{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:29:05Z","timestamp":1776371345206,"version":"3.51.2"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T00:00:00Z","timestamp":1395360000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0088242","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T20:36:19Z","timestamp":1395434179000},"page":"e88242","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Association between MTHFR C677T and A1298C Polymorphisms and NSCL\/P Risk in Asians: A Meta-Analysis"],"prefix":"10.1371","volume":"9","author":[{"given":"Mengmeng","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangwu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baosen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,3,21]]},"reference":[{"key":"ref1","unstructured":"World Health O (2003) Global registry and database on craniofacial anomalies: Report of a WHO registry meeting on craniofacial anomalies. Geneva: World Health Organization Report nr ISBN 651656510."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000337464","article-title":"Epidemiology of oral clefts 2012: an international perspective","volume":"16","author":"PA Mossey","year":"2012","journal-title":"Front Oral Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1093\/hmg\/8.10.1853","article-title":"The many faces and factors of orofacial clefts","volume":"8","author":"BC Schutte","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(82)91063-7","article-title":"Periconceptional supplementation with vitamins and folic acid to prevent recurrence of cleft lip","volume":"2","author":"M Tolarova","year":"1982","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJM200011303432204","article-title":"Folic acid antagonists during pregnancy and the risk of birth defects","volume":"343","author":"S Hern\u00e1ndez-D\u00edaz","year":"2000","journal-title":"New England journal of medicine"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"P Frosst","year":"1995","journal-title":"Nature Genetics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/jn\/129.5.919","article-title":"Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement","volume":"129","author":"LB Bailey","year":"1999","journal-title":"The Journal of nutrition"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/301825","article-title":"A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?","volume":"62","author":"NM Van der Put","year":"1998","journal-title":"American journal of human genetics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/bdra.20491","article-title":"Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate","volume":"82","author":"JL Mills","year":"2008","journal-title":"Birth Defects Research Part A: Clinical and Molecular Teratology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1590\/S0100-879X2006005000112","article-title":"Polymorphisms in genes MTHFR, MTR and MTRR are not risk factors for cleft lip\/palate in South Brazil","volume":"40","author":"AP Brandalize","year":"2007","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/aje\/kwg005","article-title":"Goorhuis-Brouwer SM, van der Biezen JJ, Kuijpers-Jagtman AM, RP S-T: Does the interaction between maternal folate intake and the methylenetetrahydrofolate reductase polymorphisms affect the risk of cleft lip with or without cleft palate?","volume":"157","author":"IA van Rooij","year":"2003","journal-title":"American journal of epidemiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/ajmg.a.32162","article-title":"Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts","volume":"146A","author":"AL Boyles","year":"2008","journal-title":"Am J Med Genet A"},{"key":"ref13","first-page":"A27","article-title":"A common mutation in the MTHFR gene is a risk factor for nonsyndromic cleft lip and palate anomalies","volume":"63","author":"M Tolarova","year":"1998","journal-title":"Am J Hum Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1136\/jmg.40.5.e64","article-title":"Maternal 677CT\/1298AC genotype of the MTHFR gene as a risk factor for cleft lip","volume":"40","author":"V Shotelersuk","year":"2003","journal-title":"J Med Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/sj.ejhg.5201187","article-title":"Maternal MTHFR interacts with the offspring's BCL3 genotypes, but not with TGFA, in increasing risk to nonsyndromic cleft lip with or without cleft palate","volume":"12","author":"DA Gaspar","year":"2004","journal-title":"Eur J Hum Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/gtmb.2008.0115","article-title":"MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population","volume":"13","author":"A Ali","year":"2009","journal-title":"Genet Test Mol Biomarkers"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/bdra.23005","article-title":"Association between MTHFR polymorphisms and orofacial clefts risk: a meta-analysis","volume":"94","author":"YL Luo","year":"2012","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1002\/ajmg.a.35503","article-title":"Infants' MTHFR polymorphisms and nonsyndromic orofacial clefts susceptibility: a meta-analysis based on 17 case-control studies","volume":"158A","author":"Y Pan","year":"2012","journal-title":"Am J Med Genet A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/ajmg.a.31684","article-title":"Hyperhomocysteinemia and MTHFR polymorphisms in association with orofacial clefts and congenital heart defects: a meta-analysis","volume":"143A","author":"A Verkleij-Hagoort","year":"2007","journal-title":"Am J Med Genet A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/ije\/dyn098","article-title":"Folate intake, markers of folate status and oral clefts: is the evidence converging?","volume":"37","author":"CY Johnson","year":"2008","journal-title":"Int J Epidemiol"},{"key":"ref21","first-page":"617","article-title":"Association between C677T and A1298C MTHFR Gene Polymorphism and Nonsyndromic Orofacial Clefts in the Turkish Population: A Case-Parent Study","volume":"54","author":"A Semi\u00e7-Jusufagi\u00e7","year":"2012","journal-title":"Turk J Pediatr"},{"key":"ref22","first-page":"464","article-title":"Association between parental MTHFR gene polymorphism 677C\/T and nonsyndromic cleft lip and palate in offspring","volume":"29","author":"SM Wang","year":"2012","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12038-013-9298-7","article-title":"Lower incidence of nonsyndromic cleft lip with or without cleft palate in females: is homocysteine a factor?","volume":"38","author":"P Kumari","year":"2013","journal-title":"J Biosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1089\/dna.2010.1185","article-title":"Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and nonsyndromic orofacial clefts susceptibility in a southern Chinese population","volume":"30","author":"Y Han","year":"2011","journal-title":"DNA and Cell Biology"},{"key":"ref25","first-page":"432","article-title":"Relationship between genetic polymorphisms of MTHFR C677T and nonsyndromic cleft lip with or without palate","volume":"41","author":"JZ Guo","year":"2009","journal-title":"Beijing Da Xue Xue Bao"},{"key":"ref26","first-page":"8","article-title":"Relationship between nonsyndromic cleft lip with or without cleft palate (NSCL\/P) and genetic polymorphisms of MTHFR C677T and A1298C","volume":"22","author":"WD Wan","year":"2006","journal-title":"Zhonghua Zheng Xing Wai Ke Za Zhi"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0088242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T19:51:57Z","timestamp":1565293917000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0088242"}},"subtitle":[],"editor":[{"given":"Zhengdong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,21]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0088242","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,21]]}}}