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Krajnak","year":"1998","journal-title":"Endocrinology"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1530\/JOE-11-0359","article-title":"GnRH increases glucose transporter-1 expression and stimulates glucose uptake in the gonadotroph","volume":"212","author":"VM Harris","year":"2012","journal-title":"J Endocrinol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1210\/me.2009-0501","article-title":"The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo","volume":"24","author":"SH You","year":"2010","journal-title":"Mol Endocrinol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"e21056","DOI":"10.1371\/journal.pone.0021056","article-title":"In cortical neurons HDAC3 activity suppresses RD4-dependent SMRT export","volume":"6","author":"FX Soriano","year":"2011","journal-title":"PLoS 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proteasome inhibition","volume":"61","author":"J Gal","year":"2012","journal-title":"Neurochem Int"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1093\/hmg\/ddr595","article-title":"Distal enhancers upstream of the Charcot-Marie-Tooth type 1A disease gene PMP22","volume":"21","author":"EA Jones","year":"2012","journal-title":"Human molecular genetics"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/jnc.12074","article-title":"Unique gene alterations are induced in FACS-purified Fos-positive neurons activated during cue-induced relapse to heroin seeking","volume":"124","author":"S Fanous","year":"2013","journal-title":"J Neurochem"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","author":"J Krol","year":"2010","journal-title":"Nat Rev Genet"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"14191","DOI":"10.1523\/JNEUROSCI.1673-11.2011","article-title":"MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34","volume":"31","author":"S Haramati","year":"2011","journal-title":"J Neurosci"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1093\/emboj\/16.9.2376","article-title":"FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands","volume":"16","author":"MT Bedford","year":"1997","journal-title":"EMBO J"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(96)00263-3","article-title":"Towards prediction of cognate complexes between the WW domain and proline-rich ligands","volume":"384","author":"A Einbond","year":"1996","journal-title":"FEBS Lett"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"25375","DOI":"10.1074\/jbc.M109.024828","article-title":"Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21)","volume":"284","author":"X Huang","year":"2009","journal-title":"J Biol Chem"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature07963","article-title":"Principles of ubiquitin and SUMO modifications in DNA repair","volume":"458","author":"S Bergink","year":"2009","journal-title":"Nature"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/cas.12047","article-title":"Small ubiquitin-like modifier 1\u20133 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival","volume":"104","author":"W Yang","year":"2013","journal-title":"Cancer Sci"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"9919","DOI":"10.1074\/jbc.M510127200","article-title":"Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein","volume":"281","author":"V Dorval","year":"2006","journal-title":"J Biol Chem"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1196\/annals.1418.016","article-title":"Prenatal alcohol exposure increases vulnerability to stress and anxiety-like disorders in adulthood","volume":"1144","author":"KG Hellemans","year":"2008","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jpsychires.2010.08.005","article-title":"Psychopathology in offspring from families of alcohol dependent female probands: a prospective study","volume":"45","author":"SY Hill","year":"2011","journal-title":"Journal of psychiatric research"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1375\/twin.12.1.53","article-title":"Paternal alcoholism and offspring ADHD problems: a children of twins design","volume":"12","author":"VS Knopik","year":"2009","journal-title":"Twin research and human genetics : the official journal of the International Society for Twin Studies"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1469-7610.2010.02219.x","article-title":"Mothers\u2019 maximum drinks ever consumed in 24 hours predicts mental health problems in adolescent offspring","volume":"51","author":"SM Malone","year":"2010","journal-title":"Journal of child psychology and psychiatry, and allied disciplines"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1111\/j.1530-0277.2010.01287.x","article-title":"Familial loading for alcoholism and offspring behavior: mediating and moderating influences","volume":"34","author":"BS Molina","year":"2010","journal-title":"Alcoholism, clinical and experimental research"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1111\/j.1530-0277.2010.01263.x","article-title":"Gender-related influences of parental alcoholism on the prevalence of psychiatric illnesses: analysis of the 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