{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:08:24Z","timestamp":1760267304631},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0091505","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T20:40:03Z","timestamp":1394570403000},"page":"e91505","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Spectrum of Chronic CD8+ T-Cell Expansions: Clinical Features in 14 Patients"],"prefix":"10.1371","volume":"9","author":[{"given":"Etienne","family":"Ghrenassia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Roulin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aude","family":"Aline-Fardin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Marzac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"F\u00e9ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Gay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9rome","family":"Pacanowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Hertig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Coppo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,3,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.7326\/0003-4819-112-1-3","article-title":"A diffuse infiltrative CD8 lymphocytosis syndrome in human immunodeficiency virus (HIV) infection: a host immune response associated with HLA-DR5","volume":"112","author":"S Itescu","year":"1990","journal-title":"Ann Intern Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0140-6736(89)92085-0","article-title":"A sicca syndrome in HIV infection: association with HLA-DR5 and CD8 lymphocytosis","volume":"2","author":"S Itescu","year":"1989","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/jcp.53.3.177","article-title":"Benign monoclonal expansion of CD8+ lymphocytes in HIV infection","volume":"53","author":"PR Smith","year":"2000","journal-title":"J Clin Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1038\/sj.leu.2402645","article-title":"Features of large granular lymphocytes (LGL) expansion following allogeneic stem cell transplantation: a long-term analysis","volume":"16","author":"M Mohty","year":"2002","journal-title":"Leukemia"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1365-2141.2012.09057.x","article-title":"Expansion of CD8+\/perforin+ T-cells predicts response to ciclosporin A therapy in patients with erythroid hypoplasia\/aplasia","volume":"157","author":"H Nitta","year":"2012","journal-title":"Br J Haematol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/ard.62.5.476","article-title":"Primary Sjogren\u2019s syndrome associated agranulocytosis: a benign disorder?","volume":"62","author":"P Coppo","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/ar1803","article-title":"Primary and secondary autoimmune neutropenia","volume":"7","author":"F Capsoni","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.autrev.2009.03.006","article-title":"Autoimmune neutropenia in adults","volume":"9","author":"M Akhtari","year":"2009","journal-title":"Autoimmun Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1189\/jlb.0809566","article-title":"CD57+ T lymphocytes and functional immune deficiency","volume":"87","author":"D Focosi","year":"2010","journal-title":"J Leukoc Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1182\/blood-2002-07-2103","article-title":"Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells","volume":"101","author":"JM Brenchley","year":"2003","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.4049\/jimmunol.155.10.5046","article-title":"CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus","volume":"155","author":"EC Wang","year":"1995","journal-title":"J Immunol"},{"key":"ref12","first-page":"79","article-title":"Phenotypic properties and cytotoxic functions of human CD8+ cells expressing the CD57 antigen","volume":"12","author":"N Yamashita","year":"1993","journal-title":"Nat Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0198-8859(96)00077-8","article-title":"Oligoclonality of CD8+ T cells in health and disease: aging, infection, or immune regulation?","volume":"48","author":"F Batliwalla","year":"1996","journal-title":"Hum Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1172\/JCI116593","article-title":"Characterization of the primary structure of T cell receptor beta chains in cells infiltrating the salivary gland in the sicca syndrome of HIV-1 infection. Evidence of antigen-driven clonal selection suggested by restricted combinations of V beta J beta gene segment usage and shared somatically encoded amino acid residues","volume":"92","author":"E Dwyer","year":"1993","journal-title":"J Clin Invest"},{"key":"ref15","first-page":"382","article-title":"Role of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence","volume":"2","author":"JN Dock","year":"2011","journal-title":"Aging Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e64702","DOI":"10.1371\/journal.pone.0064702","article-title":"Accelerated aging in HIV\/AIDS: novel biomarkers of senescent human CD8+ T cells","volume":"8","author":"JP Chou","year":"2013","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/eji.1830240707","article-title":"CD57+ T lymphocytes are derived from CD57\u2212 precursors by differentiation occurring in late immune responses","volume":"24","author":"AD d\u2019Angeac","year":"1994","journal-title":"Eur J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2249.1994.tb07020.x","article-title":"CD8 lymphocytosis in primary cytomegalovirus (CMV) infection of allograft recipients: expansion of an uncommon CD8+ CD57\u2212 subset and its progressive replacement by CD8+ CD57+ T cells","volume":"95","author":"M Labalette","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.smim.2009.02.004","article-title":"Stem cell-like plasticity of naive and distinct memory CD8+ T cell subsets","volume":"21","author":"C Stemberger","year":"2009","journal-title":"Semin Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2567.2011.03470.x","article-title":"CD8+ CD28\u2212 and CD8+ CD57+ T cells and their role in health and disease","volume":"134","author":"M Strioga","year":"2011","journal-title":"Immunology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1172\/JCI116448","article-title":"Tissue infiltration in a CD8 lymphocytosis syndrome associated with human immunodeficiency virus-1 infection has the phenotypic appearance of an antigenically driven response","volume":"91","author":"S Itescu","year":"1993","journal-title":"J Clin Invest"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/infdis\/jiq071","article-title":"T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women","volume":"203","author":"RC Kaplan","year":"2011","journal-title":"J Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/sj.ki.5002207","article-title":"Nephropathy associated with the diffuse infiltrative lymphocytosis syndrome","volume":"72","author":"L Zafrani","year":"2007","journal-title":"Kidney Int"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ejim.2004.08.009","article-title":"Antineutrophil cytoplasmic antibody-associated neutropenia","volume":"15","author":"P Coppo","year":"2004","journal-title":"Eur J Intern Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98\u20133936","volume":"17","author":"JJ van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1056\/NEJMoa1114885","article-title":"Somatic STAT3 mutations in large granular lymphocytic leukemia","volume":"366","author":"HL Koskela","year":"2012","journal-title":"N Engl J Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000330515","article-title":"Severe acquired neutropenia associated with anti-proteinase 3 antibodies","volume":"126","author":"M Loschi","year":"2011","journal-title":"Acta Haematol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1182\/blood-2010-07-296962","article-title":"How I treat LGL leukemia","volume":"117","author":"T Lamy","year":"2011","journal-title":"Blood"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/art.21980","article-title":"Changing spectrum of the diffuse infiltrative lymphocytosis syndrome","volume":"55","author":"D Basu","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0140-6736(92)90471-E","article-title":"CD8 lymphocytosis and pseudotumoral splenomegaly in HIV infection","volume":"340","author":"E Oksenhendler","year":"1992","journal-title":"Lancet"},{"key":"ref31","first-page":"49","article-title":"Cyclic neutropenia and severe hypogammaglobulinemia in a patient with excess of CD8-positive T lymphocytes: response to G-CSF therapy","volume":"78","author":"D Ferrero","year":"1993","journal-title":"Haematologica"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/(SICI)1096-8652(199803)57:3<241::AID-AJH12>3.0.CO;2-D","article-title":"Severe neutropenia associated with IgG2 subclass deficiency and bone marrow T-lymphocyte infiltration","volume":"57","author":"K Lassoued","year":"1998","journal-title":"Am J Hematol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1183\/09031936.00080209","article-title":"Rituximab-induced lung disease: A systematic literature review","volume":"35","author":"H Liote","year":"2010","journal-title":"Eur Respir J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000338259","article-title":"Rituximab-induced interstitial pneumonia due to CD8-positive T cell infiltration","volume":"128","author":"K Sato","year":"2012","journal-title":"Acta Haematol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/ni804","article-title":"Programmed contraction of CD8(+) T cells after infection","volume":"3","author":"VP Badovinac","year":"2002","journal-title":"Nat Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1126\/science.290.5495.1354","article-title":"Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma","volume":"290","author":"VP Badovinac","year":"2000","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1182\/blood.V69.4.1204.1204","article-title":"The syndrome of T8 hyperlymphocytosis: variation in phenotype and cytotoxic activities of granular cells and evaluation of their role in associated neutropenia","volume":"69","author":"C Grillot-Courvalin","year":"1987","journal-title":"Blood"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.5858\/132.11.1774","article-title":"Immunophenotypic attributes of benign peripheral blood gammadelta T cells and conditions associated with their increase","volume":"132","author":"AC Roden","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1136\/jcp.2004.020875","article-title":"Idiopathic pure red cell aplasia: first report on CD8 positive lymphocytosis in bone marrow biopsy sections","volume":"58","author":"KM Ramadan","year":"2005","journal-title":"J Clin Pathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1182\/blood-2012-12-474577","article-title":"Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia","volume":"121","author":"HL Rajala","year":"2013","journal-title":"Blood"},{"key":"ref41","first-page":"54","article-title":"In vitro inhibition of hematopoiesis by HNK1, DR-positive T cells and monocytes after allogeneic bone marrow transplantation","volume":"15","author":"G Vinci","year":"1987","journal-title":"Exp Hematol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1182\/blood-2012-06-435297","article-title":"STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia","volume":"120","author":"A Jerez","year":"2013","journal-title":"Blood"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0091505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T03:50:32Z","timestamp":1689047432000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0091505"}},"subtitle":[],"editor":[{"given":"Xu","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,11]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0091505","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,11]]}}}