{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:21:06Z","timestamp":1777616466243,"version":"3.51.4"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T00:00:00Z","timestamp":1395014400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0091569","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T20:39:52Z","timestamp":1395088792000},"page":"e91569","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["HIV-1 Infected Peripheral Blood Mononuclear Cells Modulate the Fibrogenic Activity of Hepatic Stellate Cells through Secreted TGF-\u03b2 and JNK Signaling"],"prefix":"10.1371","volume":"9","author":[{"given":"Deepti","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjusha","family":"Rani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabab","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahid","family":"Jameel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/hep.21722","article-title":"HIV and liver disease forum: conference proceedings","volume":"45","author":"KE Sherman","year":"2007","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1001\/archinte.166.15.1632","article-title":"Liver-related deaths in persons infected with the human immunodeficiency virus - The D\u2236A\u2236D study","volume":"166","author":"R Weber","year":"2006","journal-title":"Arch Intern Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1017\/S1462399408000847","article-title":"Cellular and molecular interactions in coinfection with hepatitis C virus and human immunodeficiency virus","volume":"10","author":"B Roe","year":"2008","journal-title":"Expert Rev Mol Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"SL Friedman","year":"2008","journal-title":"Physiol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1872-034X.2011.00776.x","article-title":"Evolution of hepatic fibrosis research","volume":"41","author":"N Kawada","year":"2011","journal-title":"Hepatol Res Off J Japan Soc Hepatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"121S","DOI":"10.1097\/01.alc.0000189284.98684.22","article-title":"Anti-TGF-beta strategies for the treatment of chronic liver disease","volume":"29","author":"K Breitkopf","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1053\/j.gastro.2003.11.018","article-title":"Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells","volume":"126","author":"R Bataller","year":"2004","journal-title":"Gastroenterology"},{"key":"ref8","first-page":"59","article-title":"Hepatitis B virus X protein promotes proliferation and upregulates TGF-beta1 and CTGF in human hepatic stellate cell line, LX-2","volume":"8","author":"G-H Guo","year":"2009","journal-title":"Hepatobiliary Pancreat Dis Int HBPD INT"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1126\/science.272.5263.872","article-title":"HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor","volume":"272","author":"Y Feng","year":"1996","journal-title":"Science (80-)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/hep.22890","article-title":"Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation","volume":"49","author":"F Hong","year":"2009","journal-title":"Hepatology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"G949","DOI":"10.1152\/ajpgi.00215.2003","article-title":"Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration","volume":"285","author":"RF Schwabe","year":"2003","journal-title":"Am J Physiol Gastrointest liver Physiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/hep.23679","article-title":"Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: implications for the pathogenesis of HIV\/hepatitis C virus-induced liver fibrosis","volume":"52","author":"AC Tuyama","year":"2010","journal-title":"Hepatology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/gut.2008.163287","article-title":"gp120 modulates the biology of human hepatic stellate cells: a link between HIV infection and liver fibrogenesis","volume":"59","author":"R Bruno","year":"2010","journal-title":"Gut"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e33659","DOI":"10.1371\/journal.pone.0033659","article-title":"X4 Human Immunodeficiency Virus Type 1 gp120 Promotes Human Hepatic Stellate Cell Activation and Collagen I Expression through Interactions with CXCR4","volume":"7","author":"F Hong","year":"2012","journal-title":"PLoS One"},{"key":"ref15","first-page":"142","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis","author":"L Xu","year":"2005","journal-title":"System"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods San Diego Calif"},{"key":"ref17","first-page":"1","article-title":"DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways","volume":"9656310","author":"IS Vlachos","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbrc.2005.08.085","article-title":"Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice","volume":"336","author":"K-S Hung","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"G245","DOI":"10.1152\/ajpgi.2000.279.2.G245","article-title":"Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis","volume":"279","author":"MJ Arthur","year":"2000","journal-title":"Am J Physiol Gastrointest liver Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/hep.21254","article-title":"Mechanisms of endotoxin-induced NO, IL-6, and TNF-alpha production in activated rat hepatic stellate cells: role of p38 MAPK","volume":"44","author":"C Thirunavukkarasu","year":"2006","journal-title":"Hepatology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/S0016-5085(97)70144-6","article-title":"Phosphatidylinositol 3-kinase is required for platelet-derived growth factor&apos;s actions on hepatic stellate cells","volume":"112","author":"F Marra","year":"1997","journal-title":"Gastroenterology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"9945","DOI":"10.1074\/jbc.M010303200","article-title":"Signal transduction by the chemokine receptor CXCR3: activation of Ras\/ERK, Src, and phosphatidylinositol 3-kinase\/Akt controls cell migration and proliferation in human vascular pericytes","volume":"276","author":"A Bonacchi","year":"2001","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ceb.2007.02.001","article-title":"The JNK signal transduction pathway","volume":"19","author":"CR Weston","year":"2007","journal-title":"Curr Opin Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1089\/08892220050058416","article-title":"Identification and characterization of differentially expressed mRNAs in HIV type 1-infected human T cells","volume":"16","author":"A Ryo","year":"2000","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1742-4690-5-118","article-title":"MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals","volume":"5","author":"L Houzet","year":"2008","journal-title":"Retrovirology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1371\/journal.pone.0022730","article-title":"Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1)","volume":"6","author":"A Gupta","year":"2011","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1111\/j.1440-1746.2006.04658.x","article-title":"Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis","volume":"22","author":"T Kisseleva","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/emboj\/18.5.1345","article-title":"TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway","volume":"18","author":"BA Hocevar","year":"1999","journal-title":"Eur Mol Biol Organ J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1124\/mol.62.1.65","article-title":"SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7","volume":"62","author":"GJ Inman","year":"2002","journal-title":"Mol Pharmacol"},{"key":"ref30","first-page":"1324","article-title":"TLR4 enhances TGF-b signaling and hepatic fibrosis","volume":"13","author":"J Kluwe","year":"2007","journal-title":"October"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ydbio.2005.01.002","article-title":"JNK signaling pathway required for wound healing in regenerating Drosophila wing imaginal discs","volume":"280","author":"M Bosch","year":"2005","journal-title":"Dev Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1172\/JCI18212","article-title":"NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis","volume":"112","author":"R Bataller","year":"2003","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0002-9440(10)62324-3","article-title":"Transforming growth factor-beta and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2\/3 phosphorylation in rat hepatic stellate cells after acute liver injury","volume":"166","author":"K Yoshida","year":"2005","journal-title":"Am J Pathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1053\/j.gastro.2009.09.015","article-title":"Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition","volume":"138","author":"J Kluwe","year":"2010","journal-title":"Gastroenterology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1086\/378643","article-title":"Hepatitis C and human immunodeficiency virus envelope proteins cooperatively induce hepatocytic apoptosis via an innocent bystander mechanism","volume":"188","author":"N Munshi","year":"2003","journal-title":"J Infect Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2009.01.035","article-title":"Origins and Mechanisms of miRNAs and siRNAs","volume":"136","author":"RW Carthew","year":"2009","journal-title":"Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.1182\/blood-2010-04-280156","article-title":"miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells","volume":"116","author":"H Zhou","year":"2010","journal-title":"Blood"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"R Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1053\/jhep.2003.50196","article-title":"Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis","volume":"37","author":"E Ueberham","year":"2003","journal-title":"Hepatology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1089\/088282404322875502","article-title":"Increased plasma transforming growth factor-beta1 is associated with disease progression in HIV-1-infected patients","volume":"17","author":"A Wierci\u0144ska-Drapalo","year":"2004","journal-title":"Viral Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1749-6632.1993.tb35912.x","article-title":"TGF beta and HIV infection","volume":"685","author":"M Lotz","year":"1993","journal-title":"Ann N Y Acad Sci"},{"key":"ref42","article-title":"PLOS ONE The expression of HIV-1 Vpu in monocytes causes increased secretion of TGF-\u03b2 that activates profibrogenic genes in hepatic stellate cells","author":"P Patel","year":"2014","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1086\/600107","article-title":"Association of interleukin-15-induced peripheral immune activation with hepatic stellate cell activation in persons coinfected with hepatitis C virus and HIV","volume":"200","author":"RD Allison","year":"2009","journal-title":"J Infect Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1086\/520935","article-title":"Elevated serum levels of interferon- gamma -inducible protein-10 in patients coinfected with hepatitis C virus and HIV","volume":"196","author":"B Roe","year":"2007","journal-title":"J Infect Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"480","DOI":"10.4049\/jimmunol.144.2.480","article-title":"Infection with HIV is associated with elevated IL-6 levels and production","volume":"144","author":"EC Breen","year":"1990","journal-title":"J Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1172\/JCI114230","article-title":"Production of tumor necrosis factor alpha and interleukin 1 beta by monocytic cells infected with human immunodeficiency virus","volume":"84","author":"JM Molina","year":"1989","journal-title":"J Clin Invest"},{"key":"ref47","first-page":"1","article-title":"Regulatory T Cells Prevent Liver Fibrosis During HIV Type 1 Infection in a Humanized Mouse Model","author":"J-I Nunoya","year":"2013","journal-title":"J Infect Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"584","DOI":"10.4254\/wjh.v5.i10.584","article-title":"Risk factors for liver fibrosis among human immunodeficiency virus monoinfected patients using the FIB4 index in Morocco","volume":"5","author":"M Tahiri","year":"2013","journal-title":"World J Hepatol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0091569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T07:01:45Z","timestamp":1689058905000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0091569"}},"subtitle":[],"editor":[{"given":"Neerja","family":"Kaushik-Basu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,17]]},"references-count":48,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0091569","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,17]]}}}