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Cochrane Database Syst Rev Art <volume>7<\/volume>.."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1056\/NEJMoa0801369","article-title":"Treatment of hypertension in patients 80 years of age and older","volume":"358","author":"NS Beckett","year":"2008","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"d7541","DOI":"10.1136\/bmj.d7541","article-title":"Immediate and late benefits of treating very elderly people with hypertension: results from active treatment extension to Hypertension in the Very Elderly randomised controlled trial","volume":"344","author":"N Beckett","year":"2011","journal-title":"BMJ"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1097\/HJH.0b013e328339f9c5","article-title":"Treatment of hypertension in patients 80 years and older: the lower the better? A meta-analysis of randomized controlled trials","volume":"28","author":"T Bejan-Angoulvanta","year":"2010","journal-title":"J Hypertension"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1001\/archinternmed.2007.56","article-title":"Variations Between Clinical Trial Participants and Medicare Beneficiaries in Evidence Used for Medicare National Coverage Decisions","volume":"168","author":"SS Dhruva","year":"2008","journal-title":"Arch Intern Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1161\/CIRCULATIONAHA.112.096156","article-title":"Trends in antihypertensive medication use and blood pressure control among United States adults with hypertension: The National Health and Nutrition Examination Survey, 2001 to 2010","volume":"126","author":"Q Gu","year":"2012","journal-title":"Circulation"},{"key":"ref12","unstructured":"Medicare Current Beneficiary Survey (MCBS). Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cms.gov\/Research-Statistics-Data-and-Systems\/Research\/MCBS\/index.html\" xlink:type=\"simple\">http:\/\/www.cms.gov\/Research-Statistics-Data-and-Systems\/Research\/MCBS\/index.html<\/ext-link>. Accessed 15 June 2013."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00005650-199801000-00004","article-title":"Comorbidity measures for use with administrative data","volume":"36","author":"A Elixhauser","year":"1998","journal-title":"Med Care"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","article-title":"The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure","volume":"289","author":"AV Chobanian","year":"2003","journal-title":"JAMA"},{"key":"ref15","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology (2013). Guidelines for ATC classification and DDD assignment. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.whocc.no\/filearchive\/publications\/1_2013guidelines.pdf\" xlink:type=\"simple\">http:\/\/www.whocc.no\/filearchive\/publications\/1_2013guidelines.pdf<\/ext-link>. Accessed 15 June 2013."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/pds.2312","article-title":"A systematic review of validated methods for identifying cerebrovascular accident or transient ischemic attack using administrative data","volume":"21","author":"SE Andrade","year":"2012","journal-title":"Pharmacoepidemiol and Drug Safety"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1002\/(SICI)1097-0258(19981015)17:19<2265::AID-SIM918>3.0.CO;2-B","article-title":"Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group","volume":"17","author":"RB D'Agostino Jr","year":"1998","journal-title":"Stat Med"},{"key":"ref18","unstructured":"(2010) Analysis of observational health care data using SAS. Faries DE, Leon AC, Maria Haro J, Obenchain RL, editors. Cary NC USA: SAS Institute Inc."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/sim.2458","article-title":"A mixed-effect propensity adjustment for effectiveness analyses of ordered categorical doses","volume":"26","author":"AC Leon","year":"2007","journal-title":"Stat Med"},{"key":"ref20","unstructured":"Allison PD (1999) Logistic regression using the SAS System: Theory and Application. Cary, NC: SAS Institute Inc."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/sim.3150","article-title":"A critical appraisal of propensity score matching in the medical literature from 1996 to 2003","volume":"27","author":"PC Austin","year":"2008","journal-title":"Stat Med"},{"key":"ref22","unstructured":"(1999) Applied survival analysis. Regression modeling of time to event data. Hosmer DWJ, Lemeshow S, editors. New York: John Wiley &amp; Sons, Inc."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"JP Fine","year":"1999","journal-title":"J Am Statist Assoc"},{"key":"ref24","unstructured":"Kohl M, Heinze G (2012) PSHREG: A SAS macro for proportional and nonproportional subdistribution hazards regression with competing risk data. Technical report 08\/2012 Medical University of Vienna VIENNA, Austria."},{"key":"ref25","volume":"1","unstructured":"Xu R, O&apos;Quigley J (2000) Estimating average regression effect under non-proportional hazards. Biostatistics <volume>1<\/volume>: : 443923\u2013."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/biostatistics\/kxr032","article-title":"Competing risks regression for clustered data","volume":"13","author":"B Zhou","year":"2012","journal-title":"Biostatistics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1161\/01.HYP.34.6.1181","article-title":"J-shaped relation between blood pressure and stroke in treated hypertensives","volume":"34","author":"Z Voko","year":"1999","journal-title":"Hypertension"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1447-0594.2011.00690.x","article-title":"Practitioner&apos;s trial on the efficacy of antihypertensive treatment in elderly patients with hypertension II (PATE-hypertension II study) in Japan","volume":"11","author":"T Ogihara","year":"2011","journal-title":"Geriatrics & Gerontology International"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.amjmed.2010.02.014","article-title":"Blood pressure and outcomes in very old hypertensive coronary artery disease patients: an INVEST substudy","volume":"123","author":"SJ Denardo","year":"2010","journal-title":"Am J Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"884","DOI":"10.7326\/0003-4819-144-12-200606200-00005","article-title":"Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous?","volume":"144","author":"FH Messerli","year":"2006","journal-title":"Ann Intern Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1291\/hypres.31.2115","article-title":"Principal results of the Japanese trial to assess optimal systolic blood pressure in elderly hypertensive patients (JATOS)","volume":"31","year":"2008","journal-title":"Hypertens Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0140-6736(98)08127-6","article-title":"Antihypertensive drugs in very old people: a subgroup meta-analysis of randomized controlled trials","volume":"353","author":"F Gueyffier","year":"1999","journal-title":"Lancet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1111\/j.1532-5415.2008.01948.x","article-title":"Lower systolic blood pressure is associated with greater mortality in people aged 85 and older","volume":"56","author":"L Molander","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1532-5415.2006.00742.x","article-title":"Association between blood pressure and survival over 9 years in a general population aged 85 and older","volume":"54","author":"S Rastas","year":"2006","journal-title":"J Am Geriatr Soc"},{"key":"ref35","unstructured":"Systolic Blood Pressure Intervention Trial. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01206062?term=SPRINT\" xlink:type=\"simple\">http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01206062?term=SPRINT<\/ext-link>. Accessed 5 August 2013."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1751-7176.2010.00362.x","article-title":"Prevalence of high-risk cardiovascular conditions and the status of hypertension management among hypertensive adults 65 years and older in the United States: analysis of a primary care electronic medical records database","volume":"12","author":"JE Biskupiak","year":"2010","journal-title":"J Clin Hypertension"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/aje\/kwr301","article-title":"Bias in observational studies of prevalent users: lessons for comparative effectiveness research from a meta-analysis of statins","volume":"175","author":"G Danaei","year":"2012","journal-title":"Am J Epidemiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/pds.3334","article-title":"The incident user design in comparative effectiveness research","volume":"22","author":"ES Johnson","year":"2012","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1001\/archinternmed.2009.357","article-title":"Meta-analysis of the impact of 9 medication classes on falls in elderly persons","volume":"169","author":"JC Woolcott","year":"2009","journal-title":"Arch Intern Med"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Tinetti ME, Han L, McAvay GJ, Lee DSH, Peduzzi P, <etal>et al<\/etal>.. (2014) Anti-hypertensive medications and serious fall injuries in a nationally representative sample of older adults. JAMA Internal Medicine (in press).","DOI":"10.1001\/jamainternmed.2013.14764"},{"key":"ref41","unstructured":"National Institute for Health and Clinical Excellence. Hypertension. The clinical management of primary hypertension in adults. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.nice.org.uk\/nicemedia\/live\/13561\/56007\/56007.pdf\" xlink:type=\"simple\">http:\/\/www.nice.org.uk\/nicemedia\/live\/13561\/56007\/56007.pdf<\/ext-link>. Accessed 28 June 2013."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0090733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:42:25Z","timestamp":1589010145000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0090733"}},"subtitle":[],"editor":[{"given":"Angelo","family":"Scuteri","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,10]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0090733","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,10]]}}}