{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:50:17Z","timestamp":1790769017762,"version":"4.1.0"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:00:00Z","timestamp":1391558400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0088284","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T22:20:27Z","timestamp":1391638827000},"page":"e88284","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Phosphorylation of Mutant Huntingtin at Serine 116 Modulates Neuronal Toxicity"],"prefix":"10.1371","volume":"9","author":[{"given":"Erin E.","family":"Watkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Arbez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Waldron-Roby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"O'Meally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Ratovitski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,2,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington&apos;s disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"CA Ross","year":"2011","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.tibs.2006.06.009","article-title":"Huntington&apos;s disease: seeing the pathogenic process through a genetic lens","volume":"31","author":"JF Gusella","year":"2006","journal-title":"Trends Biochem Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"pe48","DOI":"10.1126\/stke.2003.207.pe48","article-title":"Huntingtin: alive and well and working in middle management","volume":"2003","author":"ME MacDonald","year":"2003","journal-title":"Sci STKE"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1055\/s-2007-971176","article-title":"Huntington&apos;s Disease","volume":"27","author":"FO Walker","year":"2007","journal-title":"Semin Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/BJ20071619","article-title":"Huntington&apos;s disease: from pathology and genetics to potential therapies","volume":"412","author":"S Imarisio","year":"2008","journal-title":"Biochem J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biocel.2010.10.014","article-title":"Huntington&apos;s disease: From molecular basis to therapeutic advances","volume":"43","author":"S Krobitsch","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1016\/S1353-8020(11)70034-7","article-title":"Huntington&apos;s disease: new aspects on phenotype and genotype","volume":"18","author":"H Shang","year":"2012","journal-title":"Parkinsonism Relat Disord"},{"key":"ref8","volume":"3","unstructured":"Finkbeiner S (2011) Huntington&apos;s Disease. Cold Spring Harb Perspect Biol <volume>3<\/volume>.."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00041.2009","article-title":"Molecular mechanisms and potential therapeutical targets in Huntington&apos;s disease","volume":"90","author":"C Zuccato","year":"2005","journal-title":"Physiol Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1016\/S1353-8020(09)70800-4","article-title":"Huntington disease: pathogenesis, biomarkers, and approaches to experimental therapeutics","volume":"15","author":"CA Ross","year":"2009","journal-title":"Parkinsonism Relat Disord"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0070-2153(06)75002-5","article-title":"Selective neuronal degeneration in Huntington&apos;s disease","volume":"75","author":"CM Cowan","year":"2006","journal-title":"Curr Top Dev Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/B978-0-12-381328-2.00014-6","article-title":"Genetics and neuropathology of Huntington&apos;s disease","volume":"98","author":"A Reiner","year":"2011","journal-title":"Int Rev Neurobiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/B978-0-444-52014-2.00004-5","article-title":"Huntington&apos;s disease - neuropathology","volume":"100","author":"JP Vonsattel","year":"2011","journal-title":"Handb Clin Neurol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s13311-012-0112-2","article-title":"Huntington&apos;s disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease","volume":"9","author":"ME Ehrlich","year":"2012","journal-title":"Neurotherapeutics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington&apos;s disease chromosomes. The Huntington&apos;s Disease Collaborative Research Group","volume":"72","year":"1993","journal-title":"Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1007\/s00018-006-6242-0","article-title":"Huntington&apos;s disease: from huntingtin function and dysfunction to therapeutic strategies","volume":"63","author":"M Borrell-Pages","year":"2006","journal-title":"Cell Mol Life Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/etc.2075","article-title":"Evaluation of whole effluent toxicity data characteristics and use of Welch&apos;s T-test in the test of significant toxicity analysis","volume":"32","author":"L Zheng","year":"2013","journal-title":"Environ Toxicol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"M DiFiglia","year":"1997","journal-title":"Science"},{"key":"ref19","first-page":"1243","article-title":"Huntingtin processing in pathogenesis of Huntington disease","volume":"25","author":"ZH Qin","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1523\/JNEUROSCI.1305-11.2012","article-title":"Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin","volume":"32","author":"E Waldron-Roby","year":"2012","journal-title":"J Neurosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.4161\/cc.6.23.4992","article-title":"N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington&apos;s disease","volume":"6","author":"T Ratovitski","year":"2007","journal-title":"Cell Cycle"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"10855","DOI":"10.1074\/jbc.M804813200","article-title":"Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells","volume":"284","author":"T Ratovitski","year":"2009","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.cell.2006.04.026","article-title":"Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin","volume":"125","author":"RK Graham","year":"2006","journal-title":"Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","article-title":"Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation","volume":"90","author":"SW Davies","year":"1997","journal-title":"Cell"},{"key":"ref25","first-page":"397","article-title":"Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin","volume":"8","author":"G Schilling","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neuron.2010.12.035","article-title":"Huntington&apos;s disease: can mice lead the way to treatment?","volume":"69","author":"ZR Crook","year":"2011","journal-title":"Neuron"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2008.06.005","article-title":"Rodent genetic models of Huntington disease","volume":"32","author":"MY Heng","year":"2008","journal-title":"Neurobiol Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2011.12.013","article-title":"Protein aggregates in Huntington&apos;s disease","volume":"238","author":"M Arrasate","year":"2012","journal-title":"Exp Neurol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"CA Ross","year":"2004","journal-title":"Nature Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/hmg\/ddi071","article-title":"A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure","volume":"14","author":"MA Poirier","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tins.2008.09.004","article-title":"Mutant huntingtin and mitochondrial dysfunction","volume":"31","author":"E Bossy-Wetzel","year":"2008","journal-title":"Trends Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"16017","DOI":"10.1074\/jbc.M111.252577","article-title":"Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein","volume":"287","author":"LG Nucifora","year":"2012","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.stem.2012.04.027","article-title":"Induced Pluripotent Stem Cells from Patients with Huntington&apos;s Disease Show CAG-Repeat-Expansion-Associated Phenotypes","volume":"11","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nrn1806","article-title":"Normal huntingtin function: an alternative approach to Huntington&apos;s disease","volume":"6","author":"E Cattaneo","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tcb.2009.01.005","article-title":"Huntingtin as an essential integrator of intracellular vesicular trafficking","volume":"19","author":"JP Caviston","year":"2009","journal-title":"Trends Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuron.2012.05.024","article-title":"Network organization of the huntingtin proteomic interactome in mammalian brain","volume":"75","author":"DI Shirasaki","year":"2012","journal-title":"Neuron"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"21599","DOI":"10.1074\/jbc.M112.359307","article-title":"Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis","volume":"287","author":"BP Culver","year":"2012","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.4161\/cc.20423","article-title":"Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis","volume":"11","author":"T Ratovitski","year":"2012","journal-title":"Cell Cycle"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e27680","DOI":"10.1371\/journal.pone.0027680","article-title":"A quantitative method for the specific assessment of caspase-6 activity in cell culture","volume":"6","author":"DE Ehrnhoefer","year":"2011","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"23686","DOI":"10.1074\/jbc.M513507200","article-title":"Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity","volume":"281","author":"B Schilling","year":"2006","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0076-6879(06)12005-4","article-title":"Proteomics of polyglutamine aggregates","volume":"412","author":"K Mitsui","year":"2006","journal-title":"Methods Enzymol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s12264-010-1118-6","article-title":"The role of post-translational modifications of huntingtin in the pathogenesis of Huntington&apos;s disease","volume":"26","author":"Y Wang","year":"2010","journal-title":"Neurosci Bull"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e36315","DOI":"10.1371\/journal.pone.0036315","article-title":"Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-\/- mice","volume":"7","author":"FB Young","year":"2012","journal-title":"PLoS One"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1002\/pmic.201100380","article-title":"Mass spectrometric identification of novel posttranslational modification sites in Huntingtin","volume":"12","author":"G Dong","year":"2012","journal-title":"Proteomics"},{"key":"ref45","volume":"10","unstructured":"Cong X, Held JM, DeGiacomo F, Bonner A, Chen JM, <etal>et al<\/etal>.. (2011) Mass spectrometric identification of novel lysine acetylation sites in huntingtin. Mol Cell Proteomics <volume>10<\/volume> : M111 009829."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.0953-816X.2003.03131.x","article-title":"The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin","volume":"19","author":"H Rangone","year":"2004","journal-title":"Eur J Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1038\/emboj.2008.133","article-title":"Huntingtin phosphorylation acts as a molecular switch for anterograde\/retrograde transport in neurons","volume":"27","author":"E Colin","year":"2008","journal-title":"EMBO J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1093\/hmg\/ddn281","article-title":"Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons","volume":"17","author":"D Zala","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.mcn.2008.09.007","article-title":"Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments","volume":"40","author":"SC Warby","year":"2009","journal-title":"Mol Cell Neurosci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S1534-5807(02)00188-0","article-title":"The IGF-1\/Akt pathway is neuroprotective in Huntington&apos;s disease and involves Huntingtin phosphorylation by Akt","volume":"2","author":"S Humbert","year":"2002","journal-title":"Dev Cell"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1523\/JNEUROSCI.3706-05.2006","article-title":"Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421","volume":"26","author":"R Pardo","year":"2006","journal-title":"J Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"14318","DOI":"10.1523\/JNEUROSCI.1589-10.2010","article-title":"Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A","volume":"30","author":"M Metzler","year":"2010","journal-title":"J Neurosci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1523\/JNEUROSCI.6747-10.2011","article-title":"NMDA receptor excitotoxicity: impact on phosphatase activity and phosphorylation of huntingtin","volume":"31","author":"MR Jablonski","year":"2011","journal-title":"J Neurosci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1083\/jcb.200412071","article-title":"Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity","volume":"169","author":"S Luo","year":"2005","journal-title":"J Cell Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"7318","DOI":"10.1523\/JNEUROSCI.1831-07.2007","article-title":"Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons","volume":"27","author":"SL Anne","year":"2007","journal-title":"J Neurosci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/hmg\/dds554","article-title":"The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal","volume":"22","author":"T Maiuri","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.nbd.2011.04.015","article-title":"The role of IkappaB kinase complex in the neurobiology of Huntington&apos;s disease","volume":"43","author":"A Khoshnan","year":"2011","journal-title":"Neurobiol Dis"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nchembio.582","article-title":"Kinase inhibitors modulate huntingtin cell localization and toxicity","volume":"7","author":"RS Atwal","year":"2011","journal-title":"Nat Chem Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nchembio.604","article-title":"Huntington&apos;s disease: flipping a switch on huntingtin","volume":"7","author":"ER Greiner","year":"2011","journal-title":"Nat Chem Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/hmg\/ddr023","article-title":"Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation","volume":"20","author":"LS Havel","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.neuron.2009.11.020","article-title":"Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice","volume":"64","author":"X Gu","year":"2009","journal-title":"Neuron"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"29427","DOI":"10.1074\/jbc.M109.013193","article-title":"Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity","volume":"284","author":"CT Aiken","year":"2009","journal-title":"J Biol Chem"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1073\/pnas.1114502109","article-title":"Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice","volume":"109","author":"A Di Pardo","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1083\/jcb.200909067","article-title":"IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome","volume":"187","author":"LM Thompson","year":"2009","journal-title":"J Cell Biol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmb.2012.09.011","article-title":"Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties","volume":"424","author":"R Mishra","year":"2012","journal-title":"J Mol Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1074\/jbc.M008099200","article-title":"Isolation of a 40-kDa Huntingtin-associated protein","volume":"276","author":"MF Peters","year":"2001","journal-title":"J Biol Chem"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/mds.25159","article-title":"Striatal neuronal loss correlates with clinical motor impairment in Huntington&apos;s disease","volume":"27","author":"Z Guo","year":"2012","journal-title":"Mov Disord"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"10541","DOI":"10.1523\/JNEUROSCI.0146-10.2010","article-title":"Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington&apos;s disease molecular pathogenesis","volume":"30","author":"J Miller","year":"2010","journal-title":"J Neurosci"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1073\/pnas.0409777102","article-title":"Automated microscope system for determining factors that predict neuronal fate","volume":"102","author":"M Arrasate","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0896-6273(03)00258-7","article-title":"Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice","volume":"38","author":"ES Emamian","year":"2003","journal-title":"Neuron"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.arr.2012.06.003","article-title":"Tau protein kinases: involvement in Alzheimer&apos;s disease","volume":"12","author":"L Martin","year":"2013","journal-title":"Ageing Res Rev"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.1471-4159.2009.06191.x","article-title":"Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson&apos;s disease pathogenesis","volume":"110","author":"KY Chau","year":"2009","journal-title":"J Neurochem"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1750-1326-5-26","article-title":"The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6\/2 mouse model of Huntington&apos;s disease","volume":"5","author":"JH Fox","year":"2010","journal-title":"Mol Neurodegener"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0088284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T18:15:10Z","timestamp":1648232110000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0088284"}},"subtitle":[],"editor":[{"given":"David R.","family":"Borchelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,5]]},"references-count":73,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0088284","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,5]]}}}