{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:57:13Z","timestamp":1777467433172,"version":"3.51.4"},"reference-count":92,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T00:00:00Z","timestamp":1395100800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0091706","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T20:47:50Z","timestamp":1395175670000},"page":"e91706","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Proteomic Analysis of Detergent Resistant Membrane Domains during Early Interaction of Macrophages with Rough and Smooth Brucella melitensis"],"prefix":"10.1371","volume":"9","author":[{"given":"Sabine A.","family":"Lauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivas","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian V.","family":"Forst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent","family":"Bowden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nammalwar","family":"Sriranganathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,3,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00005792-199607000-00003","article-title":"Complications associated with Brucella melitensis infection: a study of 530 cases","volume":"75","author":"JD Colmenero","year":"1996","journal-title":"Medicine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/j.ijantimicag.2010.06.015","article-title":"Update on brucellosis: therapeutic challenges","volume":"36","author":"J Solera","year":"2010","journal-title":"International journal of antimicrobial agents"},{"key":"ref3","unstructured":"Corbel MJ (2006) Brucellosis in humans and animals."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1099\/ijs.0.65269-0","article-title":"Brucella ceti sp. nov. and Brucella pinnipedialis sp. nov. for Brucella strains with cetaceans and seals as their preferred hosts","volume":"57","author":"G Foster","year":"2007","journal-title":"International journal of systematic and evolutionary microbiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3201\/eid0302.970219","article-title":"Brucellosis: An overview","volume":"3","author":"MJ Corbel","year":"1997","journal-title":"EMERGING INFECTIOUS DISEASES"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1099\/00222615-46-2-101","article-title":"Recent advances in brucellosis","volume":"46","author":"MJ Corbel","year":"1997","journal-title":"Journal of Medical Microbiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s00018-006-6311-4","article-title":"Brucella as a biological weapon","volume":"63","author":"G Pappas","year":"2006","journal-title":"Cellular and molecular life sciences: CMLS"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1462-5822.2002.00195.x","article-title":"Modulation of Brucella-induced macropinocytosis by lipid rafts mediates intracellular replication","volume":"4","author":"M Watarai","year":"2002","journal-title":"Cellular Microbiology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1128\/IAI.70.9.4818-4825.2002","article-title":"Macrophage plasma membrane cholesterol contributes to Brucella abortus infection of mice","volume":"70","author":"M Watarai","year":"2002","journal-title":"Infection and Immunity"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1128\/IAI.70.3.1640-1644.2002","article-title":"Role of cholesterol and the ganglioside GM1 in entry and short-term survival of Brucella suis in murine macrophages","volume":"70","author":"A Naroeni","year":"2002","journal-title":"Infection and Immunity"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.micpath.2004.04.002","article-title":"Lipid raft microdomains mediate class A scavenger receptor-dependent infection of Brucella abortus","volume":"37","author":"S Kim","year":"2004","journal-title":"Microb Pathog"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/mpat.2002.0531","article-title":"Membrane sorting during swimming internalization of Brucella is required for phagosome trafficking decisions","volume":"33","author":"S Kim","year":"2002","journal-title":"Microb Pathog"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/ni1202","article-title":"Cyclic beta-1,2-glucan is a Brucella virulence factor required for intracellular survival","volume":"6","author":"B Arellano-Reynoso","year":"2005","journal-title":"Nat Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1128\/IAI.66.5.2387-2392.1998","article-title":"Virulent Brucella abortus prevents lysosome fusion and is distributed within autophagosome-like compartments","volume":"66","author":"J Pizarro-Cerda","year":"1998","journal-title":"Infection and Immunity"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1128\/IAI.66.12.5711-5724.1998","article-title":"Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes","volume":"66","author":"J PizarroCerda","year":"1998","journal-title":"Infection and Immunity"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S1286-4579(00)90368-X","article-title":"Invasion and intracellular trafficking of Brucella abortus in nonphagocytic cells","volume":"2","author":"J Pizarro-Cerda","year":"2000","journal-title":"Microbes and Infection"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1462-5822.2001.00102.x","article-title":"Essential role of the VirB machinery in the maturation of the Brucella abortus-containing vacuole","volume":"3","author":"DJ Comerci","year":"2001","journal-title":"Cellular Microbiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1128\/IAI.66.8.3862-3866.1998","article-title":"Vector development for the expression of foreign proteins in the vaccine strain Brucella abortus S19","volume":"66","author":"DJ Comerci","year":"1998","journal-title":"Infect Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1046\/j.1365-2958.1998.00913.x","article-title":"A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence","volume":"29","author":"A Sola-Landa","year":"1998","journal-title":"Molecular Microbiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1128\/IAI.67.8.4041-4047.1999","article-title":"Early acidification of phagosomes containing Brucella suis is essential for intracellular survival in murine macrophages","volume":"67","author":"F Porte","year":"1999","journal-title":"Infection and Immunity"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1128\/IAI.68.7.4102-4107.2000","article-title":"Identification of genes required for chronic persistence of Brucella abortus in mice","volume":"68","author":"PC Hong","year":"2000","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1046\/j.1365-2958.1999.01569.x","article-title":"A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis","volume":"33","author":"D O'Callaghan","year":"1999","journal-title":"Mol Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1073\/pnas.032514299","article-title":"The Brucella suis virB operon is induced intracellularly in macrophages","volume":"99","author":"ML Boschiroli","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1365-2958.2004.04316.x","article-title":"Integration host factor is involved in transcriptional regulation of the Brucella abortus virB operon","volume":"54","author":"R Sieira","year":"2004","journal-title":"Mol Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1128\/JB.182.17.4849-4855.2000","article-title":"A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication","volume":"182","author":"R Sieira","year":"2000","journal-title":"J Bacteriol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1084\/jem.20030088","article-title":"Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum","volume":"198","author":"J Celli","year":"2003","journal-title":"J Exp Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1073\/pnas.0406873102","article-title":"Brucella coopts the small GTPase Sar1 for intracellular replication","volume":"102","author":"J Celli","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1462-5822.2001.00131.x","article-title":"Identification of Brucella spp. genes involved in intracellular trafficking","volume":"3","author":"RM Delrue","year":"2001","journal-title":"Cell Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1462-5822.2005.00543.x","article-title":"A quorum-sensing regulator controls expression of both the type IV secretion system and the flagellar apparatus of Brucella melitensis","volume":"7","author":"RM Delrue","year":"2005","journal-title":"Cell Microbiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1128\/JB.00232-10","article-title":"Identification of the quorum-sensing target DNA sequence and N-Acyl homoserine lactone responsiveness of the Brucella abortus virB promoter","volume":"192","author":"GM Arocena","year":"2010","journal-title":"J Bacteriol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/j.1365-2958.2008.06487.x","article-title":"Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by the Brucella type IV secretion system","volume":"70","author":"MF de Jong","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1128\/JB.01124-09","article-title":"Metabolic control of virulence genes in Brucella abortus: HutC coordinates virB expression and the histidine utilization pathway by direct binding to both promoters","volume":"192","author":"R Sieira","year":"2010","journal-title":"J Bacteriol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1128\/JB.00567-10","article-title":"The two-component system BvrR\/BvrS regulates the expression of the type IV secretion system VirB in Brucella abortus","volume":"192","author":"C Martinez-Nunez","year":"2010","journal-title":"J Bacteriol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1021\/pr060636a","article-title":"Extensive cell envelope modulation is associated with virulence in Brucella abortus","volume":"6","author":"J Lamontagne","year":"2007","journal-title":"J Proteome Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"5631","DOI":"10.1128\/JB.187.16.5631-5639.2005","article-title":"The lipopolysaccharide of Brucella abortus BvrS\/BvrR mutants contains lipid A modifications and has higher affinity for bactericidal cationic peptides","volume":"187","author":"L Manterola","year":"2005","journal-title":"J Bacteriol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1128\/JB.00265-07","article-title":"Mutations of the quorum sensing-dependent regulator VjbR lead to drastic surface modifications in Brucella melitensis","volume":"189","author":"S Uzureau","year":"2007","journal-title":"J Bacteriol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/j.1462-5822.2005.00561.x","article-title":"The cholesterol-dependent cytolysin listeriolysin O aggregates rafts via oligomerization","volume":"7","author":"NO Gekara","year":"2005","journal-title":"Cellular Microbiology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.yexcr.2004.11.022","article-title":"Dynamic reorganization of chemokine receptors, cholesterol, lipid rafts, and adhesion molecules to sites of CD4 engagement","volume":"304","author":"DH Nguyen","year":"2005","journal-title":"Experimental Cell Research"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.virol.2005.09.049","article-title":"Influenza virus assembly and budding in raft-derived microdomains: A quantitative analysis of the surface distribution of HA, NA and M2 proteins","volume":"342","author":"GP Leser","year":"2005","journal-title":"Virology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0163-7827(01)00019-4","article-title":"Human immunodeficiency virus and host cell lipids. Interesting pathways in research for a new HIV therapy","volume":"41","author":"J Raulin","year":"2002","journal-title":"Prog Lipid Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1042\/bj20020503","article-title":"Extensive temporally regulated reorganization of the lipid raft proteome following T-cell antigen receptor triggering","volume":"369","author":"L Bini","year":"2003","journal-title":"Biochemical Journal"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"13798","DOI":"10.1073\/pnas.0403835101","article-title":"Visualization of plasma membrane compartmentalization with patterned lipid bilayers","volume":"101","author":"M Wu","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1073\/pnas.0631608100","article-title":"Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors","volume":"100","author":"LJ Foster","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nri1129","article-title":"Pathogens: raft hijackers","volume":"3","author":"S Manes","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s00253-007-0970-4","article-title":"Enhanced expression, detection and purification of recombinant proteins using RNA stem loop and tandem fusion tags","volume":"75","author":"M Seleem","year":"2007","journal-title":"Applied microbiology and biotechnology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1093\/bioinformatics\/bti440","article-title":"Differential network expression during drug and stress response","volume":"21","author":"L Cabusora","year":"2005","journal-title":"Bioinformatics"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1137\/S0097539795290477","article-title":"Finding the k shortest paths","volume":"28","author":"D Eppstein","year":"1998","journal-title":"SIAM Journal on Computing"},{"key":"ref48","unstructured":"Hershbereger J, Maxel M, Suri S (2003) Finding the k shortest simple paths: A new algorithm and its implementation."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref50","unstructured":"Yoav BH, Yosef (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J of the Royal Statistical Society Series B9 Methodological): 289\u2013300."},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"P Shannon","year":"2003","journal-title":"Genome Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/ijc.2910410324","article-title":"Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes","volume":"41","author":"HW Ziegler-Heitbrock","year":"1988","journal-title":"Int J Cancer"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/jac\/dkm433","article-title":"Establishment of a method for evaluating intracellular antibiotic efficacy in Brucella abortus-infected Mono Mac 6 monocytes","volume":"61","author":"MW Valderas","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.micinf.2008.01.005","article-title":"Evidence of Brucella abortus OPS dictating uptake and restricting NF-kappaB activation in murine macrophages","volume":"10","author":"J Pei","year":"2008","journal-title":"Microbes Infect"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/S0264-410X(02)00035-X","article-title":"Brucella abortus vaccine strain RB51 produces low levels of M-like O-antigen","volume":"20","author":"A Cloeckaert","year":"2002","journal-title":"VACCINE"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1074\/mcp.M900255-MCP200","article-title":"Differential protein expression profiling by iTRAQ-two-dimensional LC-MS\/MS of human bladder cancer EJ138 cells transfected with the metastasis suppressor KiSS-1 gene","volume":"9","author":"I Ruppen","year":"2010","journal-title":"Molecular & cellular proteomics: MCP"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ygeno.2007.03.013","article-title":"Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway","volume":"90","author":"H Yang","year":"2007","journal-title":"Genomics"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e1003556","DOI":"10.1371\/journal.ppat.1003556","article-title":"Brucella modulates secretory trafficking via multiple type IV secretion effector proteins","volume":"9","author":"S Myeni","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1749-6632.2010.05492.x","article-title":"Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications","volume":"1194","author":"D Crockford","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"20208","DOI":"10.1074\/jbc.M113.453282","article-title":"A Brucella virulence factor targets macrophages to trigger B-cell proliferation","volume":"288","author":"JM Spera","year":"2013","journal-title":"The Journal of biological chemistry"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng1285","article-title":"Complete sequencing and characterization of 21,243 full-length human cDNAs","volume":"36","author":"T Ota","year":"2004","journal-title":"Nat Genet"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1440-1827.2010.02547.x","article-title":"Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases","volume":"60","author":"T Shiomi","year":"2010","journal-title":"Pathol Int"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1741-7007-3-21","article-title":"Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization","volume":"3","author":"EG Reynaud","year":"2005","journal-title":"BMC Biol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.cell.2007.02.017","article-title":"The X-linked mental retardation gene SMCX\/JARID1C defines a family of histone H3 lysine 4 demethylases","volume":"128","author":"S Iwase","year":"2007","journal-title":"Cell"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.cell.2007.02.004","article-title":"Physical and functional association of a trimethyl H3K4 demethylase and Ring6a\/MBLR, a polycomb-like protein","volume":"128","author":"MG Lee","year":"2007","journal-title":"Cell"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1006\/bbrc.2000.3935","article-title":"Identification and characterization of a novel gene KE04 differentially expressed by activated human dendritic cells","volume":"279","author":"N Li","year":"2000","journal-title":"Biochemical and biophysical research communications"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"10433","DOI":"10.1074\/jbc.M809801200","article-title":"An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors","volume":"284","author":"MM Pearce","year":"2009","journal-title":"The Journal of biological chemistry"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1242\/jcs.03060","article-title":"Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER","volume":"119","author":"DT Browman","year":"2006","journal-title":"J Cell Sci"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"e1000080","DOI":"10.1371\/journal.ppat.1000080","article-title":"Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP","volume":"4","author":"D Koppers-Lalic","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"D Ron","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"e1003785","DOI":"10.1371\/journal.ppat.1003785","article-title":"Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages","volume":"9","author":"JA Smith","year":"2013","journal-title":"PLoS Pathog"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.2174\/138161206777585111","article-title":"The voltage-dependent anion channel (VDAC): function in intracellular signalling, cell life and cell death","volume":"12","author":"V Shoshan-Barmatz","year":"2006","journal-title":"Curr Pharm Des"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"5698","DOI":"10.1128\/MCB.00165-10","article-title":"Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis","volume":"30","author":"N Keinan","year":"2010","journal-title":"Mol Cell Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1128\/IAI.00050-11","article-title":"Proinflammatory caspase-2-mediated macrophage cell death induced by a rough attenuated Brucella suis strain","volume":"79","author":"F Chen","year":"2011","journal-title":"Infect Immun"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"e6830","DOI":"10.1371\/journal.pone.0006830","article-title":"Caspase-2 mediated apoptotic and necrotic murine macrophage cell death induced by rough Brucella abortus","volume":"4","author":"F Chen","year":"2009","journal-title":"PloS one"},{"key":"ref76","volume":"3","unstructured":"Bronner DN, O&apos;Riordan M, He YO (2013) Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis. Frontiers in Cellular and Infection Microbiology <volume>3<\/volume>.."},{"key":"ref77","doi-asserted-by":"crossref","first-page":"e43512","DOI":"10.1371\/journal.pone.0043512","article-title":"Caspase-2-dependent dendritic cell death, maturation, and priming of T cells in response to Brucella abortus infection","volume":"7","author":"X Li","year":"2012","journal-title":"PLoS One"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1128\/IAI.01998-05","article-title":"Brucella melitensis triggers time-dependent modulation of apoptosis and down-regulation of mitochondrion-associated gene expression in mouse macrophages","volume":"74","author":"Y He","year":"2006","journal-title":"Infection and Immunity"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.emboj.7601504","article-title":"FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies","volume":"26","author":"K Milovic-Holm","year":"2007","journal-title":"The EMBO journal"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1038\/sj.emboj.7600820","article-title":"Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100","volume":"24","author":"PD Ling","year":"2005","journal-title":"The EMBO journal"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"11928","DOI":"10.1128\/JVI.00758-11","article-title":"Human cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expression","volume":"85","author":"YE Kim","year":"2011","journal-title":"J Virol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cell.2011.02.010","article-title":"PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson&apos;s disease","volume":"144","author":"JH Shin","year":"2011","journal-title":"Cell"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1093\/bioinformatics\/bti551","article-title":"BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks","volume":"21","author":"S Maere","year":"2005","journal-title":"Bioinformatics"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1128\/IAI.68.1.342-351.2000","article-title":"In vitro Brucella suis infection prevents the programmed cell death of human monocytic cells","volume":"68","author":"A Gross","year":"2000","journal-title":"Infect Immun"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1086\/375223","article-title":"Monocyte and lymphocyte apoptosis resistance in acute and chronic brucellosis and its possible implications in clinical management","volume":"36","author":"M Tolomeo","year":"2003","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"44435","DOI":"10.1074\/jbc.M105606200","article-title":"GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes: direct activation of Cdc42","volume":"276","author":"C Guzman-Verri","year":"2001","journal-title":"J Biol Chem"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1006\/mpat.2000.0354","article-title":"Early events and implication of F-actin and annexin I associated structures in the phagocytic uptake of Brucella suis by the J-774A.1 murine cell line and human monocytes","volume":"28","author":"A Kusumawati","year":"2000","journal-title":"Microb Pathog"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1471-2180-9-81","article-title":"Brucella melitensis global gene expression study provides novel information on growth phase-specific gene regulation with potential insights for understanding Brucella:host initial interactions","volume":"9","author":"CA Rossetti","year":"2009","journal-title":"BMC Microbiol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1128\/IAI.71.4.2110-2119.2003","article-title":"Interactions between Brucella melitensis and human phagocytes: Bacterial surface O-polysaccharide inhibits phagocytosis, bacterial killing, subsequent host cell apoptosis","volume":"71","author":"CM Fernandez-Prada","year":"2003","journal-title":"Infection and Immunity"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1128\/IAI.74.5.2667-2675.2006","article-title":"Brucella abortus rough mutants induce macrophage oncosis that requires bacterial protein synthesis and direct interaction with the macrophage","volume":"74","author":"JW Pei","year":"2006","journal-title":"Infection and Immunity"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/infdis\/108.3.333","article-title":"Host-parasite relationships in brucellosis. II. Destruction of macrophage cultures by Brucella of different virulence","volume":"108","author":"BA Freeman","year":"1961","journal-title":"J. Infectious diseases"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/IAI.72.1.440-450.2004","article-title":"Brucella abortus rough mutants are cytopathic for macrophages in culture","volume":"72","author":"J Pei","year":"2004","journal-title":"Infection and Immunity"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0091706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T12:32:21Z","timestamp":1597581141000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0091706"}},"subtitle":[],"editor":[{"given":"Roy Martin","family":"Roop","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,18]]},"references-count":92,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0091706","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,18]]}}}