{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:16:20Z","timestamp":1791288980136,"version":"4.3.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T00:00:00Z","timestamp":1397692800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0094106","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T00:23:35Z","timestamp":1397780615000},"page":"e94106","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Soluble CEACAM8 Interacts with CEACAM1 Inhibiting TLR2-Triggered Immune Responses"],"prefix":"10.1371","volume":"9","author":[{"given":"Bernhard B.","family":"Singer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Opp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annina","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Binding-Liermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Carlos","family":"Berrocal-Almanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin A.","family":"Heyl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario M.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Weimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Zweigner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortense","family":"Slevogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,4,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1128\/IAI.00832-08","article-title":"Neutrophil recruitment to the lungs during bacterial pneumonia","volume":"77","author":"A Craig","year":"2009","journal-title":"Infect Immun"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1165\/rcmb.2011-0011RT","article-title":"Innate immunity in the respiratory epithelium","volume":"45","author":"D Parker","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","author":"A Mantovani","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1189\/jlb.0911483","article-title":"CD66b overexpression and homotypic aggregation of human peripheral blood neutrophils after activation by a gram-positive stimulus","volume":"91","author":"T Schmidt","year":"2012","journal-title":"J Leukoc Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.4049\/jimmunol.168.10.5139","article-title":"Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes","volume":"168","author":"BB Singer","year":"2002","journal-title":"J Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e8747","DOI":"10.1371\/journal.pone.0008747","article-title":"Deregulation of the CEACAM expression pattern causes undifferentiated cell growth in human lung adenocarcinoma cells","volume":"5","author":"BB Singer","year":"2010","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nri1864","article-title":"CEACAM1: contact-dependent control of immunity","volume":"6","author":"SD Gray-Owen","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"C1690","DOI":"10.1152\/ajpcell.00384.2006","article-title":"The actin cytoskeleton regulates exocytosis of all neutrophil granule subsets","volume":"292","author":"NR Jog","year":"2007","journal-title":"American Journal of Physiology - Cell Physiology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/jlb.52.5.551","article-title":"Augmented expression and release of nonspecific cross-reacting antigens (NCAs), members of the CEA family, by human neutrophils during cell activation","volume":"52","author":"M Kuroki","year":"1992","journal-title":"J Leukoc Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3109\/08820139509060710","article-title":"Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils","volume":"24","author":"M Kuroki","year":"1995","journal-title":"Immunol Invest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"8454","DOI":"10.4049\/jimmunol.179.12.8454","article-title":"CD66b Regulates Adhesion and Activation of Human Eosinophils","volume":"179","author":"J Yoon","year":"2007","journal-title":"The Journal of Immunology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2567.2009.03153.x","article-title":"Identification of leucocyte surface protein interactions by high-throughput screening with multivalent reagents","volume":"129","author":"L Jiang","year":"2010","journal-title":"Immunology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1462-5822.2010.01546.x","article-title":"Multicomponent Moraxella catarrhalis outer membrane vesicles induce an inflammatory response and are internalized by human epithelial cells","volume":"13","author":"V Schaar","year":"2011","journal-title":"Cell Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.1462-5822.2006.00821.x","article-title":"Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory immune response","volume":"9","author":"H Slevogt","year":"2007","journal-title":"Cellular microbiology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/ni.1661","article-title":"CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells","volume":"9","author":"H Slevogt","year":"2008","journal-title":"Nature immunology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"8053","DOI":"10.4049\/jimmunol.181.11.8053","article-title":"Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases","volume":"181","author":"D Hartl","year":"2008","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1164\/rccm.201202-0320ST","article-title":"An official American Thoracic Society clinical practice guideline: the clinical utility of bronchoalveolar lavage cellular analysis in interstitial lung disease","volume":"185","author":"KC Meyer","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1055\/s-2007-991527","article-title":"Bronchoalveolar Lavage as a Diagnostic Tool","volume":"28","author":"KC Meyer","year":"2007","journal-title":"Semin Respir Crit Care Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"L818","DOI":"10.1152\/ajplung.00428.2005","article-title":"Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reduction","volume":"290","author":"H Slevogt","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/j.1365-2141.2004.04963.x","article-title":"Subcellular localization and mobilization of carcinoembryonic antigen-related cell adhesion molecule 8 in human neutrophils","volume":"125","author":"L Zhao","year":"2004","journal-title":"Br J Haematol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/1471-2148-7-196","article-title":"Species-specific evolution of immune receptor tyrosine based activation motif-containing CEACAM1-related immune receptors in the dog","volume":"7","author":"R Kammerer","year":"2007","journal-title":"BMC Evol Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.4049\/jimmunol.0803044","article-title":"Bacterial DNA Activates Endothelial Cells and Promotes Neutrophil Adherence through TLR9 Signaling","volume":"182","author":"D El Kebir","year":"2009","journal-title":"The Journal of Immunology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.4049\/jimmunol.172.8.4956","article-title":"Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival","volume":"172","author":"MP Radsak","year":"2004","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1172\/JCI119523","article-title":"CPG-ODN motifs in bacterial DNA cause inflammation in the lower respiratory tract","volume":"100","author":"DA Schwartz","year":"1997","journal-title":"J Clin Invest"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-2249.2011.04433.x","article-title":"Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis","volume":"165","author":"AM Shields","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1189\/jlb.0109037","article-title":"Pivotal Advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner","volume":"86","author":"EO Lobo","year":"2009","journal-title":"J Leukoc Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.immuni.2010.10.009","article-title":"Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 Regulates Granulopoiesis by Inhibition of Granulocyte Colony-Stimulating Factor Receptor","volume":"33","author":"H Pan","year":"2010","journal-title":"Immunity"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e1002597","DOI":"10.1371\/journal.ppat.1002597","article-title":"CEACAM1 Negatively Regulates IL-1\u03b2 Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex","volume":"8","author":"R Lu","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1189\/jlb.1202594","article-title":"CEACAM1 is a potent regulator of B cell receptor complex-induced activation","volume":"74","author":"G Greicius","year":"2003","journal-title":"J Leukoc Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3664::AID-IMMU3664>3.0.CO;2-D","article-title":"Biliary glycoprotein (CD66a), a cell adhesion molecule of the immunoglobulin superfamily, on human lymphocytes: structure, expression and involvement in T cell activation","volume":"28","author":"R Kammerer","year":"1998","journal-title":"Eur J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0094106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T17:05:13Z","timestamp":1565370313000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0094106"}},"subtitle":[],"editor":[{"given":"Dat Quoc","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,4,17]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0094106","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,17]]}}}