injury:apoptosis and signaling mechanisms","volume":"234","author":"M Chopra","year":"2009","journal-title":"Exp Biol Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jss.2006.08.029","article-title":"Perflubron emulsion prevents PMN activation and improves myocardial functional recovery after cold ischemia and reperfusion","volume":"138","author":"SC Gale","year":"2007","journal-title":"J Surg Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s00134-005-2652-y","article-title":"Inhibition of inflammatory responses by FC-77, a perfluorochemical, in lipopolysaccharide-treated RAW 264.7 macrophages","volume":"31","author":"H Chang","year":"2005","journal-title":"Intensive Care Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/00003246-200004000-00034","article-title":"Perfluorocarbon blocks tumor necrosis factor-alpha-induced interleukin-8 release from alveolar epithelial cells in vitro","volume":"28","author":"A Baba","year":"2000","journal-title":"Crit Care Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0022-4804(03)00219-1","article-title":"Pentoxifylline reduces acute lung injury in chronic endotoxemia","volume":"115","author":"C Michetti","year":"2003","journal-title":"J Surg Res"},{"key":"ref43","first-page":"8","article-title":"Icam-1 and acute pancreatitis complicated by acute lung injury","volume":"10","author":"X Zhang","year":"2009","journal-title":"JOP"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1164\/ajrccm.161.3.9901066","article-title":"Inhibition of CD11-CD18 complex prevents acute lung injury and reduces mortality after peritonitis in rabbits","volume":"161","author":"M Gardinali","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"ref45","first-page":"363","article-title":"Protective effects of colquhounia root tablet against oleic acid induced acute lung injury in rats","volume":"26","author":"XG Ma","year":"2006","journal-title":"Chin J Anesthesiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"C1592","DOI":"10.1152\/ajpcell.00540.2001","article-title":"A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release","volume":"283","author":"TH Wyman","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.4049\/jimmunol.157.10.4609","article-title":"The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice","volume":"157","author":"CM Doerschuk","year":"1996","journal-title":"J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0087826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T18:54:28Z","timestamp":1716490468000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0087826"}},"subtitle":[],"editor":[{"given":"Ian C.","family":"Davis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,1,28]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0087826","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,28]]}}}