{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:50:10Z","timestamp":1780545010602,"version":"3.54.1"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0089921","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T22:13:01Z","timestamp":1393279981000},"page":"e89921","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Genotypic Analysis of Meningococcal Factor H-Binding Protein from Non-Culture Clinical Specimens"],"prefix":"10.1371","volume":"9","author":[{"given":"Stephen A.","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Lucidarme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne S.","family":"Newbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Borrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,2,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1016\/j.vaccine.2013.07.083","article-title":"Effectiveness of meningococcal serogroup C vaccine programmes","volume":"31","author":"R Borrow","year":"2013","journal-title":"Vaccine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"B26","DOI":"10.1016\/j.vaccine.2011.12.032","article-title":"The changing and dynamic epidemiology of meningococcal disease","volume":"30","author":"SA Halperin","year":"2012","journal-title":"Vaccine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/S0140-6736(12)61187-8","article-title":"Effect of vaccines on bacterial meningitis worldwide","volume":"380","author":"PB McIntyre","year":"2012","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Daugla D, Gami J, Gamougam K, Naibei N, Mbainadji L, et al. (2013) Effect of a serogroup A meningococcal conjugate vaccine (PsA-TT) on serogroup A meningococcal meningitis and carriage in Chad: a community trial. Lancet in press.","DOI":"10.1016\/S0140-6736(13)61612-8"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(83)90340-9","article-title":"Antigenic Similarities Between Brain Components And Bacteria Causing Meningitis: Implications for Vaccine Development and Pathogenesis","volume":"322","author":"J Finne","year":"1983","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.4161\/hv.24129","article-title":"Lessons from past programs and implications for the future vaccines against meningococcal serogroup B disease containing outer membrane vesicles (OMV )","volume":"9","author":"J Holst","year":"2013","journal-title":"Hum Vaccin Immunother"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1586\/erv.11.103","article-title":"Neisseria meningitidis B vaccines","volume":"10","author":"D Panatto","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"8738","DOI":"10.1074\/jbc.M808831200","article-title":"Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086","volume":"284","author":"A Mascioni","year":"2009","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"9022","DOI":"10.1074\/jbc.C800214200","article-title":"Solution structure of the factor H-binding protein, a survival factor and protective antigen of Neisseria meningitidis","volume":"284","author":"F Cantini","year":"2009","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1128\/IAI.72.4.2088-2100.2004","article-title":"Vaccine Potential of the Neisseria meningitidis 2086 Lipoprotein","volume":"72","author":"LD Fletcher","year":"2004","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1084\/jem.20021911","article-title":"Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870","volume":"197","author":"V Masignani","year":"2003","journal-title":"J Exp Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.4049\/jimmunol.177.1.501","article-title":"The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance","volume":"177","author":"G Madico","year":"2006","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1186\/1471-2105-11-595","article-title":"BIGSdb: Scalable analysis of bacterial genome variation at the population level","volume":"11","author":"KA Jolley","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1099\/mic.0.027995-0","article-title":"Variation of the factor H-binding protein of Neisseria meningitidis","volume":"155","author":"C Brehony","year":"2009","journal-title":"Microbiology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1016\/j.vaccine.2010.06.083","article-title":"Broad vaccine coverage predicted for a bivalent recombinant factor H binding protein based vaccine to prevent serogroup B meningococcal disease","volume":"28","author":"H-Q Jiang","year":"2010","journal-title":"Vaccine"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.1016\/j.vaccine.2012.07.065","article-title":"A bivalent Neisseria meningitidis recombinant lipidated factor H binding protein vaccine in young adults: results of a randomised, controlled, dose-escalation phase 1 trial","volume":"30","author":"PC Richmond","year":"2012","journal-title":"Vaccine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.vaccine.2013.01.021","article-title":"A phase 2 open-label safety and immunogenicity study of a meningococcal B bivalent rLP2086 vaccine in healthy adults","volume":"31","author":"HS Marshall","year":"2013","journal-title":"Vaccine"},{"key":"ref18","unstructured":"European Medicines Agency (2012) Bexsero Assessment report."},{"key":"ref19","unstructured":"Novartis (2013) Novartis Bexsero Australia Approval Press Release."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1517\/14712598.2011.585965","article-title":"Recombinant protein meningococcal serogroup B vaccine combined with outer membrane vesicles","volume":"11","author":"X Bai","year":"2011","journal-title":"Expert Opin Biol Ther"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jinf.2013.06.007","article-title":"Added value of PCR-testing for confirmation of invasive meningococcal disease in England","volume":"67","author":"E Heinsbroek","year":"2013","journal-title":"J Infect"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1128\/JCM.43.12.6007-6014.2005","article-title":"Multilocus Sequence Typing of Neisseria meningitidis Directly from Clinical Samples and Application of the Method to the Investigation of Meningococcal Disease Case Clusters","volume":"43","author":"A Birtles","year":"2005","journal-title":"J Clin Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1099\/jmm.0.05032-0","article-title":"Detection and genotyping of meningococci using a nested PCR approach","volume":"52","author":"MA Diggle","year":"2003","journal-title":"J Med Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1128\/JB.186.5.1518-1530.2004","article-title":"eBURST: Inferring Patterns of Evolutionary Descent among Clusters of Related Bacterial Genotypes from Multilocus Sequence Typing Data","volume":"186","author":"EJ Feil","year":"2004","journal-title":"J Bacteriol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1099\/mic.0.055459-0","article-title":"Ribosomal Multi-Locus Sequence Typing: universal characterisation of bacteria from domain to strain","volume":"158","author":"KA Jolley","year":"2012","journal-title":"Microbiology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1128\/CVI.00090-13","article-title":"Genetic Distribution of Noncapsular Meningococcal Group B Vaccine Antigens in Neisseria lactamica","volume":"20","author":"J Lucidarme","year":"2013","journal-title":"Clin Vaccine Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1128\/JCM.39.4.1553-1558.2001","article-title":"Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR","volume":"39","author":"CE Corless","year":"2001","journal-title":"J Clin Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1186\/1471-2164-11-652","article-title":"Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020\u201306","volume":"11","author":"JS Bennett","year":"2010","journal-title":"BMC Genomics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1128\/CVI.00055-11","article-title":"Characterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein","volume":"18","author":"J Lucidarme","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.vaccine.2005.11.006","article-title":"Sequence constancies and variations in genes encoding three new meningococcal vaccine candidate antigens","volume":"24","author":"S Jacobsson","year":"2006","journal-title":"Vaccine"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0089921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T23:02:06Z","timestamp":1565218926000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0089921"}},"subtitle":[],"editor":[{"given":"Baochuan","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,24]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0089921","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,24]]}}}