{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:37:22Z","timestamp":1790105842882,"version":"4.0.1"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0092966","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T17:15:48Z","timestamp":1395767748000},"page":"e92966","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":79,"title":["Depletion of White Adipose Tissue in Cancer Cachexia Syndrome Is Associated with Inflammatory Signaling and Disrupted Circadian Regulation"],"prefix":"10.1371","volume":"9","author":[{"given":"Maria","family":"Tsoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Schweiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne S.","family":"Vanniasinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arran","family":"Painter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Zechner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1136\/bmj.315.7117.1219","article-title":"ABC of palliative care. Anorexia, cachexia, and nutrition","volume":"315","author":"E Bruera","year":"1997","journal-title":"Br Med J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000073337","article-title":"What we have learned about cachexia in gastrointestinal cancer","volume":"21","author":"JA Palesty","year":"2003","journal-title":"Dig Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e41883","DOI":"10.1371\/journal.pone.0041883","article-title":"The relationships between body composition and the systemic inflammatory response in patients with primary operable colorectal cancer","volume":"7","author":"CH Richards","year":"2012","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2174\/1389450043490505","article-title":"The pharmacological treatment of cachexia","volume":"5","author":"JM Argiles","year":"2004","journal-title":"Curr Drug Targets"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0149-2918(05)80001-3","article-title":"Prognostic effect of weight loss prior to chemotherapy in cancer patients","volume":"69","author":"WD Dewys","year":"1980","journal-title":"Am J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/MOG.0b013e3283347e77","article-title":"Cancer cachexia","volume":"26","author":"MJ Tisdale","year":"2010","journal-title":"Curr Opin Gastroenterol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"KC Fearon","year":"2012","journal-title":"Cell Metab"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1158\/0008-5472.CAN-11-3536","article-title":"Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice","volume":"72","author":"M Tsoli","year":"2012","journal-title":"Cancer Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1038\/sj.bjc.6605665","article-title":"Adipose tissue pathways involved in weight loss of cancer cachexia","volume":"102","author":"I Dahlman","year":"2010","journal-title":"Br J Cancer"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/JES.0b013e3181f44f11","article-title":"Interleukin 6 as a key regulator of muscle mass during cachexia","volume":"38","author":"JA Carson","year":"2010","journal-title":"Exerc Sport Sci Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"E155","DOI":"10.1152\/ajpendo.00257.2004","article-title":"Acute IL-6 treatment increases fatty acid turnover in elederly humans in vivo and in tissue culture in vitro","volume":"288","author":"EW Petersen","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1172\/JCI115767","article-title":"Evidence for the involvement of interleukin 6 in experimental cancer cachexia","volume":"89","author":"G Strassman","year":"1992","journal-title":"Journal of Clinical Investigation"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1172\/JCI116816","article-title":"Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo","volume":"92","author":"G Strassman","year":"1993","journal-title":"J Clin Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"E410","DOI":"10.1152\/ajpendo.00039.2012","article-title":"JAK\/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia","volume":"303","author":"A Bonetto","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Johnston JD, Frost G, Otway DT (2009) Adipose tissue, adipocytes and the circadian timing system. Obes Rev 10 52\u201360.","DOI":"10.1111\/j.1467-789X.2009.00665.x"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tem.2011.10.005","article-title":"Regulation of metabolism: the circadian clock dictates the time","volume":"23","author":"S Sahar","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1755-8794-2-7","article-title":"Diurnal variation of the human adipose transcriptome and the link to metabolic disease","volume":"2","author":"A Loboda","year":"2009","journal-title":"BMC Med Genomics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.cell.2006.06.050","article-title":"Nuclear receptor expression links the circadian clock to metabolism","volume":"126","author":"X Yang","year":"2006","journal-title":"Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1073\/pnas.1018375108","article-title":"Disruption of circadian clocks has ramifications for metabolism, brain, and behavior","volume":"108","author":"IN Karatsoreos","year":"2011","journal-title":"Proc Nat Acad Sci USA"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrendo.2009.23","article-title":"Effects of poor and short sleep on glucose metabolism and obesity risk","volume":"5","author":"K Spiegel","year":"2009","journal-title":"Nat Rev Endocrinol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/sj.ijo.0803689","article-title":"Clock genes are implicated in the human metabolic syndrome","volume":"32","author":"P G\u00f3mez-Abell\u00e1n","year":"2008","journal-title":"Int J Obes (Lond)"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/CS20100327","article-title":"The circadian clock and metabolism","volume":"120","author":"O Froy","year":"2011","journal-title":"Clin Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/S1389-9457(08)70013-3","article-title":"Metabolic consequences of sleep and sleep loss","volume":"9","author":"E Van Cauter","year":"2008","journal-title":"Sleep Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1198973","article-title":"Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia","volume":"333","author":"SK Das","year":"2011","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1002\/cncr.23802","article-title":"Lipolysis-Not inflammation, cell death, or lipogenesis-Is involved in adipose tissue loss in cancer cachexia","volume":"113","author":"M Ryd\u00e9n","year":"2008","journal-title":"Cancer"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3109\/13813455.2011.560609","article-title":"Altered expression of genes in adipose tissues associated with reduced fat mass in patients with pancreatic cancer","volume":"1172","author":"F Haugen","year":"2011","journal-title":"Arch Physiol Biochem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cmet.2011.12.018","article-title":"Fat Signals\u2013lipases and lipolysis in lipid metabolism and signaling","volume":"15","author":"R Zechner","year":"2012","journal-title":"Cell Metab"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1002\/cncr.21013","article-title":"Body composition and time course changes in regional distribution of fat and lean tissue in unselected cancer patients on palliative care\u2013correlations with food intake, metabolism, exercise capacity, and hormones","volume":"103","author":"M Fouladiun","year":"2005","journal-title":"Cancer"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Ryd\u00e9n M, Arner P (2007) Fat loss in cachexia\u2013is there a role for adipocyte lipolysis? Clin Nutr. 1\u20136.","DOI":"10.1016\/j.clnu.2006.09.009"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1242\/dmm.008839","article-title":"Importance of functional and metabolic impairements in the characterisation of the C-26 murine model of cancer cachexia","volume":"5","author":"KT Murphy","year":"2012","journal-title":"Dis Model Mech"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Zhou X, Wang JL, Lu J, Song Y, Kwak KS, <etal>et al<\/etal>.. (2010) Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell. 531\u2013543.","DOI":"10.1016\/j.cell.2010.07.011"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism","volume":"1","author":"BB Kahn","year":"2007","journal-title":"Cell Metab"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/oby.2009.276","article-title":"High-fat Diet Followed by Fasting Disrupts Circadian Expression of Adiponectin Signaling Pathway in Muscle and Adipose Tissue","volume":"18","author":"M Barnea","year":"2010","journal-title":"Obesity"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.bjc.6603360","article-title":"Adipose atrophy in cancer cachexia: morphologic and molecular analysis of adipose tissue in tumour-bearing mice","volume":"95","author":"C Bing","year":"2006","journal-title":"Br J Cancer"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1111\/j.1349-7006.2010.01582.x","article-title":"Role of beta1-adrenoceptor in increased lipolysis in cancer cachexia","volume":"101","author":"D-X Cao","year":"2010","journal-title":"Cancer Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2044-5040-1-2","article-title":"Treating cancer cachexia to treat cancer","volume":"1","author":"S-E Lee","year":"2011","journal-title":"Skelet Muscle"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.critrevonc.2010.10.004","article-title":"Cancer cachexia: A systematic literature review of items and domains associated with involuntary weight loss in cancer","volume":"80","author":"D Blum","year":"2011","journal-title":"Cr Rev Oncol-Hem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e22538","DOI":"10.1371\/journal.pone.0022538","article-title":"STAT3 activation in skeletal muscle links muscle wasting and tehacute phase response in cancer cachexia","volume":"6","author":"A Bonetto","year":"2011","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S0006-291X(02)00230-9","article-title":"Intracerebroventricular interleukin-6 treatment decreases body fat in rats","volume":"293","author":"K Wallenius","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"962","DOI":"10.2337\/diabetes.55.04.06.db05-0873","article-title":"Characterization of peripheral circadian clocks in adipose tissues","volume":"55","author":"S Zvonic","year":"2006","journal-title":"Diabetes"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Batista ML, Neves RX, Peres SB, Yamashita AS, Shida CS, <etal>et al<\/etal>.. (2012) Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia. J Endocrinol. 363\u2013373.","DOI":"10.1530\/JOE-12-0307"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1126\/science.1209418","article-title":"Medicine. Lipases in cachexia","volume":"333","author":"P Arner","year":"2011","journal-title":"Science"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1056\/NEJMcibr1106880","article-title":"Cancer cachexia and fat-muscle physiology","volume":"365","author":"KC Fearon","year":"2011","journal-title":"N Engl J Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jnutbio.2010.03.005","article-title":"ATGL and HSL are not coordinately regulated in response to fuel partitioning in fasted rats","volume":"22","author":"F Bertile","year":"2011","journal-title":"J Nutr Biochem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1113\/jphysiol.2006.113217","article-title":"AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues","volume":"574","author":"B Xue","year":"2006","journal-title":"J Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.cmet.2011.05.002","article-title":"Desnutrin\/ATGL is regulated by AMPK and is required for a brown adipose phenotype","volume":"13","author":"M Ahmadian","year":"2011","journal-title":"Cell Metab"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism","volume":"1","author":"BB Kahn","year":"2005","journal-title":"Cell Metab"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.bbrc.2004.05.188","article-title":"AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise","volume":"320","author":"M Kelly","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s11745-010-3488-y","article-title":"mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes","volume":"45","author":"G Soliman","year":"2010","journal-title":"Lipids"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"E413","DOI":"10.1210\/jc.2009-2534","article-title":"Identification of adipocyte gens regulated by caloric intake","volume":"96","author":"N Franck","year":"2011","journal-title":"J Clin Endocr Metab"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0092966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T18:35:12Z","timestamp":1565289312000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0092966"}},"subtitle":[],"editor":[{"given":"Harpal Singh","family":"Randeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0092966","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,25]]}}}