{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:07:44Z","timestamp":1792876064831,"version":"4.5.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0088517","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T21:50:24Z","timestamp":1393451424000},"page":"e88517","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["A Novel Toxicokinetic Modeling of Cypermethrin and Permethrin and Their Metabolites in Humans for Dose Reconstruction from Biomarker Data"],"prefix":"10.1371","volume":"9","author":[{"given":"Jonathan","family":"C\u00f4t\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"Bonvalot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00e9tan","family":"Carrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Lapointe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Fuhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Tomalik-Scharte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil","family":"Wachall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,2,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.taap.2005.06.022","article-title":"Structure-activity relationships for the action of 11 pyrethroid insecticides on rat na v 1.8 sodium channels expressed in Xenopus oocytes","volume":"211","author":"JS Choi","year":"2006","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10158-006-0038-7","article-title":"Pyrethroid action on calcium channels: Neurotoxicological implications","volume":"7","author":"JM Clark","year":"2007","journal-title":"Invert Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/BF00334635","article-title":"Clinical manifestations and diagnosis of acute pyrethroid poisoning","volume":"63","author":"F He","year":"1989","journal-title":"Arch Toxicol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0300-483X(98)00097-3","article-title":"In vitro genotoxic effects of the insecticide deltamethrin in human peripheral blood leukocytes: DNA damage (\u2018comet\u2019 assay) in relation to the induction of sister-chromatid exchanges and micronuclei","volume":"130","author":"M Villarini","year":"1998","journal-title":"Toxicology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s004050100406","article-title":"Genotoxicity studies on permethrin, deet and diazinon in primary human nasal mucosal cells","volume":"259","author":"M Tisch","year":"2002","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00204-004-0616-6","article-title":"Effects of pesticides on human peripheral lymphocytes in vitro: Induction of DNA damage","volume":"79","author":"U Undeger","year":"2005","journal-title":"Arch Toxicol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mrgentox.2005.12.003","article-title":"Potential of chlorpyrifos and cypermethrin forming DNA adducts","volume":"604","author":"Y Cui","year":"2006","journal-title":"Mutat Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.chemosphere.2006.05.059","article-title":"Antiandrogenic activity of pyrethroid pesticides and their metabolite in reporter gene assay","volume":"66","author":"H Sun","year":"2007","journal-title":"Chemosphere"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.reprotox.2008.05.054","article-title":"The antiandrogenic activity of pyrethroid pesticides cyfluthrin and beta-cyfluthrin","volume":"25","author":"J Zhang","year":"2008","journal-title":"Reprod Toxicol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/jat\/28.4.238","article-title":"Cypermethrin residues determination in the milk of a lactating dairy cow by gas chromatography-ion trap mass spectrometry","volume":"28","author":"A Sassine","year":"2004","journal-title":"J Anal Toxicol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0021-9673(01)00874-3","article-title":"Determination of residues of endosulfan and five pyrethroid insecticides in virgin olive oil using gas chromatography with electron-capture detection","volume":"921","author":"C Lentza-Rizos","year":"2001","journal-title":"J Chromatogr A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1093\/jaoac\/85.6.1398","article-title":"Interlaboratory study of a multiresidue gas chromatographic method for determination of organochlorine and pyrethroid pesticides and polychlorobiphenyls in milk, fish, eggs, and beef fat","volume":"85","author":"F Bordet","year":"2002","journal-title":"J AOAC Int"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1289\/ehp.01109213","article-title":"Metabolites of pyrethroid insecticides in urine specimens: current exposure in an urban population of Germany","volume":"109","author":"U Heudorf","year":"2001","journal-title":"Environ Health Perspect"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0378-4274(02)00183-2","article-title":"Pyrethroid exposure of the general population \u2013 is this due to diet?","volume":"134","author":"T Schettgen","year":"2002","journal-title":"Toxicol Lett"},{"key":"ref15","first-page":"170","article-title":"Efficacy and transdermal absorption of permethrin in scabies patients","volume":"69","author":"HJ van der Rhee","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00228-005-0932-7","article-title":"Dermal absorption of permethrin following topical administration","volume":"61","author":"D Tomalik-Scharte","year":"2005","journal-title":"Eur J Clin Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/sj.jes.7500576","article-title":"Pesticide loadings of select organophosphate and pyrethroid pesticides in urban public housing","volume":"18","author":"R Julien","year":"2008","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"ref18","first-page":"349","article-title":"Third national report on human exposure to environmental chemicals","year":"2005","journal-title":"Department of Health and Human Services, Centers for Disease Control and Prevention"},{"key":"ref19","unstructured":"CDC (2009) Fourth national report on human exposure to environmental chemicals. Atlanta, Georgia: Department of Health and Human Services, Centers for Disease Control and Prevention."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1476-069X-7-55","article-title":"Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposure","volume":"7","author":"M-C Fortin","year":"2008","journal-title":"Environ Health"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/15459620902850907","article-title":"Characterization of exposure to pyrethroids and pyrethrins in a rural population of the Mont\u00e9r\u00e9gie area, Quebec, Canada","volume":"6","author":"C Couture","year":"2009","journal-title":"J Occup Environ Hyg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/toxsci\/kfg061","article-title":"A toxicokinetic model of malathion and its metabolites as a tool to assess human exposure and risk through measurements of urinary biomarkers","volume":"73","author":"M Bouchard","year":"2003","journal-title":"Toxicol Sci"},{"key":"ref23","first-page":"155","article-title":"Determination of biological reference values for chlorpyrifos metabolites in human urine using a toxicokinetic model","volume":"2","author":"M Bouchard","year":"2005","journal-title":"J Occup Environ Health"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00420-007-0220-1","article-title":"Assessment of absorbed doses of carbaryl and associated health risks in a group of horticultural greenhouse workers","volume":"81","author":"M Bouchard","year":"2008","journal-title":"Int Arch Occup Environ Health"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.toxlet.2011.09.023","article-title":"Toxicokinetic modeling of captan fungicide and its tetrahydrophthalimide biomarker of exposure in humans","volume":"213","author":"R Heredia-Ortiz","year":"2012","journal-title":"Toxicol Lett"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/jat.1782","article-title":"Toxicokinetic modeling of folpet fungicide and its ring-biomarkers of exposure in humans","volume":"33","author":"R Heredia-Ortiz","year":"2013","journal-title":"J Appl Toxicol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/annhyg\/mel005","article-title":"Biological monitoring of exposure to organophosphorus insecticides in a group of horticultural greenhouse workers","volume":"50","author":"M Bouchard","year":"2006","journal-title":"Ann Occup Hyg"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/toxsci\/kfl056","article-title":"Development of a physiologically based pharmacokinetic model for deltamethrin in the adult Sprague-Dawley rat","volume":"93","author":"A Mirfazaelian","year":"2006","journal-title":"Toxicol Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.taap.2009.12.034","article-title":"Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model","volume":"244","author":"R Tornero-Velez","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/toxsci\/kfs236","article-title":"A Pharmacokinetic model of cis- and trans-permethrin disposition in rats and humans with aggregate exposure application","volume":"130","author":"R Tornero-Velez","year":"2012","journal-title":"Toxicol Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3109\/00498259209049904","article-title":"The metabolism of cypermethrin in man: differences in urinary metabolite profiles following oral and dermal administration","volume":"22","author":"BH Woollen","year":"1992","journal-title":"Xenobiotica"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1021\/jf00103a033","article-title":"Metabolism of cis- and trans-cypermethrin in rats. Balance and tissue retention study","volume":"29","author":"MJ Crawford","year":"1981","journal-title":"J Agric Food Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/ps.2780120406","article-title":"The metabolism of the pyrethroid insecticide cypermethrin in rats: Excreted metabolites","volume":"12","author":"MJ Crawford","year":"1981","journal-title":"Pestic Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0041-008X(91)90284-L","article-title":"Toxicokinetics of permethrin in the rat","volume":"110","author":"A Anad\u00f3n","year":"1991","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Kaneko H, Miyamoto J (2001) Pyrethroid chemistry and metabolism. Handbook of Pesticide Toxicology, Chapter 58, volume 2, pp. 1263\u20131288.","DOI":"10.1016\/B978-012426260-7.50061-6"},{"key":"ref36","first-page":"57","article-title":"Permethrin emulsion ingestion: clinical manifestation and clearance of isomers","volume":"36","author":"Y Gotoh","year":"1998","journal-title":"Clin Toxicol"},{"key":"ref37","unstructured":"FAO (1980) Pesticide residues in food-1979. Report of the joint meeting of the FAO panel of experts on pesticide residues in food and the environment and the WHO expert group on pesticide residues. Rome: Food and Agriculture Organization of the United Nations (FAO Plant Production and Protection Paper, No. 20)."},{"key":"ref38","unstructured":"FAO (1982) Pesticide residues in food-1981. Report of the joint meeting of the FAO panel of experts on pesticide residues in food and the environment and the WHO expert group on pesticide residues. Rome: Food and Agriculture Organization of the United Nations (FAO Plant Production and Protection Paper, No. 37)."},{"key":"ref39","first-page":"215","article-title":"The metabolic fate of synthetic pyretro\u00efd insecticides in mammals","volume":"3","author":"DH Hutson","year":"1979","journal-title":"Prog Drug Metab"},{"key":"ref40","unstructured":"NRC (1994) Health effects of permethrin-impregnated army battle-dress uniforms. National Academy Press."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/BF02220819","article-title":"Structure-biodegradability relationships in pyrethroid insecticides","volume":"3","author":"JE Casida","year":"1976","journal-title":"Arch Environ Contam Toxicol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.bcp.2005.11.020","article-title":"Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases","volume":"71","author":"MK Ross","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.abb.2005.11.005","article-title":"Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2","volume":"445","author":"K Nishi","year":"2006","journal-title":"Arch Biochem Biophys"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1124\/dmd.108.022343","article-title":"In vitro metabolism of pyrethroid pesticides by rat and human hepatic microsomes and cytochrome p450 isoforms","volume":"37","author":"EJ Scollon","year":"2009","journal-title":"Drug Metab Dispos"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3109\/00498258809041697","article-title":"Human dose-excretion studies with pyrethroid insecticides cypermethrin and alphacypermethrin: relevance for biomonitoring","volume":"18","author":"CV Eadsforth","year":"1988","journal-title":"Xenobiotica"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0048-3575(02)00154-2","article-title":"In vitro human metabolism of permethrin: the role of human alcohol and aldehyde dehydrogenases","volume":"73","author":"J Choi","year":"2002","journal-title":"Pesticides Biochem Physiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/00498258309052238","article-title":"Human dose-excretion studies with the pyrethroid insecticide, cypermethrin","volume":"13","author":"CV Eadsforth","year":"1983","journal-title":"Xenobiotica"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/15287398809531107","article-title":"Percutaneous absorption of cis- and trans-permethrin in rhesus monkeys and rats: anatomic site and interspecies variation","volume":"23","author":"EW Sidon","year":"1988","journal-title":"J Toxicol Environ Health"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s001289900847","article-title":"Toxicokinetics of pyrethroid in humans: consequences for biological monitoring","volume":"62","author":"K-H K\u00fchn","year":"1999","journal-title":"Bull Environ Contam Toxicol"},{"key":"ref50","unstructured":"Berthet A, Bouchard M, Valcke M, Heredia-Ortiz R (2012) Using a toxicokinetic modeling approach to determine biological reference values (BRVs) and to assess human exposure to pesticides. In: Jokanovic M, editor. Impact of Pesticides, Academy Publish."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0088517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T20:29:55Z","timestamp":1597523395000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0088517"}},"subtitle":[],"editor":[{"given":"Raya","family":"Khanin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,26]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0088517","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,26]]}}}