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Norman: University of Oklahoma Press."},{"key":"ref7","unstructured":"Breasted JH (1930) The Edwin Smith Surgical Papyrus: Hieroglyphic transliterations, translations and commentary. Chicago: University of Chicago Press."},{"key":"ref8","unstructured":"Sanchez GM, Meltzer ES (2012) The Edwin Smith Papyrus: Updated Translation of the Trauma Treatise and Modern Medical Commentaries: Updated Translation of the Trauma Treatise and Modern Medical Commentaries. Atlanta: Lockwood Press."},{"key":"ref9","unstructured":"Mukherjee S (2010) The Emperor of All Maladies: A Biography of Cancer: Scribner."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1098\/rspb.2012.1326","article-title":"Evolutionary medicine: its scope, interest and potential","volume":"279","author":"SC Stearns","year":"2012","journal-title":"Proceedings of the Royal Society of Biological Science"},{"key":"ref11","unstructured":"Nesse RM, Williams GC (1994) Why we get sick. The new science of Darwinian medicine. New York: Vintage Books."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Manderson L (2011) Anthropologies of cancer and risk uncertainty and disruption. In: Singer M, Erickson PI, editors. A companion to medical anthropology 1st Edition. Chichester, West Sussex: Blackwell Publishing Limited. pp. 323\u2013338.","DOI":"10.1002\/9781444395303.ch16"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Brown PJ, Armelagos GJ, Maes KC (2011) Humans in a world of microbes: the anthropology of infectious diseases. In: Singer M, Erickson PI, editors. A companion to medical anthropology 1st Edition. 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Philadelphia, New York: Lippincott-Raven."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.anthro.27.1.247","article-title":"Emerging and Re-emerging Infectious Diseases: The Third Epidemiologic Transition","volume":"27","author":"R Barrett","year":"1998","journal-title":"Annual Reviews in Anthropology"},{"key":"ref19","unstructured":"Ortner DJ (2003) Identification of Pathological Conditions in Human Skeletal Remains. London: Academic Press. 645 p."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molonc.2012.10.010","article-title":"Meeting the global demands of epidemiologic transition \u2013 The indispensable role of cancer prevention","volume":"7","author":"S Franceschi","year":"2013","journal-title":"Molecular Oncology"},{"key":"ref21","unstructured":"Cox M (2000) Ageing Adults from the Skeleton. In: Cox M, Mays S, editors. Human Osteology: In Archaeology and Forensic Science. London: Greenwich Medical Media. pp. 61\u201381."},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Chamberlain A (2006) Demography in Archaeology. Cambridge: Cambridge University Press. 235 p.","DOI":"10.1017\/CBO9780511607165"},{"key":"ref23","unstructured":"Gabler K (2009) Die Medja - dein Lieferant und Helfer. Untersuchungen zu medja von Deir el-Medine anhand von Ostraka und Papyri [in German, unpublished master thesis]. M\u00fcnchen: Ludwig-Maximilians-Universit\u00e4t"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Parkin TG (2003) Old Age in the Roman World: A Cultural and Social History. Baltimore: John Hopkins University Press.","DOI":"10.56021\/9780801871283"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/ijc.20610","article-title":"Antiquity of Cancer","volume":"113","author":"LL Capasso","year":"2005","journal-title":"International Journal of Cancer"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1093\/jnci\/66.6.1192","article-title":"The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today","volume":"66","author":"R Doll","year":"1981","journal-title":"Journal of the National Cancer Institute"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Brothwell DR (2012) Tumors: Problems of Differential Diagnosis in Paleopathology. In: Grauer AL, editor. A Companion to Paleopathology. Oxford: Wiley-Blackwell. pp. 420\u2013433.","DOI":"10.1002\/9781444345940.ch23"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/oa.874","article-title":"Metastatic Carcinoma: Palaeopathology and Differential Diagnosis","volume":"17","author":"MK Marks","year":"2007","journal-title":"International Journal of Osteoarchaeology"},{"key":"ref29","first-page":"197","article-title":"Malignant tumors in two ancient populations: An approach to historical tumor epidemiology","volume":"16","author":"AG Nerlich","year":"2006","journal-title":"Oncology Reports"},{"key":"ref30","first-page":"78","article-title":"Neolithic case of a multiple myeloma from Mauer (Vienna, Austria)","volume":"28","author":"E Strouhal","year":"1990","journal-title":"Anthropologie"},{"key":"ref31","unstructured":"Gladykowska-Rzeczycka J (1991) Tumors in antiquity in East and Middle Europe. In: Ortner DJ, Aufderheide AC, editors. Human Paleopathology - Current Syntheses and Future Options. Washington, London: Smithsonian Institution Press. pp. 251\u2013256."},{"key":"ref32","unstructured":"Rokhlin D (1966) Disease in ancient man. Moskov: Nauka Ed."},{"key":"ref33","unstructured":"Strouhal E (2001) Malignant tumours in past populations in Middle Europe In: La Verghetta M, Capasso L, editors. Proceesings of the XIIIth European Meeting of the Paleopathology Association. Teramo: Edigrafical. pp. 265\u2013272."},{"key":"ref34","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/ajpa.1330450328","article-title":"Tumors in the remains of Ancient Egyptians","volume":"45","author":"E Strouhal","year":"1976","journal-title":"American Journal of Physical Anthropology"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Baker BJ, Judd M (2012) Development of Paleopathology in the Nile Valley. In: Buikstra J, Roberts C, editors. 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Cambrigde, New York: Cambridge University Press. 578 p."},{"key":"ref44","unstructured":"Ho JHC (1972) Nasopharyngeal Carcinoma. In: Klein G, Weinhouse S, editors. Advances in Cancer Research. London: Academic Press, Inc. pp. 57\u201392."},{"key":"ref45","unstructured":"Aufderheide AC (2003) The Scientific Study of Mummies. Cambridge: Cambridge University Press."},{"key":"ref46","first-page":"33","article-title":"Cancer in Egypt and Nubia","volume":"48","author":"E Esche","year":"2010","journal-title":"Anthropologie"},{"key":"ref47","unstructured":"Dupras T, de Voogt A, Francigny V, Williams L, Lacey J (2014) Advanced Metastatic Carcinoma in the Paleopathological Record: A Case Study from the Sudan. 41th Annual Meeting of the Paleopathology Association. Calgary, Alberta, Canada."},{"key":"ref48","unstructured":"Spencer P (1997) Amara West I. The architectural report. London: The Egypt Exploration Society."},{"key":"ref49","first-page":"21","article-title":"Insights into Life in occupied Kush during the New Kingdom: New Research at Amara West","volume":"23","author":"N Spencer","year":"2012","journal-title":"Der Antike Sudan"},{"key":"ref50","unstructured":"Spencer N (forthcoming) Amara West: considerations on urban life in occupied Kush. In: Welsby D, Anderson JR, editors. Proceedings of the 12th International Conference for Nubian Studies. Leuven: OLA."},{"key":"ref51","first-page":"39","article-title":"The 10th-9th century BC - New Evidence from Cemetery C of Amara West","volume":"15","author":"M Binder","year":"2011","journal-title":"Sudan & Nubia"},{"key":"ref52","unstructured":"Binder M, Spencer N, Millet M (2011) Cemetery D at Amara West: the Ramesside Period and its aftermath. British Museum Studies in Ancient Egypt and Sudan."},{"key":"ref53","first-page":"37","article-title":"Reassessing the abandonment of Amara West: the impact of a changing Nile?","volume":"16","author":"N Spencer","year":"2012","journal-title":"Sudan & Nubia"},{"key":"ref54","first-page":"97","article-title":"Archaeobotanical research in a pharaonic town in ancient Nubia","volume":"6","author":"P Ryan","year":"2012","journal-title":"The British Museum Technical Research Bulletin"},{"key":"ref55","unstructured":"Binder M, Spencer N (In Press) The bioarchaeology of Amara West in Nubia: Investigating the impacts of political, cultural and environmental change on health and diet. In: Fletcher A, Antoine D, Hill JD, editors. Regarding the Dead. London: British Museum Press."},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Van Pelt WP (forthcoming) Revising Egypto-Nubian Relationss in New Kingdom Lower Nubia: From Egyptianization to Cultural Entanglement. Cambridge Archaeological Journal 23.","DOI":"10.1017\/S0959774313000528"},{"key":"ref57","unstructured":"Smith ST (2003) Wretched Kush. London, New York: Routledge."},{"key":"ref58","unstructured":"Buikstra JE, Ubelaker DH (1994) Standards for Data Collection from Human Remains. Lafayetteville, Arkansas: Arkansas Archaeological Survey. 206 p."},{"key":"ref59","unstructured":"Brickley M, McKinley JI, editors (2004) Guidelines to the Standards for Recording Human Remains. Reading: Institute of Field Archaeologists Paper Number 7."},{"key":"ref60","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/ajpa.10012","article-title":"A method for visual determination of sex, using the human hip bone","volume":"117","author":"J Bruzek","year":"2002","journal-title":"American Journal of Physical Anthropology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02437238","article-title":"Skeletal age determination based on the os pubis: a comparison of the Acs\u00e1di-Nemesk\u00e9ri and Suchey-Brooks methods","volume":"5","author":"S Brooks","year":"1990","journal-title":"Human Evolution"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Scheuer L, Black S (2000) Developmental juvenile osteology. San Diego: Academic Press.","DOI":"10.1016\/B978-012624000-9\/50004-6"},{"key":"ref63","unstructured":"Resnick D (1995) Diagnosis of Bone and Joint Disorders. St. Louis, MO: W. B. Saunders."},{"key":"ref64","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/(SICI)1096-8644(199802)105:2<241::AID-AJPA10>3.0.CO;2-0","article-title":"Clues Potentially Distinguishing Lytic Lesions of Multiple Myeloma From Those of Metastatic Carcinoma","volume":"105","author":"BM Rothschild","year":"1998","journal-title":"American Journal of Physical Anthropology"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2141.2010.08141.x","article-title":"Advances in the understanding of myeloma bone disease and tumour growth","volume":"149","author":"S Yaccoby","year":"2010","journal-title":"British Journal of Haematology"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1634\/theoncologist.2009-0003","article-title":"Myeloma Bone Disease: Recent Advances in Biology, Diagnosis, and Treatment","volume":"14","author":"O Sezer","year":"2009","journal-title":"The Oncologist"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/(SICI)1096-8644(199805)106:1<47::AID-AJPA4>3.0.CO;2-A","article-title":"Clues to recognition of fungal origin of lytic skeletal lesions","volume":"106","author":"I Hershkovitz","year":"1998","journal-title":"American Journal of Physical Anthropology"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/oa.1110","article-title":"Taphonomic Evidence of a Human Skeleton Gnawed by Termites in a Moche-Civilisation Grave at Huaca de la Luna, Peru","volume":"21","author":"JB Huchet","year":"2011","journal-title":"International Journal of Osteoarchaeology"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1016\/j.jas.2013.04.025","article-title":"Identification of dermestid pupal chambers on Southern Levant human bones: inference for reconstruction of Middle Bronze Age mortuary practices","volume":"40","author":"JB Huchet","year":"2013","journal-title":"Journal of Archaeological Science"},{"key":"ref70","doi-asserted-by":"crossref","unstructured":"Layer D (2005) Skelettmetastasen. In: Freyschmidt J, St\u00e4bler A, editors. Handbuch diagnostische Radiologie - Muskoloskelettales System 2: Springer. pp. 327\u2013338.","DOI":"10.1007\/3-540-26388-8_11"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1200\/JCO.2009.23.8162","article-title":"Male Breast Cancer: A Population-Based Comparison With Female Breast Cancer","volume":"28","author":"WF Anderson","year":"2010","journal-title":"Journal of Clinical Oncology"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/ajpa.1330960404","article-title":"Comparison of Radiologic and Gross Examination for Detection of Cancer in Defleshed Skeletons","volume":"97","author":"BM Rothschild","year":"1995","journal-title":"American Journal of Physical Anthropology"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/j.1749-6632.1963.tb13433.x","article-title":"Environmental Carcinogenesis in Man and Animals","volume":"108","author":"WC Hueper","year":"1963","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1378\/chest.128.1.124","article-title":"Lung cancer pathogenesis associated with wood smoke exposure","volume":"128","author":"J Delgado","year":"2005","journal-title":"Chest"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.scitotenv.2010.09.010","article-title":"Cancer in the Sudan: An overview of the current status of knowledge on tumor patterns and risk factors","volume":"423","author":"KD Awadelkarim","year":"2012","journal-title":"Science of the Total Environment"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0048-9697(02)00279-6","article-title":"Bitumen fumes: review of work on the potential risk to workers and the present knowledge on its origin","volume":"300","author":"S Binet","year":"2002","journal-title":"Science of the Total Environment"},{"key":"ref77","unstructured":"Serpico M, White R (2000) Resins, amber and bitumen. In: Nicholson PT, Shaw I, editors. Ancient Egyptian Materials and Technology. Cambridge: Cambridge University Press."},{"key":"ref78","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1590\/S0074-02762003000900015","article-title":"The State of the Art of Paleoparasitological Research in the Old World","volume":"98","author":"F Bouchet","year":"2003","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/bmj.304.6826.555","article-title":"Palaeoepidemiology of schistosoma infection in mummies","volume":"304","author":"RL Miller","year":"1992","journal-title":"British Medical Journal"},{"key":"ref80","first-page":"470","article-title":"Autopsy of an Egyptian mummy. 5. Histopathologic investigation","volume":"117","author":"TA Reyman","year":"1977","journal-title":"Canadian Medical Association Journal"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S1470-2045(08)70198-0","article-title":"Part II: Cancer in Indigenous Africans - causes and control","volume":"9","author":"F Sitas","year":"2008","journal-title":"Lancet Oncology"},{"key":"ref82","first-page":"1361","article-title":"Breast cancer in men","volume":"17","author":"AU Buzdar","year":"2003","journal-title":"Oncology (Williston Park)"},{"key":"ref83","unstructured":"Mustacchi P (2003) Schistosomiasis. In: Kufe DW, Pollock RE, Wechselbaum RR, editors. Holland-Frei, Cancer Medicine 6th edition. Hamilton (ON): BC Decker."},{"key":"ref84","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/ajpa.21493","article-title":"Irrigation and infection: The immunoepidemiology of schistosomiasis in ancient Nubia","volume":"145","author":"CA Hibbs","year":"2011","journal-title":"American Journal of Physical Anthropology"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nature05562","article-title":"An African origin for the intimate association between humans and Helicobacter pylori","volume":"445","author":"B Linz","year":"2007","journal-title":"Nature"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nrc2857","article-title":"Helicobacter pylori: gastric cancer and beyond","volume":"10","author":"DB Polk","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1086\/204084","article-title":"The Osteological Paradox - Problems of Inferring Prehistoric Health from Skeletal Samples","volume":"33","author":"JW Wood","year":"1992","journal-title":"Current Anthropology"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-540-37696-5_2","article-title":"Genetic risk profiles for cancer susceptibility and therapy response","volume":"174","author":"H Bartsch","year":"2007","journal-title":"Recent Results in Cancer Research"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nrg1450","article-title":"Genetic predisposition to cancer - insights from population genetics","volume":"5","author":"SA Frank","year":"2004","journal-title":"Nature Reviews: Genetics"},{"key":"ref90","doi-asserted-by":"crossref","unstructured":"Zuckerman MK, Turner BL, Armelagos GJ (2012) Evolutionary thought in paleopathology and the rise of the biocultural approach. In: Grauer A, editor. A companion to paleopathology. Oxford: Wiley Blackwell.","DOI":"10.1002\/9781444345940.ch3"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/(SICI)1099-1212(199909\/10)9:5<302::AID-OA487>3.0.CO;2-V","article-title":"K-ras mutation in the tumour of King Ferrante I of Aragon (1431\u20131494) and environmental mutagens at the Aragonese court of Naples","volume":"9","author":"G Fornaciari","year":"1999","journal-title":"International Journal of Osteoarchaeology"},{"key":"ref92","first-page":"4117","article-title":"Detection and analysis of cancer genes amplified from bone material of a Scythian royal burial in Arzhan near Tuva, Siberia","volume":"27","author":"T Schlott","year":"2007","journal-title":"Anticancer Research"},{"key":"ref93","unstructured":"Strouhal E (1994) Malignant Tumors in the Old World. Paleopathology Newsletter 85 (supplement): 1\u20136."},{"key":"ref94","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/oa.1390010314","article-title":"Myeloma Multiplex versus Osteolytic Metastatic Carcinoma: Differential Diagnosis in Dry Bones","volume":"1","author":"E Strouhal","year":"1991","journal-title":"International Journal of Osteoarchaeology"},{"key":"ref95","first-page":"290","article-title":"Ancient Egyptian case of carcinoma","volume":"54","author":"E Strouhal","year":"1978","journal-title":"Bulletin of the New York Academy of Medicine"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1002\/ijc.23073","article-title":"Oldest known case of metastasizing prostate carcinoma diagnosed in the skeleton of a 2,700-year-old Scythian King from Arzhan (Siberia, Russia)","volume":"121","author":"M Schultz","year":"2007","journal-title":"International Journal of Cancer"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0090924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T07:02:09Z","timestamp":1689058929000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0090924"}},"subtitle":[],"editor":[{"given":"Michael D.","family":"Petraglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,17]]},"references-count":96,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0090924","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,17]]}}}