{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:02:06Z","timestamp":1792501326245,"version":"4.5.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0094653","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T17:10:15Z","timestamp":1397149815000},"page":"e94653","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":74,"title":["Host and Bacterial Proteins That Repress Recruitment of LC3 to Shigella Early during Infection"],"prefix":"10.1371","volume":"9","author":[{"given":"Leigh A.","family":"Baxt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia B.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3201\/eid0505.990502","article-title":"Food-related illness and death in the United States","volume":"5","author":"PS Mead","year":"1999","journal-title":"Emerg Infect Dis"},{"key":"ref2","first-page":"651","article-title":"Global burden of Shigella infections: implications for vaccine development and implementation of control strategies","volume":"77","author":"KL Kotloff","year":"1999","journal-title":"Bulletin of the World Health Organization"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study","volume":"382","author":"KL Kotloff","year":"2013","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1128\/IAI.55.11.2681-2688.1987","article-title":"Entry of Shigella flexneri into HeLa cells: evidence for directed phagocytosis involving actin polymerization and myosin accumulation","volume":"55","author":"P Clerc","year":"1987","journal-title":"Infect Immun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1002\/j.1460-2075.1994.tb06863.x","article-title":"The secretion of the Shigella flexneri Ipa invasins is activated by epithelial cells and controlled by IpaB and IpaD","volume":"13","author":"R Menard","year":"1994","journal-title":"EMBO J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1128\/MMBR.65.4.595-626.2001","article-title":"Actin-based motility of intracellular microbial pathogens","volume":"65","author":"MB Goldberg","year":"2001","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/embo-reports\/kve197","article-title":"Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells","volume":"2","author":"S Lommel","year":"2001","journal-title":"EMBO Rep"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ncb1001-897","article-title":"N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility","volume":"3","author":"SB Snapper","year":"2001","journal-title":"Nat Cell Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1083\/jcb.146.6.1319","article-title":"Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2\/3 complex and bacterial actin-based motility","volume":"146","author":"C Egile","year":"1999","journal-title":"J Cell Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1093\/emboj\/17.10.2767","article-title":"Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri","volume":"17","author":"T Suzuki","year":"1998","journal-title":"EMBO J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.chom.2007.10.011","article-title":"Bacterial actin assembly requires toca-1 to relieve N-wasp autoinhibition","volume":"3","author":"Y Leung","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cell.2004.06.027","article-title":"Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex","volume":"118","author":"HY Ho","year":"2004","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1083\/jcb.200403127","article-title":"Regulation of WASP\/WAVE proteins: making a long story short","volume":"166","author":"G Bompard","year":"2004","journal-title":"J Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1126\/science.1235771","article-title":"Bacterial subversion of host innate immune pathways","volume":"340","author":"LA Baxt","year":"2013","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.1106036","article-title":"Escape of intracellular Shigella from autophagy","volume":"307","author":"M Ogawa","year":"2005","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nature06421","article-title":"Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis","volume":"450","author":"MA Sanjuan","year":"2007","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"985","DOI":"10.4161\/auto.24406","article-title":"Host and bacterial factors that regulate LC3 recruitment to Listeria monocytogenes during the early stages of macrophage infection","volume":"9","author":"GY Lam","year":"2013","journal-title":"Autophagy"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"17396","DOI":"10.1073\/pnas.1113421108","article-title":"Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells","volume":"108","author":"J Martinez","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"KA Datsenko","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/jnci\/51.5.1417","article-title":"In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors","volume":"51","author":"DJ Giard","year":"1973","journal-title":"J Natl Cancer Inst"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1074\/jbc.M110.157974","article-title":"Transducer of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasiveness","volume":"286","author":"J Hu","year":"2011","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"10465","DOI":"10.1073\/pnas.0611308104","article-title":"IQGAP1 modulates activation of B-Raf","volume":"104","author":"JG Ren","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ni.1823","article-title":"Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry","volume":"11","author":"LH Travassos","year":"2010","journal-title":"Nat Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.chom.2010.07.002","article-title":"A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy","volume":"8","author":"S Shahnazari","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4049\/jimmunol.1102108","article-title":"Autophagy: an emerging immunological paradigm","volume":"189","author":"V Deretic","year":"2012","journal-title":"J Immunology"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Boyle KB, Randow F (2013) The role of \u2018eat-me\u2019 signals and autophagy cargo receptors in innate immunity. Curr Opin Microbiol.","DOI":"10.1016\/j.mib.2013.03.010"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"744","DOI":"10.4161\/auto.6246","article-title":"Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines","volume":"4","author":"M Cullinane","year":"2008","journal-title":"Autophagy"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1073\/pnas.0811045106","article-title":"Activation of antibacterial autophagy by NADPH oxidases","volume":"106","author":"J Huang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e8610","DOI":"10.1371\/journal.pone.0008610","article-title":"Listeriolysin O is necessary and sufficient to induce autophagy during Listeria monocytogenes infection","volume":"5","author":"N Meyer-Morse","year":"2010","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.chom.2009.07.005","article-title":"Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy","volume":"6","author":"N Dupont","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1128\/IAI.51.2.461-469.1986","article-title":"Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid-mediated contact hemolysis","volume":"51","author":"PJ Sansonetti","year":"1986","journal-title":"Infect Immun"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1023\/B:GLYC.0000014072.34840.04","article-title":"Introduction to galectins","volume":"19","author":"H Leffler","year":"2004","journal-title":"Glycoconj J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1462-5822.2009.01415.x","article-title":"Galectin-3, a marker for vacuole lysis by invasive pathogens","volume":"12","author":"I Paz","year":"2010","journal-title":"Cell Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nature10744","article-title":"Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion","volume":"482","author":"TL Thurston","year":"2012","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.4049\/jimmunol.0803050","article-title":"A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy","volume":"182","author":"A Huett","year":"2009","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1462-5822.2008.01251.x","article-title":"Modulation of ubiquitin dynamics and suppression of DALIS formation by the Legionella pneumophila Dot\/Icm system","volume":"11","author":"SS Ivanov","year":"2009","journal-title":"Cell Microbiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e1002743","DOI":"10.1371\/journal.ppat.1002743","article-title":"The Salmonella deubiquitinase SseL inhibits selective autophagy of cytosolic aggregates","volume":"8","author":"FS Mesquita","year":"2012","journal-title":"PLoS Pathogens"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.chom.2012.04.012","article-title":"Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program","volume":"11","author":"I Tattoli","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e17852","DOI":"10.1371\/journal.pone.0017852","article-title":"The Burkholderia pseudomallei type III secretion system and BopA are required for evasion of LC3-associated phagocytosis","volume":"6","author":"L Gong","year":"2011","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.chom.2011.04.010","article-title":"A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens","volume":"9","author":"M Ogawa","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1073\/pnas.86.10.3867","article-title":"Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin","volume":"86","author":"ML Bernardini","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1128\/jb.171.1.353-359.1989","article-title":"<italic>virG<\/italic>, a plasmid-coded virulence gene of <italic>Shigella flexneri<\/italic>: identification of the <italic>virG<\/italic> protein and determination of the complete coding sequence","volume":"171","author":"M-C Lett","year":"1989","journal-title":"J Bacteriol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e1000675","DOI":"10.1371\/journal.pgen.1000675","article-title":"Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis","volume":"5","author":"C Giuliani","year":"2009","journal-title":"PLoS Genetics"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1242\/jcs.118422","article-title":"The F-BAR protein Cip4\/Toca-1 antagonizes the formin Diaphanous in membrane stabilization and compartmentalization","volume":"126","author":"S Yan","year":"2013","journal-title":"J Cell Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.cub.2009.07.058","article-title":"Drosophila Cip4\/Toca-1 integrates membrane trafficking and actin dynamics through WASP and SCAR\/WAVE","volume":"19","author":"R Fricke","year":"2009","journal-title":"Curr Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.semcdb.2013.01.005","article-title":"Biochemical and functional significance of F-BAR domain proteins interaction with WASP\/N-WASP","volume":"24","author":"Y Chen","year":"2013","journal-title":"Sem Cell Dev Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1128\/JB.88.5.1503-1518.1964","article-title":"Epithelial Cell Penetration as an Essential Step in the Pathogenesis of Bacillary Dysentery","volume":"88","author":"EH Labrec","year":"1964","journal-title":"J Bacteriol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-2958.1999.01356.x","article-title":"The unipolar Shigella surface protein IcsA is targeted directly to the bacterial old pole: IcsP cleavage of IcsA occurs over the entire bacterial surface","volume":"32","author":"J Steinhauer","year":"1999","journal-title":"Mol Microbiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","article-title":"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing","volume":"19","author":"Y Kabeya","year":"2000","journal-title":"EMBO J"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0094653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T12:10:43Z","timestamp":1597666243000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0094653"}},"subtitle":[],"editor":[{"given":"Dipshikha","family":"Chakravortty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,4,10]]},"references-count":49,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0094653","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,10]]}}}