{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:26:34Z","timestamp":1790238394997,"version":"4.1.0"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0089020","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T23:19:44Z","timestamp":1392851984000},"page":"e89020","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Neuronal-Specific Deficiency of the Splicing Factor Tra2b Causes Apoptosis in Neurogenic Areas of the Developing Mouse Brain"],"prefix":"10.1371","volume":"9","author":[{"given":"Markus","family":"Storbeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Hupperich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Antonydas","family":"Gaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesavan","family":"Meganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Mart\u00ednez Carrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agapios","family":"Sachinidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunhilde","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature08909","article-title":"Expansion of the eukaryotic proteome by alternative splicing","volume":"463","author":"TW Nilsen","year":"2010","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1093\/nar\/gki834","article-title":"Evolutionarily conserved and diverged alternative splicing events show different expression and functional profiles","volume":"33","author":"Z Kan","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/nature05676","article-title":"Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements","volume":"446","author":"LF Lareau","year":"2007","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.tibs.2008.06.001","article-title":"Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?","volume":"33","author":"NJ McGlincy","year":"2008","journal-title":"Trends Biochem Sci"},{"key":"ref5","first-page":"386","article-title":"Understanding alternative splicing: towards a cellular code","volume":"6","author":"AJ Matlin","year":"2005","journal-title":"NatRevMolCell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1097-2765(03)00270-3","article-title":"Pre-mRNA splicing: awash in a sea of proteins","volume":"12","author":"MS Jurica","year":"2003","journal-title":"Mol Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1101\/gad.1048803","article-title":"Pre-mRNA splicing and human disease","volume":"17","author":"NA Faustino","year":"2003","journal-title":"Genes Dev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"8928","DOI":"10.1093\/nar\/gkr481","article-title":"Efficient internal exon recognition depends on near equal contributions from the 3\u2032 and 5\u2032 splice sites","volume":"39","author":"PJ Shepard","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1074\/jbc.R700035200","article-title":"Combinatorial control of exon recognition","volume":"283","author":"KJ Hertel","year":"2008","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0092-8674(00)81153-8","article-title":"Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing","volume":"93","author":"R Tacke","year":"1998","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nsmb.2001","article-title":"Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-beta1","volume":"18","author":"A Clery","year":"2011","journal-title":"Nat Struct Mol Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1093\/nar\/gkq854","article-title":"Structural basis for the dual RNA-recognition modes of human Tra2-beta RRM","volume":"39","author":"K Tsuda","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1261\/rna.037044.112","article-title":"Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms","volume":"19","author":"S Erkelenz","year":"2013","journal-title":"RNA"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/nar\/gkr713","article-title":"Activation and repression functions of an SR splicing regulator depend on exonic versus intronic-binding position","volume":"40","author":"M Shen","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref15","first-page":"108","article-title":"Regulation of the neuron-specific exon of clathrin light chain B. Brain ResMolBrain Res","volume":"64","author":"S Stamm","year":"1999"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"8092","DOI":"10.1093\/nar\/gkr495","article-title":"Molecular design of a splicing switch responsive to the RNA binding protein Tra2beta","volume":"39","author":"SN Grellscheid","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e1002390","DOI":"10.1371\/journal.pgen.1002390","article-title":"Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2beta in development","volume":"7","author":"S Grellscheid","year":"2011","journal-title":"PLoS Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0012-1606(83)90054-4","article-title":"The dual functions of a sex determination gene in Drosophila melanogaster","volume":"95","author":"JM Belote","year":"1983","journal-title":"Dev Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1073\/pnas.79.5.1568","article-title":"Sex determination in Drosophila melanogaster: analysis of transformer-2, a sex-transforming locus","volume":"79","author":"JM Belote","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1002\/j.1460-2075.1986.tb04689.x","article-title":"The sex-determining gene tra of Drosophila: molecular cloning and transformation studies","volume":"5","author":"B Butler","year":"1986","journal-title":"EMBO J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1093\/hmg\/ddq094","article-title":"Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN\/Smn splicing","volume":"19","author":"Y Mende","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"9618","DOI":"10.1073\/pnas.160181697","article-title":"Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2)","volume":"97","author":"Y Hofmann","year":"2000","journal-title":"ProcNatlAcadSciUSA"},{"key":"ref23","first-page":"2037","article-title":"hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1","volume":"11","author":"Y Hofmann","year":"2002","journal-title":"HumMolGenet"},{"key":"ref24","first-page":"2481","article-title":"Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy","volume":"12","author":"L Brichta","year":"2003","journal-title":"HumMolGenet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1471-4159.2005.03552.x","article-title":"The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer\u2019s disease","volume":"96","author":"DC Glatz","year":"2006","journal-title":"JNeurochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1356-9597.2004.00709.x","article-title":"Tra2 beta, SF2\/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA","volume":"9","author":"S Kondo","year":"2004","journal-title":"Genes Cells"},{"key":"ref27","first-page":"18997","article-title":"Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta","volume":"278","author":"Z Jiang","year":"2003","journal-title":"JBiolChem"},{"key":"ref28","first-page":"14230","article-title":"Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1","volume":"280","author":"Y Wang","year":"2005","journal-title":"JBiolChem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1093\/nar\/20.19.5097","article-title":"Clathrin light chain B: gene structure and neuron-specific splicing","volume":"20","author":"S Stamm","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1074\/jbc.270.5.2395","article-title":"The interaction of calmodulin with clathrin-coated vesicles, triskelions, and light chains. Localization of a binding site","volume":"270","author":"UM Pley","year":"1995","journal-title":"J Biol Chem"},{"key":"ref31","first-page":"485","article-title":"Tra2beta as a novel mediator of vascular smooth muscle diversification","volume":"103","author":"S Shukla","year":"2008","journal-title":"CircRes"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cmet.2011.06.007","article-title":"Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis","volume":"14","author":"J Pihlajamaki","year":"2011","journal-title":"Cell Metab"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"30378","DOI":"10.1074\/jbc.M003781200","article-title":"Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein","volume":"275","author":"RT Richardson","year":"2000","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"21526","DOI":"10.1074\/jbc.M603816200","article-title":"Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation","volume":"281","author":"RT Richardson","year":"2006","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1477-7827-9-50","article-title":"Depletion of the histone chaperone tNASP inhibits proliferation and induces apoptosis in prostate cancer PC-3 cells","volume":"9","author":"OM Alekseev","year":"2011","journal-title":"Reprod Biol Endocrinol"},{"key":"ref36","first-page":"101","article-title":"The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA\/protein levels in spinal muscular atrophy cells","volume":"120","author":"M Riessland","year":"2006","journal-title":"HumGenet"},{"key":"ref37","first-page":"332","article-title":"Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy","volume":"47","author":"R Davis","year":"1994","journal-title":"Drugs"},{"key":"ref38","first-page":"CD003196","article-title":"Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder","volume":"10","author":"A Cipriani","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"ref39","first-page":"CD010611","article-title":"Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults","volume":"6","author":"M Linde","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2217\/fon.12.173","article-title":"Effects of treatment with histone deacetylase inhibitors in solid tumors: a review based on 30 clinical trials","volume":"9","author":"T Qiu","year":"2013","journal-title":"Future Oncol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.3892\/or.2013.2747","article-title":"Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis","volume":"30","author":"BR Han","year":"2013","journal-title":"Oncol Rep"},{"key":"ref42","article-title":"Valproic Acid Sensitizes TRAIL-Resistant Anaplastic Thyroid Carcinoma Cells to Apoptotic Cell Death","author":"HY Cha","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.neuron.2009.03.027","article-title":"Functional and evolutionary insights into human brain development through global transcriptome analysis","volume":"62","author":"MB Johnson","year":"2009","journal-title":"Neuron"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"R74","DOI":"10.1186\/gb-2004-5-10-r74","article-title":"Variation in alternative splicing across human tissues","volume":"5","author":"G Yeo","year":"2004","journal-title":"Genome Biol"},{"key":"ref45","article-title":"Alternative pre-mRNA splicing in neurons: growing up and extending its reach","author":"S Zheng","year":"2013","journal-title":"Trends Genet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.cell.2009.02.011","article-title":"RNA and disease","volume":"136","author":"TA Cooper","year":"2009","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuron.2006.09.017","article-title":"Splicing regulation in neurologic disease","volume":"52","author":"DD Licatalosi","year":"2006","journal-title":"Neuron"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/12703","article-title":"Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety","volume":"23","author":"F Tronche","year":"1999","journal-title":"Nat Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0165-3806(94)00162-S","article-title":"Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system","volume":"84","author":"J Dahlstrand","year":"1995","journal-title":"Brain Res Dev Brain Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/cne.10964","article-title":"Neural stem and progenitor cells in nestin-GFP transgenic mice","volume":"469","author":"JL Mignone","year":"2004","journal-title":"JComp Neurol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"BM Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"Article3","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"GK Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1073\/pnas.032068699","article-title":"Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes","volume":"99","author":"M Peitz","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/aja.1001940306","article-title":"Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons","volume":"194","author":"NR Cashman","year":"1992","journal-title":"Dev Dyn"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1099\/0022-1317-36-1-59","article-title":"Characteristics of a human cell line transformed by DNA from human adenovirus type 5","volume":"36","author":"FL Graham","year":"1977","journal-title":"J Gen Virol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1126\/science.3291116","article-title":"Specification of cerebral cortical areas","volume":"241","author":"P Rakic","year":"1988","journal-title":"Science"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/35055553","article-title":"Neurons derived from radial glial cells establish radial units in neocortex","volume":"409","author":"SC Noctor","year":"2001","journal-title":"Nature"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.283.5398.70","article-title":"Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain","volume":"283","author":"C Ikonomidou","year":"1999","journal-title":"Science"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/mrdd.1036","article-title":"Apoptosis and brain development","volume":"7","author":"KA Roth","year":"2001","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"ref60","first-page":"509","article-title":"Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA","volume":"13","author":"P Stoilov","year":"2004","journal-title":"HumMolGenet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1042\/BST20120036","article-title":"How does Tra2beta protein regulate tissue-specific RNA splicing?","volume":"40","author":"DJ Elliott","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrn1075","article-title":"Thalamocortical development: how are we going to get there?","volume":"4","author":"G Lopez-Bendito","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"9593","DOI":"10.1523\/JNEUROSCI.2815-06.2006","article-title":"High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly","volume":"26","author":"PE Forni","year":"2006","journal-title":"JNeurosci"},{"key":"ref64","article-title":"Splicing factor TRA2B is required for neural progenitor survival","author":"JM Roberts","year":"2013","journal-title":"J Comp Neurol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1101\/gad.475308","article-title":"Shugoshin-2 is essential for the completion of meiosis but not for mitotic cell division in mice","volume":"22","author":"E Llano","year":"2008","journal-title":"Genes Dev"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000323793","article-title":"The role of shugoshin in meiotic chromosome segregation","volume":"133","author":"D Clift","year":"2011","journal-title":"Cytogenet Genome Res"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ydbio.2004.01.026","article-title":"Delta-tubulin is a component of intercellular bridges and both the early and mature perinuclear rings during spermatogenesis","volume":"269","author":"A Kato","year":"2004","journal-title":"Dev Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0960-9822(00)00418-8","article-title":"Tissue-specific expression and subcellular localisation of mammalian delta-tubulin","volume":"10","author":"OW Smrzka","year":"2000","journal-title":"Curr Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-cellbio-101011-155716","article-title":"Diversity of clathrin function: new tricks for an old protein","volume":"28","author":"FM Brodsky","year":"2012","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"a005645","DOI":"10.1101\/cshperspect.a005645","article-title":"Synaptic vesicle endocytosis","volume":"4","author":"Y Saheki","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nrn2948","article-title":"Protein scaffolds in the coupling of synaptic exocytosis and endocytosis","volume":"12","author":"V Haucke","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nn.2355","article-title":"Ca(2+) and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal","volume":"12","author":"XS Wu","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref73","first-page":"148","article-title":"Microtubule-associated protein tau in development, degeneration and protection of neurons","volume":"85","author":"JZ Wang","year":"2008","journal-title":"ProgNeurobiol"},{"key":"ref74","first-page":"S10","article-title":"Alternative splicing of exon 10 in the tau gene as a target for treatment of tauopathies","volume":"9","author":"J Zhou","year":"2008","journal-title":"BMCNeurosci"},{"key":"ref75","first-page":"28660","article-title":"Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome","volume":"283","author":"J Shi","year":"2008","journal-title":"JBiolChem"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(93)90499-G","article-title":"The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases","volume":"75","author":"JW Harper","year":"1993","journal-title":"Cell"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1073\/pnas.0711030105","article-title":"p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus","volume":"105","author":"RN Pechnick","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM196507152730301","article-title":"Symptomatic Occult Hydrocephalus with \u201cNormal\u201d Cerebrospinal-Fluid Pressure. A Treatable Syndrome","volume":"273","author":"RD Adams","year":"1965","journal-title":"N Engl J Med"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"8846","DOI":"10.1074\/jbc.M210352200","article-title":"Overexpression of the Linker histone-binding protein tNASP affects progression through the cell cycle","volume":"278","author":"OM Alekseev","year":"2003","journal-title":"J Biol Chem"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1074\/jbc.M410397200","article-title":"Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei","volume":"280","author":"OM Alekseev","year":"2005","journal-title":"J Biol Chem"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"e1000227","DOI":"10.1371\/journal.pgen.1000227","article-title":"Depletion of human histone H1 variants uncovers specific roles in gene expression and cell growth","volume":"4","author":"M Sancho","year":"2008","journal-title":"PLoS Genet"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"843781","DOI":"10.1155\/2013\/843781","article-title":"Expression of Tra2 beta in Cancer Cells as a Potential Contributory Factor to Neoplasia and Metastasis","volume":"2013","author":"A Best","year":"2013","journal-title":"Int J Cell Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0089020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T19:57:03Z","timestamp":1565207823000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0089020"}},"subtitle":[],"editor":[{"given":"Debra L.","family":"Silver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,19]]},"references-count":82,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0089020","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,19]]}}}