{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:09:58Z","timestamp":1768410598079,"version":"3.49.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0090448","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T22:16:10Z","timestamp":1393625770000},"page":"e90448","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Ciprofloxacin Enhances Stress Erythropoiesis in Spleen and Increases Survival after Whole-Body Irradiation Combined with Skin-Wound Trauma"],"prefix":"10.1371","volume":"9","author":[{"given":"Risaku","family":"Fukumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"True M.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliann G.","family":"Kiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1667\/RR1892.1","article-title":"Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection","volume":"173","author":"JG Kiang","year":"2010","journal-title":"Radiat Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/2045-3701-2-20","article-title":"Wound trauma alters ionizing radiation dose assessment","volume":"2","author":"JG Kiang","year":"2012","journal-title":"Cell Biosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e58389","DOI":"10.1371\/journal.pone.0058389","article-title":"Ciprofloxacin modulates cytokine\/chemokine profile in serum, improves bone marrow repopulation, and limits apoptosis and autophagy in ileum after whole body ionizing irradiation combined with skin-wound trauma","volume":"8","author":"R Fukumoto","year":"2013","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/00000658-195411000-00012","article-title":"The combined effects of thermal burns and whole-body X irradiation. II. Anemia","volume":"140","author":"AK Davis","year":"1954","journal-title":"Ann Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1182\/blood-2005-07-3046","article-title":"The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?","volume":"107","author":"E Beutler","year":"2006","journal-title":"Blood"},{"key":"ref6","unstructured":"Marie Curie and the radioactivity, The 1903 Nobel Prize in Physics. Nobel Media AB 2013 Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.nobelprize.org\/educational\/nobelprize_info\/curie-edu.html\" xlink:type=\"simple\">http:\/\/www.nobelprize.org\/educational\/nobelprize_info\/curie-edu.html<\/ext-link> Accessed 10 September 2013."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1182\/blood-2010-04-281840","article-title":"Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation","volume":"116","author":"S Millot","year":"2010","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/ibd.20077","article-title":"Immunomodulatory effects of ciprofloxacin in TNBS-induced colitis in mice","volume":"13","author":"G Lahat","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ibd.20608","article-title":"Ciprofloxacin or metronidazole for the treatment of perianal fistulas in patients with Crohn\u2019s disease: a randomized, double-blind, placebo-controlled pilot study","volume":"15","author":"KT Thia","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"ref10","first-page":"216","article-title":"Protective effects of ciprofloxacin against type II collagen induced arthritis in rats","volume":"19","author":"M Breban","year":"1992","journal-title":"J Rheumatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1056\/NEJM199907293410501","article-title":"A double-blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy","volume":"341","author":"A Freifeld","year":"1999","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1182\/blood.V77.3.419.419","article-title":"Erythropoietin","volume":"77","author":"SB Krantz","year":"1991","journal-title":"Blood"},{"key":"ref13","unstructured":"Rubin P, Casarett GW (1968) Clinical Radiation Pathology."},{"key":"ref14","first-page":"836","article-title":"Expression of high affinity receptors for erythropoietin on human bone marrow cells and on the human erythroleukemic cell line, HEL","volume":"16","author":"JK Fraser","year":"1988","journal-title":"Exp Hematol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5631","DOI":"10.1182\/blood-2010-11-320564","article-title":"Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment","volume":"117","author":"S Singbrant","year":"2011","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0300-9084(98)80024-2","article-title":"Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review","volume":"80","author":"D Bratosin","year":"1998","journal-title":"Biochimie"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000067907","article-title":"Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency","volume":"12","author":"KS Lang","year":"2002","journal-title":"Cell Physiol Biochem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/sj.cdd.4401144","article-title":"Cation channels trigger apoptotic death of erythrocytes","volume":"10","author":"KS Lang","year":"2003","journal-title":"Cell Death Differ"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1182\/blood-2008-03-077883","article-title":"Erythroblastic islands: niches for erythropoiesis","volume":"112","author":"JA Chasis","year":"2008","journal-title":"Blood"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1473-3099(03)00658-3","article-title":"Immunomodulatory effects of quinolones","volume":"3","author":"A Dalhoff","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"ref21","first-page":"360","article-title":"Ciprofloxacin enhances hematopoiesis and the peritoneal neutrophil function in lethally irradiated, bone marrow-transplanted mice","volume":"22","author":"Y Kletter","year":"1994","journal-title":"Exp Hematol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-0609.1997.tb00930.x","article-title":"Enhanced hematopoiesis in sublethally irradiated mice treated with various quinolones","volume":"58","author":"I Shalit","year":"1997","journal-title":"Eur J Haematol"},{"key":"ref23","first-page":"606","article-title":"Impact of ciprofloxacin and cotrimoxazole on bone marrow growth as measured by CFU-GM and BFU-E assays","volume":"1","author":"BE De Pauw","year":"1989","journal-title":"J Chemother"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35004599","article-title":"A clonogenic common myeloid progenitor that gives rise to all myeloid lineages","volume":"404","author":"K Akashi","year":"2000","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1182\/blood-2008-12-195651","article-title":"Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications","volume":"113","author":"I Theurl","year":"2009","journal-title":"Blood"},{"key":"ref26","unstructured":"Ibuki Y, Goto R (2004) Ionizing radiation-induced macrophage activation: augmentation of nitric oxide production and its significance. Cell Mol Biol (Noisy-le-grand) 50 Online Pub: OL617\u2013626."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nm.3057","article-title":"CD169(+) macrophages provide a niche promoting erythropoiesis under homeostasis and stress","volume":"19","author":"A Chow","year":"2013","journal-title":"Nat Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1084\/jem.20101709","article-title":"Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation","volume":"208","author":"D Hashimoto","year":"2011","journal-title":"J Exp Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1574-6976.2011.00295.x","article-title":"Emergence and spread of antibiotic resistance following exposure to antibiotics","volume":"35","author":"R Canton","year":"2011","journal-title":"FEMS Microbiol Rev"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0090448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T22:16:33Z","timestamp":1597529793000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0090448"}},"subtitle":[],"editor":[{"given":"Bernhard","family":"Ryffel","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,2,28]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,2,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0090448","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,28]]}}}