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Elanco: 1\u20135."},{"key":"ref41","unstructured":"Radostitis O, Gay C, Hinchcliff K, Constable P (2007) Veterinary medicine: a textbook of the diseases of cattle, horses, sheep, pigs, and goats; Radostitis O, Gay C, Hinchcliff K, Constable P, editors. London: WB Saunders, London. 2156."},{"key":"ref42","unstructured":"Apralan (2013) <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.drugs.com\/vet\/apralan-can.html\" xlink:type=\"simple\">http:\/\/www.drugs.com\/vet\/apralan-can.html<\/ext-link>."},{"key":"ref43","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0034-5288(97)90199-5","article-title":"Kinetic disposition, systemic bioavailability and tissue distribution of apramycin in broiler chickens","volume":"62","author":"NA Afifi","year":"1997","journal-title":"Res Vet Sci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1939-165X.2005.tb00041.x","article-title":"Selection and interpretation of clinical pathology indicators of hepatic injury in preclinical studies","volume":"34","author":"L Boone","year":"2005","journal-title":"Vet Clin Pathol"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Schneider G, Grazioli L, Saini S (2006) MRI of the liver: imaging techniques, contrast enhancement, differential diagnosis. New York: Springer.","DOI":"10.1007\/88-470-0469-1"},{"key":"ref46","unstructured":"Kaneko JJ, Harvey JW, Bruss ML (2008) Clinical biochemistry of domestic animals. Oxford, UK: Academic press."},{"key":"ref47","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1017\/S0007114512002607","article-title":"Effects of feeding Bt MON810 maize to sows during first gestation and lactation on maternal and offspring health indicators","volume":"109","author":"MC Walsh","year":"2013","journal-title":"Br J Nutr"},{"key":"ref48","unstructured":"Weiss DJ, Wardrop KJ (2011) Schalm&apos;s veterinary hematology: Wiley-Blackwell."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1177\/0148607199023006337","article-title":"Total parenteral nutrition alters molecular and cellular indices of intestinal inflammation in neonatal piglets","volume":"23","author":"D Ganessunker","year":"1999","journal-title":"J Parenter Enteral Nutr"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2527\/1990.681163x","article-title":"Hematological and clinicochemical profiles of healthy swine and swine with inflammatory processes","volume":"68","author":"JJFM Odink","year":"1990","journal-title":"J Anim Sci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0088599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T20:41:39Z","timestamp":1565210499000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0088599"}},"subtitle":[],"editor":[{"given":"Gunnar","family":"Loh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,26]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0088599","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,26]]}}}