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Best Pract Res Clin Endocrinol Metab <volume>25<\/volume>: : 585\u2013591. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21872800\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21872800<\/ext-link>. Accessed 16 July 2012."},{"key":"ref3","volume":"75","unstructured":"Pilz S, Tomaschitz A, M\u00e4rz W, Drechsler C, Ritz E, <etal>et al<\/etal>.. (2011) Vitamin D, cardiovascular disease and mortality. Clin Endocrinol (Oxf) <volume>75<\/volume>: : 575\u2013584. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21682758\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21682758<\/ext-link>. Accessed 16 July 2012."},{"key":"ref4","unstructured":"Saliba W, Barnett-Griness O, Rennert G (2012) The relationship between obesity and the increase in serum 25(OH)D levels in response to vitamin D supplementation. Osteoporos Int 25. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22955311\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22955311<\/ext-link>. Accessed 18 September 2012."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Sung CC, Liao MT, Lu KC, Wu CC (2012) Role of vitamin d in insulin resistance. J Biomed Biotechnol 2012: 634195. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22988423\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22988423<\/ext-link>. Accessed 19 September 2012.","DOI":"10.1155\/2012\/634195"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Brown SD, Calvert HH, Fitzpatrick AM (2012) Vitamin D and asthma: 137\u2013145.","DOI":"10.4161\/derm.20434"},{"key":"ref7","volume":"18","unstructured":"Weinstock-Guttman B, Mehta BK, Ramanathan M, Karmon Y, Henson LJ, <etal>et al<\/etal>.. (2012) Vitamin D and multiple sclerosis. Neurologist <volume>18<\/volume>: : 179\u2013183. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22735240\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22735240<\/ext-link>. Accessed 18 September 2012."},{"key":"ref8","volume":"128","unstructured":"Gandini S, Boniol M, Haukka J, Byrnes G, Cox B, <etal>et al<\/etal>.. (2011) Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer <volume>128<\/volume>: : 1414\u20131424. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20473927\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20473927<\/ext-link>. Accessed 3 August 2011."},{"key":"ref9","volume":"25","unstructured":"Durup D, J\u00f8rgensen HL, Christensen J, Schwarz P, Heegaard AM, <etal>et al<\/etal>.. (2012) A Reverse J-Shaped Association of All-Cause Mortality with Serum 25-Hydroxyvitamin D in General Practice, the CopD Study. J Clin Endocrinol Metab <volume>25<\/volume>: : 1\u20139. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22573406\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22573406<\/ext-link>. Accessed 16 May 2012."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1001\/archinte.168.15.1629","article-title":"25-hydroxyvitamin D levels and the risk of mortality in the general population","volume":"168","author":"ML Melamed","year":"2008","journal-title":"Arch Intern Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1998.78.4.1193","article-title":"Current understanding of the molecular actions of vitamin D.","volume":"78","author":"G Jones","year":"1998","journal-title":"Physiol Rev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2174\/138945011793591608","article-title":"Accuracy of 25-hydroxyvitamin D assays: confronting the issues","volume":"12","author":"GD Carter","year":"2011","journal-title":"Curr Drug Targets"},{"key":"ref13","volume":"92","unstructured":"Dastani Z, Li R, Richards B (2013) Genetic regulation of vitamin d levels. Calcif Tissue Int <volume>92<\/volume>: : 106\u2013117. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23114382\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23114382<\/ext-link>. Accessed 4 February 2013."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/ajcn\/86.5.1399","article-title":"Associations of diet, supplement use, and ultraviolet B radiation exposure with vitamin D status in Swedish women during winter","volume":"86","author":"A Burgaz","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"ref15","volume":"63","unstructured":"Shea MK, Benjamin EJ, Dupuis J, Massaro JM, Jacques PF, <etal>et al<\/etal>.. (2009) Genetic and non-genetic correlates of vitamins K and D. Eur J Clin Nutr <volume>63<\/volume>: : 458\u2013464. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2681093&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2681093&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 1 March 2012."},{"key":"ref16","volume":"94","unstructured":"Arguelles LM, Langman CB, Ariza AJ, Ali FN, Dilley K, <etal>et al<\/etal>.. (2009) Heritability and environmental factors affecting vitamin D status in rural Chinese adolescent twins. J Clin Endocrinol Metab <volume>94<\/volume>: : 3273\u20133281. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2741721&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2741721&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 1 March 2012."},{"key":"ref17","volume":"93","unstructured":"Engelman CD, Fingerlin TE, Langefeld CD, Hicks PJ, Rich SS, <etal>et al<\/etal>.. (2008) Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab <volume>93<\/volume>: : 3381\u20133388. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2567851&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2567851&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 1 March 2012."},{"key":"ref18","first-page":"371","article-title":"Genetic Contribution of Bone Metabolism, Calcium Excretion and Vitamin D and Parathyroid Hormone Regulation","volume":"16","author":"D Hunter","year":"2001"},{"key":"ref19","first-page":"1393","article-title":"Heritability and seasonal variability of vitamin D concentrations","volume":"25","author":"C Karohl","year":"2010"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Snellman G, Melhus H, Gedeborg R, Olofsson S, Wolk A, <etal>et al<\/etal>.. (2009) Seasonal genetic influence on serum 25-hydroxyvitamin D levels: a twin study. PLoS One 4: e7747. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2774516&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2774516&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 13 September 2012.","DOI":"10.1371\/journal.pone.0007747"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Wjst M, Altm\u00fcller J, Faus-Kessler T, Braig C, Bahnweg M, <etal>et al<\/etal>.. (2006) Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway. Respir Res 7: 60. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=1508148&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=1508148&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 1 March 2012.","DOI":"10.1186\/1465-9921-7-60"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Signorello LB, Shi J, Cai Q, Zheng W, Williams SM, <etal>et al<\/etal>.. (2011) Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans. PLoS One 6: e28623. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3244405&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3244405&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 1 March 2012.","DOI":"10.1371\/journal.pone.0028623"},{"key":"ref23","volume":"121","unstructured":"McGrath JJ, Saha S, Burne TH, Eyles DW (2010) A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J Steroid Biochem Mol Biol <volume>121<\/volume>: : 471\u2013477. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20363324\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20363324<\/ext-link>. Accessed 29 February 2012."},{"key":"ref24","volume":"19","unstructured":"Ahn J, Yu K, Stolzenberg-Solomon R, Simon KC, McCullough ML, <etal>et al<\/etal>.. (2010) Genome-wide association study of circulating vitamin D levels. Hum Mol Genet <volume>19<\/volume>: : 2739\u20132745. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2883344&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2883344&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 17 June 2011."},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, <etal>et al<\/etal>.. (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3086761&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3086761&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 1 March 2012.","DOI":"10.1016\/S0140-6736(10)60588-0"},{"key":"ref26","volume":"50","unstructured":"Thuesen B, Husemoen L, Fenger M, Jakobsen J, Schwarz P, <etal>et al<\/etal>.. (2012) Determinants of vitamin D status in a general population of Danish adults. Bone <volume>50<\/volume>: : 605\u2013610. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22227435\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22227435<\/ext-link>. Accessed 19 March 2012."},{"key":"ref27","volume":"103","unstructured":"Hollis BW, Wagner CL, Drezner MK, Binkley NC (2007) Circulating vitamin D3 and 25-hydroxyvitamin D in humans: An important tool to define adequate nutritional vitamin D status. J Steroid Biochem Mol Biol <volume>103<\/volume>: : 631\u2013634. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=1868557&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=1868557&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 4 December 2013."},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Madsen KH, Rasmussen LB, Andersen R, M\u00f8lgaard C, Jakobsen J, <etal>et al<\/etal>.. (2013) Randomized controlled trial of the effects of vitamin D \u2013 fortified milk and bread on serum 25-hydroxyvitamin D concentrations in families in Denmark during winter: the VitmaD study 1 \u2013 3. Am J Clin Nutr: 1\u20139. doi:10.3945\/ajcn.113.059469.","DOI":"10.3945\/ajcn.113.059469"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"55404","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"S Miller","year":"1988","journal-title":"NucleicAcids Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1136\/bmj.320.7244.1240","article-title":"Establishing a standard definition for child overweight and obesity worldwide: international survey","volume":"320","author":"TJ Cole","year":"2000","journal-title":"BMJ"},{"key":"ref31","first-page":"1","article-title":"Obesity: preventing and managing the global epidemic. Report of a WHO consultation","volume":"894","year":"2000","journal-title":"WHO Heal Organ Tech Rep Ser"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/dmrr.719","article-title":"CYP2R1 ( vitamin D 25-hydroxylase ) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans","volume":"1","author":"E Ramos-lopez","year":"2007","journal-title":"Diabetes Metab Res Rev"},{"key":"ref33","volume":"128","unstructured":"Bu FX, Armas L, Lappe J, Zhou Y, Gao G, <etal>et al<\/etal>.. (2010) Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects. Hum Genet <volume>128<\/volume>: : 549\u2013556. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20809279\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20809279<\/ext-link>. Accessed 16 August 2011."},{"key":"ref34","volume":"131","unstructured":"Lasky-Su J, Lange N, Brehm JM, Damask A, Soto-Quiros M, <etal>et al<\/etal>.. (2012) Genome-wide association analysis of circulating vitamin D levels in children with asthma. Hum Genet <volume>131<\/volume>: : 1495\u20131505. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22673963\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22673963<\/ext-link>. Accessed 29 August 2012."},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Zhang Z, He JW, Fu WZ, Zhang CQ, Zhang ZL (2013) An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population. J Bone Miner Res. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23505139\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23505139<\/ext-link>. Accessed 25 March 2013.","DOI":"10.1002\/jbmr.1926"},{"key":"ref36","first-page":"17","article-title":"Vitamin D Intake and Season Modify the Effects of the GC and CYP2R1 Genes on 25-hydroxyvitamin D concentrations","volume":"25","author":"CD Engelman","year":"2013"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1210\/jcem-63-4-954","article-title":"Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein","volume":"63","author":"D Bikle","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"ref38","volume":"17","unstructured":"Abbas S, Linseisen J, Slanger T, Kropp S, Mutschelknauss EJ, <etal>et al<\/etal>.. (2008) The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status. Cancer Epidemiol Biomarkers Prev<volume> 17<\/volume>: : 1339\u20131343. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18559548\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18559548<\/ext-link>. Accessed 1 March 2012."},{"key":"ref39","volume":"42","unstructured":"Fu L, Yun F, Oczak M, Wong BY, Vieth R, <etal>et al<\/etal>.. (2009) Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation. Clin Biochem <volume>42<\/volume>: : 1174\u20131177. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19302999\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19302999<\/ext-link>. Accessed 1 March 2012."},{"key":"ref40","volume":"85","unstructured":"Fang Y, van Meurs JB, Arp P, van Leeuwen JP, Hofman A, <etal>et al<\/etal>.. (2009) Vitamin D binding protein genotype and osteoporosis. Calcif Tissue Int <volume>85<\/volume>: : 85\u201393. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2729412&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2729412&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 1 March 2012."},{"key":"ref41","volume":"127","unstructured":"Gozdzik A, Zhu J, Wong BY, Fu L, Cole DE, <etal>et al<\/etal>.. (2011) Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry. J Steroid Biochem Mol Biol <volume>127<\/volume>: :405\u2013412. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21684333\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21684333<\/ext-link>. Accessed 25 October 2011."},{"key":"ref42","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3945\/ajcn.2008.26445","article-title":"Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women 1 \u2013 3","volume":"25","author":"M Sinotte","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"ref43","volume":"77","unstructured":"Lauridsen AL, Vestergaard P, Hermann AP, Brot C, Heickendorff L, <etal>et al<\/etal>.. (2005) Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women. Calcif Tissue Int <volume>77<\/volume>: : 15\u201322. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15868280\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15868280<\/ext-link>. Accessed 1 March 2012."},{"key":"ref44","volume":"114","unstructured":"Kurylowicz A, Ramos-Lopez E, Bednarczuk T, Badenhoop K (2006) Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves\u2019 disease and the vitamin D status in a Polish population study. Exp Clin Endocrinol Diabetes <volume>114<\/volume>: :329\u2013335 Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16868893\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16868893<\/ext-link>. Accessed 1 March 2012."},{"key":"ref45","volume":"131","unstructured":"Lu L, Sheng H, Li H, Gan W, Liu C, <etal>et al<\/etal>.. (2012) Associations between common variants in GC and DHCR7\/NADSYN1 and vitamin D concentration in Chinese Hans. Hum Genet <volume>131<\/volume>: :505\u2013512 Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21972121\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21972121<\/ext-link>. Accessed 1 March 2012."},{"key":"ref46","volume":"92","unstructured":"Arnaud J, Constans J (1993) Affinity differences for vitamin D metabolites associaated with the genetic isoforms of the human serum carrier protein (DBP). Hum Genet <volume>92<\/volume>: :183\u2013188 Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/link.springer.com\/article\/10.1007\/BF00219689\" xlink:type=\"simple\">http:\/\/link.springer.com\/article\/10.1007\/BF00219689<\/ext-link>. Accessed 25 July 2013."},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Kawakami M, Blum C, Ramakrishnan R, Dell R, Goodman D (1981) Turnover of the plasma binding protein for vitamin D and its metabolites in normal human subjects. J Clin Endocrinol Metab: 1110\u20131116.","DOI":"10.1210\/jcem-53-6-1110"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF00290950","article-title":"Ethnic variation in vitamin D-binding protein (GC): a review of isoelectric focusing studies in human populations","volume":"72","author":"MI Kamboh","year":"1986","journal-title":"Hum Genet"},{"key":"ref49","volume":"24","unstructured":"Perna L (2013) Genetic Variatons in the Vitamin D Binding Protein and Season-Specific Levels of Vitamin D Among Older Aldults. Epidemiology <volume>24<\/volume>: : 104\u2013109. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3150431&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3150431&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 5 June 2013."},{"key":"ref50","volume":"30","unstructured":"Ahn J, Albanes D, Berndt SI, Peters U, Chatterjee N, <etal>et al<\/etal>.. (2009) Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. Carcinogenesis <volume>30<\/volume>: : 769\u2013776 Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2675652&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2675652&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 1 March 2012."},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Jorde R, Schirmer H, Wilsgaard T, Joakimsen RM, Mathiesen EB, <etal>et al<\/etal>.. (2012) Polymorphisms related to the serum 25-hydroxyvitamin d level and risk of myocardial infarction, diabetes, cancer and mortality. The troms\u00f8 study. PLoS One 7: e37295. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3359337&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3359337&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. Accessed 7 June 2012.","DOI":"10.1371\/journal.pone.0037295"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Berry DJ, Vimaleswaran KS, Whittaker JC, Hingorani AD, Hypp\u00f6nen E (2012) Evaluation of Genetic Markers as Instruments for Mendelian Randomization Studies on Vitamin D. PLoS One 7: e37465. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.plos.org\/10.1371\/journal.pone.0037465\" xlink:type=\"simple\">http:\/\/dx.plos.org\/10.1371\/journal.pone.0037465<\/ext-link>. Accessed 21 May 2012.","DOI":"10.1371\/journal.pone.0037465"},{"key":"ref53","unstructured":"National Board of Health (2010) Forebyggelse, diagnostik og behandling af D-vitaminmangel (Prevention, diagnostics and treatment of vitamin D defiency). Natl Board Heal. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/sundhedsstyrelsen.dk\/~\/media\/FA2FC43A29D146918C9695BEC2716A33.ashx\" xlink:type=\"simple\">http:\/\/sundhedsstyrelsen.dk\/~\/media\/FA2FC43A29D146918C9695BEC2716A33.ashx<\/ext-link>. Accessed 2014 February 1."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0089907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T01:45:06Z","timestamp":1565228706000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0089907"}},"subtitle":[],"editor":[{"given":"Nathan A.","family":"Ellis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,27]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0089907","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,27]]}}}