{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T15:01:06Z","timestamp":1768489266985,"version":"3.49.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T00:00:00Z","timestamp":1393804800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0089835","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T21:38:18Z","timestamp":1393882698000},"page":"e89835","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Gpr48 Deficiency Induces Polycystic Kidney Lesions and Renal Fibrosis in Mice by Activating Wnt Signal Pathway"],"prefix":"10.1371","volume":"9","author":[{"given":"Yongyan","family":"Dang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingya","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimiao","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1210\/mend.12.12.0211","article-title":"Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region","volume":"12","author":"SY Hsu","year":"1998","journal-title":"Mol Endocrinol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1210\/me.2004-0133","article-title":"Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality","volume":"18","author":"S Mazerbourg","year":"2004","journal-title":"Mol Endocrinol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"36687","DOI":"10.1074\/jbc.M800721200","article-title":"Inactivation of G protein-coupled receptor 48 (Gpr48\/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway","volume":"283","author":"HP Song","year":"2008","journal-title":"J Biol Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1167\/iovs.08-1860","article-title":"GPR48 regulates epithelial cell proliferation and migration by activating EGFR during eyelid development","volume":"49","author":"C Jin","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ydbio.2005.11.043","article-title":"Defective postnatal development of the male reproductive tract in LGR4 knockout mice","volume":"290","author":"F Mendive","year":"2006","journal-title":"Dev Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1002\/dvdy.21639","article-title":"Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4","volume":"237","author":"Y Mohri","year":"2008","journal-title":"Dev Dyn"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/dvdy.21900","article-title":"Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice","volume":"238","author":"R Yamashita","year":"2009","journal-title":"Dev Dyn"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1159\/000093999","article-title":"Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice","volume":"104","author":"S Kato","year":"2006","journal-title":"Nephron Exp Nephrol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"11623","DOI":"10.1158\/0008-5472.CAN-06-2629","article-title":"Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis","volume":"66","author":"Y Gao","year":"2006","journal-title":"Cancer Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.gde.2006.12.002","article-title":"Roles of G-protein-coupled receptor signaling in cancer biology and gene transcription","volume":"17","author":"BD Spiegelberg","year":"2006","journal-title":"Curr Opin Genet Dev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1038\/sj.onc.1204825","article-title":"Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene","volume":"20","author":"S Saadi-Kheddouci","year":"2001","journal-title":"Oncogene"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4161\/org.4.2.5849","article-title":"Wnt signaling in kidney development and disease","volume":"4","author":"K Pulkkinen","year":"2008","journal-title":"Organogenesis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1073\/pnas.0708257105","article-title":"Deletion of G-protein coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2","volume":"105","author":"J Weng","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/path.2734","article-title":"Elevated TGF\u03b2-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease","volume":"222","author":"S Hassane","year":"2010","journal-title":"J Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.2337\/diabetes.52.10.2586","article-title":"Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes","volume":"52","author":"S Okada","year":"2003","journal-title":"Diabetes"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1056\/NEJMra022161","article-title":"Polycystic kidney disease","volume":"350","author":"PD Wilson","year":"2004","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1681\/ASN.2010101079","article-title":"Targeted inhibition of \u03b2-catenin\/CBP signaling ameliorates renal interstitial fibrosis","volume":"22","author":"S Hao","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1158\/0008-5472.CAN-05-2700","article-title":"Protein kinase B\/Akt phosphorylation of glycogen synthase kinase-3beta in irradiated vascular endothelium","volume":"66","author":"J Tan","year":"2006","journal-title":"Cancer Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1046\/j.1523-1755.2000.00205.x","article-title":"Progressive renal fibrosis in murine polycystic kidney disease: an immunohistochemical observation","volume":"58","author":"H Okada","year":"2000","journal-title":"Kidney Int"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1046\/j.1523-1755.2003.00939.x","article-title":"Increased expression of MMP-2, MMP-9 (type IV collagenases\/gelatinases), and MT1-MMP in canine X-linked Alport syndrome (XLAS)","volume":"63","author":"VH Rao","year":"2003","journal-title":"Kidney Int"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"F494","DOI":"10.1152\/ajprenal.00416.2006","article-title":"Canonical WNT signaling during kidney development","volume":"293","author":"DM Iglesias","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1681\/ASN.2008060566","article-title":"Wnt\/beta-catenin signaling promotes renal interstitial fibrosis","volume":"20","author":"W He","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1242\/dev.006155","article-title":"Wnt\/beta-catenin signaling regulates nephron induction during mouse kidney development","volume":"134","author":"JS Park","year":"2007","journal-title":"Development"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e26533","DOI":"10.1371\/journal.pone.0026533","article-title":"Expression of Wnt signaling components during Xenopus pronephros development","volume":"6","author":"B Zhang","year":"2011","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.mod.2008.11.007","article-title":"Requirement of Wnt\/beta-catenin signaling in pronephric kidney development","volume":"126","author":"JP Lyons","year":"2009","journal-title":"Mech Devel"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.molmed.2010.05.004","article-title":"Cystic kidney disease: the role of Wnt signaling","volume":"16","author":"MA Lancaster","year":"2010","journal-title":"Trends Mol Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"F431","DOI":"10.1152\/ajprenal.0009.2001","article-title":"A role for Wnt-4 in renal fibrosis","volume":"282","author":"K Surendran","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"8692","DOI":"10.1073\/pnas.1100328108","article-title":"Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo","volume":"108","author":"L Qian","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1128\/MCB.25.11.4371-4376.2005","article-title":"Mouse axin and axin2\/conductin proteins are functionally equivalent in vivo","volume":"25","author":"IV Chia","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1681\/ASN.2006121355","article-title":"Wnt signaling in polycystic kidney disease","volume":"18","author":"T Benzing","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1681\/ASN.2004090800","article-title":"Extracellular signal-regualted kinase inhibition slows disease progression in mice with polycystic kidney disease","volume":"17","author":"S Omori","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"a002915","DOI":"10.1101\/cshperspect.a002915","article-title":"Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling","volume":"2","author":"J Heuberger","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"F540","DOI":"10.1152\/ajprenal.2001.280.3.F540","article-title":"A possible role for metalloproteinases in renal cyst development","volume":"280","author":"N Oberm\u00fcller","year":"2001","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/10408360290795574","article-title":"CD44 in cancer","volume":"39","author":"D Naor","year":"2002","journal-title":"Crit Rev Clin Lab Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1093\/ndt\/14.11.2554","article-title":"The proinflammatory role of hyaluronan\u2013CD44 interactions in renal injury","volume":"14","author":"RP Wuthrich","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1097\/01.ASN.0000033611.79556.AE","article-title":"TGF-beta signaling in renal diseases","volume":"13","author":"EP B\u00f6ttinger","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1097\/01.ASN.0000014252.37680.E4","article-title":"Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation","volume":"13","author":"JH Li","year":"2002","journal-title":"J Am Soc Nephrol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0089835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T23:32:44Z","timestamp":1597534364000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0089835"}},"subtitle":[],"editor":[{"given":"Vincenzo","family":"Coppola","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,3]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0089835","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,3]]}}}