{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:42:49Z","timestamp":1788586969362,"version":"build-2803163510"},"reference-count":115,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0092267","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T16:57:46Z","timestamp":1395334666000},"page":"e92267","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["Meta-Analysis: Diagnostic Accuracy of Antinuclear Antibodies, Smooth Muscle Antibodies and Antibodies to a Soluble Liver Antigen\/Liver Pancreas in Autoimmune Hepatitis"],"prefix":"10.1371","volume":"9","author":[{"given":"Wen-Chao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Rong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Xian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/j.1749-6632.1965.tb19000.x","article-title":"Autoimmune hepatitis","volume":"124","author":"IR Mackay","year":"1965","journal-title":"Ann NY Acad Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1111\/j.1572-0241.2002.05921.x","article-title":"Gender effects and synergisms with histocompatibility leukocyte antigens in type 1 autoimmune hepatitis","volume":"97","author":"AJ Czaja","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMra050408","article-title":"Autoimmune hepatitis","volume":"354","author":"EL Krawitt","year":"2006","journal-title":"New Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0140-6736(72)92149-6","article-title":"Association of autoimmune active chronic hepatitis with HL-A1, 8","volume":"2","author":"IR Mackay","year":"1972","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0016-5085(80)90080-3","article-title":"HLA associations with autoimmune-type chronic active hepatitis: identification of B8-DRw3 haplotype by family studies","volume":"79","author":"IR Mackay","year":"1980","journal-title":"Gastroenterology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/hep.1840130415","article-title":"Susceptibility to autoimmune chronic active hepatitis: human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors","volume":"13","author":"PT Donaldson","year":"1991","journal-title":"Hepatology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1034\/j.1600-0528.2002.017401.x","article-title":"Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis","volume":"174","author":"AJ Czaja","year":"2000","journal-title":"Immunol Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/hep.1840180435","article-title":"Meeting report: international autoimmune hepatitis group","volume":"18","author":"PJ Johnson","year":"1993","journal-title":"Hepatology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International Autoimmune Hepatitis Group Report: review criteria for the diagnosis of autoimmune hepatitis","volume":"31","author":"F Alvarez","year":"1999","journal-title":"J Hepatol"},{"key":"ref10","unstructured":"Nishioka M (1992) Nuclear antigens in autoimmune hepatitis. In: Meyer zum Buschenfelde K-H, Hoofnagle J, Manns MP, editors. Immunology and Liver. Dordrecht: Kluwer Academic. 193\u2013205."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/hep.22322","article-title":"Simplified criteria for the diagnosis of autoimmune hepatitis","volume":"48","author":"EM Hennes","year":"2008","journal-title":"Hepatology"},{"key":"ref12","first-page":"435","article-title":"Autoimmune hepatitis. Evolving concepts and treatment strategies","volume":"40","author":"AJ Czaja","year":"1995","journal-title":"Dig Dis Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"588","DOI":"10.7326\/0003-4819-125-7-199610010-00009","article-title":"The variant forms of autoimmune hepatitis","volume":"125","author":"AJ Czaja","year":"1996","journal-title":"Ann Intern Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1056\/NEJM199604043341406","article-title":"Autoimmune hepatitis","volume":"334","author":"EL Krawitt","year":"1996","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1080\/00365520802130183","article-title":"Epidemiology and the initial presentation of autoimmune hepatitis in Sweden: a nationwide study","volume":"43","author":"M Werner","year":"2008","journal-title":"Scand J Gastroenterol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1002\/hep.23584","article-title":"Diagnosis and management of autoimmune hepatitis","volume":"51","author":"MP Manns","year":"2010","journal-title":"Hepatology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1053\/jhep.2002.34944","article-title":"Diagnosis and treatment of autoimmune hepatitis","volume":"36","author":"AJ Czaja","year":"2002","journal-title":"Hepatology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jhep.2010.06.032","article-title":"Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese","volume":"54","author":"DK Qiu","year":"2011","journal-title":"J Hepaol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/hep.20539","article-title":"Treatment challenges and investigational opportunities in autoimmune hepatitis","volume":"41","author":"AJ Czaja","year":"2005","journal-title":"Hepatology"},{"key":"ref20","first-page":"1206","article-title":"The validity and importance of subtypes in autoimmune hepatitis: a point of view","volume":"90","author":"AJ Czaja","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.1840070626","article-title":"Chronic active hepatitis associated with anti liver\/kidney microsome type 1: a second type of \u201cautoimmune\u201d hepatitis","volume":"7","author":"JC Homberg","year":"1987","journal-title":"Hepatology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0168-8278(00)80361-X","article-title":"Antibodies to soluble liver antigen: an additional marker in type 1 auto-immune hepatitis","volume":"33","author":"E Ballot","year":"2000","journal-title":"J Hepatol"},{"key":"ref23","first-page":"25","article-title":"Presentation of two bone marrow elements: The \u201ctart\u201d cells and the \u201cL.E\u201d cell","volume":"27","author":"M Hargraves","year":"1948","journal-title":"Mayo Clin Proc"},{"key":"ref24","first-page":"252","article-title":"[Absorption of L. E. factor by isolated cell nuclei.] Experientia","volume":"10","author":"P Miescher","year":"1954"},{"key":"ref25","first-page":"1323","article-title":"Lupoid hepatitis","volume":"271","author":"DC Cowling","year":"1956","journal-title":"Lancet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0140-6736(59)91136-5","article-title":"Lupoid hepatitis and the hepatic lesions of systemic lupus erythematosus","volume":"1","author":"IR Mackay","year":"1959","journal-title":"Lancet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/gast.2001.20223","article-title":"Autoantibodies in liver disease","volume":"120","author":"AJ Czaja","year":"2001","journal-title":"Gastroenterology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1136\/bmj.1.5331.656","article-title":"Antinuclear factor and other antibodies in blood and liver diseases","volume":"1","author":"EJ Holborow","year":"1963","journal-title":"Br Med J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jhep.2004.08.002","article-title":"Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group","volume":"41","author":"D Vergani","year":"2004","journal-title":"J Hepatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(65)92505-5","article-title":"Antibody to smooth muscle in patients with liver disease","volume":"2","author":"GD Johnson","year":"1965","journal-title":"Lancet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0016-5085(19)34365-3","article-title":"Smooth muscle autoantibody in \u201cautoimmune\u201d hepatitis","volume":"51","author":"S Whittingham","year":"1966","journal-title":"Gastroenterology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/jcp.29.5.403","article-title":"Classification of smooth muscle autoantibodies detected by immunofluorescence","volume":"29","author":"GF Bottazzo","year":"1976","journal-title":"J Clin Pathol"},{"key":"ref33","first-page":"473","article-title":"Human smooth muscle autoantibody. Its identification as antiactin antibody and a study of its binding to \u201cnonmuscular\u201d cells","volume":"72","author":"G Gabbiani","year":"1973","journal-title":"Am J Pathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0140-6736(87)92024-1","article-title":"Characterisation of a new subgroup of autoimmune chronic active hepatitis by autoantibodies against a soluble liver antigen","volume":"1","author":"M Manns","year":"1987","journal-title":"Lancet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.1840180102","article-title":"Characterization and clinical relevance of liver-pancreas antibodies in autoimmune hepatitis","volume":"18","author":"E Stechemesser","year":"1993","journal-title":"Hepatology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/S0140-6736(00)02166-8","article-title":"Identification of target antigen for SLA\/LP autoantibodies in autoimmune hepatitis","volume":"355","author":"I Wies","year":"2000","journal-title":"Lancet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/gut.51.2.259","article-title":"Establishment of standardised SLA\/LP immunoassays: specificity for autoimmune hepatitis, worldwide occurrence, and clinical characteristics","volume":"51","author":"M Baeres","year":"2002","journal-title":"Gut"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"667","DOI":"10.7326\/0003-4819-120-8-199404150-00008","article-title":"Guidelines for meta-analyses evaluating diagnostic tests","volume":"120","author":"L Irwig","year":"1994","journal-title":"Ann Intern Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2288-6-9","article-title":"Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studies (update)","volume":"6","author":"P Whiting","year":"2006","journal-title":"BMC Med Res Methodol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1258\/096914103321610806","article-title":"A likelihood ratio approach to meta-analysis of diagnostic studies","volume":"10","author":"D Stengel","year":"2003","journal-title":"J Med Screen"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0895-4356(03)00177-X","article-title":"The diagnostic odds ratio: a single indicator of test performance","volume":"56","author":"AS Glas","year":"2003","journal-title":"J Clin Epidemiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/sim.4780121403","article-title":"Combining independent studies of a diagnostic test into a summary ROC curve: data-analytic approaches and some additional considerations","volume":"12","author":"LE Moses","year":"1993","journal-title":"Stat Med"},{"key":"ref43","first-page":"97","article-title":"Meta-Disc software in meta-analysis of diagnostic tests","volume":"2","author":"TS Zhang","year":"2008","journal-title":"Chin J Evid-based Med"},{"key":"ref44","first-page":"6","article-title":"Application of review manager 5 software for meta-analysis of diagnostic test accuracy","volume":"32","author":"XT Zeng","year":"2013","journal-title":"J HBUM"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1478-3231.1999.tb00021.x","article-title":"Autoimmune cholangitis and primary biliary cirrhosis\u2013an autoimmune enigma","volume":"19","author":"H Kinoshita","year":"1999","journal-title":"Liver"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0168-8278(96)80290-X","article-title":"Identification of cyclin A as a molecular target of antinuclear antibodies (ANA) in hepatic and non-hepatic autoimmune diseases","volume":"25","author":"CP Strassburg","year":"1996","journal-title":"J Hepatol"},{"key":"ref47","first-page":"49","article-title":"A comparison of the prevalence of autoantibodies in individuals with chronic hepatitis C and those with autoimmune hepatitis","volume":"1","author":"E Sh. Al-Obeidy","year":"2006","journal-title":"Iraqi J Gastroenterol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1007\/s10620-011-1756-1","article-title":"Prevalence of autoimmune liver disease related autoantibodies in Chinese patients with primary biliary cirrhosis","volume":"56","author":"C Hu","year":"2011","journal-title":"Dig Dis Sci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1053\/jhep.2002.32092","article-title":"Antibodies to conformational epitopes of soluble liver antigen define a severe form of autoimmune liver disease","volume":"35","author":"Y Ma","year":"2002","journal-title":"Hepatology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0896-8411(03)00084-2","article-title":"Low frequency of anti-SLA\/LP autoantibody in Japanese adult patients with autoimmune liver diseases: analysis with recombinant antigen assay","volume":"21","author":"H Miyakawa","year":"2003","journal-title":"J Autoimmun"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1440-1746.1997.tb00384.x","article-title":"Antibodies to P450IID6, SLA, PDH-E2 and BCKD-E2 in Japanese patients with chronic hepatitis","volume":"12","author":"M Nishioka","year":"1997","journal-title":"J Gastroenterol Hepatol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/liv.12022","article-title":"Antibodies to soluble liver antigen in patients with various liver diseases: a multicentre study","volume":"33","author":"C Efe","year":"2013","journal-title":"Liver Int"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1111\/j.1572-0241.2006.00830.x","article-title":"Evaluation of F-actin ELISA for the diagnosis of autoimmune hepatitis","volume":"101","author":"C Frenzel","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/hep.510260305","article-title":"Serum autoantibodies in chronic hepatitis C: comparison with autoimmune hepatitis and impact on the disease profile","volume":"26","author":"F Cassani","year":"1997","journal-title":"Hepatology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/0891693021000054066","article-title":"Smooth muscle antibodies and type 1 autoimmune hepatitis","volume":"35","author":"P Muratori","year":"2002","journal-title":"Autoimmunity"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0016-5085(98)70485-8","article-title":"Members of the glutathione S-transferase gene family are antigens in autoimmune hepatitis","volume":"114","author":"J Wesierska-Gadek","year":"1998","journal-title":"Gastroenterology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/08916930701619896","article-title":"Diagnostic accuracy of four different immunological methods for the detection of anti-F-actin autoantibodies in type 1 autoimmune hepatitis and other liver-related disorders","volume":"41","author":"D Villalta","year":"2008","journal-title":"Autoimmunity"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1136\/jcp.2005.027367","article-title":"Antibodies to filamentous actin (F-actin) in type 1 autoimmune hepatitis","volume":"59","author":"A Granito","year":"2006","journal-title":"J Clin Pathol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-3083.2011.02592.x","article-title":"Resistin is associated with breach of tolerance and anti-nuclear antibodies in patients with hepatobiliary inflammation","volume":"74","author":"EA Bostr\u00f6m","year":"2011","journal-title":"Scand J Immunol"},{"key":"ref60","first-page":"1258","article-title":"The diagnostic value of six serum auto-antibodies in autoimmune hepatitis","volume":"10","author":"L Zhang","year":"2012","journal-title":"Chin Lab Med Clin"},{"key":"ref61","first-page":"1061","article-title":"A survey of auto-antibodies in 161 patients with autoimmune liver disease","volume":"12","author":"LM Tan","year":"2012","journal-title":"Chin J Immunol"},{"key":"ref62","first-page":"697","article-title":"Clinical value of anti-myeloperoxidase antibody on diagnosis of autoimmune hepatitis","volume":"6","author":"LM Tan","year":"2009","journal-title":"Chin J Immunol"},{"key":"ref63","first-page":"131","article-title":"Evaluation of antibodies to soluble liver antigen for the diagnosis of autoimmune liver disease","volume":"12","author":"H Long","year":"2012","journal-title":"Chin J Trauma Disability Med"},{"key":"ref64","first-page":"147","article-title":"Diagnostic value of ANA and ASMA in chronic hepatitis C: comparison with autoimmune hepatitis","volume":"2","author":"JW Deng","year":"2010","journal-title":"Chin Exp Lab Med"},{"key":"ref65","first-page":"82","article-title":"Clinical practice of auto-antibodies in autoimmune liver disease","volume":"25","author":"S Lv","year":"2006","journal-title":"Shandong J Med"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"834","DOI":"10.2957\/kanzo.35.834","article-title":"A study of antinuclear envelope antibody in primary biliary cirrhosis","volume":"35","author":"Y Onozuka","year":"1994","journal-title":"Jap Hepatol"},{"key":"ref67","first-page":"839","article-title":"Survey on the detection of anti-myeloperoxidase antibody and anti-lactoferrin antibody in patients with autoimmune hepatitis","volume":"8","author":"LM Tan","year":"2013","journal-title":"Chin J Immunol"},{"key":"ref68","first-page":"1962","article-title":"Diagnostic significance of combined detection of autoantibodies in autoimmune hepatitis","volume":"12","author":"JL Zhang","year":"2007","journal-title":"Guangdong J Med"},{"key":"ref69","first-page":"538","article-title":"Clinical significance of auto-antibody determination in autoimmune hepatitis for the examination of oneself antibody of SLA","volume":"6","author":"XC Li","year":"2006","journal-title":"J BHU (Nat Sci)"},{"key":"ref70","first-page":"463","article-title":"Detection of auto-antibodies for diagnosing autoimmunous hepatitis","volume":"6","author":"LM Tan","year":"2006","journal-title":"Chin J Hepatol"},{"key":"ref71","first-page":"166","article-title":"A survey of serum biomarkers and auto-antibodies in autoimmune liver disease","volume":"3","author":"BC Zhang","year":"2004","journal-title":"Chin J Lab Med"},{"key":"ref72","first-page":"1030","article-title":"Detection and significance of antibodies to soluble liver antigen\/liver pancreas antigen in patients with autoimmune hepatitis","volume":"12","author":"YX Ma","year":"2012","journal-title":"Beijing J Med"},{"key":"ref73","first-page":"2801","article-title":"Detection of autoantibodies for diagnosis of autoimmune hepatitis","volume":"14","author":"LM Tan","year":"2006","journal-title":"World J Gastroenterol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/08916930410001686260","article-title":"Anti-soluble liver antigen (SLA) antibodies in chronic HCV infection","volume":"37","author":"S Vitozzi","year":"2004","journal-title":"Autoimmunity"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/0016-5085(93)90160-E","article-title":"Antibodies to soluble liver antigen, P450IID6, and mitochondrial complexes in chronic hepatitis","volume":"105","author":"AJ Czaja","year":"1993","journal-title":"Gastroenterology"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/0891693021000054101","article-title":"Frequency and significance of antibodies to soluble liver antigen\/liver pancreas in variant autoimmune hepatitis","volume":"35","author":"AJ Czaja","year":"2002","journal-title":"Autoimmunity"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0168-8278(01)81660-3","article-title":"Anti-SLA antibody is a marker of severity of liver damage in patients with autoimmune liver disease","volume":"34","author":"Y Ma","year":"2001","journal-title":"J Hepatol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"9739","DOI":"10.1073\/pnas.89.20.9739","article-title":"Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion","volume":"89","author":"C Gelpi","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1572-0241.2002.05479.x","article-title":"Antibodies to soluble liver antigen\/liver pancreas and HLA risk factors for type 1 autoimmune hepatitis","volume":"97","author":"AJ Czaja","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/08916930410001702469","article-title":"Nonstandard antibodies as prognostic markers in autoimmune hepatitis","volume":"37","author":"AJ Czaja","year":"2004","journal-title":"Autoimmunity"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1172\/JCI113949","article-title":"Major antigen of liver kidney microsomal antibodies in idiopathic autoimmune hepatitis is cytochrome P450db1","volume":"83","author":"MP Manns","year":"1989","journal-title":"J Clin Invest"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S1089-3261(02)00018-1","article-title":"Pathogenesis of autoimmune hepatitis","volume":"6","author":"D Vergani","year":"2002","journal-title":"Clin Liver Dis"},{"key":"ref83","first-page":"313","article-title":"Diverse manifestations and evolving treatments of autoimmune hepatitis","volume":"51","author":"AJ Czaja","year":"2005","journal-title":"Minerva Gastroenterol Dietol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00004836-200207000-00016","article-title":"Prognosis of symptomatic versus asymptomatic autoimmune hepatitis: a study of 68 patients","volume":"35","author":"J Kogan","year":"2002","journal-title":"J Clin Gastroenterol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/hep.20732","article-title":"Autoimmune hepatitis: effect of symptoms and cirrhosis on natural history and outcome","volume":"42","author":"JJ Feld","year":"2005","journal-title":"Hepatology"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1542-3565(04)00246-0","article-title":"Fulminant hepatic failure as the initial presentation of acute autoimmune hepatitis","volume":"2","author":"WR Kessler","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/lt.21036","article-title":"Usefulness of corticosteroids for the treatment of severe and fulminant forms of autoimmune hepatitis","volume":"13","author":"P Ichai","year":"2007","journal-title":"Liver Transpl"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1023\/A:1018836004279","article-title":"Immune phenotype of chronic liver disease","volume":"43","author":"AJ Czaja","year":"1998","journal-title":"Dig Dis Sci"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/hep.510250308","article-title":"Autoimmune hepatitis in childhood. A 20 year survey","volume":"25","author":"GV Gregorio","year":"1997","journal-title":"Hepatology"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0198-8859(94)90008-6","article-title":"Chronic active autoimmune hepatitis in children. Strong association with a particular HLA DR6 (DRB1*1301) haplotype","volume":"41","author":"L Fainboim","year":"1994","journal-title":"Hum Immunol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0016-5085(92)90041-V","article-title":"HLA class II molecules and autoimmune hepatitis susceptibility in Japanese patients","volume":"103","author":"T Seki","year":"1992","journal-title":"Gastroenterology"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1111\/j.1572-0241.1998.1394a.x","article-title":"Different HLA profiles confer susceptibility to autoimmune hepatitis type 1 and 2","volume":"93","author":"PL Bittencourt","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1046\/j.1440-1746.2001.02602.x","article-title":"Autoimmune hepatitis in the Indian subcontinent: 7 years experience","volume":"16","author":"R Gupta","year":"2001","journal-title":"J Gastroenterol Hepatol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1111\/j.1572-0241.2001.05272.x","article-title":"Autoimmune hepatitis in African Americans: presenting features and response to therapy","volume":"96","author":"KN Lim","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0016-5085(19)33223-8","article-title":"Clinical, biochemical, and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis","volume":"63","author":"RD Soloway","year":"1972","journal-title":"Gastroenterology"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0140-6736(73)92125-9","article-title":"Controlled trial of prednisone and azathioprine in active chronic hepatitis","volume":"1","author":"IM Murray-Lyon","year":"1973","journal-title":"Lancet"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/oxfordjournals.qjmed.a067264","article-title":"Controlled prospective trial of corticosteroid therapy in active chronic hepatitis","volume":"40","author":"GC Cook","year":"1971","journal-title":"Q J Med"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1034\/j.1600-0641.2000.033004543.x","article-title":"High prevalence of autoimmune hepatitis among patients with primary sclerosing cholangitis","volume":"33","author":"HR van Buuren","year":"2000","journal-title":"J Hepatol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1023\/A:1005670111068","article-title":"Shared genetic risk factors in autoimmune liver disease","volume":"46","author":"AJ Czaja","year":"2001","journal-title":"Dig Dis Sci"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1053\/jhep.2002.30902","article-title":"Primary biliary cirrhosis with additional features of autoimmune hepatitis: response to therapy with ursodeoxycholic acid","volume":"35","author":"S Joshi","year":"2002","journal-title":"Hepatology"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/hep.510280203","article-title":"Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome: clinical features and response to therapy","volume":"28","author":"O Chazouilleres","year":"1998","journal-title":"Hepatology"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/hep.510290409","article-title":"Characterization of the overlap syndrome of primary biliary cirrhosis (PBC) and autoimmune hepatitis: evidence for it being a hepatitic form of PBC in genetically susceptible individuals","volume":"29","author":"AW Lohse","year":"1999","journal-title":"Hepatology"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1572-0241.1998.224_a.x","article-title":"Autoimmune hepatitis overlapping with primary sclerosing cholangitis in five cases","volume":"93","author":"AN McNair","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jhep.2005.10.017","article-title":"Long term outcome and response to therapy of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome","volume":"44","author":"O Chazouilleres","year":"2006","journal-title":"J Hepatol"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1600-0676.1984.tb00914.x","article-title":"Manifestations of nonsuppurative cholangitis in chronic hepatobiliary diseases: morphologic spectrum, clinical correlations and terminology","volume":"4","author":"J Ludwig","year":"1984","journal-title":"Liver"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1053\/jhep.2001.27562","article-title":"Autoimmune hepatitis with incidental histologic features of bile duct injury","volume":"34","author":"AJ Czaja","year":"2001","journal-title":"Hepatology"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1478-3231.2004.0924.x","article-title":"Diagnostic and therapeutic implications of bile duct injury in autoimmune hepatitis","volume":"24","author":"AJ Czaja","year":"2004","journal-title":"Liver Int"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1111\/j.1572-0241.2005.41841.x","article-title":"Clinical course and outcome of autoimmune hepatitis\/primary sclerosing cholangitis overlap syndrome","volume":"100","author":"A Floreani","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jhep.2005.11.037","article-title":"Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis: a foray across diagnostic boundaries","volume":"44","author":"AJ Czaja","year":"2006","journal-title":"J Hepatol"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0016-5085(94)90078-7","article-title":"Patterns of nuclear immunofluorescence and reactivities to recombinant nuclear antigens in autoimmune hepatitis","volume":"107","author":"AJ Czaja","year":"1994","journal-title":"Gastroenterology"},{"key":"ref111","first-page":"993","article-title":"Detection of antinuclear antibodies. Comparative evaluation of enzyme immunoassay and indirect immunofluorescence methods","volume":"122","author":"HA Homburger","year":"1998","journal-title":"Arch Pathol Lab Med"},{"key":"ref112","first-page":"266","article-title":"Anti-actin specificity of human smooth muscle antibodies in chronic active hepatitis","volume":"24","author":"K Lidman","year":"1976","journal-title":"Clin Exp Immunol"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1002\/hep.510230525","article-title":"Heat serum inactivation as a mandatory procedure for antiactin antibody detection in cell culture","volume":"23","author":"ELR Cancado","year":"1996","journal-title":"Hepatology"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/hep.20732","article-title":"Autoimmune hepatitis: effect of symptoms and cirrhosis on natural history and outcome","volume":"42","author":"JJ Feld","year":"2005","journal-title":"Hepatology"},{"key":"ref115","first-page":"331","article-title":"Prednisone for chronic active hepatitis: pharmacokinetics and serum binding in patients with chronic active hepatitis and steroid major side effects","volume":"6","author":"M Uribe","year":"1984","journal-title":"J Clin Gastroenterol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0092267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T14:50:37Z","timestamp":1565275837000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0092267"}},"subtitle":[],"editor":[{"given":"Matthias Johannes","family":"Schnell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,20]]},"references-count":115,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0092267","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,20]]}}}