{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:11:09Z","timestamp":1789495869948,"version":"build-2803163510"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0090681","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T16:42:09Z","timestamp":1395333729000},"page":"e90681","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Therapeutic Interaction of Systemically-Administered Mesenchymal Stem Cells with Peri-Implant Mucosa"],"prefix":"10.1371","volume":"9","author":[{"given":"Ryosuke","family":"Kondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikiru","family":"Atsuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Ayukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Yamaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Furuhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Tsukiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Koyano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0142-9612(83)90065-0","article-title":"Osseointegrated titanium fixtures in the treatment of edentulousness","volume":"4","author":"PI Br\u00e5nemark","year":"1983","journal-title":"Biomaterials"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1902\/jop.1992.63.3.225","article-title":"Soft tissue reactions to non-submerged unloaded titanium implants in beagle dogs","volume":"63","author":"D Buser","year":"1992","journal-title":"J Periodontol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0022-3913(84)90459-1","article-title":"Ultrastructural study of the attachment of human gingiva to titanium in vivo","volume":"52","author":"TR Gould","year":"1984","journal-title":"J Prosthet Dent"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0301-0503(81)80007-0","article-title":"The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces","volume":"9","author":"A Schroeder","year":"1981","journal-title":"J Maxillofac Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10266-011-0029-y","article-title":"The difference of fibroblast behavior on titanium substrata with different surface characteristics","volume":"100","author":"A Furuhashi","year":"2012","journal-title":"Odontology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1902\/jop.2000.71.6.961","article-title":"Ultrastructural and immunoelectron microscopic studies of the peri-implant epithelium-implant (Ti-6Al-4V) interface of rat maxilla","volume":"71","author":"H Ikeda","year":"2000","journal-title":"J Periodontol"},{"key":"ref7","first-page":"83","article-title":"Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method","volume":"2","author":"AJ Friedenstein","year":"1974","journal-title":"Exp Hematol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","article-title":"Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo","volume":"97","author":"S Gronthos","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1182\/blood-2003-05-1670","article-title":"Isolation of multipotent mesenchymal stem cells from umbilical cord blood","volume":"103","author":"OK Lee","year":"2004","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/107632701300062859","article-title":"Multilineage cells from human adipose tissue: implications for cell-based therapies","volume":"7","author":"PA Zuk","year":"2001","journal-title":"Tissue Eng"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"M Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1742-2094-10-106","article-title":"Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury","volume":"10","author":"R Zhang","year":"2013","journal-title":"J Neuroinflammation"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0140-6736(08)60690-X","article-title":"Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study","volume":"371","author":"K Le Blanc","year":"2008","journal-title":"Lancet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1007\/s10350-005-0052-6","article-title":"A phase I clinical trial of the treatment of Crohn&apos;s fistula by adipose mesenchymal stem cell transplantation","volume":"48","author":"D Garc\u00eda-Olmo","year":"2004","journal-title":"Dis Colon Rectum"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.biomaterials.2004.05.033","article-title":"Changes in the distribution of laminin-5 during peri-implant epithelium formation after immediate titanium implantation in rats","volume":"26","author":"I Atsuta","year":"2005","journal-title":"Biomaterials"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1007\/s10620-005-2803-6","article-title":"Cellular and molecular mechanisms of gastrointestinal ulcer healing","volume":"50 Suppl 1","author":"AS Tarnawski","year":"2005","journal-title":"Dig Dis Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1600-0757.1998.tb00122.x","article-title":"The interface between the mucosa and the implant","volume":"17","author":"J Lindhe","year":"1998","journal-title":"Periodontology 2000"},{"key":"ref18","first-page":"459","article-title":"Evaluations of epithelial sealing and peri-implant epithelial down-growth around \u201cstep-type\u201d implants","volume":"223","author":"I Atsuta","year":"2012","journal-title":"Clin Implant Dent Relat Res"},{"key":"ref19","article-title":"Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis","author":"T Takano","year":"2014","journal-title":"Lab Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e2615","DOI":"10.1371\/journal.pone.0002615","article-title":"Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents","volume":"3","author":"T Yamaza","year":"2008","journal-title":"PloS one"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.freeradbiomed.2007.01.008","article-title":"Bcl-2 protects against hyperoxia-induced apoptosis through inhibition of the mitochondria-dependent pathway","volume":"42","author":"I M\u00e9trailler-Ruchonnet","year":"2007","journal-title":"Free Radic Biol Med"},{"issue":"32","key":"ref22","doi-asserted-by":"crossref","first-page":"6280","DOI":"10.1016\/j.biomaterials.2005.03.046","article-title":"Ultrastructural localization of laminin-5 (gamma2 chain) in the rat peri-implant oral mucosa around a titanium-dental implant by immuno-electron microscopy","volume":"26","author":"I Atsuta","year":"2005","journal-title":"Biomaterials"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1034\/j.1600-0501.2002.130303.x","article-title":"Difference in penetration of horseradish peroxidase tracer as a foreign substance into the peri-implant or junctional epithelium of rat gingivae","volume":"13","author":"H Ikeda","year":"2002","journal-title":"Clin Oral Implants Res"},{"key":"ref24","article-title":"In Vivo and In Vitro Studies of Epithelial Cell Behavior around Titanium Implants with Machined and Rough Surfaces","author":"I Atsuta","year":"2013","journal-title":"Clin Oral Implants Res"},{"key":"ref25","article-title":"Promotive effect of insulin-like growth factor-1 for epithelial sealing to titanium implants","author":"I Atsuta","year":"2013","journal-title":"J Biomed Mater Res A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1902\/jop.2002.73.8.852","article-title":"A study of the initial attachment and subsequent behavior of rat oral epithelial cells cultured on titanium","volume":"73","author":"M Shiraiwa","year":"2002","journal-title":"J Periodontol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s13758-012-0027-9","article-title":"Effect of titanium surface calcium and magnesium on adhesive activity of epithelial-like cells and fibroblasts","volume":"7","author":"H Okawachi","year":"2012","journal-title":"Biointerphases"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jpor.2012.06.001","article-title":"Stem cells in dentistry\u2013part I: stem cell sources","volume":"56","author":"H Egusa","year":"2012","journal-title":"J Prosthodont Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.joen.2007.11.021","article-title":"Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study","volume":"34","author":"W Sonoyama","year":"2008","journal-title":"J Endod"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.stem.2008.03.003","article-title":"Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2","volume":"2","author":"F Belema-Bedada","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1034\/j.1600-0501.1997.080502.x","article-title":"Immunohistochemistry of soft tissues surrounding late failures of Branemark implants","volume":"8","author":"M Esposito","year":"1997","journal-title":"Clin Oral Implants Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2009.05.003","article-title":"Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6","volume":"5","author":"RH Lee","year":"2009","journal-title":"Cell Stem Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-1-61779-860-3_11","article-title":"Lineage differentiation of mesenchymal stem cells from dental pulp, apical papilla, and periodontal ligament","volume":"887","author":"K Akiyama","year":"2012","journal-title":"Methods Mol Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/scrt322","article-title":"Mesenchymal stem cells inhibit multiple myeloma cells via the Fas\/Fas ligand pathway","volume":"4","author":"I Atsuta","year":"2013","journal-title":"Stem Cell Res Ther"},{"key":"ref35","first-page":"536","article-title":"Healing and regeneration following periodontal treatment","volume":"41","author":"HE Schroeder","year":"1986","journal-title":"Dtsch Zahnarztl Z"},{"key":"ref36","article-title":"IFN-gamma and TNF-alpha Synergistically Induce Mesenchymal Stem Cell Impairment and Tumorigenesis via NFkappaB Signaling","author":"L Wang","year":"2013","journal-title":"Stem cells"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/jmicro\/52.6.627","article-title":"Biological characteristics of the junctional epithelium","volume":"52","author":"M Shimono","year":"2003","journal-title":"J Electron Microsc (Tokyo)"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-0765.1997.tb00536.x","article-title":"Coating of titanium alloy with soluble laminin-5 promotes cell attachment and hemidesmosome assembly in gingival epithelial cells: potential application to dental implants","volume":"32","author":"RN Tamura","year":"1997","journal-title":"J Periodontal Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1167\/iovs.07-1085","article-title":"In vivo confocal microscopic evaluation of corneal wound healing after epi-LASIK","volume":"4","author":"WL Chen","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0090681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T04:42:47Z","timestamp":1540269767000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0090681"}},"subtitle":[],"editor":[{"given":"Zoran","family":"Ivanovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,20]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0090681","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,20]]}}}