{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:46:45Z","timestamp":1767847605120,"version":"3.49.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0092603","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T03:48:05Z","timestamp":1395719285000},"page":"e92603","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Time-Lapse Imaging as a Tool to Investigate Contractility of the Epididymal Duct \u2013 Effects of Cgmp Signaling"],"prefix":"10.1371","volume":"9","author":[{"given":"Andrea","family":"Mietens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Tasch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Stammler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Konrad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Feuerstacke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Middendorff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"key":"ref1","first-page":"213","article-title":"New insights into epididymal biology and function","volume":"15(2)","author":"GA Cornwall","year":"2009","journal-title":"Hum Reprod Update"},{"key":"ref2","first-page":"229","article-title":"Structure and function of the epididymis","volume":"14(5)","author":"MJ Cosentino","year":"1986","journal-title":"Urol Res"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Robaire B, Hinton BT, Orgebin-Crist MC (2006) The epididymis. In: Neil J (ed), Knobile and Neill&apos;s Physiology of Reproduction, 3rd ed, San Diego CA, Elsevier 1071\u20131148.","DOI":"10.1016\/B978-012515400-0\/50027-0"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.1939-4640.1998.tb02463.x","article-title":"The autonomic innervation of the epididymis: its effects on epididymal function and fertility","volume":"19(1)","author":"DD Ricker","year":"1998","journal-title":"J Androl"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2605.1996.tb00530.x","article-title":"Neuronal input from the inferior mesenteric ganglion (IMG) affects sperm transport within the rat cauda epididymis","volume":"19(6)","author":"DD Ricker","year":"1996","journal-title":"Int J Androl"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1530\/jrf.0.0740497","article-title":"Enhancement of sperm transport through the rat epididymis after castration","volume":"74(2)","author":"S Sujarit","year":"1985","journal-title":"J Reprod Fertil"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF00331243","article-title":"Arrangement, ultrastructure, and adrenergic innervation of smooth musculature of the ductuli efferentes, ductus epididymidis and ductus deferens of man","volume":"120(1)","author":"HG Baumgarten","year":"1971","journal-title":"Z Zellforsch Mikrosk Anat"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1530\/rep.0.1240887","article-title":"Mediation of contraction in rat cauda epididymidis by alpha-adrenoceptors","volume":"124(6)","author":"G Chaturapanich","year":"2002","journal-title":"Reproduction"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/j.1939-4640.1984.tb02399.x","article-title":"Regulation of rat caput epididymidis contractility by prostaglandins","volume":"5(3)","author":"MJ Cosentino","year":"1984","journal-title":"J Androl"},{"key":"ref10","first-page":"3797","article-title":"Gene expression of endothelin-1, endothelin-converting enzyme-1, and endothelin receptors in human epididymis","volume":"82(11)","author":"A Peri","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1095\/biolreprod56.2.416","article-title":"Oxytocin and oxytocin receptor expression in reproductive tissues of the male marmoset monkey","volume":"56(2)","author":"A Einspanier","year":"1997","journal-title":"Biol Reprod"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0303-7207(02)00101-6","article-title":"Identification, localization and functional activity of oxytocin receptors in epididymis","volume":"193(1\u20132)","author":"S Filippi","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/1097-4652(200009)184:3<409::AID-JCP16>3.0.CO;2-K","article-title":"Molecular mechanism of cGMP-mediated smooth muscle relaxation","volume":"184(3)","author":"JA Carvajal","year":"2000","journal-title":"J Cell Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1095\/biolreprod.106.054577","article-title":"Mechanisms regulating spontaneous contractions in the bovine epididymal duct","volume":"75(4)","author":"M Mewe","year":"2006","journal-title":"Biol Reprod"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.mce.2011.09.039","article-title":"Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not","volume":"349(2)","author":"A Mietens","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1210\/en.2005-1324","article-title":"Regulation of spontaneous contractile activity in the bovine epididymal duct by cyclic guanosine 5\u2032-monophosphate-dependent pathways","volume":"147(4)","author":"M Mewe","year":"2006","journal-title":"Endocrinology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1046\/j.1365-2680.1998.18598.x","article-title":"Effect of calcium antagonists on the response to noradrenaline in the whole and bisected rat vas deferens","volume":"18(5)","author":"C Boselli","year":"1998","journal-title":"J Auton Pharmacol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0090-4295(99)00535-X","article-title":"Effects of antidepressants in adrenergic neurotransmission of human vas deferens","volume":"55(4)","author":"P Medina","year":"2000","journal-title":"Urology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1745-7262.2007.00302.x","article-title":"Segment boundaries of the adult rat epididymis limit interstitial signaling by potential paracrine factors and segments lose differential gene expression after efferent duct ligation","volume":"9(4)","author":"TT Turner","year":"2007","journal-title":"Asian J Andrology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/ar.1091750205","article-title":"The ultrastructure of the principal cells and intraepithelial leucocytes in the initial segment of the rat epididymis","volume":"175(2)","author":"AP Hoffer","year":"1973","journal-title":"Anat Rec"},{"key":"ref21","first-page":"ra27","article-title":"Male fertility fepends on Ca2+ absorption by TRPV6 in epididymal epithelia","volume":"4(171)","author":"P Weissgerber","year":"2011","journal-title":"Sci Signal"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1210\/en.143.1.23","article-title":"Central nervous system-specific glycosylation of the type A natriuretic peptide receptor","volume":"143(1)","author":"D M\u00fcller","year":"2002","journal-title":"Endocrinology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0169-328X(99)00324-1","article-title":"Guanylyl cyclase-B represents the predominant natriuretic peptide receptor expressed at exceptionally high levels in the pineal gland","volume":"75(2)","author":"D M\u00fcller","year":"2000","journal-title":"Brain Res Mol Brain Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1365-2605.2002.00323.x","article-title":"The effects of oxytocin and arginine vasopressin in vitro on epididymal contractility in the rat","volume":"25(2)","author":"PW Studdard","year":"2002","journal-title":"Int J Androl"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1530\/REP-07-0220","article-title":"Differential modulation of bovine epididymal activity by oxytocin and noradrenaline","volume":"134(3)","author":"M Mewe","year":"2007","journal-title":"Reproduction"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"R895","DOI":"10.1152\/ajpregu.00521.2007","article-title":"Erg K+ channels modulate contractile activity in the bovine epididymal duct","volume":"294(3)","author":"M Mewe","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1530\/jrf.0.0570423","article-title":"Spontaneous electrical activity of the rat epididymis in vitro","volume":"57(2)","author":"A Talo","year":"1979","journal-title":"J Reprod Fertil"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1530\/jrf.0.0710173","article-title":"Intraluminal pressures in the seminiferous tubules and in different regions of the epididymis in the rat","volume":"71(1)","author":"C Pholpramool","year":"1984","journal-title":"J Reprod Fertil"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1113\/jphysiol.1983.sp014590","article-title":"Movements of the luminal contents in two different regions of the caput epididymidis of the rat in vitro","volume":"336","author":"UM Jaakkola","year":"1983","journal-title":"J Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1530\/jrf.0.0680465","article-title":"Regional variations in transport of the luminal contents of the rat epididymis in vivo","volume":"68(2)","author":"UM Jaakkola","year":"1983","journal-title":"J Reprod Fertil"},{"key":"ref31","first-page":"33","article-title":"The dog as a model system to study epididymal gene expression","author":"R Ivell","year":"1998","journal-title":"J Reprod Fertil"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/gcen.1999.7445","article-title":"Localization of receptors for natriuretic peptide and endothelin in the duct of the epididymis of the freshwater turtle","volume":"118(1)","author":"SZ Kim","year":"2000","journal-title":"Gen Comp Endocrinol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1530\/REP-10-0517","article-title":"Cyclic GMP signaling in rat urinary bladder, prostate, and epididymis: tissue-specific changes with aging and in response to Leydig cell depletion","volume":"142(2)","author":"D M\u00fcller","year":"2011","journal-title":"Reproduction"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.regpep.2007.09.022","article-title":"ProCNP and CNP are expressed primarily in male genital organs","volume":"146(1\u20133)","author":"SJ Nielsen","year":"2008","journal-title":"Regul Pept"},{"key":"ref35","first-page":"234","article-title":"Neutral endopeptidase (CD10) is abundantly expressed in the epididymis and localized to a distinct population of epithelial cells - Its relevance for CNP degradation","volume":"382(1)","author":"A Thong","year":"2013","journal-title":"Mol Cell Endocrinol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1095\/biolreprod55.5.935","article-title":"Immunohistochemical localization of endothelial nitric oxide synthase in human testis, epididymis, and vas deferens suggests a possible role for nitric oxide in spermatogenesis, sperm maturation, and programmed cell death","volume":"55(5)","author":"A Zini","year":"1996","journal-title":"Biol Reprod"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF00297196","article-title":"Nitric oxide synthase activity in the human urogenital tract","volume":"22(5)","author":"I Ehr\u00e9n","year":"1994","journal-title":"Urol Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1210\/en.2003-1699","article-title":"Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa","volume":"145(5)","author":"A Morelli","year":"2004","journal-title":"Endocrinology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"S311","DOI":"10.1055\/s-2006-957199","article-title":"Treatment of pulmonary arterial hypertension: phosphodiesterase-5 inhibitors","volume":"131","author":"HA Ghofrani","year":"2006","journal-title":"Dtsch Med Wochenschr"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0092603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T09:34:29Z","timestamp":1716629669000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0092603"}},"subtitle":[],"editor":[{"given":"Laszlo","family":"Csernoch","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,24]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0092603","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,24]]}}}