{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:17:59Z","timestamp":1793067479957,"version":"4.5.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T00:00:00Z","timestamp":1397692800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0092449","type":"journal-article","created":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T20:11:04Z","timestamp":1397765464000},"page":"e92449","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":57,"title":["Anti-Cyclic Citrullinated Peptide Antibody Is Associated with Interstitial Lung Disease in Patients with Rheumatoid Arthritis"],"prefix":"10.1371","volume":"9","author":[{"given":"Yufeng","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangliang","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,4,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"FC Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1136\/ard.62.8.722","article-title":"Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years","volume":"62","author":"C Turesson","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/rheumatology\/keq035","article-title":"Interstitial lung disease has a poor prognosis in rheumatoid arthritis: results from an inception cohort","volume":"49","author":"G Koduri","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1164\/rccm.201004-0622OC","article-title":"Rheumatoid arthritis-interstitial lung disease-associated mortality","volume":"183","author":"AL Olson","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00002281-200405000-00007","article-title":"Management of extra-articular disease manifestations in rheumatoid arthritis","volume":"16","author":"C Turesson","year":"2004","journal-title":"Curr Opin Rheumatol"},{"key":"ref6","first-page":"1451","article-title":"Diagnostic value of anti-cyclic citrullinated Peptide antibody in patients with rheumatoid arthritis","volume":"30","author":"X Zeng","year":"2003","journal-title":"J Rheumatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/art.22089","article-title":"Association of anti-cyclic citrullinated peptide and anti-Sa\/citrullinated vimentin autoantibodies in rheumatoid arthritis","volume":"55","author":"M Rodriguez-Mahou","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","article-title":"Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis","volume":"48","author":"S Rantap\u00e4\u00e4-Dahlqvist","year":"2003","journal-title":"Arthritis & Rheumatism"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/1529-0131(200101)44:1<41::AID-ANR6>3.0.CO;2-0","article-title":"Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis","volume":"44","author":"CC Reparon-Schuijt","year":"2001","journal-title":"Arthritis Rheum"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/art.24390","article-title":"Association between anti-cyclic citrullinated peptide antibodies and ischemic heart disease in patients with rheumatoid arthritis","volume":"61","author":"FJ Lopez-Longo","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/art.24362","article-title":"Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis","volume":"60","author":"KP Liao","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10067-007-0800-1","article-title":"Anti-cyclic citrullinated peptide-2 (CCP2) autoantibodies and extra-articular manifestations in Greek patients with rheumatoid arthritis","volume":"27","author":"I Alexiou","year":"2008","journal-title":"Clin Rheumatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1136\/ard.2007.073718","article-title":"Association of anti-cyclic citrullinated peptide antibodies with subclinical atherosclerosis in patients with rheumatoid arthritis","volume":"67","author":"R Gerli","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/oxfordjournals.rheumatology.a031490","article-title":"Prognostic factors in early rheumatoid arthritis","volume":"39","author":"DL Scott","year":"2000","journal-title":"Rheumatology (Oxford)"},{"key":"ref15","first-page":"2074","article-title":"Rheumatoid factor and antibodies to cyclic citrullinated Peptide differentiate rheumatoid arthritis from undifferentiated polyarthritis in patients with early arthritis","volume":"29","author":"AL Jansen","year":"2002","journal-title":"J Rheumatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.clinbiochem.2008.06.014","article-title":"Anti-cyclic citrullinated peptide antibodies in lung diseases associated with rheumatoid arthritis","volume":"41","author":"N Inui","year":"2008","journal-title":"Clin Biochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.3899\/jrheum.111478","article-title":"Level of anticitrullinated peptide\/protein antibody is not associated with lung diseases in rheumatoid arthritis","volume":"39","author":"LH Jearn","year":"2012","journal-title":"J Rheumatol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3899\/jrheum.101261","article-title":"High levels of anti-cyclic citrullinated peptide autoantibodies are associated with co-occurrence of pulmonary diseases with rheumatoid arthritis","volume":"38","author":"F Aubart","year":"2011","journal-title":"J Rheumatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1164\/ajrccm.165.2.ats01","article-title":"American Thoracic Society\/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001","volume":"165","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/ard.49.11.916","article-title":"Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score","volume":"49","author":"DM van der Heijde","year":"1990","journal-title":"Ann Rheum Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/RHU.0b013e3181fe8ad1","article-title":"The safety and effectiveness of a chloroform\/methanol extract of Tripterygium wilfordii Hook F (T2) plus methotrexate in treating rheumatoid arthritis","volume":"16","author":"W Zhang","year":"2010","journal-title":"J Clin Rheumatol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"E41","DOI":"10.1002\/oby.20033","article-title":"VAT = TAAT-SAAT: innovative anthropometric model to predict visceral adipose tissue without resort to CT-Scan or DXA","volume":"21","author":"H Samouda","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1136\/bmj.2.4583.816","article-title":"Rheumatoid disease with joint and pulmonary manifestations","volume":"2","author":"P Ellman","year":"1948","journal-title":"Br Med J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1513\/pats.200703-045MS","article-title":"Rheumatoid lung disease","volume":"4","author":"KK Brown","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/ar3097","article-title":"Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management","volume":"12","author":"FV Castelino","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/ard.2004.021477","article-title":"Diagnostic value of anti-cyclic citrullinated peptide antibodies to detect rheumatoid arthritis in patients with Sjogren&apos;s syndrome","volume":"64","author":"C van Noord","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"ref27","first-page":"542","article-title":"Anti-cyclic citrullinated peptide antibody in systemic sclerosis","volume":"26","author":"Y Morita","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1136\/ard.2004.029603","article-title":"Anti-cyclic citrullinated peptide antibodies in patients with primary Sjogren&apos;s syndrome","volume":"64","author":"GJ Tobon","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/ard.2003.019794","article-title":"Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sjogren&apos;s syndrome","volume":"64","author":"JE Gottenberg","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/rheumatology\/keg466","article-title":"Reducing the risk of methotrexate pneumonitis in rheumatoid arthritis","volume":"43","author":"V Saravanan","year":"2004","journal-title":"Rheumatology (Oxford)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10067-005-1158-x","article-title":"Pulmonary involvement in lifelong non-smoking patients with rheumatoid arthritis and ankylosing spondylitis without respiratory symptoms","volume":"25","author":"FF Ayhan-Ardic","year":"2006","journal-title":"Clin Rheumatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.rmed.2012.07.006","article-title":"Different risk factors between interstitial lung disease and airway disease in rheumatoid arthritis","volume":"106","author":"S Mori","year":"2012","journal-title":"Respir Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/art.27405","article-title":"Incidence and mortality of interstitial lung disease in rheumatoid arthritis: a population-based study","volume":"62","author":"T Bongartz","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jbspin.2004.02.001","article-title":"Correlations between high-resolution computed tomography of the chest and clinical function in patients with rheumatoid arthritis. Prospective study in 75 patients","volume":"72","author":"SH Zrour","year":"2005","journal-title":"Joint Bone Spine"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1001\/archinternmed.2007.59","article-title":"Progressive preclinical interstitial lung disease in rheumatoid arthritis","volume":"168","author":"BR Gochuico","year":"2008","journal-title":"Arch Intern Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/rheumatology\/keq017","article-title":"Rheumatoid arthritis and interstitial lung disease","volume":"49","author":"G Brusselle","year":"2010","journal-title":"Rheumatology (Oxford)"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0092449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:24:34Z","timestamp":1588965874000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0092449"}},"subtitle":[],"editor":[{"given":"Song Guo","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,4,17]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0092449","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,17]]}}}