{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:06:10Z","timestamp":1769148370278,"version":"3.49.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0088711","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T22:14:05Z","timestamp":1392761645000},"page":"e88711","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Job Strain and the Risk of Inflammatory Bowel Diseases: Individual-Participant Meta-Analysis of 95\u00a0000 Men and Women"],"prefix":"10.1371","volume":"9","author":[{"given":"Katriina","family":"Heikkil\u00e4","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida E. H.","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solja T.","family":"Nyberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonor I.","family":"Fransson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsi","family":"Ahola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Alfredsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob B.","family":"Bjorner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Borritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Burr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico","family":"Dragano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane E.","family":"Ferrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Knutsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku","family":"Koskenvuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Koskinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin L.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Nordin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan H.","family":"Pejtersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaana","family":"Pentti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiner","family":"Rugulies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuula","family":"Oksanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"Shipley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakari B.","family":"Suominen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00f6res","family":"Theorell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari","family":"V\u00e4\u00e4n\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jussi","family":"Vahtera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Virtanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Westerlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J. M.","family":"Westerholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. David","family":"Batty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Singh-Manoux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Kivim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the IPD-Work Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1053\/j.gastro.2011.01.055","article-title":"Epidemiology and natural history of inflammatory bowel diseases","volume":"140","author":"J Cosnes","year":"2011","journal-title":"Gastroenterology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMra1102942","article-title":"Ulcerative colitis","volume":"365","author":"S Danese","year":"2011","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ng.764","article-title":"Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47","volume":"43","author":"CA Anderson","year":"2011","journal-title":"Nat Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.3748\/wjg.v18.i29.3814","article-title":"Impact of environmental and dietary factors on the course of inflammatory bowel disease","volume":"18","author":"E Cabre","year":"2012","journal-title":"World J Gastroenterol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.mrfmmm.2009.09.002","article-title":"Environmental factors in the development of chronic inflammation: a case-control study on risk factors for Crohn's disease within New Zealand","volume":"690","author":"DY Han","year":"2010","journal-title":"Mutat Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1016\/S0399-8320(09)73150-1","article-title":"Environmental risk factors in Crohn's disease and ulcerative colitis: an update","volume":"33","author":"F Carbonnel","year":"2009","journal-title":"Gastroenterol Clin Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s10620-010-1541-6","article-title":"Is obesity a risk factor for Crohn's disease?","volume":"56","author":"MA Mendall","year":"2011","journal-title":"Dig Dis Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2174\/156652408784533832","article-title":"The role of stress in the development and clinical course of inflammatory bowel disease: epidemiological evidence","volume":"8","author":"RG Maunder","year":"2008","journal-title":"Curr Mol Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1136\/gut.2005.064261","article-title":"Psychological stress in IBD: new insights into pathogenic and therapeutic implications","volume":"54","author":"JE Mawdsley","year":"2005","journal-title":"Gut"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"106502","DOI":"10.1155\/2012\/106502","article-title":"Psychological Issues in Inflammatory Bowel Disease: An Overview","volume":"2012","author":"MS Sajadinejad","year":"2012","journal-title":"Gastroenterol Res Pract"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJM199604253341707","article-title":"The enteric nervous system","volume":"334","author":"RK Goyal","year":"1996","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1136\/gut.2007.134817","article-title":"Predicting relapse in Crohn's disease: a biopsychosocial model","volume":"57","author":"A Bitton","year":"2008","journal-title":"Gut"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1038\/ajg.2010.140","article-title":"A prospective population-based study of triggers of symptomatic flares in IBD","volume":"105","author":"CN Bernstein","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1053\/j.gastro.2012.10.003","article-title":"Brain-gut interactions in inflammatory bowel disease","volume":"144","author":"BL Bonaz","year":"2013","journal-title":"Gastroenterology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1572-0241.2006.00931.x","article-title":"Stressful life events as a risk factor for inflammatory bowel disease onset: A population-based case-control study","volume":"102","author":"E Lerebours","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/j.1572-0241.2004.04155.x","article-title":"Psychological stress and inflammatory bowel disease: a follow-up study in parents who lost a child in Denmark","volume":"99","author":"J Li","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"ref17","first-page":"1491","article-title":"Job strain as a risk factor for future coronary heart disease: Collaborative meta-analysis of 2358 events in 197,473 men and women","volume":"380","author":"M Kivimaki","year":"2012","journal-title":"Lancet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1037\/1076-8998.3.4.322","article-title":"The Job Content Questionnaire (JCQ): an instrument for internationally comparative assessments of psychosocial job characteristics","volume":"3","author":"R Karasek","year":"1998","journal-title":"J Occup Health Psychol"},{"key":"ref19","unstructured":"Karasek R, Theorell T (1990) Healthy work: Stress, productivity, and the reconstruction of working life. New York: Basic Books."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2458-12-62","article-title":"Comparison of alternative versions of the job demand-control scales in 17 European cohort studies: the IPD-Work consortium","volume":"12","author":"EI Fransson","year":"2012","journal-title":"BMC Public Health"},{"key":"ref21","unstructured":"Martikainen J, Rajaniemi S (2002) Drug Reimbursement System in EU Member States, Iceland and Norway. Helsinki."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00420-009-0477-7","article-title":"Gender moderates the health-effects of job strain in managers","volume":"83","author":"MC Gadinger","year":"2010","journal-title":"Int Arch Occup Environ Health"},{"key":"ref23","first-page":"153","article-title":"What is healthy work for women and men? - A case-control study of gender- and sector-specific effects of psycho-social working conditions on long-term sickness absence","volume":"27","author":"U Lidwall","year":"2006","journal-title":"Work"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.socscimed.2007.02.052","article-title":"The effect of pre-employment factors on job control, job strain and psychological distress: a 31-year longitudinal study","volume":"65","author":"M Elovainio","year":"2007","journal-title":"Soc Sci Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e35463","DOI":"10.1371\/journal.pone.0035463","article-title":"Job Strain and Tobacco Smoking: An Individual-participant Data Meta-analysis of 166 130 Adults in 15 European Studies","volume":"7","author":"K Heikkil\u00e4","year":"2012","journal-title":"PLoS ONE"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2796.2011.02482.x","article-title":"Job strain in relation to body mass index: pooled analysis of 160 000 adults from 13 cohort studies","volume":"272","author":"ST Nyberg","year":"2012","journal-title":"Journal of Internal Medicine"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"JP Higgins","year":"2003","journal-title":"British Medical Journal"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.psyneuen.2009.10.004","article-title":"Psychological adjustment and autonomic disturbances in inflammatory bowel diseases and irritable bowel syndrome","volume":"35","author":"S Pellissier","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.cgh.2011.05.016","article-title":"Common symptoms and stressors among individuals with inflammatory bowel diseases","volume":"9","author":"S Singh","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1403494811401482","article-title":"The Danish National Patient Register","volume":"39","author":"E Lynge","year":"2011","journal-title":"Scand J Public Health"},{"key":"ref31","unstructured":"HESonline Hospital Episode Statistics. The Health and Social Care Information Centre, the National Health Service, United Kingdom. Accessed October 2013."},{"key":"ref32","unstructured":"Jacobsson A, Serden L (2013) Kodningskvalitet i patientregistret \u2013 Ett nytt verktyg f\u00f6r att m\u00e4ta kvalitet. Socialstyrelsen, Stockholm, Sweden."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0088711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T10:47:50Z","timestamp":1540291670000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0088711"}},"subtitle":[],"editor":[{"given":"Yvette","family":"Tache","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,18]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0088711","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,18]]}}}