{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T18:59:54Z","timestamp":1774897194051,"version":"3.50.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0088822","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T22:18:42Z","timestamp":1392243522000},"page":"e88822","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Heat Shock Factor 2 Levels Are Associated with the Severity of Ulcerative Colitis"],"prefix":"10.1371","volume":"9","author":[{"given":"Jiarong","family":"Miao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junkun","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxia","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinglei","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2009.02.006","article-title":"Advances in the pathogenesis and treatment of IBD","volume":"132","author":"NA Braus","year":"2009","journal-title":"Clinical Immunology"},{"key":"ref2","first-page":"408","article-title":"The emergence of inflammatory bowel disease in the Asian Pacific region","volume":"21","author":"Q Ouyang","year":"2005","journal-title":"Current opinion in gastroenterology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/ibd.21375","article-title":"Genetics of ulcerative colitis","volume":"17","author":"AI Thompson","year":"2011","journal-title":"Inflammatory bowel diseases"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e34349","DOI":"10.1371\/journal.pone.0034349","article-title":"Analysis of IL12B gene variants in inflammatory bowel disease","volume":"7(3)","author":"J Glas","year":"2012","journal-title":"PLoS one"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrmicro2403","article-title":"The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models","volume":"8","author":"S Nell","year":"2010","journal-title":"Nature Reviews Microbiology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"E86","DOI":"10.1111\/j.1749-6632.2010.05711.x","article-title":"Gut-associated lymphoid tissue, T cell trafficking, and chronic intestinal inflammation","volume":"1207","author":"I Koboziev","year":"2010","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1111\/j.1440-1746.2011.06846.x","article-title":"Update of fecal markers of inflammation in inflammatory bowel disease","volume":"26","author":"TA Judd","year":"2011","journal-title":"Journal of gastroenterology and hepatology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1053\/j.gastro.2010.11.058","article-title":"The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease","volume":"140","author":"JD Lewis","year":"2011","journal-title":"Gastroenterology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jprot.2011.03.030","article-title":"Advances in top-down proteomics for disease biomarker discovery","volume":"74","author":"D Calligaris","year":"2011","journal-title":"Journal of proteomics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s00535-009-0183-y","article-title":"Protein profiles of peripheral blood mononuclear cells are useful for differential diagnosis of ulcerative colitis and Crohn&apos;s disease","volume":"45","author":"M Hatsugai","year":"2010","journal-title":"Journal of gastroenterology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/MIB.0b013e318280e75f","article-title":"Correlation between the endoscopic and histologic score in assessing the activity of Ulcerative Colitis","volume":"19","author":"B Lemmens","year":"2013","journal-title":"Inflammatory bowel diseases"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/(SICI)1522-2683(20000401)21:6<1037::AID-ELPS1037>3.0.CO;2-V","article-title":"The current state of two-dimensional electrophoresis with immobilized pH gradients","volume":"21","author":"G Boguth","year":"2000","journal-title":"Electrophoresis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e33590","DOI":"10.1371\/journal.pone.0033590","article-title":"Proteomic profiling and protein identification by MALDI-TOF mass spectrometry in unsequenced parasitic nematodes","volume":"7(3)","author":"P Millares","year":"2012","journal-title":"PloS one"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1746-1596-7-45","article-title":"Serum peptidome patterns of breast cancer based on magnetic bead separation and mass spectrometry analysis","volume":"7","author":"NJ Fan","year":"2012","journal-title":"Diagn Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/gene.2010.16","article-title":"CTLA4\u2212 1661A\/G and 3\u2032 UTR long repeat polymorphisms are associated with ulcerative colitis and influence CTLA4 mRNA and protein expression","volume":"11(7)","author":"Z Chen","year":"2010","journal-title":"Genes and Immunity"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ejphar.2006.08.087","article-title":"Inhibition of phosphorylation of p38 MAPK involved in the protection of nephropathy by emodin in diabetic rats","volume":"553(1)","author":"J Wang","year":"2006","journal-title":"European journal of pharmacology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2144\/96201pf01","article-title":"Vectors for expression and secretion of FLAG epitope-tagged proteins in mammalian cells","volume":"20(1)","author":"RG Chubet","year":"1996","journal-title":"Biotechniques"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.trsl.2012.01.001","article-title":"Biomarkers in inflammatory bowel disease: current practices and recent advances","volume":"159","author":"HN Iskandar","year":"2012","journal-title":"Translational Research"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"23240","DOI":"10.1074\/jbc.M704081200","article-title":"Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis","volume":"282(32)","author":"K Tanaka","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.4081\/ejh.2011.e38","article-title":"Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy","volume":"55(4)","author":"G Tomasello","year":"2011","journal-title":"European journal of histochemistry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.jinsphys.2005.08.002","article-title":"Role of HSF activation for resistance to heat, cold and high-temperature knock-down","volume":"51","author":"M Muhlig Nielsen","year":"2005","journal-title":"Journal of insect physiology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s12038-007-0059-3","article-title":"Heat shock genes-integrating cell survival and death","volume":"32","author":"R Arya","year":"2007","journal-title":"Journal of biosciences"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrm2938","article-title":"Heat shock factors: integrators of cell stress, development and lifespan","volume":"11","author":"M \u00c5kerfelt","year":"2010","journal-title":"Nature reviews Molecular cell biology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1159\/000225957","article-title":"The shock of aging: molecular chaperones and the heat shock response in longevity and aging\u2013a mini-review","volume":"55","author":"SK Calderwood","year":"2009","journal-title":"Gerontology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1146\/annurev-biochem-060809-095203","article-title":"Regulation of HSF1 function in the heat stress response: implications in aging and disease","volume":"80","author":"J Anckar","year":"2011","journal-title":"Annual review of biochemistry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"S168","DOI":"10.1002\/ibd.20598","article-title":"What histologic features best differentiate Crohn&apos;s disease from ulcerative colitis?","volume":"14(S2)","author":"K Geboes","year":"2008","journal-title":"Inflammatory bowel diseases"},{"key":"ref27","first-page":"349","article-title":"Histopathologic study of the rectum in 1,438 consecutive rectal specimens in a single Japanese hospital: I. benign lesions","volume":"6(3)","author":"T Terada","year":"2013","journal-title":"International journal of clinical and experimental pathology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3748\/wjg.v16.i5.583","article-title":"Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis","volume":"16(5)","author":"H Sokol","year":"2010","journal-title":"World journal of gastroenterology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1379\/1466-1268(2002)007<0191:THSRAC>2.0.CO;2","article-title":"The heat shock response and cytoprotection of the intestinal epithelium","volume":"7(2)","author":"JJ Malago","year":"2002","journal-title":"Cell stress & chaperones"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00011-012-0442-x","article-title":"HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-\u03baB pathways","volume":"61","author":"SK Shimp 3rd","year":"2012","journal-title":"Inflammation Research"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3109\/00365521.2011.627449","article-title":"Candidate mucosal and surrogate biomarkers of inflammatory bowel disease in the era of new technology","volume":"46","author":"J Florholmen","year":"2011","journal-title":"Scandinavian journal of gastroenterology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.2217\/imt.11.122","article-title":"Cytokine blockade in inflammatory bowel diseases","volume":"3","author":"C Perrier","year":"2011","journal-title":"Immunotherapy"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0088822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T15:45:08Z","timestamp":1565192708000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0088822"}},"subtitle":[],"editor":[{"given":"Emiko","family":"Mizoguchi","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,12]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0088822","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,12]]}}}