{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:27:51Z","timestamp":1773408471918,"version":"3.50.1"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0094122","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T21:48:42Z","timestamp":1396993722000},"page":"e94122","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Sample Limited Characterization of a Novel Disulfide-Rich Venom Peptide Toxin from Terebrid Marine Snail Terebra variegata"],"prefix":"10.1371","volume":"9","author":[{"given":"Prachi","family":"Anand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Grigoryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed H.","family":"Bhuiyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrix","family":"Ueberheide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Quino\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Moy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian T.","family":"Chait","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien F.","family":"Poget","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mand\u00eb","family":"Holford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,4,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.toxicon.2011.03.017","article-title":"From snake venom toxins to therapeutics\u2013cardiovascular examples","volume":"59","author":"CY Koh","year":"2012","journal-title":"Toxicon"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-ento-120811-153650","article-title":"Spider-venom peptides: structure, pharmacology, and potential for control of insect pests","volume":"58","author":"GF King","year":"2013","journal-title":"Annu Rev Entomol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.2174\/156802612802652457","article-title":"Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)","volume":"12","author":"I Vetter","year":"2012","journal-title":"Curr Top Med Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1517\/14712598.2011.621940","article-title":"Venoms as a platform for human drugs: translating toxins into therapeutics","volume":"11","author":"GF King","year":"2011","journal-title":"Expert Opin Biol Ther"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jmb.2006.03.017","article-title":"Structural classification of small, disulfide-rich protein domains","volume":"359","author":"S Cheek","year":"2006","journal-title":"J Mol Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1161\/01.HYP.17.4.589","article-title":"History of the design of captopril and related inhibitors of angiotensin converting enzyme","volume":"17","author":"DW Cushman","year":"1991","journal-title":"Hypertension"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.2174\/0929867043363884","article-title":"Ziconotide: Neuronal Calcium Channel Blocker for Treating Severe Chronic Pain","volume":"11","author":"GP Miljanich","year":"2004","journal-title":"Curr Med Chem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.toxicon.2012.04.340","article-title":"Towards an integrated venomics approach for accelerated conopeptide discovery","volume":"60","author":"JR Prashanth","year":"2012","journal-title":"Toxicon"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"13315","DOI":"10.1074\/jbc.R109.076596","article-title":"Use of venom peptides to probe ion channel structure and function","volume":"285","author":"S Dutertre","year":"2010","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.toxicon.2006.01.020","article-title":"Mass spectrometry strategies for venom mapping and peptide sequencing from crude venoms: Case applications with single arthropod specimen","volume":"47","author":"P Favreau","year":"2006","journal-title":"Toxicon"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.coph.2009.05.006","article-title":"Marine snail venoms: use and trends in receptor and channel neuropharmacology","volume":"9","author":"P Favreau","year":"2009","journal-title":"Curr Opinion Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jms.1389","article-title":"Venomics: unravelling the complexity of animal venoms with mass spectrometry","volume":"43","author":"P Escoubas","year":"2008","journal-title":"J Mass Spectrom"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00726-010-0516-4","article-title":"Venomics: a new paradigm for natural products-based drug discovery","volume":"40","author":"I Vetter","year":"2011","journal-title":"Amino Acids"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1021\/pr070142t","article-title":"New Method for Characterizing Highly Disulfide-Bridged Peptides in Complex Mixtures: Application to Toxin Identification from Crude research articles","volume":"6","author":"L Quinton","year":"2007","journal-title":"J Proteome Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1021\/pr901032r","article-title":"Proteomic analysis provides insights on venom processing in Conus textile","volume":"9","author":"LL Tayo","year":"2010","journal-title":"J Proteome Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1039\/c3mb25534d","article-title":"Rapid mass spectrometric determination of disulfide connectivity in peptides and proteins","volume":"9","author":"M Bhattacharyya","year":"2013","journal-title":"Mol Biosyst"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1021\/pr300312h","article-title":"Constrained de novo sequencing of conotoxins","volume":"11","author":"S Bhatia","year":"2012","journal-title":"J Proteome Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ympev.2012.03.001","article-title":"Macroevolution of venom apparatus innovations in auger snails (Gastropoda; Conoidea; Terebridae)","volume":"64","author":"M Castelin","year":"2012","journal-title":"Mol Phylogenet Evol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/molbev\/msn211","article-title":"Evolution of the Toxoglossa venom apparatus as inferred by molecular phylogeny of the Terebridae","volume":"26","author":"M Holford","year":"2009","journal-title":"Mol Biol Evol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1124\/mi.7.5.7","article-title":"Diversity of the neurotoxic Conus peptides","volume":"7","author":"BM Olivera","year":"2007","journal-title":"Mol Interv"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"31173","DOI":"10.1074\/jbc.R600020200","article-title":"Conus peptides: biodiversity-based discovery and exogenomics","volume":"281","author":"BM Olivera","year":"2006","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1152\/physrev.00020.2003","article-title":"Conus venoms: a rich source of novel ion channel-targeted peptides","volume":"84","author":"H Terlau","year":"2004","journal-title":"Physiol Rev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.1111\/j.1742-4658.2006.05493.x","article-title":"Characterization of novel M-superfamily conotoxins with new disulfide linkage","volume":"273","author":"Y-H Han","year":"2006","journal-title":"FEBS J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cbpa.2008.07.012","article-title":"Integrating the discovery pipeline for novel compounds targeting ion channels","volume":"12","author":"G Bulaj","year":"2008","journal-title":"Curr Opin Chem Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0041-0101(03)00169-7","article-title":"The augertoxins: biochemical characterization of venom components from the toxoglossate gastropod <italic>Terebra subulata<\/italic>","volume":"41","author":"JS Imperial","year":"2003","journal-title":"Toxicon"},{"key":"ref26","first-page":"744","article-title":"Venomous Auger Snail Hastula (Impages ) hectica (Linnaeus, 1758 ): Molecular Phylogeny, Foregut Anatomy and Comparative Toxinology","volume":"308B","author":"JS Imperial","year":"2007"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.1073\/pnas.0900745106","article-title":"Rapid sensitive analysis of cysteine rich peptide venom components","volume":"106","author":"BM Ueberheide","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"8082","DOI":"10.1021\/ac0607764","article-title":"De Novo Sequencing and Disulfide Mapping of a Bromotryptophan-Containing Conotoxin by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry","volume":"78","author":"SS Nair","year":"2006","journal-title":"Anal Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1021\/ac0494376","article-title":"Sequencing and mass profiling highly modified conotoxins using global reduction\/alkylation followed by mass spectrometry","volume":"76","author":"JA Jakubowski","year":"2004","journal-title":"Anal Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"48188","DOI":"10.1074\/jbc.M308771200","article-title":"Disulfide Mapping of the Cyclotide Kalata B1","volume":"278","author":"U Goransson","year":"2003","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"8176","DOI":"10.1021\/bi047541b","article-title":"Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms","volume":"44","author":"GP Corpuz","year":"2005","journal-title":"Biochemistry"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"17596","DOI":"10.1074\/jbc.M309654200","article-title":"The A-superfamily of conotoxins: structural and functional divergence","volume":"279","author":"AD Santos","year":"2004","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1111\/j.1742-4658.2007.05795.x","article-title":"Solution structure of an M-1 conotoxin with a novel disulfide linkage","volume":"274","author":"W-H Du","year":"2007","journal-title":"FEBS J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1021\/bi0353732","article-title":"Three-dimensional structure of the mini-M conotoxin mr3a","volume":"43","author":"OM McDougal","year":"2004","journal-title":"Biochemistry"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00018-009-0125-0","article-title":"The M-superfamily of conotoxins: a review","volume":"67","author":"RB Jacob","year":"2010","journal-title":"Cell Mol Life Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0959-440X(96)80058-3","article-title":"Surprising similarities in structure comparison","volume":"6","author":"J-F Gibrat","year":"1996","journal-title":"Curr Opin Struct Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1107\/S0907444904026460","article-title":"Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions","volume":"60","author":"E Krissinel","year":"2004","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1002\/anie.201107011","article-title":"Structurally diverse \u00b5-conotoxin PIIIA isomers block sodium channel NaV 1.4","volume":"51","author":"AA Tietze","year":"2012","journal-title":"Angew Chem Int Ed Engl"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3390\/toxins5051043","article-title":"Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors","volume":"5","author":"Y Kendel","year":"2013","journal-title":"Toxins (Basel)"},{"key":"ref40","first-page":"1724","article-title":"An inordinate fondness for turrids. Deep-Sea Res","volume":"56","author":"P Bouchet","year":"2009","journal-title":"II"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ab.2008.02.025","article-title":"Picomole-level mapping of protein disulfides by mass spectrometry following partial reduction and alkylation","volume":"377","author":"SF Foley","year":"2008","journal-title":"Anal Biochem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00197809","article-title":"NMRPipe: a multidimensional spectral processing system based on UNIX pipes","volume":"6","author":"F Delaglio","year":"1995","journal-title":"J Biomol NMR"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/prot.20449","article-title":"The CCPN data model for NMR spectroscopy: development of a software pipeline","volume":"59","author":"WF Vranken","year":"2005","journal-title":"Proteins"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10858-009-9333-z","article-title":"TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts","volume":"44","author":"Y Shen","year":"2009","journal-title":"J Biomol NMR"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/bioinformatics\/btl589","article-title":"ARIA2: automated NOE assignment and data integration in NMR structure calculation","volume":"23","author":"W Rieping","year":"2007","journal-title":"Bioinformatics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","article-title":"Crystallography &amp; NMR System: A New Software Suite for Macromolecular Structure Determination","volume":"D54","author":"AT Br\u00fcnger","year":"1998","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF00228148","article-title":"AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR","volume":"8","author":"RA Laskowski","year":"1996","journal-title":"J Biomol NMR"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"23026","DOI":"10.1074\/jbc.M800084200","article-title":"Tyrosine-rich conopeptides affect voltage-gated K+ channels","volume":"283","author":"JS Imperial","year":"2008","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.toxicon.2007.12.007","article-title":"Two different groups of signal sequence in M-superfamily conotoxins","volume":"51","author":"Q Wang","year":"2008","journal-title":"Toxicon"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/bioinformatics\/btm596","article-title":"ConoServer, a database for conopeptide sequences and structures","volume":"24","author":"Q Kaas","year":"2008","journal-title":"Bioinformatics"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1021\/bi702388b","article-title":"Three-dimensional structure of conotoxin tx3a: An m-1 branch peptide of the M-superfamily","volume":"47","author":"OM McDougal","year":"2008","journal-title":"Biochemistry"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Franco A, Pisarewicz K, Moller C, Mora D, Fields GB, et al. (2006) Hyperhydroxylation: anew strategy for neuronal targeting by venomous marine molluscs. In Muller E.G. Werner, editor. Progress in Molecular and Subcellular Biology. Springer. pp. 83\u201399.","DOI":"10.1007\/978-3-540-30880-5_4"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.toxicon.2008.10.017","article-title":"Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from <italic>Conus bullatus<\/italic>","volume":"53","author":"M Holford","year":"2009","journal-title":"Toxicon"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1021\/bi052162j","article-title":"Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels","volume":"45","author":"M-M Zhang","year":"2006","journal-title":"Biochemistry"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"30699","DOI":"10.1074\/jbc.M704616200","article-title":"Structure\/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels","volume":"282","author":"M-M Zhang","year":"2007","journal-title":"J Biol Chem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/(SICI)1098-2299(199903\/04)46:3\/4<219::AID-DDR7>3.0.CO;2-S","article-title":"Conotoxins and their potential pharmaceutical applications","volume":"46","author":"DJ Adams","year":"1999","journal-title":"Drug Dev Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"15388","DOI":"10.1021\/bi0265628","article-title":"Mu-conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons","volume":"41","author":"PJ West","year":"2002","journal-title":"Biochemistry"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"10940","DOI":"10.1021\/bi801010u","article-title":"Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA","volume":"47","author":"S Yao","year":"2008","journal-title":"Biochemistry"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1523\/JNEUROSCI.18-12-04473.1998","article-title":"mu-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes","volume":"18","author":"KJ Shon","year":"1998","journal-title":"J Neurosci"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jasms.2006.05.017","article-title":"Side-chain fragmentation of alkylated cysteine residues in electron capture dissociation mass spectrometry","volume":"17","author":"RJ Chalkley","year":"2006","journal-title":"J Am Soc Mass Spectrom"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"46805","DOI":"10.1074\/jbc.M309222200","article-title":"Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA","volume":"278","author":"DW Keizer","year":"2003","journal-title":"J Biol Chem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"9826","DOI":"10.1021\/bi301256s","article-title":"Distinct disulfide isomers of \u00b5-conotoxins KIIIA and KIIIB block voltage-gated sodium channels","volume":"51","author":"KK Khoo","year":"2012","journal-title":"Biochemistry"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0094122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T10:04:36Z","timestamp":1565345076000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0094122"}},"subtitle":[],"editor":[{"given":"Paulo Lee","family":"Ho","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,4,8]]},"references-count":62,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0094122","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,8]]}}}