{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:42:26Z","timestamp":1782938546667,"version":"3.54.5"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0090438","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T22:54:16Z","timestamp":1393973656000},"page":"e90438","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Variations in the MHC Region Confer Risk to Esophageal Squamous Cell Carcinoma on the Subjects from High-Incidence Area in Northern China"],"prefix":"10.1371","volume":"9","author":[{"given":"Fang-Fang","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bin","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-You","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Ke","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Na","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Sha","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Long","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Li","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"A Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"ref2","first-page":"249","article-title":"Esophageal cancer in migrants from high- or low-risk areas in China","volume":"2","author":"L Haocai","year":"1983","journal-title":"Ecol Dis"},{"key":"ref3","first-page":"2633","article-title":"Research on esophageal cancer in China: a review","volume":"40","author":"CS Yang","year":"1980","journal-title":"Cancer Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/ijc.20616","article-title":"Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China","volume":"113","author":"GD Tran","year":"2005","journal-title":"Int J Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"534","DOI":"10.2174\/138920209789503888","article-title":"Current gene expression studies in esophageal carcinoma","volume":"10","author":"W Guo","year":"2009","journal-title":"Curr Genomics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S1072-7515(00)00238-6","article-title":"Esophageal cancer: results of an American College of Surgeons Patient Care Evaluation Study","volume":"190","author":"JM Daly","year":"2000","journal-title":"J Am Coll Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/ng.2411","article-title":"Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions","volume":"44","author":"C Wu","year":"2012","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/ng.649","article-title":"A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma","volume":"42","author":"CC Abnet","year":"2010","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ng.648","article-title":"Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54","volume":"42","author":"LD Wang","year":"2010","journal-title":"Nat Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1002\/ijc.28160","article-title":"Barrett associated MHC and FOXF1 variants also increase esophageal carcinoma risk","volume":"133","author":"P Dura","year":"2013","journal-title":"Int J Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nrg1489","article-title":"Gene map of the extended human MHC","volume":"5","author":"R Horton","year":"2004","journal-title":"Nat Rev Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1080\/00365520902998679","article-title":"Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: association with disease progression","volume":"44","author":"Q Liu","year":"2009","journal-title":"Scand J Gastroenterol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/carcin\/22.10.1615","article-title":"DNA hypermethylation is a mechanism for loss of expression of the HLA class I genes in human esophageal squamous cell carcinomas","volume":"22","author":"Y Nie","year":"2001","journal-title":"Carcinogenesis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1136\/jcp.2005.031575","article-title":"Loss of human leucocyte antigen class I and gain of class II expression are early events in carcinogenesis: clues from a study of Barrett's oesophagus","volume":"59","author":"S Rajendra","year":"2006","journal-title":"J Clin Pathol"},{"key":"ref15","first-page":"1783","article-title":"Accumulation of p53 protein in human esophageal precancerous lesions: a possible early biomarker for carcinogenesis","volume":"53","author":"LD Wang","year":"1993","journal-title":"Cancer Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"AL Price","year":"2006","journal-title":"Nat Genet"},{"key":"ref17","first-page":"571","article-title":"Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains","volume":"3","author":"M Takahashi","year":"1988","journal-title":"Oncogene"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0968-0004(96)80017-X","article-title":"Does this have a familiar RING?","volume":"21","author":"AJ Saurin","year":"1996","journal-title":"Trends Biochem Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"31902","DOI":"10.1074\/jbc.M304062200","article-title":"The Ret finger protein induces apoptosis via its RING finger-B box-coiled-coil motif","volume":"278","author":"SH Dho","year":"2003","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1128\/MCB.7.4.1378","article-title":"ret transforming gene encodes a fusion protein homologous to tyrosine kinases","volume":"7","author":"M Takahashi","year":"1987","journal-title":"Mol Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nrc864","article-title":"Live or let die: the cell's response to p53","volume":"2","author":"KH Vousden","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00251-003-0563-z","article-title":"Mutations in the HLA class II genes leading to loss of expression of HLA-DR and HLA-DQ in diffuse large B-cell lymphoma","volume":"55","author":"ES Jordanova","year":"2003","journal-title":"Immunogenetics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0092-8674(94)90336-0","article-title":"MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation","volume":"76","author":"RN Germain","year":"1994","journal-title":"Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/BF02048033","article-title":"Heat shock protein 70 and HLA-DR molecules tissue expression. Prognostic implications in colorectal cancer","volume":"38","author":"AC Lazaris","year":"1995","journal-title":"Dis Colon Rectum"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00251-002-0470-8","article-title":"Identification of novel candidate genes in the diffuse panbronchiolitis critical region of the class I human MHC","volume":"54","author":"Y Matsuzaka","year":"2002","journal-title":"Immunogenetics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/ijc.23044","article-title":"Genetic polymorphisms and esophageal cancer risk","volume":"121","author":"T Hiyama","year":"2007","journal-title":"Int J Cancer"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s10147-010-0056-7","article-title":"Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention","volume":"15","author":"M Morita","year":"2010","journal-title":"Int J Clin Oncol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/JTO.0b013e3181ee80ef","article-title":"Contribution of the TP53, OGG1, CHRNA3, and HLA-DQA1 genes to the risk for lung squamous cell carcinoma","volume":"6","author":"T Kohno","year":"2011","journal-title":"J Thorac Oncol"},{"key":"ref29","first-page":"269","article-title":"[Association between HLA-DQA1 gene copy number polymorphisms and susceptibility to gastric cancer]","volume":"34","author":"LM Huang","year":"2012","journal-title":"Zhonghua Zhong Liu Za Zhi"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0090438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:23:24Z","timestamp":1588991004000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0090438"}},"subtitle":[],"editor":[{"given":"Suminori","family":"Akiba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,4]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0090438","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,4]]}}}