{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:33:10Z","timestamp":1780345990501,"version":"3.54.1"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0090393","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T17:12:38Z","timestamp":1393607558000},"page":"e90393","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Optimization and In Vivo Toxicity Evaluation of G4.5 Pamam Dendrimer-Risperidone Complexes"],"prefix":"10.1371","volume":"9","author":[{"given":"Maria Jimena","family":"Prieto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahuel Eduardo","family":"del Rio Zabala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian Hern\u00e1n","family":"Marotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Carre\u00f1o Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Ar\u00e9valo Ar\u00e9valo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia Silvia","family":"Chiaramoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia del Valle","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijpharm.2008.03.029","article-title":"Intranasal nanoemulsion based brain targeting drug delivery system of risperidone","volume":"358","author":"M Kumar","year":"2008","journal-title":"Int J Pharm"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.neuron.2007.10.016","article-title":"Mapping early brain development in autism","volume":"56","author":"E Courchesne","year":"2007","journal-title":"Neuron"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ajhg.2007.12.009","article-title":"Structural variation of chromosomes in autism spectrum disorder","volume":"82","author":"CR Marshall","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2165\/00003495-200969050-00003","article-title":"The role of antipsychotics in the management of behavioural symptoms in children and adolescents with autism","volume":"69","author":"RP Malone","year":"2009","journal-title":"Drugs"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/BF02244986","article-title":"Plasma protein binding of risperidone and its distribution in blood","volume":"114","author":"G Mannens","year":"1994","journal-title":"Psychopharmacology (Berl)"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ejpb.2008.09.023","article-title":"Dendrimers as versatile platform in drug delivery applications","volume":"71","author":"S Svenson","year":"2009","journal-title":"Eur J Pharm Biopharm"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ijpharm.2006.05.068","article-title":"Nanomolar cationic dendrimeric sulfadiazine as potential antitoxoplasmic agent","volume":"326","author":"MJ Prieto","year":"2006","journal-title":"International Journal of Pharmaceutics"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ijpharm.2008.04.045","article-title":"Brain and muscle of Wistar rats are the main targets of intravenous dendrimeric sulfadiazine","volume":"360","author":"MJ Prieto","year":"2008","journal-title":"Int J Pharm"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ejmech.2010.12.021","article-title":"Optimization and in vitro toxicity evaluation of G4 PAMAM dendrimer-risperidone complexes","volume":"46","author":"MJ Prieto","year":"2011","journal-title":"Eur J Med Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1021\/ma971199b","article-title":"Rheology of dendrimers. I. Newtonian flowbehaviour of medium and highly concentrated solutions of polyamidoamine (PAMAM) dendrimers in ethylenediamide (EDA) solvent","volume":"31","author":"S Uppuluri","year":"1998","journal-title":"Macromolecules"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1021\/ma990634u","article-title":"Rheology of dendrimers. 2. Bulk polyamidoamine dendrimers under steady shear, creep and dynamic oscillator","volume":"33","author":"S Uppuluri","year":"2000","journal-title":"Macromolecules"},{"key":"ref12","first-page":"242","article-title":"Polimeros dendr\u00edticos: propiedades y aplicaciones","volume":"86","author":"P Bosch","year":"2003","journal-title":"Revista Plasticos Modernos"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0378-4371(01)00548-9","article-title":"Scaling properties in the internal structure of dendrimer systems","volume":"304","author":"F Mallamace","year":"2002","journal-title":"Physica A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0168-583X(03)01536-2","article-title":"Molecular dynamic analysis of the structure of dendrimers","volume":"213","author":"E Canetta","year":"2004","journal-title":"Nucl Instrum Meth Phys Res B"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1016\/j.polymer.2005.02.107","article-title":"Molecular dynamics simulation of PAMAM dendrimer in aqueous solution","volume":"46","author":"M Han","year":"2005","journal-title":"Polymer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.ejmech.2007.09.030","article-title":"Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies","volume":"43","author":"Y Cheng","year":"2008","journal-title":"Eur J Med Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.ejmech.2006.12.035","article-title":"Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: An in vitro study","volume":"42","author":"Y Cheng","year":"2007","journal-title":"European Journal of Medicinal Chemistry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"CB Kimmel","year":"1995","journal-title":"Dev Dyn"},{"key":"ref19","first-page":"3351","article-title":"Toxicity evaluation of biodegradable chitosan nanoparticles using a zebrafish embryo model","volume":"6","author":"YL Hu","year":"2011","journal-title":"Int J Nanomedicine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-pharmtox-010611-134751","article-title":"Systematic approaches to toxicology in the zebrafish","volume":"52","author":"RT Peterson","year":"2012","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2174\/138920009787522197","article-title":"Zebrafish: a complete animal model for in vivo drug discovery and development","volume":"10","author":"C Chakraborty","year":"2009","journal-title":"Curr Drug Metab"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.drudis.2008.03.002","article-title":"Zebrafish: a predictive model for assessing drug-induced toxicity","volume":"13","author":"P McGrath","year":"2008","journal-title":"Drug Discov Today"},{"key":"ref23","unstructured":"Sravan Kumar M, Anton Smith A, Alagumani Vasagam G, Kottai Muthu A, Manavalan R (2010) Development of Analytical Method for Risperidone by UV Spectrophotometry. International Journal of Pharma Sciences and Research: 122\u2013126"},{"key":"ref24","unstructured":"Prieto M, del Rio Zabala N, Marotta C, Bichara D, Simonetta S, et al. (2013) 4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model. J Nanomedine Biotherapeutic Discov 4."},{"key":"ref25","first-page":"155","article-title":"Binding Constants: The Measurement of Molecular Complex Stability","volume":"62","author":"K Connors","year":"1996","journal-title":"J Inorg Biochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1021\/bm1013102","article-title":"Bundling an aggregation of DNA by Cationic Dendrimers","volume":"12","author":"E Froehlich","year":"2011","journal-title":"Biomacromolecules"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4236\/ojmc.2012.24016","article-title":"Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish","volume":"2","author":"MJ Prieto","year":"2012","journal-title":"Open Journal of Medicinal Chemistry"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0891-0618(00)00046-6","article-title":"Distribution of the calcium-binding proteins parvalbumin, calbindin D-28k and calretinin in the retina of two teleosts","volume":"19","author":"E Weruaga","year":"2000","journal-title":"J Chem Neuroanat"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0006-8993(01)03279-6","article-title":"Effects of axotomy on the expression of NADPH-diaphorase in the visual pathway of the tench","volume":"925","author":"D Clemente","year":"2002","journal-title":"Brain Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ntt.2006.02.001","article-title":"Teratogenic effects of ethanol exposure on zebrafish visual system development","volume":"28","author":"FJ Arenzana","year":"2006","journal-title":"Neurotoxicol Teratol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00429-006-0084-2","article-title":"Tyrosine hydroxylase immunoreactivity in the developing visual pathway of the zebrafish","volume":"211","author":"FJ Arenzana","year":"2006","journal-title":"Anat Embryol (Berl)"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1021\/ma980198w","article-title":"Tunning the density profile of dendritic poly-electrolytes","volume":"31","author":"P Welch","year":"1998","journal-title":"Macromolecules"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1126\/science.266.5188.1226","article-title":"Encapsulation of Guest Molecules into a Dendritic Box","volume":"266","author":"JF Jansen","year":"1994","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejmech.2006.07.015","article-title":"Evaluation of polyamidoamine (PAMAM) dendrimers as drug carriers of anti-bacterial drugs using sulfamethoxazole (SMZ) as a model drug","volume":"42","author":"M Ma","year":"2007","journal-title":"Eur J Med Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1021\/jo9014134","article-title":"Tweezering the Core of Dendrimers: Medium Effect on the Kinetic and Thermodynamic Properties","volume":"74","author":"C Giansante","year":"2009","journal-title":"J Org Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1002\/chem.200400157","article-title":"Polarity effects on the photophysics of dendrimers with an oligophenylenevinylene core and peripheral fullerene units","volume":"10","author":"M Gutierrez-Nava","year":"2004","journal-title":"Chemistry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0378-5173(00)00679-7","article-title":"Transport of poly amidoamine dendrimers across Madin-Darby canine kidney cells","volume":"215","author":"F Tajarobi","year":"2001","journal-title":"Int J Pharm"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1021\/bm0055495","article-title":"Quaternary ammonium functionalized poly(propylene imine) dendrimers as effective antimicrobials: structure-activity studies","volume":"1","author":"CZ Chen","year":"2000","journal-title":"Biomacromolecules"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jconrel.2009.04.022","article-title":"Transepithelial transport of PEGylated anionic poly(amidoamine) dendrimers: implications for oral drug delivery","volume":"138","author":"DM Sweet","year":"2009","journal-title":"J Control Release"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jconrel.2004.07.027","article-title":"Enhanced transfection efficiency of PAMAM dendrimer by surface modification with L-arginine","volume":"99","author":"JS Choi","year":"2004","journal-title":"J Control Release"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/jps.20251","article-title":"Structure\/function relationships of polyamidoamine\/DNA dendrimers as gene delivery vehicles","volume":"94","author":"CS Braun","year":"2005","journal-title":"J Pharm Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1002\/adma.200702770","article-title":"Dendrimer-Functionalized Shell-crosslinked Iron Oxide Nanoparticles for In-Vivo Magnetic Resonance Imaging of Tumors","volume":"20","author":"S Xiangyang","year":"2008","journal-title":"Adv Mater"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ntt.2007.07.005","article-title":"Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC)","volume":"29","author":"MJ Airhart","year":"2007","journal-title":"Neurotoxicol Teratol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.addr.2007.11.008","article-title":"Suspensions for intravenous (IV) injection: a review of development, preclinical and clinical aspects","volume":"60","author":"J Wong","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.tiv.2008.10.003","article-title":"Antipsychotic drugs inhibit nucleotide hydrolysis in zebrafish (Danio rerio) brain membranes","volume":"23","author":"KJ Seibt","year":"2009","journal-title":"Toxicol In Vitro"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jcis.2008.01.034","article-title":"Modification of membrane heterogeneity by antipsychotic drugs: an X-ray diffraction comparative study","volume":"320","author":"C Tessier","year":"2008","journal-title":"J Colloid Interface Sci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s10529-007-9454-y","article-title":"Liposome\/DNA systems: correlation between association, hydrophobicity and cell viability","volume":"29","author":"NS Chiaramoni","year":"2007","journal-title":"Biotechnol Lett"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0009-3084(02)00190-1","article-title":"Characterization of diacetylenic liposomes as carriers for oral vaccines","volume":"122","author":"S Alonso-Romanowski","year":"2003","journal-title":"Chem Phys Lipids"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/10717540490280769","article-title":"Stability of liposomal formulations in physiological conditions for oral drug delivery","volume":"11","author":"MC Taira","year":"2004","journal-title":"Drug Deliv"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.addr.2005.09.012","article-title":"Dendrimer-drug interactions","volume":"57","author":"A D'Emanuele","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0142-9612(02)00445-3","article-title":"In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis","volume":"24","author":"D Fischer","year":"2003","journal-title":"Biomaterials"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.chemphyslip.2004.09.001","article-title":"Direct observation of lipid bilayer disruption by poly(amidoamine) dendrimers","volume":"132","author":"A Mecke","year":"2004","journal-title":"Chem Phys Lipids"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0090393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T03:58:27Z","timestamp":1540007907000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0090393"}},"subtitle":[],"editor":[{"given":"Bing","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,28]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0090393","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,28]]}}}