{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:53:28Z","timestamp":1792144408076,"version":"4.4.0"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T00:00:00Z","timestamp":1393804800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0090645","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T21:59:57Z","timestamp":1393883997000},"page":"e90645","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":104,"title":["Brain Region-Specific Expression of MeCP2 Isoforms Correlates with DNA Methylation within Mecp2 Regulatory Elements"],"prefix":"10.1371","volume":"9","author":[{"given":"Carl O.","family":"Olson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robby M.","family":"Zachariah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinelo D.","family":"Ezeonwuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vichithra R. B.","family":"Liyanage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Rastegar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2217\/epi.09.13","article-title":"Evolving role of MeCP2 in Rett syndrome and autism","volume":"1","author":"JM LaSalle","year":"2009","journal-title":"Epigenomics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"415825","DOI":"10.1155\/2012\/415825","article-title":"Linking epigenetics to human disease and Rett syndrome: the emerging novel and challenging concepts in MeCP2 research","volume":"2012","author":"RM Zachariah","year":"2012","journal-title":"Neural Plast"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/diseases2010045","article-title":"MeCP2-Related Diseases and Animal Models","volume":"2","author":"C Ezeonwuka","year":"2014","journal-title":"Diseases"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Tunc-Ozcan E, Ullmann TM, Shukla PK, Redei EE (2013) Low-Dose Thyroxine Attenuates Autism-Associated Adverse Effects of Fetal Alcohol in Male Offspring&apos;s Social Behavior and Hippocampal Gene Expression. Alcohol Clin Exp Res.","DOI":"10.1111\/acer.12183"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s11064-012-0960-5","article-title":"Effects of Ethanol Exposure During Early Pregnancy in Hyperactive, Inattentive and Impulsive Behaviors and MeCP2 Expression in Rodent Offspring","volume":"38","author":"P Kim","year":"2013","journal-title":"Neurochem Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuroscience.2012.07.071","article-title":"Maternal separation and proclivity for ethanol intake: a potential role of the endocannabinoid system in rats","volume":"223","author":"A Romano-Lopez","year":"2012","journal-title":"Neuroscience"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Repunte-Canonigo V, Chen J, Lefebvre C, Kawamura T, Kreifeldt M, <etal>et al<\/etal>.. (2013) MeCP2 regulates ethanol sensitivity and intake. Addict Biol.","DOI":"10.1111\/adb.12047"},{"key":"ref8","unstructured":"Liyanage VRB, Zachariah RM, Delcuve GP, Davie JR, Rastegar M (2012) New Developments in Chromatin Research: An Epigenetic Perspective. In: Simpson NM, Stewart VJ, editors. New Developments in Chromatin Research: Nova Science Publishers pp. 29\u201358."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/jcp.21678","article-title":"Epigenetic control","volume":"219","author":"GP Delcuve","year":"2009","journal-title":"J Cell Physiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1093\/nar\/20.19.5085","article-title":"Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA","volume":"20","author":"RR Meehan","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.cell.2012.11.022","article-title":"MeCP2 binds to 5 hmC enriched within active genes and accessible chromatin in the nervous system","volume":"151","author":"M Mellen","year":"2012","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/1947601913489020","article-title":"Identification of TET1 Partners That Control Its DNA-Demethylating Function","volume":"4","author":"PF Cartron","year":"2013","journal-title":"Genes Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1093\/nar\/gkh349","article-title":"The major form of MeCP2 has a novel N-terminus generated by alternative splicing","volume":"32","author":"S Kriaucionis","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/ng1327","article-title":"A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome","volume":"36","author":"GN Mnatzakanian","year":"2004","journal-title":"Nat Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1523\/JNEUROSCI.5841-11.2012","article-title":"Isoform-specific toxicity of Mecp2 in postmitotic neurons: suppression of neurotoxicity by FoxG1","volume":"32","author":"SG Dastidar","year":"2012","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"13859","DOI":"10.1074\/jbc.M111.309864","article-title":"Methyl CpG-binding protein isoform MeCP2_e2 is dispensable for Rett syndrome phenotypes but essential for embryo viability and placenta development","volume":"287","author":"M Itoh","year":"2012","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/2040-2392-4-46","article-title":"Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells","volume":"4","author":"VR Liyanage","year":"2013","journal-title":"Mol Autism"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e6810","DOI":"10.1371\/journal.pone.0006810","article-title":"MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy","volume":"4","author":"M Rastegar","year":"2009","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.yexcr.2004.05.035","article-title":"Suppression of MeCP2\u03b2 expression inhibits neurite extension in PC12 cells","volume":"299","author":"SM Cusack","year":"2004","journal-title":"Exp Cell Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/cne.21264","article-title":"Differential distribution of the MeCP2 splice variants in the postnatal mouse brain","volume":"501","author":"JM Dragich","year":"2007","journal-title":"J Comp Neurol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e49763","DOI":"10.1371\/journal.pone.0049763","article-title":"Novel MeCP2 isoform-specific antibody reveals the endogenous MeCP2E1 expression in murine brain, primary neurons and astrocytes","volume":"7","author":"RM Zachariah","year":"2012","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Yasui DH, Gonzales ML, Aflatooni JO, Crary FK, Hu DJ, <etal>et al<\/etal>.. (2014) Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome. Hum Mol Genet.","DOI":"10.1093\/hmg\/ddu496"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/jmg.2005.036244","article-title":"Lost in translation: translational interference from a recurrent mutation in exon 1 of MECP2","volume":"43","author":"A Saxena","year":"2006","journal-title":"J Med Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1750-1172-8-108","article-title":"A synonymous change, p.Gly16Gly in MECP2 Exon 1, causes a cryptic splice event in a Rett syndrome patient","volume":"8","author":"TI Sheikh","year":"2013","journal-title":"Orphanet J Rare Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1136\/jmg.2006.041285","article-title":"Comprehensive diagnosis of Rett&apos;s syndrome relying on genetic, epigenetic and expression evidence of deficiency of the methyl-CpG-binding protein 2 gene: study of a cohort of Israeli patients","volume":"43","author":"Y Petel-Galil","year":"2006","journal-title":"J Med Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/hmg\/ddn026","article-title":"Targeted delivery of an Mecp2 transgene to forebrain neurons improves the behavior of female Mecp2-deficient mice","volume":"17","author":"DG Jugloff","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/hmg\/ddl099","article-title":"Identification of cis-regulatory elements for MECP2 expression","volume":"15","author":"J Liu","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1093\/hmg\/ddi402","article-title":"A segment of the Mecp2 promoter is sufficient to drive expression in neurons","volume":"14","author":"M Adachi","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1093\/nar\/gkn591","article-title":"MECP2 genomic structure and function: insights from ENCODE","volume":"36","author":"J Singh","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4161\/epi.1.4.3514","article-title":"Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation","volume":"1","author":"RP Nagarajan","year":"2006","journal-title":"Epigenetics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/aur.24","article-title":"MECP2 promoter methylation and X chromosome inactivation in autism","volume":"1","author":"RP Nagarajan","year":"2008","journal-title":"Autism Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.biopsych.2010.05.036","article-title":"Epigenetic transmission of the impact of early stress across generations","volume":"68","author":"TB Franklin","year":"2010","journal-title":"Biol Psychiatry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/neu.10201","article-title":"The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells","volume":"55","author":"BP Jung","year":"2003","journal-title":"J Neurobiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/hmg\/11.2.115","article-title":"Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation","volume":"11","author":"MD Shahbazian","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"J Guy","year":"2001","journal-title":"Nat Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2040-2392-4-3","article-title":"MeCP2 modulates gene expression pathways in astrocytes","volume":"4","author":"DH Yasui","year":"2013","journal-title":"Mol Autism"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nn.2275","article-title":"Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology","volume":"12","author":"N Ballas","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/ana.410340220","article-title":"Neuroanatomy of Rett syndrome: a volumetric imaging study","volume":"34","author":"AL Reiss","year":"1993","journal-title":"Ann Neurol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1212\/WNL.48.2.399","article-title":"Neuroanatomy in Rett syndrome: cerebral cortex and posterior fossa","volume":"48","author":"B Subramaniam","year":"1997","journal-title":"Neurology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0887-8994(90)90022-S","article-title":"Rett syndrome: cerebellar pathology","volume":"6","author":"A Oldfors","year":"1990","journal-title":"Pediatr Neurol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/ana.10633","article-title":"Olfactory biopsies demonstrate a defect in neuronal development in Rett&apos;s syndrome","volume":"54","author":"GV Ronnett","year":"2003","journal-title":"Ann Neurol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1177\/08830738050200082401","article-title":"Neuropathology of Rett syndrome","volume":"20","author":"DD Armstrong","year":"2005","journal-title":"J Child Neurol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/hmg\/ddh063","article-title":"Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders","volume":"13","author":"RC Samaco","year":"2004","journal-title":"Hum Mol Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.expneurol.2012.09.005","article-title":"Regional MeCP2 expression levels in the female MeCP2-deficient mouse brain correlate with specific behavioral impairments","volume":"239","author":"RG Wither","year":"2013","journal-title":"Exp Neurol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.neuron.2008.07.030","article-title":"Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress","volume":"59","author":"SL Fyffe","year":"2008","journal-title":"Neuron"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.biopsych.2005.07.025","article-title":"Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice","volume":"59","author":"T Gemelli","year":"2006","journal-title":"Biol Psychiatry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"RZ Chen","year":"2001","journal-title":"Nat Genet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nature09582","article-title":"Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes","volume":"468","author":"HT Chao","year":"2010","journal-title":"Nature"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1523\/JNEUROSCI.4225-08.2009","article-title":"MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome","volume":"29","author":"M Adachi","year":"2009","journal-title":"J Neurosci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"9941","DOI":"10.1523\/JNEUROSCI.2540-09.2009","article-title":"MeCP2 function in the basolateral amygdala in Rett syndrome","volume":"29","author":"SH Wu","year":"2009","journal-title":"J Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1523\/JNEUROSCI.6000-11.2012","article-title":"A mouse model for MeCP2 duplication syndrome: MeCP2 overexpression impairs learning and memory and synaptic transmission","volume":"32","author":"ES Na","year":"2012","journal-title":"J Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature10907","article-title":"Wild-type microglia arrest pathology in a mouse model of Rett syndrome","volume":"484","author":"NC Derecki","year":"2012","journal-title":"Nature"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1523\/JNEUROSCI.0324-09.2009","article-title":"Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions","volume":"29","author":"I Maezawa","year":"2009","journal-title":"J Neurosci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e35354","DOI":"10.1371\/journal.pone.0035354","article-title":"Alterations of gene expression and glutamate clearance in astrocytes derived from an MeCP2-null mouse model of Rett syndrome","volume":"7","author":"Y Okabe","year":"2012","journal-title":"PLoS One"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature10214","article-title":"A role for glia in the progression of Rett&apos;s syndrome","volume":"475","author":"DT Lioy","year":"2011","journal-title":"Nature"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/WNR.0b013e32833da500","article-title":"A novel transcriptional regulator of myelin gene expression: implications for neurodevelopmental disorders","volume":"21","author":"P Vora","year":"2010","journal-title":"Neuroreport"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1179\/016164111X13214359296301","article-title":"Downregulation of CNPase in a MeCP2 deficient mouse model of Rett syndrome","volume":"34","author":"W Wu","year":"2012","journal-title":"Neurol Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1182\/blood.V95.5.1608.005k32_1608_1615","article-title":"Spatial associations of centromeres in the nuclei of hematopoietic cells: evidence for cell-type-specific organizational patterns","volume":"95","author":"I Alcobia","year":"2000","journal-title":"Blood"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2121-6-44","article-title":"Common themes and cell type specific variations of higher order chromatin arrangements in the mouse","volume":"6","author":"R Mayer","year":"2005","journal-title":"BMC Cell Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.1523\/JNEUROSCI.2043-12.2012","article-title":"Insights into the cellular and molecular contributions of MeCP2 overexpression to disease pathophysiology","volume":"32","author":"MM Taylor","year":"2012","journal-title":"J Neurosci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1093\/hmg\/ddp181","article-title":"Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus","volume":"18","author":"S Ben-Shachar","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription","volume":"320","author":"M Chahrour","year":"2008","journal-title":"Science"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e8888","DOI":"10.1371\/journal.pone.0008888","article-title":"The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing","volume":"5","author":"Y Huang","year":"2010","journal-title":"PLoS One"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2144\/000113403","article-title":"Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA","volume":"48","author":"C Nestor","year":"2010","journal-title":"Biotechniques"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0092-8674(00)80243-3","article-title":"Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation","volume":"89","author":"M Marin","year":"1997","journal-title":"Cell"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-2199-9-39","article-title":"DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription","volume":"9","author":"T Furuta","year":"2008","journal-title":"BMC Mol Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1128\/MCB.23.12.4056-4065.2003","article-title":"Methylation of adjacent CpG sites affects Sp1\/Sp3 binding and activity in the p21(Cip1) promoter","volume":"23","author":"WG Zhu","year":"2003","journal-title":"Mol Cell Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ng570","article-title":"CTCF-binding sites flank CTG\/CAG repeats and form a methylation-sensitive insulator at the DM1 locus","volume":"28","author":"GN Filippova","year":"2001","journal-title":"Nat Genet"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nature10442","article-title":"CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing","volume":"479","author":"S Shukla","year":"2011","journal-title":"Nature"},{"key":"ref70","doi-asserted-by":"crossref","unstructured":"Barber BA, Liyanage VR, Zachariah RM, Olson CO, Bailey MA, <etal>et al<\/etal>.. (2013) Dynamic expression of MEIS1 homeoprotein in E14.5 forebrain and differentiated forebrain-derived neural stem cells. Ann Anat.","DOI":"10.1016\/j.aanat.2013.04.005"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"25926","DOI":"10.1074\/jbc.M602555200","article-title":"Interplay between chromatin and trans-acting factors regulating the Hoxd4 promoter during neural differentiation","volume":"281","author":"L Kobrossy","year":"2006","journal-title":"J Biol Chem"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ydbio.2006.08.061","article-title":"Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis","volume":"299","author":"C Nolte","year":"2006","journal-title":"Dev Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"8090","DOI":"10.1128\/MCB.24.18.8090-8103.2004","article-title":"Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments","volume":"24","author":"M Rastegar","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1210\/endo.141.5.7478","article-title":"CCAAT\/enhancer-binding protein-alpha is a component of the growth hormone-regulated network of liver transcription factors","volume":"141","author":"M Rastegar","year":"2000","journal-title":"Endocrinology"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"7006","DOI":"10.1038\/sj.onc.1204893","article-title":"beta(2)-microglobulin induces apoptosis in HL-60 human leukemia cell line and its multidrug resistant variants overexpressing MRP1 but lacking Bax or overexpressing P-glycoprotein","volume":"20","author":"CH Wu","year":"2001","journal-title":"Oncogene"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/ijc.10828","article-title":"Beta2-microglobulin induces caspase-dependent apoptosis in the CCRF-HSB-2 human leukemia cell line independently of the caspase-3, -8 and -9 pathways but through increased reactive oxygen species","volume":"103","author":"J Gordon","year":"2003","journal-title":"Int J Cancer"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0101030","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0090645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T23:33:23Z","timestamp":1597534403000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0090645"}},"subtitle":[],"editor":[{"given":"Nicoletta","family":"Landsberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,3]]},"references-count":76,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0090645","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0101030","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,3]]}}}