{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:11:02Z","timestamp":1772842262675,"version":"3.50.1"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T00:00:00Z","timestamp":1391990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0088391","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T21:56:41Z","timestamp":1392069401000},"page":"e88391","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["eNOS-Dependent Antisenscence Effect of a Calcium Channel Blocker in Human Endothelial Cells"],"prefix":"10.1371","volume":"9","author":[{"given":"Toshio","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoe","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasufumi","family":"Sakakibara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morihiko","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Kuzuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,2,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1001\/jama.299.22.2611","article-title":"IOM: focus on case for aging population","volume":"299","author":"R Voelker","year":"2008","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1161\/CIRCULATIONAHA.107.187998","article-title":"Heart disease and stroke statistics - - 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"117","author":"W Rosamond","year":"2008","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1196\/annals.1395.038","article-title":"Vascular smooth muscle and endothelial functions in aging","volume":"1100","author":"O Yildiz","year":"2007","journal-title":"Ann NY Acad Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/S0531-5565(01)00105-X","article-title":"Replicative senescence of human endothelial cells in vitro involves GI arrest, polyploidization and senescence-associated apoptosis","volume":"36","author":"M Wagner","year":"2001","journal-title":"Exp Gerontol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/01.ATV.0000253884.13901.e4","article-title":"Implications of early structural-functional changes in the endothelium for vascular disease","volume":"27","author":"M Simionescu","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1113\/expphysiol.2008.043356","article-title":"The ageing endothelium, cardiovascular risk and disease in man","volume":"94","author":"D Veisari","year":"2009","journal-title":"Exp Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/01.RES.0000122141.18795.9C","article-title":"Telomeres and cardiovascular disease: does size matter?","volume":"94","author":"AL Serrano","year":"2004","journal-title":"Circ Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cardiores.2004.09.007","article-title":"Aging, telomeres, and atherosclerosis","volume":"66","author":"MD Edo","year":"2005","journal-title":"Cardiovasc Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1096\/fj.00-0051com","article-title":"Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF\/VEGF: evidence for senescent cells in vivo at sites of atherosclerosis","volume":"15","author":"E Vasile","year":"2001","journal-title":"FASEB J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1161\/01.CIR.0000013836.85741.17","article-title":"Endothelial cell senescence in human atherosclerosis: role of endothelial dysfunction","volume":"105","author":"T Minamino","year":"2002","journal-title":"Circulation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.0000256837.40544.4a","article-title":"Vascular cell senescence. Contribution to atherosclerosis","volume":"100","author":"T Minamino","year":"2007","journal-title":"Circ Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"17018","DOI":"10.1073\/pnas.0607873103","article-title":"Endothelial cellular senescence is inhibited by nitric oxide: Implications in athero-sclerosis associated with menopause and diabetes","volume":"103","author":"T Hayashi","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1124\/jpet.110.177584","article-title":"Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: A relationship between telomeres and nitric oxide","volume":"337","author":"H Matsui-Hirai","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.2337\/db05-1607","article-title":"Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells","volume":"55","author":"T Yokoi","year":"2006","journal-title":"Diabetes"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1242\/jcs.113.20.3613","article-title":"Senescence-associated \u03b2-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells","volume":"113","author":"DJ Kurz","year":"2000","journal-title":"J Cell Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1182\/blood-2003-02-0562","article-title":"Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells","volume":"102","author":"J Chandra","year":"2003","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1124\/jpet.106.111641","article-title":"17\u03b2-Estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease","volume":"320","author":"A Miyazaki-Akita","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pharmthera.2008.09.002","article-title":"Nitric oxide and endothelial cellular senescence","volume":"120","author":"T Hayashi","year":"2008","journal-title":"Pharmacol Ther"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(94)90131-7","article-title":"Hydrogen peroxide mediates amyloid beta protein toxicity","volume":"77","author":"C Behl","year":"1994","journal-title":"Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.2337\/diabetes.51.8.2648","article-title":"Glucose increases endothelial-dependent superoxide formation in coronary arteries by NAD(P)H oxidase activation. Attenuation by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin","volume":"51","author":"M Christ","year":"2002","journal-title":"Diabetes"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"23317","DOI":"10.1074\/jbc.271.38.23317","article-title":"p22<italic><sup>phox<\/sup><\/italic> is a critical component of the superoxide-generating NADH\/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells","volume":"271","author":"M Ushio-Fukai","year":"1996","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation","volume":"399","author":"S Dimmeler","year":"1999","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"31629031639","DOI":"10.1074\/jbc.M212831200","article-title":"Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells","volume":"278","author":"VA Morrow","year":"2003","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"496","DOI":"10.2337\/diabetes.55.02.06.db05-1064","article-title":"Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase","volume":"55","author":"BJ Davis","year":"2006","journal-title":"Diabetes"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1172\/JCI110384","article-title":"Suppression of atherogenesis in cholesterol-fed rabbit treated with nifedipine","volume":"68","author":"PD Henry","year":"1981","journal-title":"J Clin Invest"},{"key":"ref26","first-page":"250","article-title":"Antiatherosclerotic effects of nicardipine and nifedipine in cholesterol-fed rabbits","volume":"5","author":"AL Willis","year":"1985","journal-title":"Atherosclerosis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(97)00158-7","article-title":"Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanisms of antiatherosclerotic effects of vitamin E, lovaststin and amlodipine","volume":"30","author":"L Chen","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1097\/00004872-200018100-00010","article-title":"The calcium-channel blocker lacidipine reduces the development of atherosclerotic lesions in the apoE-deficient mouse","volume":"18","author":"P Cristofori","year":"2000","journal-title":"J Hypertens"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1124\/jpet.105.089847","article-title":"Calcium channel blocker inhibits Western-type diest-evoked atherosclerosis development in ApoE-deficient mice","volume":"315","author":"J Kyselovic","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.atherosclerosis.2007.03.036","article-title":"Azelnidipine has anti-atherosclerotic effects independent of its blood pressure-lowering actions in monkeys and mice","volume":"196","author":"K Nakano","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref31","first-page":"497","article-title":"Modified-release nifedipine. A review of the use of modified-release formulations in the treatment of hypertension and angina pectoris","volume":"66","author":"KF Croom","year":"2006","journal-title":"Drugs"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.jchromb.2011.04.034","article-title":"Determination of nifedipine in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study","volume":"879","author":"D Wang","year":"2011","journal-title":"J Chromatography B"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1055\/s-0032-1331713","article-title":"A more rapid, sensitive, and specific HPLC-MS\/MS method for nifedipine analysis in human plasma and application to a pharmacokinetic study","volume":"63","author":"R Chen","year":"2013","journal-title":"Drug Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/0140-6736(90)91121-P","article-title":"Retardation of angiographic progression of coronary artery disease by nifedipine. Results of the International Nifedipine Trial on Antiatherosclerotic Therapy (INTACT). INTACT Group Investigators","volume":"335","author":"PR Lichtlen","year":"1990","journal-title":"Lancet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1161\/01.CIR.82.6.1940","article-title":"A controlled clinical trial to assess the effect of a calcium channel blocker on the progression of coronary atherosclerosis","volume":"82","author":"D Waters","year":"1990","journal-title":"Circulation"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00045391-200311000-00006","article-title":"Calcium antagonists and atherosclerosis protection in hypertension","volume":"10","author":"RH Hem\u00e1ndez","year":"2003","journal-title":"Am J Ther"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"693","DOI":"10.5551\/jat.12450","article-title":"Anti-atherosclerotic potential of dihydropyridine calcium channel blockers","volume":"19","author":"N Ishii","year":"2012","journal-title":"J Atheroscler Thromb"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0088391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T06:18:55Z","timestamp":1648275535000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0088391"}},"subtitle":[],"editor":[{"given":"Ryuichi","family":"Morishita","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,10]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0088391","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,10]]}}}