{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:51:41Z","timestamp":1789865501990,"version":"4.0.1"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T00:00:00Z","timestamp":1397001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0092762","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T20:36:43Z","timestamp":1397075803000},"page":"e92762","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Osteopontin Is Induced by TGF-\u03b22 and Regulates Metabolic Cell Activity in Cultured Human Optic Nerve Head Astrocytes"],"prefix":"10.1371","volume":"9","author":[{"given":"Carolin","family":"Neumann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Garreis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Paulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco T.","family":"Birke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"HA Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"ref2","first-page":"327","article-title":"Glaucoma and optic nerve repair. Cell Tissue Res","volume":"353(2)","author":"H Diekmann","year":"2013"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.neuro.051508.135728","article-title":"Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy","volume":"35","author":"RW Nickells","year":"2012","journal-title":"Annu Rev Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1167\/iovs.09-5101","article-title":"Qualitative and quantitative morphologic changes in the vasculature and extracellular matrix of the prelaminar optic nerve head in eyes with POAG","volume":"51","author":"OY Tektas","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2005.02.008","article-title":"Morphological changes in glaucomatous eyes and the role of TGFbeta2 for the pathogenesis of the disease","volume":"81","author":"E Lutjen-Drecoll","year":"2005","journal-title":"Exp Eye Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1167\/iovs.05-0289","article-title":"Pathophysiologic changes in the optic nerves of eyes with primary open angle and pseudoexfoliation glaucoma","volume":"46","author":"J Gottanka","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1167\/iovs.04-0649","article-title":"Transforming growth factor-beta 2 modulated extracellular matrix component expression in cultured human optic nerve head astrocytes","volume":"46","author":"R Fuchshofer","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1167\/iovs.07-1053","article-title":"The effect of TGF-beta2 on elastin, type VI collagen, and components of the proteolytic degradation system in human optic nerve astrocytes","volume":"49","author":"C Neumann","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1167\/iovs.06-0296","article-title":"Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma","volume":"48","author":"RJ Wordinger","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00441-011-1274-7","article-title":"The role of TGF-beta in the pathogenesis of primary open-angle glaucoma","volume":"347","author":"R Fuchshofer","year":"2012","journal-title":"Cell Tissue Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0014-4835(03)00220-3","article-title":"The effect of TGF-beta2 on human trabecular meshwork extracellular proteolytic system","volume":"77","author":"R Fuchshofer","year":"2003","journal-title":"Exp Eye Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s004170000252","article-title":"Transforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development","volume":"239","author":"G Picht","year":"2001","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1006\/exer.1994.1158","article-title":"Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2","volume":"59","author":"RC Tripathi","year":"1994","journal-title":"Exp Eye Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1741-7007-4-20","article-title":"Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma","volume":"4","author":"MG Anderson","year":"2006","journal-title":"BMC Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.exer.2010.09.001","article-title":"Loss of retinal function in aged DBA\/2J mice - New insights into retinal neurodegeneration","volume":"91","author":"P Heiduschka","year":"2010","journal-title":"Exp Eye Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0079-6123(08)01122-9","article-title":"Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection","volume":"173","author":"GR Howell","year":"2008","journal-title":"Prog Brain Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1167\/iovs.05-0925","article-title":"Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA\/2 mouse model of glaucoma","volume":"47","author":"DM Inman","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1083\/jcb.200506099","article-title":"Retinal ganglion cell degeneration is topological but not cell type specific in DBA\/2J mice","volume":"171","author":"TC Jakobs","year":"2005","journal-title":"J Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1167\/iovs.07-0745","article-title":"Dependency of intraocular pressure elevation and glaucomatous changes in DBA\/2J and DBA\/2J-Rj mice","volume":"49","author":"M Scholz","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1167\/iovs.10-5558","article-title":"Changes of osteopontin in the aqueous humor of the DBA2\/J glaucoma model correlated with optic nerve and RGC degenerations","volume":"51","author":"MT Birke","year":"2010","journal-title":"Investigative ophthalmology & visual science"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Wang KX, Denhardt DT (2008) Osteopontin: Role in immune regulation and stress responses. Cytokine Growth Factor Rev.","DOI":"10.1016\/j.cytogfr.2008.08.001"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1523\/JNEUROSCI.4805-06.2007","article-title":"Osteopontin-deficient mice exhibit less inflammation, greater tissue damage, and impaired locomotor recovery from spinal cord injury compared with wild-type controls","volume":"27","author":"M Hashimoto","year":"2007","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/ATVBAHA.107.144824","article-title":"Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease","volume":"27","author":"M Scatena","year":"2007","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Comi C, Carecchio M, Chiocchetti A, Nicola S, Galimberti D, et al. (2009) Osteopontin is Increased in the Cerebrospinal Fluid of Patients with Alzheimer\u2019s Disease and Its Levels Correlate with Cognitive Decline. J Alzheimers Dis.","DOI":"10.3233\/JAD-2010-1309"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.brainres.2006.08.036","article-title":"Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson\u2019s disease","volume":"1118","author":"J Iczkiewicz","year":"2006","journal-title":"Brain Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.brainres.2005.12.013","article-title":"Increased expression of osteopontin in the brain with scrapie infection","volume":"1072","author":"JK Jin","year":"2006","journal-title":"Brain Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.nbd.2006.10.020","article-title":"Osteopontin is elevated in Parkinson\u2019s disease and its absence leads to reduced neurodegeneration in the MPTP model","volume":"25","author":"W Maetzler","year":"2007","journal-title":"Neurobiol Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/sj.jcbfm.9600022","article-title":"Neuroprotection by osteopontin in stroke","volume":"25","author":"R Meller","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1093\/brain\/awl094","article-title":"Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice","volume":"129","author":"M Schroeter","year":"2006","journal-title":"Brain : a journal of neurology"},{"key":"ref30","first-page":"913","article-title":"Multiple sclerosis: a complicated picture of autoimmunity","volume":"8","author":"HF McFarland","year":"2007"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.exer.2006.12.008","article-title":"Hypoxia\/reoxygenation and TGF-beta increase alphaB-crystallin expression in human optic nerve head astrocytes","volume":"84","author":"AL Yu","year":"2007","journal-title":"Experimental eye research"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"MW Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.271.5248.509","article-title":"Receptor-ligand interaction between CD44 and osteopontin (Eta-1)","volume":"271","author":"GF Weber","year":"1996","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1167\/iovs.10-5679","article-title":"TGF-{beta}2 induces senescence-associated changes in human trabecular meshwork cells","volume":"51","author":"AL Yu","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1167\/iovs.03-0796","article-title":"Effects of TGF-beta2 in perfused human eyes","volume":"45","author":"J Gottanka","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1210\/endo.137.5.8612558","article-title":"Insulin-like growth factor I-enhanced renal expression of osteopontin after acute ischemic injury in rats","volume":"137","author":"BJ Padanilam","year":"1996","journal-title":"Endocrinology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3748\/wjg.v10.i2.205","article-title":"Enhancement of osteopontin expression in HepG2 cells by epidermal growth factor via phosphatidylinositol 3-kinase signaling pathway","volume":"10","author":"GX Zhang","year":"2004","journal-title":"World J Gastroenterol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"13916","DOI":"10.1016\/S0021-9258(18)68331-0","article-title":"Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor","volume":"263","author":"M Noda","year":"1988","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1359\/JBMR.041004","article-title":"Upregulation of osteopontin by osteocytes deprived of mechanical loading or oxygen","volume":"20","author":"TS Gross","year":"2005","journal-title":"J Bone Miner Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-006-9368-3","article-title":"Osteopontin and cardiovascular system","volume":"300","author":"H Okamoto","year":"2007","journal-title":"Mol Cell Biochem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s00109-005-0008-2","article-title":"Gene expression profiling of human alveolar macrophages of phenotypically normal smokers and nonsmokers reveals a previously unrecognized subset of genes modulated by cigarette smoking","volume":"84","author":"A Heguy","year":"2006","journal-title":"J Mol Med (Berl)"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Denhardt DT, Noda M (1998) Osteopontin expression and function: role in bone remodeling. J Cell Biochem Suppl 30\u201331: 92\u2013102.","DOI":"10.1002\/(SICI)1097-4644(1998)72:30\/31+<92::AID-JCB13>3.0.CO;2-A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0304-3940(99)00526-1","article-title":"Transient upregulation of osteopontin mRNA in hippocampus and striatum following global forebrain ischemia in rats","volume":"271","author":"MY Lee","year":"1999","journal-title":"Neurosci Lett"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1167\/iovs.07-0726","article-title":"Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuries","volume":"49","author":"G Chidlow","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/glia.21155","article-title":"GDNF-induced osteopontin from Muller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration","volume":"59","author":"P Del Rio","year":"2011","journal-title":"Glia"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Wahl V, Vogler S, Grosche A, Pannicke T, Ueffing M, et al. (2013) Osteopontin inhibits osmotic swelling of retinal glial (Muller) cells by inducing release of VEGF. Neuroscience.","DOI":"10.1016\/j.neuroscience.2013.04.045"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/jcb.21558","article-title":"Control of osteopontin signaling and function by post-translational phosphorylation and protein folding","volume":"102","author":"CC Kazanecki","year":"2007","journal-title":"J Cell Biochem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1350-9462(99)00017-8","article-title":"The optic nerve head in glaucoma: role of astrocytes in tissue remodeling","volume":"19","author":"MR Hernandez","year":"2000","journal-title":"Prog Retin Eye Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0079-6123(08)01125-4","article-title":"Astrocytes in glaucomatous optic neuropathy","volume":"173","author":"MR Hernandez","year":"2008","journal-title":"Prog Brain Res"},{"key":"ref50","first-page":"2303","article-title":"Increased elastin expression in astrocytes of the lamina cribrosa in response to elevated intraocular pressure","volume":"42","author":"JD Pena","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1167\/iovs.12-9681","article-title":"Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow","volume":"53","author":"P Iyer","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.exer.2009.01.008","article-title":"Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells","volume":"88","author":"B Junglas","year":"2009","journal-title":"Exp Eye Res"},{"key":"ref53","first-page":"131","article-title":"Of mice and men. The function of plasminogen activator inhibitors (PAIs) in vivo","volume":"425","author":"DT Eitzman","year":"1997","journal-title":"Adv Exp Med Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1167\/iovs.08-1961","article-title":"Reactivation of optic nerve head astrocytes by TGF-beta2 and H2O2 is accompanied by increased Hsp32 and Hsp47 expression","volume":"50","author":"AL Yu","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1165\/rcmb.2008-0307OC","article-title":"Osteopontin induces airway remodeling and lung fibroblast activation in a murine model of asthma","volume":"41","author":"M Kohan","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e251","DOI":"10.1371\/journal.pmed.0020251","article-title":"Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis","volume":"2","author":"A Pardo","year":"2005","journal-title":"PLoS Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.ajpath.2011.01.048","article-title":"Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosis","volume":"178","author":"T Sabo-Attwood","year":"2011","journal-title":"Am J Pathol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1172\/JCI37662","article-title":"Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-beta","volume":"119","author":"SA Vetrone","year":"2009","journal-title":"J Clin Invest"},{"key":"ref59","first-page":"493043","article-title":"Osteopontin and other regulators of angiogenesis and fibrogenesis in the vitreous from patients with proliferative vitreoretinal disorders","volume":"2012","author":"AM Abu El-Asrar","year":"2012","journal-title":"Mediators of inflammation"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1167\/iovs.02-0873","article-title":"Osteopontin: a component of matrix in capsular opacification and subcapsular cataract","volume":"44","author":"S Saika","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0002-9394(14)75984-7","article-title":"Changes in the extracellular matrix of the human optic nerve head in primary open-angle glaucoma","volume":"109","author":"MR Hernandez","year":"1990","journal-title":"Am J Ophthalmol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1042\/CBI20120172","article-title":"Osteopontin alters the functional profile of porcine microglia in vitro","volume":"36","author":"BR Tambuyzer","year":"2012","journal-title":"Cell Biol Int"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1128\/MCB.20.8.2734-2742.2000","article-title":"Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage colony-stimulating factor","volume":"20","author":"YH Lin","year":"2000","journal-title":"Mol Cell Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0092762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T05:56:19Z","timestamp":1648792579000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0092762"}},"subtitle":[],"editor":[{"given":"Raghavan","family":"Raju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,4,9]]},"references-count":63,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0092762","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,9]]}}}