{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:23:48Z","timestamp":1790753028871,"version":"4.1.0"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0092098","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T03:41:21Z","timestamp":1395718881000},"page":"e92098","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Direct Visualization of CHIP-Mediated Degradation of Alpha-Synuclein In Vivo: Implications for PD Therapeutics"],"prefix":"10.1371","volume":"9","author":[{"given":"Hemi","family":"Dimant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura N.","family":"Kibuuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanyun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley T.","family":"Hyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/00005072-199804000-00005","article-title":"Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity","volume":"57","author":"MC Irizarry","year":"1998","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(04)17103-1","article-title":"Alpha-synuclein locus duplication as a cause of familial Parkinson's disease","volume":"364","author":"MC Chartier-Harlin","year":"2004","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1073\/pnas.1100976108","article-title":"In vivo demonstration that alpha-synuclein oligomers are toxic","volume":"108","author":"B Winner","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","article-title":"alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies","volume":"95","author":"MG Spillantini","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2174\/187152710793237386","article-title":"Molecular chaperones as rational drug targets for Parkinson's disease therapeutics","volume":"9","author":"SK Kalia","year":"2010","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bbrc.2006.10.085","article-title":"Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation","volume":"351","author":"TF Outeiro","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1096\/fj.10-164624","article-title":"Heat-shock protein 70 modulates toxic extracellular alpha-synuclein oligomers and rescues trans-synaptic toxicity","volume":"25","author":"KM Danzer","year":"2011","journal-title":"FASEB J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"17962","DOI":"10.1074\/jbc.M802283200","article-title":"CHIP targets toxic alpha-Synuclein oligomers for degradation","volume":"283","author":"JE Tetzlaff","year":"2008","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e14695","DOI":"10.1371\/journal.pone.0014695","article-title":"Ubiquitinylation of alpha-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5)","volume":"6","author":"LV Kalia","year":"2011","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2051-5960-1-6","article-title":"Direct detection of alpha synuclein oligomers in vivo","volume":"1","author":"H Dimant","year":"2013","journal-title":"Acta Neuropathologica Communications"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"23727","DOI":"10.1074\/jbc.M503326200","article-title":"The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways","volume":"280","author":"Y Shin","year":"2005","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/j.1471-4159.2005.03272.x","article-title":"In vivo evidence of CHIP up-regulation attenuating tau aggregation","volume":"94","author":"N Sahara","year":"2005","journal-title":"J Neurochem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1126\/science.286.5446.1888","article-title":"Posttranslational quality control: folding, refolding, and degrading proteins","volume":"286","author":"S Wickner","year":"1999","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1096\/fj.10-162636","article-title":"Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor","volume":"24","author":"CH Woo","year":"2010","journal-title":"FASEB J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1379\/CSC-90R.1","article-title":"C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis","volume":"10","author":"JR Hwang","year":"2005","journal-title":"Cell Stress Chaperones"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2010.12.017","article-title":"Tyrosine hydroxylase and regulation of dopamine synthesis","volume":"508","author":"SC Daubner","year":"2011","journal-title":"Arch Biochem Biophys"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1523\/JNEUROSCI.3001-05.2005","article-title":"CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo","volume":"25","author":"VM Miller","year":"2005","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/hmg\/ddh083","article-title":"CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation","volume":"13","author":"L Petrucelli","year":"2004","journal-title":"Hum Mol Genet"},{"key":"ref19","unstructured":"McFarland NR, Fan Z, Lee JS, Sena-Esteves M, Stern EA, et al. (2007) Comparison of adeno-associated viral serotypes for gene delivery to the nigrostriatal system. Society for Neuroscience. San Fancisco, CA."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0092098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T19:17:46Z","timestamp":1540235866000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0092098"}},"subtitle":[],"editor":[{"given":"Pedro","family":"Fernandez-Funez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,24]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0092098","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,24]]}}}