{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:44:11Z","timestamp":1789922651831,"version":"4.0.1"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0089759","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T21:45:32Z","timestamp":1393623932000},"page":"e89759","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Expression of a Subset of Heat Stress Induced Genes of Mycobacterium tuberculosis Is Regulated by 3',5'-Cyclic AMP"],"prefix":"10.1371","volume":"9","author":[{"given":"Eira","family":"Choudhary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Bishai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisheeth","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature08123","article-title":"Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase","volume":"460","author":"N Agarwal","year":"2009","journal-title":"Nature"},{"key":"ref2","first-page":"393","article-title":"cAMP signaling in Mycobacterium tuberculosis","volume":"47","author":"N Agarwal","year":"2009","journal-title":"Indian J Exp Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/0024-3205(77)90502-1","article-title":"Adenosine 3', 5'-monophosphate in mycobacteria","volume":"20","author":"H Padh","year":"1977","journal-title":"Life Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1101\/gr.10.2.204","article-title":"Functional classification of cNMP-binding proteins and nucleotide cyclases with implications for novel regulatory pathways in Mycobacterium tuberculosis","volume":"10","author":"LA McCue","year":"2000","journal-title":"Genome Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/cfg.349","article-title":"A survey of nucleotide cyclases in actinobacteria: unique domain organization and expansion of the class III cyclase family in Mycobacterium tuberculosis","volume":"5","author":"AR Shenoy","year":"2004","journal-title":"Comp Funct Genomics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.tim.2006.10.005","article-title":"New messages from old messengers: cAMP and mycobacteria","volume":"14","author":"AR Shenoy","year":"2006","journal-title":"Trends Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1016\/j.febslet.2006.05.034","article-title":"Mycobacterial adenylyl cyclases: biochemical diversity and structural plasticity","volume":"580","author":"AR Shenoy","year":"2006","journal-title":"FEBS Lett"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1093\/emboj\/20.14.3667","article-title":"Adenylyl cyclase Rv1625c of Mycobacterium tuberculosis: a progenitor of mammalian adenylyl cyclases","volume":"20","author":"YL Guo","year":"2001","journal-title":"EMBO J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"35141","DOI":"10.1074\/jbc.M104108200","article-title":"Eukaryotic-like adenylyl cyclases in Mycobacterium tuberculosis H37Rv: cloning and characterization","volume":"276","author":"SK Reddy","year":"2001","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.jmb.2005.12.017","article-title":"A structural basis for the role of nucleotide specifying residues in regulating the oligomerization of the Rv1625c adenylyl cyclase from M. tuberculosis","volume":"356","author":"AD Ketkar","year":"2006","journal-title":"J Mol Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"15271","DOI":"10.1074\/jbc.M200235200","article-title":"Adenylyl cyclase Rv1264 from Mycobacterium tuberculosis has an autoinhibitory N-terminal domain","volume":"277","author":"JU Linder","year":"2002","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1126\/science.1107642","article-title":"The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme","volume":"308","author":"I Tews","year":"2005","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1111\/j.1432-1033.2004.04172.x","article-title":"The effect of HAMP domains on class IIIb adenylyl cyclases from Mycobacterium tuberculosis","volume":"271","author":"JU Linder","year":"2004","journal-title":"Eur J Biochem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1111\/j.1742-4658.2005.04722.x","article-title":"Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection","volume":"272","author":"LI Castro","year":"2005","journal-title":"Febs J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1042\/BJ20041040","article-title":"Characterization of phylogenetically distant members of the adenylate cyclase family from mycobacteria: Rv1647 from Mycobacterium tuberculosis and its orthologue ML1399 from M. leprae","volume":"387","author":"AR Shenoy","year":"2005","journal-title":"Biochem J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1111\/j.1742-4658.2006.05420.x","article-title":"Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv","volume":"273","author":"A Abdel Motaal","year":"2006","journal-title":"FEBS J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/sj.emboj.7600573","article-title":"Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c","volume":"24","author":"SC Sinha","year":"2005","journal-title":"EMBO J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"7795","DOI":"10.1128\/JB.187.22.7795-7804.2005","article-title":"Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein","volume":"187","author":"G Bai","year":"2005","journal-title":"J Bacteriol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/j.1365-2958.2005.04609.x","article-title":"A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor","volume":"56","author":"L Rickman","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1099\/mic.0.28924-0","article-title":"Regulation of the expression of whiB1 in Mycobacterium tuberculosis: role of cAMP receptor protein","volume":"152","author":"N Agarwal","year":"2006","journal-title":"Microbiology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ijmm.2007.04.009","article-title":"Novel biochemical properties of a CRP\/FNR family transcription factor from Mycobacterium tuberculosis","volume":"297","author":"Y Akhter","year":"2007","journal-title":"Int J Med Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1365-2958.2008.06541.x","article-title":"Rv1675c (cmr) regulates intramacrophage and cyclic AMP-induced gene expression in Mycobacterium tuberculosis-complex mycobacteria","volume":"71","author":"MA Gazdik","year":"2009","journal-title":"Mol Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"7016","DOI":"10.1074\/jbc.M109.047720","article-title":"Mycobacterium tuberculosis cAMP receptor protein (Rv3676) differs from the Escherichia coli paradigm in its cAMP binding and DNA binding properties and transcription activation properties","volume":"285","author":"M Stapleton","year":"2010","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1365-2958.2011.07806.x","article-title":"Dysregulation of serine biosynthesis contributes to the growth defect of a Mycobacterium tuberculosis crp mutant","volume":"82","author":"G Bai","year":"2011","journal-title":"Mol Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1099\/00221287-144-8-2131","article-title":"Glutamate and cyclic AMP regulate the expression of galactokinase in Mycobacterium smegmatis","volume":"8)","author":"S Raychaudhuri","year":"1998","journal-title":"Microbiology 144 ( Pt"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1128\/JB.187.8.2681-2692.2005","article-title":"Identification of cyclic AMP-regulated genes in Mycobacterium tuberculosis complex bacteria under low-oxygen conditions","volume":"187","author":"MA Gazdik","year":"2005","journal-title":"J Bacteriol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"24313","DOI":"10.1074\/jbc.M110.118398","article-title":"cAMP-regulated protein lysine acetylases in mycobacteria","volume":"285","author":"S Nambi","year":"2010","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1021\/bi200156t","article-title":"Reversible acetylation and inactivation of Mycobacterium tuberculosis acetyl-CoA synthetase is dependent on cAMP","volume":"50","author":"H Xu","year":"2011","journal-title":"Biochemistry"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"14114","DOI":"10.1074\/jbc.M113.463992","article-title":"Cyclic AMP-dependent Protein Lysine Acylation in Mycobacteria Regulates Fatty Acid and Propionate Metabolism","volume":"288","author":"S Nambi","year":"2013","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1128\/JB.132.3.1031-1033.1977","article-title":"Identification of adenosine 3',5'-monophosphate in Mycobacterium smegmatis","volume":"132","author":"CH Lee","year":"1977","journal-title":"J Bacteriol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF00413269","article-title":"Metabolism of cyclic AMP in non-pathogenic Mycobacterium smegmatis","volume":"120","author":"CH Lee","year":"1979","journal-title":"Arch Microbiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"15695","DOI":"10.1021\/bi0512391","article-title":"The Rv0805 gene from Mycobacterium tuberculosis encodes a 3',5'-cyclic nucleotide phosphodiesterase: biochemical and mutational analysis","volume":"44","author":"AR Shenoy","year":"2005","journal-title":"Biochemistry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1574-695X.2008.00500.x","article-title":"cAMP levels within Mycobacterium tuberculosis and Mycobacterium bovis BCG increase upon infection of macrophages","volume":"55","author":"G Bai","year":"2009","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1462-5822.2010.01562.x","article-title":"Cyclic AMP signalling in mycobacteria: redirecting the conversation with a common currency","volume":"13","author":"G Bai","year":"2011","journal-title":"Cell Microbiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4161\/viru.22329","article-title":"Virulence factors of the Mycobacterium tuberculosis complex","volume":"4","author":"MA Forrellad","year":"2013","journal-title":"Virulence"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1128\/IAI.01395-06","article-title":"Characterization of the Mycobacterium tuberculosis sigma factor SigM by assessment of virulence and identification of SigM-dependent genes","volume":"75","author":"N Agarwal","year":"2007","journal-title":"Infect Immun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1099\/00221287-148-10-3129","article-title":"Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays","volume":"148","author":"GR Stewart","year":"2002","journal-title":"Microbiology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0003-9861(63)90046-8","article-title":"Excretion of adenosine-3',5'-phosphate in the culture broth of Brevibacterium liquefaciens","volume":"100","author":"T Okabayashi","year":"1963","journal-title":"Arch Biochem Biophys"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0021-9258(18)97576-9","article-title":"Adenosine 3',5'-Phosphate in Escherichia Coli","volume":"240","author":"RS Makman","year":"1965","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/0006-291X(68)90563-9","article-title":"Cyclic 3'5-AMP: stimulation of beta-galactosidase and tryptophanase induction in E. coli","volume":"30","author":"R Perlman","year":"1968","journal-title":"Biochem Biophys Res Commun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0014-5793(68)80100-0","article-title":"Cyclic AMP as an antagonist of catabolite repression in Escherichia coli","volume":"2","author":"A Ullmann","year":"1968","journal-title":"FEBS Lett"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/j.1742-4658.2008.06852.x","article-title":"Polyphosphates from Mycobacterium bovis--potent inhibitors of class III adenylate cyclases","volume":"276","author":"YL Guo","year":"2009","journal-title":"FEBS J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1128\/JB.00038-13","article-title":"Polyphosphate Deficiency in Mycobacterium tuberculosis Is Associated with Enhanced Drug Susceptibility and Impaired Growth in Guinea Pigs","volume":"195","author":"R Singh","year":"2013","journal-title":"J Bacteriol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1089\/104454901753340659","article-title":"Cold-stimulated increase in a regulatory subunit of cAMP-dependent protein kinase in human hepatoblastoma cells","volume":"20","author":"Y Ohsaka","year":"2001","journal-title":"DNA Cell Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbaexp.2006.02.001","article-title":"dps expression in Escherichia coli O157:H7 requires an extended -10 region and is affected by the cAMP receptor protein","volume":"1759","author":"KC Jeong","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1099\/mic.0.026021-0","article-title":"Interplay of cellular cAMP levels, {sigma}S activity and oxidative stress resistance in Escherichia coli","volume":"155","author":"E Barth","year":"2009","journal-title":"Microbiology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.4014\/jmb.0903.03030","article-title":"Polyphosphate kinase affects oxidative stress response by modulating cAMP receptor protein and rpoS expression in Salmonella typhimurium","volume":"19","author":"Y Cheng","year":"2009","journal-title":"J Microbiol Biotechnol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1128\/IAI.00796-12","article-title":"Adenylate cyclase and the cyclic AMP receptor protein modulate stress resistance and virulence capacity of uropathogenic Escherichia coli","volume":"81","author":"GT Donovan","year":"2013","journal-title":"Infect Immun"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1128\/JB.183.20.6119-6125.2001","article-title":"The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis","volume":"183","author":"S Raman","year":"2001","journal-title":"J Bacteriol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/89113","article-title":"Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection","volume":"7","author":"GR Stewart","year":"2001","journal-title":"Nat Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1574-6968.1999.tb08744.x","article-title":"Fluorescence-based detection of lacZ reporter gene expression in intact and viable bacteria including Mycobacterium species","volume":"179","author":"B Rowland","year":"1999","journal-title":"FEMS Microbiol Lett"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0089759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T02:19:01Z","timestamp":1648433941000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0089759"}},"subtitle":[],"editor":[{"given":"Deepak","family":"Kaushal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,28]]},"references-count":51,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0089759","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,28]]}}}