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Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/pag.ias2011.org\/session.aspx?s=54\" xlink:type=\"simple\">http:\/\/pag.ias2011.org\/session.aspx?s=54<\/ext-link>. Accessed 2014 March 25."},{"key":"ref10","unstructured":"INSERM U943 F-AC (n.d.) Retour d&apos;informations clinico-\u00e9pid\u00e9miologiques. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ccde.fr\" xlink:type=\"simple\">http:\/\/www.ccde.fr<\/ext-link>. Accessed 2014 March 25."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1097\/QAD.0b013e32833f4b1b","article-title":"Entry and retention in medical care among HIV-diagnosed persons: a meta-analysis","volume":"24","author":"G Marks","year":"2010","journal-title":"AIDS"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Lee M, Rayment M, Scourfield A, Gazzard B (2013) Comparison of two cohorts of patients presenting with AIDS: patients with previously known HIV diagnoses and true late presenters. Sex Transm Infect. doi:10.1136\/sextrans-2012-050966.","DOI":"10.1136\/sextrans-2012-050966"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3109\/00365548.2013.777778","article-title":"Pneumocystis jirovecii pneumonia in HIV-1-infected patients in the late-HAART era in developed countries","volume":"45","author":"JM Llibre","year":"2013","journal-title":"Scand J Infect Dis"},{"key":"ref14","unstructured":"Mary-Krause M, Grabar S, Li\u00e8vre L, Abgrall S, Costagliola D, <etal>et al<\/etal>.. (2014) Cohort Profile: French Hospital Database on HIV (FHDH-ANRS CO4). International Journal of Epidemiology. In press."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/00126334-200102010-00007","article-title":"Pneumocystis carinii pneumonia recurrence in HIV patients on highly active antiretroviral therapy: secondary prophylaxis","volume":"26","author":"S Abgrall","year":"2001","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1086\/695852","article-title":"The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options","volume":"48","author":"L Gazzola","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1086\/651689","article-title":"Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications","volume":"50","author":"E Negredo","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jcv.2011.09.018","article-title":"CD4 T cell nadir independently predicts the magnitude of the HIV reservoir after prolonged suppressive antiretroviral therapy","volume":"53","author":"M-R Boulassel","year":"2012","journal-title":"J Clin Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1086\/655151","article-title":"Rate of CD4+ cell count increase over periods of viral load suppression: relationship with the number of previous virological failures","volume":"51","author":"MP Trotta","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/ije\/dyr164","article-title":"All-cause mortality in treated HIV-infected adults with CD4\u2265500\/mm3 compared with the general population: evidence from a large European observational cohort collaboration","volume":"41","author":"C Lewden","year":"2012","journal-title":"Int J Epidemiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0094183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:22:16Z","timestamp":1540340536000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0094183"}},"subtitle":[],"editor":[{"given":"Wenzhe","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,4,11]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0094183","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,11]]}}}