{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:13:19Z","timestamp":1768093999342,"version":"3.49.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0092677","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T23:50:09Z","timestamp":1395705009000},"page":"e92677","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Expression of the sFLT1 Gene in Cord Blood Cells Is Associated to Maternal Arsenic Exposure and Decreased Birth Weight"],"prefix":"10.1371","volume":"9","author":[{"given":"Sylvie","family":"Remy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Govarts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbeth","family":"Bruckers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Paulussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britt","family":"Wens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elly Den","family":"Hond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Nelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willy","family":"Baeyens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"van Larebeke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilse","family":"Loots","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Sioen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greet","family":"Schoeters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/0960312021000000998","article-title":"Arsenic contamination in Bangladesh groundwater: a major environmental and social disaster","volume":"12","author":"MG Alam","year":"2002","journal-title":"Int J Environ Health Res"},{"key":"ref2","first-page":"14","article-title":"Arsenic and lead in juice: apple, citrus, and apple-base","volume":"75","author":"D Wilson","year":"2012","journal-title":"J Environ Health"},{"key":"ref3","first-page":"575","article-title":"Carcinogenic and systemic health effects associated with arsenic exposure\u2013a critical review","volume":"31","author":"PB Tchounwou","year":"2003","journal-title":"Toxicol Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0300-483X(02)00285-8","article-title":"Mechanisms of arsenic biotransformation","volume":"181\u2013182","author":"M Vahter","year":"2002","journal-title":"Toxicology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/toxsci\/44.2.185","article-title":"Exposure to inorganic arsenic metabolites during early human development","volume":"44","author":"G Concha","year":"1998","journal-title":"Toxicol Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1093\/jn\/137.12.2798","article-title":"Interactions between arsenic-induced toxicity and nutrition in early life","volume":"137","author":"ME Vahter","year":"2007","journal-title":"J Nutr"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Leonce J, Brockton N, Robinson S, Venkatesan S, Bannister P, et al. (2006) Glucose production in the human placenta. Placenta 27 Suppl A: S103\u2013S108.","DOI":"10.1016\/j.placenta.2006.02.006"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1053\/plac.1999.0448","article-title":"Glucose transporters in the human placenta","volume":"21","author":"NP Illsley","year":"2000","journal-title":"Placenta"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0002-9440(10)63803-5","article-title":"Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies","volume":"162","author":"E Jauniaux","year":"2003","journal-title":"Am J Pathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1210\/jcem.87.6.8563","article-title":"Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy","volume":"87","author":"GJ Burton","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.sste.2012.05.001","article-title":"When are fetuses and young children most susceptible to soil metal concentrations of arsenic, lead and mercury","volume":"3","author":"S McDermott","year":"2012","journal-title":"Spat Spatiotemporal Epidemiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1289\/ehp.11094","article-title":"Breast-feeding protects against arsenic exposure in Bangladeshi infants","volume":"116","author":"B Fangstrom","year":"2008","journal-title":"Environ Health Perspect"},{"key":"ref13","first-page":"89","article-title":"Decrease in birth weight and gestational age by arsenic among the newborn in Shanghai, China","volume":"58","author":"L Xu","year":"2011","journal-title":"Nihon Koshu Eisei Zasshi"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s12011-012-9396-7","article-title":"Prenatal exposure to arsenic and its effects on fetal development in the general population of Dalian","volume":"149","author":"H Guan","year":"2012","journal-title":"Biol Trace Elem Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/jat.2717","article-title":"Epigenetic targets of some toxicologically relevant metals: a review of the literature","volume":"32","author":"TF Cheng","year":"2012","journal-title":"J Appl Toxicol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0378-4274(01)00365-4","article-title":"Both hypomethylation and hypermethylation of DNA associated with arsenite exposure in cultures of human cells identified by methylation-sensitive arbitrarily-primed PCR","volume":"122","author":"CX Zhong","year":"2001","journal-title":"Toxicol Lett"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1289\/ehp.1104173","article-title":"Prenatal arsenic exposure and DNA methylation in maternal and umbilical cord blood leukocytes","volume":"120","author":"ML Kile","year":"2012","journal-title":"Environ Health Perspect"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e37147","DOI":"10.1371\/journal.pone.0037147","article-title":"Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA","volume":"7","author":"JR Pilsner","year":"2012","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1476-069X-11-31","article-title":"Effects of arsenic exposure on DNA methylation in cord blood samples from newborn babies and in a human lymphoblast cell line","volume":"11","author":"P Intarasunanont","year":"2012","journal-title":"Environ Health"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.tox.2007.03.021","article-title":"Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic","volume":"236","author":"Y Xie","year":"2007","journal-title":"Toxicology"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Gosse JA, Taylor VF, Jackson BP, Hamilton JW, Bodwell JE (2013) Monomethylated trivalent arsenic species disrupt steroid receptor interactions with their DNA response elements at non-cytotoxic cellular concentrations. J Appl Toxicol. doi:<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1002\/jat.2898\" xlink:type=\"simple\">10.1002\/jat.2898<\/ext-link>.","DOI":"10.1002\/jat.2898"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1021\/tx060122q","article-title":"Arsenic disruption of steroid receptor gene activation: Complex dose-response effects are shared by several steroid receptors","volume":"19","author":"JE Bodwell","year":"2006","journal-title":"Chem Res Toxicol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/toxsci\/61.2.314","article-title":"Stress-related gene expression in mice treated with inorganic arsenicals","volume":"61","author":"J Liu","year":"2001","journal-title":"Toxicol Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.taap.2007.01.018","article-title":"Transplacental exposure to inorganic arsenic at a hepatocarcinogenic dose induces fetal gene expression changes in mice indicative of aberrant estrogen signaling and disrupted steroid metabolism","volume":"220","author":"J Liu","year":"2007","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0891-5849(99)00186-0","article-title":"Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite","volume":"27","author":"A Barchowsky","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/(SICI)1097-4652(199611)169:2<256::AID-JCP5>3.0.CO;2-N","article-title":"Arsenite induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species","volume":"169","author":"TS Wang","year":"1996","journal-title":"J Cell Physiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-4274(01)00373-3","article-title":"Suppression of Fas ligand expression on endothelial cells by arsenite through reactive oxygen species","volume":"123","author":"SH Tsai","year":"2001","journal-title":"Toxicol Lett"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e207","DOI":"10.1371\/journal.pgen.0030207","article-title":"Activation of inflammation\/NF-kappaB signaling in infants born to arsenic-exposed mothers","volume":"3","author":"RC Fry","year":"2007","journal-title":"PLoS Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1289\/ehp.02110331","article-title":"Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water","volume":"110","author":"J Pi","year":"2002","journal-title":"Environ Health Perspect"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1476-069X-12-58","article-title":"Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study","volume":"12","author":"DL Fei","year":"2013","journal-title":"Environ Health"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ijheh.2011.11.006","article-title":"Concept of the Flemish human biomonitoring programme","volume":"215","author":"G Schoeters","year":"2012","journal-title":"Int J Hyg Environ Health"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.chemosphere.2007.11.053","article-title":"Internal exposure to pollutants measured in blood and urine of Flemish adolescents in function of area of residence","volume":"71","author":"C Schroijen","year":"2008","journal-title":"Chemosphere"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuroscience.2012.07.057","article-title":"Negative effects of ultrafine particle exposure during forced exercise on the expression of Brain-Derived Neurotrophic Factor in the hippocampus of rats","volume":"223","author":"I Bos","year":"2012","journal-title":"Neuroscience"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"J Vandesompele","year":"2002","journal-title":"Genome Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1186\/gb-2007-8-2-r19","article-title":"qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data","volume":"8","author":"J Hellemans","year":"2007","journal-title":"Genome Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"817","DOI":"10.2307\/1912934","article-title":"A Heteroskedasticity-Consistent Covariance-Matrix Estimator and A Direct Test for Heteroskedasticity","volume":"48","author":"H White","year":"1980","journal-title":"Econometrica"},{"key":"ref37","unstructured":"Neter J, Kutner MH, Wasserman W, Nachtsheim CJ (1996) Applied Linear Regression Models. McGraw Hill College."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations","volume":"51","author":"RM Baron","year":"1986","journal-title":"J Pers Soc Psychol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/01.RES.0000147365.86159.f5","article-title":"Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia","volume":"95","author":"S Ahmad","year":"2004","journal-title":"Circ Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1053\/j.semperi.2008.02.006","article-title":"Vasculogenesis and angiogenesis in the IUGR placenta","volume":"32","author":"JA Arroyo","year":"2008","journal-title":"Semin Perinatol"},{"key":"ref41","first-page":"349","article-title":"Metabolism of inorganic arsenic and non-cancerous health hazards associated with chronic exposure in humans","volume":"28","author":"CH Tseng","year":"2007","journal-title":"J Environ Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/HYPERTENSIONAHA.110.164079","article-title":"Expression of placental FLT1 transcript variants relates to both gestational hypertensive disease and fetal growth","volume":"58","author":"J Jebbink","year":"2011","journal-title":"Hypertension"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.placenta.2004.09.001","article-title":"Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women","volume":"26","author":"A Rajakumar","year":"2005","journal-title":"Placenta"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.ki.5002175","article-title":"Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1","volume":"71","author":"A Makris","year":"2007","journal-title":"Kidney Int"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/toxsci\/kfm162","article-title":"Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion","volume":"99","author":"W He","year":"2007","journal-title":"Toxicol Sci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/toxsci\/kfn236","article-title":"Arsenic and cardiovascular disease","volume":"107","author":"JC States","year":"2009","journal-title":"Toxicol Sci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1161\/01.HYP.33.1.74","article-title":"Hypertension and arsenic exposure in Bangladesh","volume":"33","author":"M Rahman","year":"1999","journal-title":"Hypertension"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1161\/01.CIR.0000015862.64816.B2","article-title":"Biological gradient between long-term arsenic exposure and carotid atherosclerosis","volume":"105","author":"CH Wang","year":"2002","journal-title":"Circulation"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0021-9150(98)00178-6","article-title":"Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure","volume":"141","author":"YM Hsueh","year":"1998","journal-title":"Atherosclerosis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0891-5849(00)00209-4","article-title":"Decreased serum concentrations of nitric oxide metabolites among Chinese in an endemic area of chronic arsenic poisoning in inner Mongolia","volume":"28","author":"J Pi","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"123717","DOI":"10.1155\/2011\/123717","article-title":"Disrupted balance of angiogenic and antiangiogenic signalings in preeclampsia","volume":"2011","author":"M Furuya","year":"2011","journal-title":"J Pregnancy"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.placenta.2013.09.015","article-title":"Evidence of sexual dimorphism in the placental function with severe preeclampsia","volume":"34","author":"S Muralimanoharan","year":"2013","journal-title":"Placenta"},{"key":"ref53","first-page":"418","article-title":"Gender-specific effect of overexpression of sFlt-1 in pregnant mice on fetal programming of blood pressure in the offspring later in life","volume":"197","author":"F Lu","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/01.HYP.0000053448.95913.3D","article-title":"Placental insufficiency leads to development of hypertension in growth-restricted offspring","volume":"41","author":"BT Alexander","year":"2003","journal-title":"Hypertension"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"R758","DOI":"10.1152\/ajpregu.00311.2006","article-title":"Testosterone contributes to marked elevations in mean arterial pressure in adult male intrauterine growth restricted offspring","volume":"292","author":"NB Ojeda","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0092677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T17:34:58Z","timestamp":1565285698000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0092677"}},"subtitle":[],"editor":[{"given":"Nick","family":"Ashton","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,24]]},"references-count":55,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0092677","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,24]]}}}