{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:45:45Z","timestamp":1791924345005,"version":"4.3.4"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T00:00:00Z","timestamp":1391385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0087871","type":"journal-article","created":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T22:07:50Z","timestamp":1391465270000},"page":"e87871","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":117,"title":["Caveolin-1 Is a Critical Determinant of Autophagy, Metabolic Switching, and Oxidative Stress in Vascular Endothelium"],"prefix":"10.1371","volume":"9","author":[{"given":"Takashi","family":"Shiroto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano L.","family":"Sartoretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Kalwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shimokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev-pathol-011811-120856","article-title":"Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms","volume":"7","author":"F Sotgia","year":"2012","journal-title":"Annu Rev Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cardiores.2007.03.023","article-title":"Life history of eNOS: partners and pathways","volume":"75","author":"DM Dudzinski","year":"2007","journal-title":"Cardiovasc Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1126\/science.1062688","article-title":"Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice","volume":"293","author":"M Drab","year":"2001","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"38121","DOI":"10.1074\/jbc.M105408200","article-title":"Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities","volume":"276","author":"B Razani","year":"2001","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"8635","DOI":"10.1074\/jbc.M110970200","article-title":"Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities","volume":"277","author":"B Razani","year":"2002","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cmet.2012.01.004","article-title":"Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1","volume":"15","author":"IW Asterholm","year":"2012","journal-title":"Cell Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cub.2011.03.030","article-title":"Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility","volume":"21","author":"M Bosch","year":"2011","journal-title":"Curr Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"11375","DOI":"10.1073\/pnas.172360799","article-title":"Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice","volume":"99","author":"YY Zhao","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1172\/JCI33338","article-title":"Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration","volume":"119","author":"YY Zhao","year":"2009","journal-title":"J Clin Invest"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1096\/fj.12-215798","article-title":"Mitochondria-localized caveolin in adaptation to cellular stress and injury","volume":"26","author":"HN Fridolfsson","year":"2012","journal-title":"FASEB J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1089\/ars.2010.3642","article-title":"Regulation of endothelial function by mitochondrial reactive oxygen species","volume":"15","author":"ME Widlansky","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"17343","DOI":"10.1073\/pnas.0907409106","article-title":"Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells","volume":"106","author":"BY Jin","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"15792","DOI":"10.1073\/pnas.1111331108","article-title":"Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis","volume":"108","author":"JL Sartoretto","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1172\/JCI15211","article-title":"The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance","volume":"111","author":"D Vicent","year":"2003","journal-title":"J Clin Invest"},{"key":"ref15","first-page":"110","article-title":"PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice","volume":"119","author":"T Kanda","year":"2009","journal-title":"J Clin Invest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1476-5381.1994.tb14021.x","article-title":"Endothelial function in the isolated perfused mesentery and aortae of rats with streptozotocin-induced diabetes: effect of treatment with the aldose reductase inhibitor, ponalrestat","volume":"111","author":"PD Taylor","year":"1994","journal-title":"Br J Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"H3404","DOI":"10.1152\/ajpheart.00761.2007","article-title":"Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitrite","volume":"293","author":"C Quijano","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"40659","DOI":"10.1074\/jbc.M407051200","article-title":"Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells","volume":"279","author":"E Gonzalez","year":"2004","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"20351","DOI":"10.1074\/jbc.M702182200","article-title":"Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -&gt; Rac1 -&gt; Akt -&gt; endothelial nitric-oxide synthase pathway","volume":"282","author":"YC Levine","year":"2007","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/B978-0-12-391856-7.00032-9","article-title":"In vivo real-time visualization of leukocytes and intracellular hydrogen peroxide levels during a zebrafish acute inflammation assay","volume":"506","author":"L Pase","year":"2012","journal-title":"Methods Enzymol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1073\/pnas.1019393108","article-title":"Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome","volume":"108","author":"ZJ Reitman","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/bioinformatics\/19.2.295","article-title":"Matrix2png: a utility for visualizing matrix data","volume":"19","author":"P Pavlidis","year":"2003","journal-title":"Bioinformatics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1074\/jbc.273.6.3125","article-title":"The endothelial nitric-oxide synthase-caveolin regulatory cycle","volume":"273","author":"O Feron","year":"1998","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"H1285","DOI":"10.1152\/ajpheart.2000.278.4.H1285","article-title":"Caveolin-1 regulates shear stress-dependent activation of extracellular signal-regulated kinase","volume":"278","author":"H Park","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/abio.1997.2391","article-title":"A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases","volume":"253","author":"M Zhou","year":"1997","journal-title":"Anal Biochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0891-5849(01)00480-4","article-title":"Redox environment of the cell as viewed through the redox state of the glutathione disulfide\/glutathione couple","volume":"30","author":"FQ Schafer","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e14564","DOI":"10.1371\/journal.pone.0014564","article-title":"Hydrogen peroxide probes directed to different cellular compartments","volume":"6","author":"M Malinouski","year":"2011","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/CIRCULATIONAHA.105.602532","article-title":"Endothelial nitric oxide synthase in vascular disease: from marvel to menace","volume":"113","author":"U Forstermann","year":"2006","journal-title":"Circulation"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"15038","DOI":"10.1073\/pnas.0601945103","article-title":"Selective fluorescent imaging of superoxide in vivo using ethidium-based probes","volume":"103","author":"KM Robinson","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0092-8674(92)90143-Z","article-title":"Caveolin, a protein component of caveolae membrane coats","volume":"68","author":"KG Rothberg","year":"1992","journal-title":"Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1242\/jcs.114.7.1397","article-title":"Cell-specific targeting of caveolin-1 to caveolae, secretory vesicles, cytoplasm or mitochondria","volume":"114","author":"WP Li","year":"2001","journal-title":"J Cell Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-med-061511-134747","article-title":"Application of metabolomics to diagnosis of insulin resistance","volume":"64","author":"MV Milburn","year":"2013","journal-title":"Annu Rev Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/BJ20111451","article-title":"Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling","volume":"441","author":"J Lee","year":"2012","journal-title":"Biochem J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4161\/auto.5338","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes","volume":"4","author":"DJ Klionsky","year":"2008","journal-title":"Autophagy"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1083\/jcb.201102095","article-title":"Signal transduction by reactive oxygen species","volume":"194","author":"T Finkel","year":"2011","journal-title":"J Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1172\/JCI200318174","article-title":"Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling","volume":"111","author":"C Nathan","year":"2003","journal-title":"J Clin Invest"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/01.ATV.0000152605.64964.c0","article-title":"Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans","volume":"25","author":"JD Morrow","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0891-5849(94)90249-6","article-title":"Hydrogen peroxide production by red blood cells","volume":"16","author":"C Giulivi","year":"1994","journal-title":"Free Radic Biol Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/01.HYP.32.3.488","article-title":"Role of NADH\/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy","volume":"32","author":"AM Zafari","year":"1998","journal-title":"Hypertension"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"8745","DOI":"10.1073\/pnas.93.16.8745","article-title":"Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits","volume":"93","author":"CR White","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1210\/me.2009-0115","article-title":"The trafficking\/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric oxide production","volume":"23","author":"H Wang","year":"2009","journal-title":"Mol Endocrinol"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Chaudhri VK, Salzler GG, Dick SA, Buckman MS, Sordella R, <etal>et al<\/etal>.. (2013) Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor. Mol Cancer Res.","DOI":"10.1158\/1541-7786.MCR-12-0437-T"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"999","DOI":"10.4161\/auto.6.7.12754","article-title":"Under the ROS...thiol network is the principal suspect for autophagy commitment","volume":"6","author":"G Filomeni","year":"2010","journal-title":"Autophagy"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1089\/ars.2009.2524","article-title":"Autophagy, redox signaling, and ventricular remodeling","volume":"11","author":"N Gurusamy","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/sj.emboj.7601623","article-title":"Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4","volume":"26","author":"R Scherz-Shouval","year":"2007","journal-title":"EMBO J"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0087871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T05:44:11Z","timestamp":1648187051000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0087871"}},"subtitle":[],"editor":[{"given":"Nanette H.","family":"Bishopric","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,3]]},"references-count":45,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0087871","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,3]]}}}